| Variable . | All (n = 67) . | CFR ≥2.0 (n = 30) . | CFR <2.0 (n = 37) . | P-value . | Age-adjusted P-value . |
|---|---|---|---|---|---|
| Semi-quantitative scales | |||||
| MMSE (max. 30) | 27.9 (±2.03) | 28.5 (±1.8) | 27.4 (±2.1) | 0.025 | 0.041 |
| ACE-III (global) (max. 100) | 85.1 (±10.1) | 87.0 (±8.2) | 83.6 (±11.3) | 0.184 | 0.242 |
| ACE-III (attention) (max. 18) | 16.5 (±1.8) | 17.0 (±1.2) | 16.0 (±2.0) | 0.023 | 0.032 |
| Digit span forward | 5.3 (±0.89) | 5.37 (±0.89) | 5.33 (±0.89) | 0.880 | 0.939 |
| Digit span backwards | 3.8 (±0.85) | 3.8 (±0.85) | 3.8 (±0.87) | 1.000 | 0.872 |
| TMT-A | 56.2 (±27.1) | 48.6 (±18.3) | 62.8 (±31.7) | 0.034 | 0.055 |
| TMT-B | 121.6 (±56.7) | 107.2 (±36.3) | 133.7 (±67.6) | 0.073 | 0.113 |
| TMT-B/TMT-A | 2.37 (±0.62) | 2.39 (±0.63) | 2.35 (±0.61) | 0.792 | 0.781 |
| SDMT | 31.2 (±12.2) | 32.5 (±11.3) | 30.1 (±13.0) | 0.426 | 0.732 |
| Interference (Stroop Colour Word Interference Test) | −3.03 (±7.9) | −1.83 (±8.7) | −4.01 (±7.3) | 0.286 | 0.251 |
| ToL (correct movements) (max. 10) | 3.87 (±1.8) | 4.04 (±1.9) | 3.74 (±1.72) | 0.521 | 0.535 |
| ToL (total movements) | 33.4 (±18.0) | 31.4 (±15.5) | 35.1 (±19.8) | 0.424 | 0.442 |
| Semantic verbal fluency (animals) | 16.8 (±4.5) | 16.3 (±3.8) | 17.3 (±5.0) | 0.398 | 0.231 |
| FCRST—total recall (max. 48) | 39.4 (±8.4) | 40.7 (±6.5) | 38.3 (±9.6) | 0.253 | 0.336 |
| FCRST—total delayed recall (max. 16) | 13.2 (±3.2) | 13.7 (±2.8) | 12.9 (±3.5) | 0.284 | 0.396 |
| Variable . | All (n = 67) . | CFR ≥2.0 (n = 30) . | CFR <2.0 (n = 37) . | P-value . | Age-adjusted P-value . |
|---|---|---|---|---|---|
| Semi-quantitative scales | |||||
| MMSE (max. 30) | 27.9 (±2.03) | 28.5 (±1.8) | 27.4 (±2.1) | 0.025 | 0.041 |
| ACE-III (global) (max. 100) | 85.1 (±10.1) | 87.0 (±8.2) | 83.6 (±11.3) | 0.184 | 0.242 |
| ACE-III (attention) (max. 18) | 16.5 (±1.8) | 17.0 (±1.2) | 16.0 (±2.0) | 0.023 | 0.032 |
| Digit span forward | 5.3 (±0.89) | 5.37 (±0.89) | 5.33 (±0.89) | 0.880 | 0.939 |
| Digit span backwards | 3.8 (±0.85) | 3.8 (±0.85) | 3.8 (±0.87) | 1.000 | 0.872 |
| TMT-A | 56.2 (±27.1) | 48.6 (±18.3) | 62.8 (±31.7) | 0.034 | 0.055 |
| TMT-B | 121.6 (±56.7) | 107.2 (±36.3) | 133.7 (±67.6) | 0.073 | 0.113 |
| TMT-B/TMT-A | 2.37 (±0.62) | 2.39 (±0.63) | 2.35 (±0.61) | 0.792 | 0.781 |
| SDMT | 31.2 (±12.2) | 32.5 (±11.3) | 30.1 (±13.0) | 0.426 | 0.732 |
| Interference (Stroop Colour Word Interference Test) | −3.03 (±7.9) | −1.83 (±8.7) | −4.01 (±7.3) | 0.286 | 0.251 |
| ToL (correct movements) (max. 10) | 3.87 (±1.8) | 4.04 (±1.9) | 3.74 (±1.72) | 0.521 | 0.535 |
| ToL (total movements) | 33.4 (±18.0) | 31.4 (±15.5) | 35.1 (±19.8) | 0.424 | 0.442 |
| Semantic verbal fluency (animals) | 16.8 (±4.5) | 16.3 (±3.8) | 17.3 (±5.0) | 0.398 | 0.231 |
| FCRST—total recall (max. 48) | 39.4 (±8.4) | 40.7 (±6.5) | 38.3 (±9.6) | 0.253 | 0.336 |
| FCRST—total delayed recall (max. 16) | 13.2 (±3.2) | 13.7 (±2.8) | 12.9 (±3.5) | 0.284 | 0.396 |
Results are shown as mean (±standard deviation). MMSE, mini mental state examination; ACE-III, Addenbrooke’s Cognitive Examination III; TMT, Trail Making Test; SDMT, symbol digit modalities test; ToL, Tower of London; FCRST, free and cued selective reminding test. Interference of Stroop is calculated as Stroop C − [(A × B)/(A + B)] (A, word reading; B, colour naming; C, interference between word and colour).
| Variable . | All (n = 67) . | CFR ≥2.0 (n = 30) . | CFR <2.0 (n = 37) . | P-value . | Age-adjusted P-value . |
|---|---|---|---|---|---|
| Semi-quantitative scales | |||||
| MMSE (max. 30) | 27.9 (±2.03) | 28.5 (±1.8) | 27.4 (±2.1) | 0.025 | 0.041 |
| ACE-III (global) (max. 100) | 85.1 (±10.1) | 87.0 (±8.2) | 83.6 (±11.3) | 0.184 | 0.242 |
| ACE-III (attention) (max. 18) | 16.5 (±1.8) | 17.0 (±1.2) | 16.0 (±2.0) | 0.023 | 0.032 |
| Digit span forward | 5.3 (±0.89) | 5.37 (±0.89) | 5.33 (±0.89) | 0.880 | 0.939 |
| Digit span backwards | 3.8 (±0.85) | 3.8 (±0.85) | 3.8 (±0.87) | 1.000 | 0.872 |
| TMT-A | 56.2 (±27.1) | 48.6 (±18.3) | 62.8 (±31.7) | 0.034 | 0.055 |
| TMT-B | 121.6 (±56.7) | 107.2 (±36.3) | 133.7 (±67.6) | 0.073 | 0.113 |
| TMT-B/TMT-A | 2.37 (±0.62) | 2.39 (±0.63) | 2.35 (±0.61) | 0.792 | 0.781 |
| SDMT | 31.2 (±12.2) | 32.5 (±11.3) | 30.1 (±13.0) | 0.426 | 0.732 |
| Interference (Stroop Colour Word Interference Test) | −3.03 (±7.9) | −1.83 (±8.7) | −4.01 (±7.3) | 0.286 | 0.251 |
| ToL (correct movements) (max. 10) | 3.87 (±1.8) | 4.04 (±1.9) | 3.74 (±1.72) | 0.521 | 0.535 |
| ToL (total movements) | 33.4 (±18.0) | 31.4 (±15.5) | 35.1 (±19.8) | 0.424 | 0.442 |
| Semantic verbal fluency (animals) | 16.8 (±4.5) | 16.3 (±3.8) | 17.3 (±5.0) | 0.398 | 0.231 |
| FCRST—total recall (max. 48) | 39.4 (±8.4) | 40.7 (±6.5) | 38.3 (±9.6) | 0.253 | 0.336 |
| FCRST—total delayed recall (max. 16) | 13.2 (±3.2) | 13.7 (±2.8) | 12.9 (±3.5) | 0.284 | 0.396 |
| Variable . | All (n = 67) . | CFR ≥2.0 (n = 30) . | CFR <2.0 (n = 37) . | P-value . | Age-adjusted P-value . |
|---|---|---|---|---|---|
| Semi-quantitative scales | |||||
| MMSE (max. 30) | 27.9 (±2.03) | 28.5 (±1.8) | 27.4 (±2.1) | 0.025 | 0.041 |
| ACE-III (global) (max. 100) | 85.1 (±10.1) | 87.0 (±8.2) | 83.6 (±11.3) | 0.184 | 0.242 |
| ACE-III (attention) (max. 18) | 16.5 (±1.8) | 17.0 (±1.2) | 16.0 (±2.0) | 0.023 | 0.032 |
| Digit span forward | 5.3 (±0.89) | 5.37 (±0.89) | 5.33 (±0.89) | 0.880 | 0.939 |
| Digit span backwards | 3.8 (±0.85) | 3.8 (±0.85) | 3.8 (±0.87) | 1.000 | 0.872 |
| TMT-A | 56.2 (±27.1) | 48.6 (±18.3) | 62.8 (±31.7) | 0.034 | 0.055 |
| TMT-B | 121.6 (±56.7) | 107.2 (±36.3) | 133.7 (±67.6) | 0.073 | 0.113 |
| TMT-B/TMT-A | 2.37 (±0.62) | 2.39 (±0.63) | 2.35 (±0.61) | 0.792 | 0.781 |
| SDMT | 31.2 (±12.2) | 32.5 (±11.3) | 30.1 (±13.0) | 0.426 | 0.732 |
| Interference (Stroop Colour Word Interference Test) | −3.03 (±7.9) | −1.83 (±8.7) | −4.01 (±7.3) | 0.286 | 0.251 |
| ToL (correct movements) (max. 10) | 3.87 (±1.8) | 4.04 (±1.9) | 3.74 (±1.72) | 0.521 | 0.535 |
| ToL (total movements) | 33.4 (±18.0) | 31.4 (±15.5) | 35.1 (±19.8) | 0.424 | 0.442 |
| Semantic verbal fluency (animals) | 16.8 (±4.5) | 16.3 (±3.8) | 17.3 (±5.0) | 0.398 | 0.231 |
| FCRST—total recall (max. 48) | 39.4 (±8.4) | 40.7 (±6.5) | 38.3 (±9.6) | 0.253 | 0.336 |
| FCRST—total delayed recall (max. 16) | 13.2 (±3.2) | 13.7 (±2.8) | 12.9 (±3.5) | 0.284 | 0.396 |
Results are shown as mean (±standard deviation). MMSE, mini mental state examination; ACE-III, Addenbrooke’s Cognitive Examination III; TMT, Trail Making Test; SDMT, symbol digit modalities test; ToL, Tower of London; FCRST, free and cued selective reminding test. Interference of Stroop is calculated as Stroop C − [(A × B)/(A + B)] (A, word reading; B, colour naming; C, interference between word and colour).
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