Table 2 Open in new tab Relationship...

Highest Level of Play	Adjusted for Age at Death^a	Further Adjusted for Selection Bias^b
High school	1.00	Referent		1.00	Referent
College	1.82	1.23, 2.68	1.77	2.38	1.16, 5.94	2.00
Professional	2.13	1.44, 3.08	2.08	2.47	1.46, 4.79	2.25

Highest Level of Play	Adjusted for Age at Death^a	Further Adjusted for Selection Bias^b
High school	1.00	Referent		1.00	Referent
College	1.82	1.23, 2.68	1.77	2.38	1.16, 5.94	2.00
Professional	2.13	1.44, 3.08	2.08	2.47	1.46, 4.79	2.25

Table 2

Relationship Between Highest Level of American Football Played and Diagnosis of CTE, Before and After Adjustment for Selection Bias, When CTE Was Conditioned on Death Among Brain Donors From the VA-BU-CLF Brain Bank, 2008–2019

Highest Level of Play	Adjusted for Age at Death^a			Further Adjusted for Selection Bias^b
Highest Level of Play	Mean RR	95% CI	Median RR	Mean RR	95% SI	Median RR
High school	1.00	Referent		1.00	Referent
College	1.82	1.23, 2.68	1.77	2.38	1.16, 5.94	2.00
Professional	2.13	1.44, 3.08	2.08	2.47	1.46, 4.79	2.25

Highest Level of Play	Adjusted for Age at Death^a			Further Adjusted for Selection Bias^b
Highest Level of Play	Mean RR	95% CI	Median RR	Mean RR	95% SI	Median RR
High school	1.00	Referent		1.00	Referent
College	1.82	1.23, 2.68	1.77	2.38	1.16, 5.94	2.00
Professional	2.13	1.44, 3.08	2.08	2.47	1.46, 4.79	2.25

Abbreviations: CI, confidence interval; CTE, chronic traumatic encephalopathy; RR, risk ratio; SI, simulation interval; VA-BU-CLF, Veterans Affairs–Boston University–Concussion Legacy Foundation.

^a The RR estimate is the mean (and median) value of the bootstrapped distribution; the 95% CI was constructed from the 2.5th and 97.5th percentiles of the bootstrapped distribution.

^b The RR estimate is the mean (and median) value of the sampling distribution; the 95% SI was constructed from the 2.5th and 97.5th percentiles of the sampling distribution.

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