Table 1: Open in new tab Oversight of...

Table 1:

Oversight of the various equations to estimate kidney function.

(i) The Cockcroft–Gault equation to estimate 24-h creatinine clearance (in mL/min), developed in 1976 [2]:

(140 – age in years) × weight in kg/(0.81 × serum creatinine in µmol/L) (× 0.85 for women)

(ii) The 4-variable MDRD equation to estimate GFR (in mL/min/1.73 m²), developed in 1999 [5, 6]:

175 × (serum creatinine in µmol/L)/88.4)^−1.154× age in years^−0.203 (× 0.742 for women) (× 1.210 if individual is Black)

(iii) The 2009 CKD-EPI equation to estimate GFR (in mL/min/1.73 m²), developed in 2009 with race coefficient [7]:

Female and SCr ≤0.7 mg/dL: 144 × (SCr/0.7)^−0.329 × 0.9929^age × 1.159 (if individual is Black)

Female and SCr >0.7 mg/dL: 144 × (SCr/0.7)^−1.209 × 0.9929^age × 1.159 (if individual is Black)

Male and SCr ≤0.9 mg/dL: 141 × (SCr/0.9)^−0.411 × 0.9929^age × 1.159 (if individual is Black)

Male and SCr >0.9 mg/dL: 141 × (SCr/0.9)^−1.209 × 0.9929^age × 1.159 (if individual is Black)

(iv) The 2021 CKD-EPI equation to estimate GFR (in mL/min/1.73 m²), developed in 2021 without race coefficient [12]:

Female and SCr ≤0.7 mg/dL: 143 × (SCr/0.7)^−0.241 × 0.9938^{age in years}

Female and SCr >0.7 mg/dL: 143 × (SCr/0.7)^−1.200 × 0.9938^{age in years}

Male and SCr ≤0.9 mg/dL: 142 × (SCr/0.9)^−0.302 × 0.9938^{age in years}

Male and SCr >0.9 mg/dL: 142 × (SCr/0.9)^−1.200 × 0.9938 ^{age in years}

(v) The EKFC equation to estimate GFR (in mL/min/1.73 m²), developed in 2021 [18, 20]:

2–40 years and SCr/Q <1: 107.3 × (SCr/Q)^−0.322

2–40 years and SCr/Q ≥1: 107.3 × (SCr/Q)^−1.132

>40 years and SCr/Q <1: 107.3 × (SCr/Q)^−0.322 × 0.990^{(age in years – 40)}

>40 years and SCr/Q ≥1: 07.3 × (SCr/Q)^−1.132 × 0.990^{(age in years – 40)}

Q-values

For ages 18–25 years, males:

ln(Q) = 3.2 + 0.259 × age – 0.543 × ln(age) – 0.00763 × age² + 0.000079 × age³

For ages 18–25 years, females:

ln(Q) = 3.08 + 0.177 × age – 0.223 × ln(age) – 0.00596 × age² + 0.0000686 × age³

For ages ≥25 years, Caucasian European males: Q = 0.90 mg/dL

For ages ≥25 years, Caucasian European females: Q = 0.70 mg/dL

For Black Africans, females: Q = Q + 0.02

For Black Africans, males: Q = Q + 0.06

For Black European, females: Q = Q + 0.04

For Black European, males: Q = Q + 0.12

SCr, serum creatinine.