Summary of relationships between veno-arterial carbon dioxide gradient and normal or abnormal Fick cardiac index
| Parameter . | Outcome . | Odds ratio (95% conf. int) . | Comments . |
|---|---|---|---|
| PvaCO2, 1 mmHg increase | Direct Fick CI <2.5 L/min/m2 | 1.88 (1.55, 2.35) | Optimal cut-off > 6 mmHg |
| Best NPV < 4 mmHg (87.5%) | |||
| Best PPV > 8 mmHg (90.1%) | |||
| PvaCO2, increase from 25th to 75th percentile | Direct Fick CI <2.5 L/min/m2 | 6.66 (3.58, 11.39) | 25th percentile is PvaCO2 = 5 mmHg; 75th percentile = 8 mmHg |
| PvaCO2 ≤ 6 when thermodilution CI < 2.0 L/min/m2 | Direct Fick CI ≥2.5 L/min/m2 | 2.76 (1.20, 6.53) | |
| PvaCO2 ≤ 6 when thermodilution CI < 2.5 L/min/m2 | Direct Fick CI ≥2.5 L/min/m2 | 9.06 (3.11, 33.15) |
| Parameter . | Outcome . | Odds ratio (95% conf. int) . | Comments . |
|---|---|---|---|
| PvaCO2, 1 mmHg increase | Direct Fick CI <2.5 L/min/m2 | 1.88 (1.55, 2.35) | Optimal cut-off > 6 mmHg |
| Best NPV < 4 mmHg (87.5%) | |||
| Best PPV > 8 mmHg (90.1%) | |||
| PvaCO2, increase from 25th to 75th percentile | Direct Fick CI <2.5 L/min/m2 | 6.66 (3.58, 11.39) | 25th percentile is PvaCO2 = 5 mmHg; 75th percentile = 8 mmHg |
| PvaCO2 ≤ 6 when thermodilution CI < 2.0 L/min/m2 | Direct Fick CI ≥2.5 L/min/m2 | 2.76 (1.20, 6.53) | |
| PvaCO2 ≤ 6 when thermodilution CI < 2.5 L/min/m2 | Direct Fick CI ≥2.5 L/min/m2 | 9.06 (3.11, 33.15) |
Conf. int, confidence interval; PvaCO2, veno-arterial carbon dioxide gradient; CI, cardiac index; NPV, negative predictive value; PPV, positive predictive value.
Summary of relationships between veno-arterial carbon dioxide gradient and normal or abnormal Fick cardiac index
| Parameter . | Outcome . | Odds ratio (95% conf. int) . | Comments . |
|---|---|---|---|
| PvaCO2, 1 mmHg increase | Direct Fick CI <2.5 L/min/m2 | 1.88 (1.55, 2.35) | Optimal cut-off > 6 mmHg |
| Best NPV < 4 mmHg (87.5%) | |||
| Best PPV > 8 mmHg (90.1%) | |||
| PvaCO2, increase from 25th to 75th percentile | Direct Fick CI <2.5 L/min/m2 | 6.66 (3.58, 11.39) | 25th percentile is PvaCO2 = 5 mmHg; 75th percentile = 8 mmHg |
| PvaCO2 ≤ 6 when thermodilution CI < 2.0 L/min/m2 | Direct Fick CI ≥2.5 L/min/m2 | 2.76 (1.20, 6.53) | |
| PvaCO2 ≤ 6 when thermodilution CI < 2.5 L/min/m2 | Direct Fick CI ≥2.5 L/min/m2 | 9.06 (3.11, 33.15) |
| Parameter . | Outcome . | Odds ratio (95% conf. int) . | Comments . |
|---|---|---|---|
| PvaCO2, 1 mmHg increase | Direct Fick CI <2.5 L/min/m2 | 1.88 (1.55, 2.35) | Optimal cut-off > 6 mmHg |
| Best NPV < 4 mmHg (87.5%) | |||
| Best PPV > 8 mmHg (90.1%) | |||
| PvaCO2, increase from 25th to 75th percentile | Direct Fick CI <2.5 L/min/m2 | 6.66 (3.58, 11.39) | 25th percentile is PvaCO2 = 5 mmHg; 75th percentile = 8 mmHg |
| PvaCO2 ≤ 6 when thermodilution CI < 2.0 L/min/m2 | Direct Fick CI ≥2.5 L/min/m2 | 2.76 (1.20, 6.53) | |
| PvaCO2 ≤ 6 when thermodilution CI < 2.5 L/min/m2 | Direct Fick CI ≥2.5 L/min/m2 | 9.06 (3.11, 33.15) |
Conf. int, confidence interval; PvaCO2, veno-arterial carbon dioxide gradient; CI, cardiac index; NPV, negative predictive value; PPV, positive predictive value.
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