| Formulation . | Route of administration . | Frequency of administration . | Advantages . | Disadvantages . |
|---|---|---|---|---|
| Testosterone 1% and 2% gel available | Transdermal gel | Applied daily, requires dose titration | Fast onset; provide uniform and normal serum levels for 24 hours | Skin irritation at application site Potential for interpersonal transfer Non-compliance long term |
| Testosterone undecanoate | Oral capsules | Once or twice daily | Lymphatic absorption decrease liver involvement | Levels fluctuate Daily or twice-daily commitment Must be taken with food |
| Testosterone undecanoate | Intramuscular injection | Every 10–14 wk adjusted to maintain trough testosterone level > 12 nmol/L | Steady-state levels Lower frequency of administration improves compliance | Long duration of action prevents drug withdrawal in the event of adverse side effects |
| Testosterone enanthate | Intramuscular injection | Every 2–3 wk | Short duration of action allows drug withdrawal if there are adverse side effects | Levels fluctuate |
| Testosterone propionate | Intramuscular injection | Currently available as 1 of 4 testosterone esters used in sustanon 250, which is usually administered every 3 wk; sustanon’s duration of action prevents drug withdrawal in the event of adverse side effects127 | ||
| Formulation . | Route of administration . | Frequency of administration . | Advantages . | Disadvantages . |
|---|---|---|---|---|
| Testosterone 1% and 2% gel available | Transdermal gel | Applied daily, requires dose titration | Fast onset; provide uniform and normal serum levels for 24 hours | Skin irritation at application site Potential for interpersonal transfer Non-compliance long term |
| Testosterone undecanoate | Oral capsules | Once or twice daily | Lymphatic absorption decrease liver involvement | Levels fluctuate Daily or twice-daily commitment Must be taken with food |
| Testosterone undecanoate | Intramuscular injection | Every 10–14 wk adjusted to maintain trough testosterone level > 12 nmol/L | Steady-state levels Lower frequency of administration improves compliance | Long duration of action prevents drug withdrawal in the event of adverse side effects |
| Testosterone enanthate | Intramuscular injection | Every 2–3 wk | Short duration of action allows drug withdrawal if there are adverse side effects | Levels fluctuate |
| Testosterone propionate | Intramuscular injection | Currently available as 1 of 4 testosterone esters used in sustanon 250, which is usually administered every 3 wk; sustanon’s duration of action prevents drug withdrawal in the event of adverse side effects127 | ||
| Formulation . | Route of administration . | Frequency of administration . | Advantages . | Disadvantages . |
|---|---|---|---|---|
| Testosterone 1% and 2% gel available | Transdermal gel | Applied daily, requires dose titration | Fast onset; provide uniform and normal serum levels for 24 hours | Skin irritation at application site Potential for interpersonal transfer Non-compliance long term |
| Testosterone undecanoate | Oral capsules | Once or twice daily | Lymphatic absorption decrease liver involvement | Levels fluctuate Daily or twice-daily commitment Must be taken with food |
| Testosterone undecanoate | Intramuscular injection | Every 10–14 wk adjusted to maintain trough testosterone level > 12 nmol/L | Steady-state levels Lower frequency of administration improves compliance | Long duration of action prevents drug withdrawal in the event of adverse side effects |
| Testosterone enanthate | Intramuscular injection | Every 2–3 wk | Short duration of action allows drug withdrawal if there are adverse side effects | Levels fluctuate |
| Testosterone propionate | Intramuscular injection | Currently available as 1 of 4 testosterone esters used in sustanon 250, which is usually administered every 3 wk; sustanon’s duration of action prevents drug withdrawal in the event of adverse side effects127 | ||
| Formulation . | Route of administration . | Frequency of administration . | Advantages . | Disadvantages . |
|---|---|---|---|---|
| Testosterone 1% and 2% gel available | Transdermal gel | Applied daily, requires dose titration | Fast onset; provide uniform and normal serum levels for 24 hours | Skin irritation at application site Potential for interpersonal transfer Non-compliance long term |
| Testosterone undecanoate | Oral capsules | Once or twice daily | Lymphatic absorption decrease liver involvement | Levels fluctuate Daily or twice-daily commitment Must be taken with food |
| Testosterone undecanoate | Intramuscular injection | Every 10–14 wk adjusted to maintain trough testosterone level > 12 nmol/L | Steady-state levels Lower frequency of administration improves compliance | Long duration of action prevents drug withdrawal in the event of adverse side effects |
| Testosterone enanthate | Intramuscular injection | Every 2–3 wk | Short duration of action allows drug withdrawal if there are adverse side effects | Levels fluctuate |
| Testosterone propionate | Intramuscular injection | Currently available as 1 of 4 testosterone esters used in sustanon 250, which is usually administered every 3 wk; sustanon’s duration of action prevents drug withdrawal in the event of adverse side effects127 | ||
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
