Engineered regulatory pathways in model strains to increase cellulase production in the presence of cellulosic substrates.
| Wild-type strain . | Target regulatory genes . | Regulatory elements . | Increase in cellulase activity . | Ref. . |
|---|---|---|---|---|
| N. crassa OR8-1a | gna-3,gnb-1 | Transporter involved in CCR | >3-fold | Collier et al. (2020) |
| N. crassa 74-OR23-1V | clr-2 | Transcription factor | 10-folda | Matsu-ura et al. (2018) |
| P. oxalicum 114-2 (CGMCC 5302) | clr-B, creA | Transcription factors | 11- to 58-foldb | Li et al. (2015) |
| P. oxalicum 114-2 (CGMCC 5302) | bgl2,creA,clrB | Transcription factors | 10-fold | Yao et al. (2015) |
| Wild-type strain . | Target regulatory genes . | Regulatory elements . | Increase in cellulase activity . | Ref. . |
|---|---|---|---|---|
| N. crassa OR8-1a | gna-3,gnb-1 | Transporter involved in CCR | >3-fold | Collier et al. (2020) |
| N. crassa 74-OR23-1V | clr-2 | Transcription factor | 10-folda | Matsu-ura et al. (2018) |
| P. oxalicum 114-2 (CGMCC 5302) | clr-B, creA | Transcription factors | 11- to 58-foldb | Li et al. (2015) |
| P. oxalicum 114-2 (CGMCC 5302) | bgl2,creA,clrB | Transcription factors | 10-fold | Yao et al. (2015) |
Cellulase overproduction. bDepending on enzyme.
Engineered regulatory pathways in model strains to increase cellulase production in the presence of cellulosic substrates.
| Wild-type strain . | Target regulatory genes . | Regulatory elements . | Increase in cellulase activity . | Ref. . |
|---|---|---|---|---|
| N. crassa OR8-1a | gna-3,gnb-1 | Transporter involved in CCR | >3-fold | Collier et al. (2020) |
| N. crassa 74-OR23-1V | clr-2 | Transcription factor | 10-folda | Matsu-ura et al. (2018) |
| P. oxalicum 114-2 (CGMCC 5302) | clr-B, creA | Transcription factors | 11- to 58-foldb | Li et al. (2015) |
| P. oxalicum 114-2 (CGMCC 5302) | bgl2,creA,clrB | Transcription factors | 10-fold | Yao et al. (2015) |
| Wild-type strain . | Target regulatory genes . | Regulatory elements . | Increase in cellulase activity . | Ref. . |
|---|---|---|---|---|
| N. crassa OR8-1a | gna-3,gnb-1 | Transporter involved in CCR | >3-fold | Collier et al. (2020) |
| N. crassa 74-OR23-1V | clr-2 | Transcription factor | 10-folda | Matsu-ura et al. (2018) |
| P. oxalicum 114-2 (CGMCC 5302) | clr-B, creA | Transcription factors | 11- to 58-foldb | Li et al. (2015) |
| P. oxalicum 114-2 (CGMCC 5302) | bgl2,creA,clrB | Transcription factors | 10-fold | Yao et al. (2015) |
Cellulase overproduction. bDepending on enzyme.
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