| ApoA1 level (g/L) . | 0.42–1.17 . | 1.18–1.24 . | 1.25–1.30 . | 1.31–1.36 . | 1.37–1.41 . | 1.42–1.47 . | 1.48–1.53 . | 1.54–1.61 . | 1.62–1.73 . | 1.74–2.50 . | P-value . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | 18 198 | 18 106 | 18 214 | 18 137 | 17 987 | 18 253 | 18 087 | 18 028 | 18 135 | 18 111 | |
| Age, years | 54.8 ± 8.5 | 55.2 ± 8.4 | 55.6 ± 8.3 | 55.9 ± 8.3 | 56.1 ± 8.2 | 56.4 ± 8.1 | 56.6 ± 8.1 | 57.0 ± 8.0 | 57.3 ± 7.9 | 57.9 ± 7.7 | <0.001 |
| White (%) | 14 346 (78.83) | 14 669 (81.02) | 15 003 (82.37) | 15 050 (82.98) | 15 091 (83.9) | 15 343 (84.06) | 15 315 (84.67) | 15 427 (85.57) | 15 464 (85.27) | 15 458 (85.35) | <0.001 |
| Hypertension (%) | 5608 (31.03) | 5375 (29.82) | 5281 (29.11) | 5171 (28.62) | 5047 (28.13) | 4931 (27.1) | 4907 (27.2) | 4853 (27) | 4806 (26.57) | 5158 (28.56) | <0.001 |
| Diabetes (%) | 2062 (11.42) | 1512 (8.41) | 1245 (6.87) | 1153 (6.39) | 914 (5.1) | 863 (4.74) | 815 (4.52) | 715 (3.98) | 675 (3.73) | 613 (3.4) | <0.001 |
| eGFR, mL/min/1.73 m2 | 91.6 ± 14.6 | 91.5 ± 13.7 | 91.3 ± 13.2 | 91.1 ± 13.2 | 91.1 ± 12.8 | 91.0 ± 12.7 | 91.3 ± 12.5 | 91.1 ± 12.4 | 91.5 ± 12.1 | 91.7 ± 12.1 | <0.001 |
| Frequent alcohol use (%)a | 5088 (28.09) | 6405 (35.47) | 7394 (40.72) | 8120 (44.88) | 8806 (49.04) | 9734 (53.41) | 10 509 (58.19) | 11 328 (62.95) | 12 537 (69.25) | 14 114 (78.09) | <0.001 |
| Alcohol use, graded 0–5 b | 2.6 ± 1.5 | 2.9 ± 1.5 | 3.0 ± 1.5 | 3.2 ± 1.4 | 3.3 ± 1.4 | 3.4 ± 1.4 | 3.6 ± 1.3 | 3.7 ± 1.3 | 3.9 ± 1.2 | 4.2 ± 1.1 | <0.001 |
| Current/former smoker (%) | 9083 (50.29) | 8788 (48.82) | 8755 (48.32) | 8597 (47.66) | 8636 (48.25) | 8850 (48.69) | 8735 (48.49) | 8893 (49.57) | 9310 (51.57) | 9854 (54.6) | <0.001 |
| BMI, kg/m2 | 29.4 ± 4.6 | 28.9 ± 4.4 | 28.5 ± 4.2 | 28.2 ± 4.1 | 27.9 ± 4.1 | 27.6 ± 3.9 | 27.3 ± 3.9 | 27.0 ± 3.8 | 26.6 ± 3.7 | 25.9 ± 3.6 | <0.001 |
| Total cholesterol, mg/dL | 194.3 ± 44.0 | 204.9 ± 42.0 | 210.1 ± 41.9 | 212.2 ± 41.5 | 215.0 ± 41.2 | 217.7 ± 40.5 | 220.2 ± 40.3 | 222.8 ± 39.9 | 226.1 ± 39.1 | 233.2 ± 38.7 | <0.001 |
| LDL-C, mg/dL | 128.2 ± 33.1 | 134.8 ± 32.6 | 137.4 ± 32.6 | 138.2 ± 32.6 | 139.0 ± 32.5 | 139.7 ± 32.0 | 140.0 ± 32.2 | 139.9 ± 31.9 | 139.2 ± 31.5 | 137.4 ± 31.5 | <0.001 |
| HDL-C, mg/dL | 34.2 ± 4.4 | 39.2 ± 3.9 | 42.0 ± 4.0 | 44.6 ± 4.1 | 47.0 ± 4.3 | 49.6 ± 4.5 | 52.5 ± 4.8 | 56.0 ± 5.2 | 60.9 ± 5.9 | 71.8 ± 10.1 | <0.001 |
| Triglycerides, mg/dL | 224.9 ± 132.5 | 205.4 ± 112.5 | 196.9 ± 107.4 | 184.1 ± 99.1 | 177.0 ± 96.1 | 169.1 ± 92.2 | 162.1 ± 87.5 | 153.9 ± 84.2 | 145.3 ± 81.6 | 132.6 ± 78.7 | <0.001 |
| Testosterone, nmol/L | 11.2 ± 3.7 | 11.4 ± 3.6 | 11.6 ± 3.6 | 11.8 ± 3.6 | 12.0 ± 3.6 | 12.2 ± 3.6 | 12.3 ± 3.7 | 12.5 ± 3.7 | 12.7 ± 3.8 | 12.9 ± 3.9 | <0.001 |
| PGS (z score) | −0.47 ± 0.99 | −0.30 ± 0.96 | −0.18 ± 0.96 | −0.09 ± 0.96 | −0.03 ± 0.94 | 0.04 ± 0.95 | 0.11 ± 0.96 | 0.21 ± 0.96 | 0.30 ± 0.98 | 0.48 ± 0.98 | <0.001 |
| All-cause death (%) | 1813 (9.96) | 1520 (8.4) | 1371 (7.53) | 1315 (7.25) | 1279 (7.11) | 1261 (6.91) | 1245 (6.88) | 1264 (7.01) | 1327 (7.32) | 1658 (9.15) | <0.001 |
| Cardiovascular death (%) | 677 (3.72) | 539 (2.98) | 470 (2.58) | 418 (2.3) | 446 (2.48) | 432 (2.37) | 374 (2.07) | 417 (2.31) | 384 (2.12) | 526 (2.9) | <0.001 |
| ApoA1 level (g/L) . | 0.42–1.17 . | 1.18–1.24 . | 1.25–1.30 . | 1.31–1.36 . | 1.37–1.41 . | 1.42–1.47 . | 1.48–1.53 . | 1.54–1.61 . | 1.62–1.73 . | 1.74–2.50 . | P-value . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | 18 198 | 18 106 | 18 214 | 18 137 | 17 987 | 18 253 | 18 087 | 18 028 | 18 135 | 18 111 | |
| Age, years | 54.8 ± 8.5 | 55.2 ± 8.4 | 55.6 ± 8.3 | 55.9 ± 8.3 | 56.1 ± 8.2 | 56.4 ± 8.1 | 56.6 ± 8.1 | 57.0 ± 8.0 | 57.3 ± 7.9 | 57.9 ± 7.7 | <0.001 |
| White (%) | 14 346 (78.83) | 14 669 (81.02) | 15 003 (82.37) | 15 050 (82.98) | 15 091 (83.9) | 15 343 (84.06) | 15 315 (84.67) | 15 427 (85.57) | 15 464 (85.27) | 15 458 (85.35) | <0.001 |
| Hypertension (%) | 5608 (31.03) | 5375 (29.82) | 5281 (29.11) | 5171 (28.62) | 5047 (28.13) | 4931 (27.1) | 4907 (27.2) | 4853 (27) | 4806 (26.57) | 5158 (28.56) | <0.001 |
| Diabetes (%) | 2062 (11.42) | 1512 (8.41) | 1245 (6.87) | 1153 (6.39) | 914 (5.1) | 863 (4.74) | 815 (4.52) | 715 (3.98) | 675 (3.73) | 613 (3.4) | <0.001 |
| eGFR, mL/min/1.73 m2 | 91.6 ± 14.6 | 91.5 ± 13.7 | 91.3 ± 13.2 | 91.1 ± 13.2 | 91.1 ± 12.8 | 91.0 ± 12.7 | 91.3 ± 12.5 | 91.1 ± 12.4 | 91.5 ± 12.1 | 91.7 ± 12.1 | <0.001 |
| Frequent alcohol use (%)a | 5088 (28.09) | 6405 (35.47) | 7394 (40.72) | 8120 (44.88) | 8806 (49.04) | 9734 (53.41) | 10 509 (58.19) | 11 328 (62.95) | 12 537 (69.25) | 14 114 (78.09) | <0.001 |
| Alcohol use, graded 0–5 b | 2.6 ± 1.5 | 2.9 ± 1.5 | 3.0 ± 1.5 | 3.2 ± 1.4 | 3.3 ± 1.4 | 3.4 ± 1.4 | 3.6 ± 1.3 | 3.7 ± 1.3 | 3.9 ± 1.2 | 4.2 ± 1.1 | <0.001 |
| Current/former smoker (%) | 9083 (50.29) | 8788 (48.82) | 8755 (48.32) | 8597 (47.66) | 8636 (48.25) | 8850 (48.69) | 8735 (48.49) | 8893 (49.57) | 9310 (51.57) | 9854 (54.6) | <0.001 |
| BMI, kg/m2 | 29.4 ± 4.6 | 28.9 ± 4.4 | 28.5 ± 4.2 | 28.2 ± 4.1 | 27.9 ± 4.1 | 27.6 ± 3.9 | 27.3 ± 3.9 | 27.0 ± 3.8 | 26.6 ± 3.7 | 25.9 ± 3.6 | <0.001 |
| Total cholesterol, mg/dL | 194.3 ± 44.0 | 204.9 ± 42.0 | 210.1 ± 41.9 | 212.2 ± 41.5 | 215.0 ± 41.2 | 217.7 ± 40.5 | 220.2 ± 40.3 | 222.8 ± 39.9 | 226.1 ± 39.1 | 233.2 ± 38.7 | <0.001 |
| LDL-C, mg/dL | 128.2 ± 33.1 | 134.8 ± 32.6 | 137.4 ± 32.6 | 138.2 ± 32.6 | 139.0 ± 32.5 | 139.7 ± 32.0 | 140.0 ± 32.2 | 139.9 ± 31.9 | 139.2 ± 31.5 | 137.4 ± 31.5 | <0.001 |
| HDL-C, mg/dL | 34.2 ± 4.4 | 39.2 ± 3.9 | 42.0 ± 4.0 | 44.6 ± 4.1 | 47.0 ± 4.3 | 49.6 ± 4.5 | 52.5 ± 4.8 | 56.0 ± 5.2 | 60.9 ± 5.9 | 71.8 ± 10.1 | <0.001 |
| Triglycerides, mg/dL | 224.9 ± 132.5 | 205.4 ± 112.5 | 196.9 ± 107.4 | 184.1 ± 99.1 | 177.0 ± 96.1 | 169.1 ± 92.2 | 162.1 ± 87.5 | 153.9 ± 84.2 | 145.3 ± 81.6 | 132.6 ± 78.7 | <0.001 |
| Testosterone, nmol/L | 11.2 ± 3.7 | 11.4 ± 3.6 | 11.6 ± 3.6 | 11.8 ± 3.6 | 12.0 ± 3.6 | 12.2 ± 3.6 | 12.3 ± 3.7 | 12.5 ± 3.7 | 12.7 ± 3.8 | 12.9 ± 3.9 | <0.001 |
| PGS (z score) | −0.47 ± 0.99 | −0.30 ± 0.96 | −0.18 ± 0.96 | −0.09 ± 0.96 | −0.03 ± 0.94 | 0.04 ± 0.95 | 0.11 ± 0.96 | 0.21 ± 0.96 | 0.30 ± 0.98 | 0.48 ± 0.98 | <0.001 |
| All-cause death (%) | 1813 (9.96) | 1520 (8.4) | 1371 (7.53) | 1315 (7.25) | 1279 (7.11) | 1261 (6.91) | 1245 (6.88) | 1264 (7.01) | 1327 (7.32) | 1658 (9.15) | <0.001 |
| Cardiovascular death (%) | 677 (3.72) | 539 (2.98) | 470 (2.58) | 418 (2.3) | 446 (2.48) | 432 (2.37) | 374 (2.07) | 417 (2.31) | 384 (2.12) | 526 (2.9) | <0.001 |
Mean ± SD shown unless stated. GFR, glomerular filtration rate; BMI, body mass index; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; PGS, polygenic score. ANOVA for continuous variables and χ2 test for categorical variables were used to compare clinical characteristics across ApoA1 groups.
Frequent alcohol use defined as alcohol consumption ≥3 times per week.
Alcohol use quantified as graded variable as follows: 0 = Never; 1 = Special occasions only; 2 = One to three times a month; 3 = Once or twice a week; 4 = Three or four times a week; 5 = Daily or almost daily.
| ApoA1 level (g/L) . | 0.42–1.17 . | 1.18–1.24 . | 1.25–1.30 . | 1.31–1.36 . | 1.37–1.41 . | 1.42–1.47 . | 1.48–1.53 . | 1.54–1.61 . | 1.62–1.73 . | 1.74–2.50 . | P-value . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | 18 198 | 18 106 | 18 214 | 18 137 | 17 987 | 18 253 | 18 087 | 18 028 | 18 135 | 18 111 | |
| Age, years | 54.8 ± 8.5 | 55.2 ± 8.4 | 55.6 ± 8.3 | 55.9 ± 8.3 | 56.1 ± 8.2 | 56.4 ± 8.1 | 56.6 ± 8.1 | 57.0 ± 8.0 | 57.3 ± 7.9 | 57.9 ± 7.7 | <0.001 |
| White (%) | 14 346 (78.83) | 14 669 (81.02) | 15 003 (82.37) | 15 050 (82.98) | 15 091 (83.9) | 15 343 (84.06) | 15 315 (84.67) | 15 427 (85.57) | 15 464 (85.27) | 15 458 (85.35) | <0.001 |
| Hypertension (%) | 5608 (31.03) | 5375 (29.82) | 5281 (29.11) | 5171 (28.62) | 5047 (28.13) | 4931 (27.1) | 4907 (27.2) | 4853 (27) | 4806 (26.57) | 5158 (28.56) | <0.001 |
| Diabetes (%) | 2062 (11.42) | 1512 (8.41) | 1245 (6.87) | 1153 (6.39) | 914 (5.1) | 863 (4.74) | 815 (4.52) | 715 (3.98) | 675 (3.73) | 613 (3.4) | <0.001 |
| eGFR, mL/min/1.73 m2 | 91.6 ± 14.6 | 91.5 ± 13.7 | 91.3 ± 13.2 | 91.1 ± 13.2 | 91.1 ± 12.8 | 91.0 ± 12.7 | 91.3 ± 12.5 | 91.1 ± 12.4 | 91.5 ± 12.1 | 91.7 ± 12.1 | <0.001 |
| Frequent alcohol use (%)a | 5088 (28.09) | 6405 (35.47) | 7394 (40.72) | 8120 (44.88) | 8806 (49.04) | 9734 (53.41) | 10 509 (58.19) | 11 328 (62.95) | 12 537 (69.25) | 14 114 (78.09) | <0.001 |
| Alcohol use, graded 0–5 b | 2.6 ± 1.5 | 2.9 ± 1.5 | 3.0 ± 1.5 | 3.2 ± 1.4 | 3.3 ± 1.4 | 3.4 ± 1.4 | 3.6 ± 1.3 | 3.7 ± 1.3 | 3.9 ± 1.2 | 4.2 ± 1.1 | <0.001 |
| Current/former smoker (%) | 9083 (50.29) | 8788 (48.82) | 8755 (48.32) | 8597 (47.66) | 8636 (48.25) | 8850 (48.69) | 8735 (48.49) | 8893 (49.57) | 9310 (51.57) | 9854 (54.6) | <0.001 |
| BMI, kg/m2 | 29.4 ± 4.6 | 28.9 ± 4.4 | 28.5 ± 4.2 | 28.2 ± 4.1 | 27.9 ± 4.1 | 27.6 ± 3.9 | 27.3 ± 3.9 | 27.0 ± 3.8 | 26.6 ± 3.7 | 25.9 ± 3.6 | <0.001 |
| Total cholesterol, mg/dL | 194.3 ± 44.0 | 204.9 ± 42.0 | 210.1 ± 41.9 | 212.2 ± 41.5 | 215.0 ± 41.2 | 217.7 ± 40.5 | 220.2 ± 40.3 | 222.8 ± 39.9 | 226.1 ± 39.1 | 233.2 ± 38.7 | <0.001 |
| LDL-C, mg/dL | 128.2 ± 33.1 | 134.8 ± 32.6 | 137.4 ± 32.6 | 138.2 ± 32.6 | 139.0 ± 32.5 | 139.7 ± 32.0 | 140.0 ± 32.2 | 139.9 ± 31.9 | 139.2 ± 31.5 | 137.4 ± 31.5 | <0.001 |
| HDL-C, mg/dL | 34.2 ± 4.4 | 39.2 ± 3.9 | 42.0 ± 4.0 | 44.6 ± 4.1 | 47.0 ± 4.3 | 49.6 ± 4.5 | 52.5 ± 4.8 | 56.0 ± 5.2 | 60.9 ± 5.9 | 71.8 ± 10.1 | <0.001 |
| Triglycerides, mg/dL | 224.9 ± 132.5 | 205.4 ± 112.5 | 196.9 ± 107.4 | 184.1 ± 99.1 | 177.0 ± 96.1 | 169.1 ± 92.2 | 162.1 ± 87.5 | 153.9 ± 84.2 | 145.3 ± 81.6 | 132.6 ± 78.7 | <0.001 |
| Testosterone, nmol/L | 11.2 ± 3.7 | 11.4 ± 3.6 | 11.6 ± 3.6 | 11.8 ± 3.6 | 12.0 ± 3.6 | 12.2 ± 3.6 | 12.3 ± 3.7 | 12.5 ± 3.7 | 12.7 ± 3.8 | 12.9 ± 3.9 | <0.001 |
| PGS (z score) | −0.47 ± 0.99 | −0.30 ± 0.96 | −0.18 ± 0.96 | −0.09 ± 0.96 | −0.03 ± 0.94 | 0.04 ± 0.95 | 0.11 ± 0.96 | 0.21 ± 0.96 | 0.30 ± 0.98 | 0.48 ± 0.98 | <0.001 |
| All-cause death (%) | 1813 (9.96) | 1520 (8.4) | 1371 (7.53) | 1315 (7.25) | 1279 (7.11) | 1261 (6.91) | 1245 (6.88) | 1264 (7.01) | 1327 (7.32) | 1658 (9.15) | <0.001 |
| Cardiovascular death (%) | 677 (3.72) | 539 (2.98) | 470 (2.58) | 418 (2.3) | 446 (2.48) | 432 (2.37) | 374 (2.07) | 417 (2.31) | 384 (2.12) | 526 (2.9) | <0.001 |
| ApoA1 level (g/L) . | 0.42–1.17 . | 1.18–1.24 . | 1.25–1.30 . | 1.31–1.36 . | 1.37–1.41 . | 1.42–1.47 . | 1.48–1.53 . | 1.54–1.61 . | 1.62–1.73 . | 1.74–2.50 . | P-value . |
|---|---|---|---|---|---|---|---|---|---|---|---|
| n (%) | 18 198 | 18 106 | 18 214 | 18 137 | 17 987 | 18 253 | 18 087 | 18 028 | 18 135 | 18 111 | |
| Age, years | 54.8 ± 8.5 | 55.2 ± 8.4 | 55.6 ± 8.3 | 55.9 ± 8.3 | 56.1 ± 8.2 | 56.4 ± 8.1 | 56.6 ± 8.1 | 57.0 ± 8.0 | 57.3 ± 7.9 | 57.9 ± 7.7 | <0.001 |
| White (%) | 14 346 (78.83) | 14 669 (81.02) | 15 003 (82.37) | 15 050 (82.98) | 15 091 (83.9) | 15 343 (84.06) | 15 315 (84.67) | 15 427 (85.57) | 15 464 (85.27) | 15 458 (85.35) | <0.001 |
| Hypertension (%) | 5608 (31.03) | 5375 (29.82) | 5281 (29.11) | 5171 (28.62) | 5047 (28.13) | 4931 (27.1) | 4907 (27.2) | 4853 (27) | 4806 (26.57) | 5158 (28.56) | <0.001 |
| Diabetes (%) | 2062 (11.42) | 1512 (8.41) | 1245 (6.87) | 1153 (6.39) | 914 (5.1) | 863 (4.74) | 815 (4.52) | 715 (3.98) | 675 (3.73) | 613 (3.4) | <0.001 |
| eGFR, mL/min/1.73 m2 | 91.6 ± 14.6 | 91.5 ± 13.7 | 91.3 ± 13.2 | 91.1 ± 13.2 | 91.1 ± 12.8 | 91.0 ± 12.7 | 91.3 ± 12.5 | 91.1 ± 12.4 | 91.5 ± 12.1 | 91.7 ± 12.1 | <0.001 |
| Frequent alcohol use (%)a | 5088 (28.09) | 6405 (35.47) | 7394 (40.72) | 8120 (44.88) | 8806 (49.04) | 9734 (53.41) | 10 509 (58.19) | 11 328 (62.95) | 12 537 (69.25) | 14 114 (78.09) | <0.001 |
| Alcohol use, graded 0–5 b | 2.6 ± 1.5 | 2.9 ± 1.5 | 3.0 ± 1.5 | 3.2 ± 1.4 | 3.3 ± 1.4 | 3.4 ± 1.4 | 3.6 ± 1.3 | 3.7 ± 1.3 | 3.9 ± 1.2 | 4.2 ± 1.1 | <0.001 |
| Current/former smoker (%) | 9083 (50.29) | 8788 (48.82) | 8755 (48.32) | 8597 (47.66) | 8636 (48.25) | 8850 (48.69) | 8735 (48.49) | 8893 (49.57) | 9310 (51.57) | 9854 (54.6) | <0.001 |
| BMI, kg/m2 | 29.4 ± 4.6 | 28.9 ± 4.4 | 28.5 ± 4.2 | 28.2 ± 4.1 | 27.9 ± 4.1 | 27.6 ± 3.9 | 27.3 ± 3.9 | 27.0 ± 3.8 | 26.6 ± 3.7 | 25.9 ± 3.6 | <0.001 |
| Total cholesterol, mg/dL | 194.3 ± 44.0 | 204.9 ± 42.0 | 210.1 ± 41.9 | 212.2 ± 41.5 | 215.0 ± 41.2 | 217.7 ± 40.5 | 220.2 ± 40.3 | 222.8 ± 39.9 | 226.1 ± 39.1 | 233.2 ± 38.7 | <0.001 |
| LDL-C, mg/dL | 128.2 ± 33.1 | 134.8 ± 32.6 | 137.4 ± 32.6 | 138.2 ± 32.6 | 139.0 ± 32.5 | 139.7 ± 32.0 | 140.0 ± 32.2 | 139.9 ± 31.9 | 139.2 ± 31.5 | 137.4 ± 31.5 | <0.001 |
| HDL-C, mg/dL | 34.2 ± 4.4 | 39.2 ± 3.9 | 42.0 ± 4.0 | 44.6 ± 4.1 | 47.0 ± 4.3 | 49.6 ± 4.5 | 52.5 ± 4.8 | 56.0 ± 5.2 | 60.9 ± 5.9 | 71.8 ± 10.1 | <0.001 |
| Triglycerides, mg/dL | 224.9 ± 132.5 | 205.4 ± 112.5 | 196.9 ± 107.4 | 184.1 ± 99.1 | 177.0 ± 96.1 | 169.1 ± 92.2 | 162.1 ± 87.5 | 153.9 ± 84.2 | 145.3 ± 81.6 | 132.6 ± 78.7 | <0.001 |
| Testosterone, nmol/L | 11.2 ± 3.7 | 11.4 ± 3.6 | 11.6 ± 3.6 | 11.8 ± 3.6 | 12.0 ± 3.6 | 12.2 ± 3.6 | 12.3 ± 3.7 | 12.5 ± 3.7 | 12.7 ± 3.8 | 12.9 ± 3.9 | <0.001 |
| PGS (z score) | −0.47 ± 0.99 | −0.30 ± 0.96 | −0.18 ± 0.96 | −0.09 ± 0.96 | −0.03 ± 0.94 | 0.04 ± 0.95 | 0.11 ± 0.96 | 0.21 ± 0.96 | 0.30 ± 0.98 | 0.48 ± 0.98 | <0.001 |
| All-cause death (%) | 1813 (9.96) | 1520 (8.4) | 1371 (7.53) | 1315 (7.25) | 1279 (7.11) | 1261 (6.91) | 1245 (6.88) | 1264 (7.01) | 1327 (7.32) | 1658 (9.15) | <0.001 |
| Cardiovascular death (%) | 677 (3.72) | 539 (2.98) | 470 (2.58) | 418 (2.3) | 446 (2.48) | 432 (2.37) | 374 (2.07) | 417 (2.31) | 384 (2.12) | 526 (2.9) | <0.001 |
Mean ± SD shown unless stated. GFR, glomerular filtration rate; BMI, body mass index; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; PGS, polygenic score. ANOVA for continuous variables and χ2 test for categorical variables were used to compare clinical characteristics across ApoA1 groups.
Frequent alcohol use defined as alcohol consumption ≥3 times per week.
Alcohol use quantified as graded variable as follows: 0 = Never; 1 = Special occasions only; 2 = One to three times a month; 3 = Once or twice a week; 4 = Three or four times a week; 5 = Daily or almost daily.
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