Correlation analysis of carriers of two IL36RN mutations or one to two IL36RN mutations vs. noncarriers in 61 patients with generalized pustular psoriasis (GPP)
| Category and subcategory | Group A, carriers of two IL36RN mutations (n =15) | Group B, carriers of one to two IL36RN mutations (n =20) | Group C, noncarriers of IL36RN mutation (n =41) | P‐value (A vs. C) | P‐value (B vs. C) |
| Sex | |||||
| Male | 4 (27) | 5 (25) | 13 (32) | 1 | 0·76 |
| Female | 11 (73) | 15 (75) | 28 (68) | ||
| Course of diseasea | |||||
| Episodic | 13 (93) | 15 (83) | 26 (70) | 0·14 | 0·34 |
| Continuous | 1 (7) | 3 (17) | 11 (30) | ||
| Palmoplantar pustular psoriasis | |||||
| Yes | 3 (20) | 5 (25) | 4 (10) | 0·36 | 0·13 |
| No | 12 (80) | 15 (75) | 37 (90) | ||
| Tongue affectedb | |||||
| Yes | 4 (27) | 5 (25) | 8 (21) | 0·71 | 0·74 |
| No | 11 (73) | 15 (75) | 31 (79) | ||
| Psoriasis vulgarisc | |||||
| Yes | 3 (20) | 5 (25) | 20 (50) | 0·066 | 0·095 |
| No | 12 (80) | 15 (75) | 20 (50) | ||
| Nails affected | |||||
| Yes | 5 (33) | 5 (25) | 11 (27) | 0·74 | 1 |
| No | 10 (67) | 15 (75) | 30 (73) | ||
| Joints affected | |||||
| Yes | 4 (27) | 6 (30) | 12 (29) | 1 | 1 |
| No | 11 (73) | 14 (70) | 29 (71) | ||
| Cholangitis | |||||
| Yes | 1 (7) | 1 (5) | 1 (2) | 0·46 | 1 |
| No | 14 (93) | 19 (95) | 40 (98) | ||
| Family history positived | |||||
| Yes | 9 (60) | 11 (58) | 17 (43) | 0·36 | 0·4 |
| No | 6 (40) | 8 (42) | 23 (58) | ||
| Consanguinity | |||||
| Yes | 3 (20) | 3 (15) | 0 (0) | 0·016 | 0·032 |
| No | 12 (80) | 17 (85) | 41 (100) | ||
| Category and subcategory | Group A, carriers of two IL36RN mutations (n =15) | Group B, carriers of one to two IL36RN mutations (n =20) | Group C, noncarriers of IL36RN mutation (n =41) | P‐value (A vs. C) | P‐value (B vs. C) |
| Sex | |||||
| Male | 4 (27) | 5 (25) | 13 (32) | 1 | 0·76 |
| Female | 11 (73) | 15 (75) | 28 (68) | ||
| Course of diseasea | |||||
| Episodic | 13 (93) | 15 (83) | 26 (70) | 0·14 | 0·34 |
| Continuous | 1 (7) | 3 (17) | 11 (30) | ||
| Palmoplantar pustular psoriasis | |||||
| Yes | 3 (20) | 5 (25) | 4 (10) | 0·36 | 0·13 |
| No | 12 (80) | 15 (75) | 37 (90) | ||
| Tongue affectedb | |||||
| Yes | 4 (27) | 5 (25) | 8 (21) | 0·71 | 0·74 |
| No | 11 (73) | 15 (75) | 31 (79) | ||
| Psoriasis vulgarisc | |||||
| Yes | 3 (20) | 5 (25) | 20 (50) | 0·066 | 0·095 |
| No | 12 (80) | 15 (75) | 20 (50) | ||
| Nails affected | |||||
| Yes | 5 (33) | 5 (25) | 11 (27) | 0·74 | 1 |
| No | 10 (67) | 15 (75) | 30 (73) | ||
| Joints affected | |||||
| Yes | 4 (27) | 6 (30) | 12 (29) | 1 | 1 |
| No | 11 (73) | 14 (70) | 29 (71) | ||
| Cholangitis | |||||
| Yes | 1 (7) | 1 (5) | 1 (2) | 0·46 | 1 |
| No | 14 (93) | 19 (95) | 40 (98) | ||
| Family history positived | |||||
| Yes | 9 (60) | 11 (58) | 17 (43) | 0·36 | 0·4 |
| No | 6 (40) | 8 (42) | 23 (58) | ||
| Consanguinity | |||||
| Yes | 3 (20) | 3 (15) | 0 (0) | 0·016 | 0·032 |
| No | 12 (80) | 17 (85) | 41 (100) | ||
Data are n (%). aGroup A, n =14; group B, n =18 and group C, n =37; bgroup C, n =39; cgroup C, n =40; dgroup B, n =19 and group C, n =40.
Correlation analysis of carriers of two IL36RN mutations or one to two IL36RN mutations vs. noncarriers in 61 patients with generalized pustular psoriasis (GPP)
| Category and subcategory | Group A, carriers of two IL36RN mutations (n =15) | Group B, carriers of one to two IL36RN mutations (n =20) | Group C, noncarriers of IL36RN mutation (n =41) | P‐value (A vs. C) | P‐value (B vs. C) |
| Sex | |||||
| Male | 4 (27) | 5 (25) | 13 (32) | 1 | 0·76 |
| Female | 11 (73) | 15 (75) | 28 (68) | ||
| Course of diseasea | |||||
| Episodic | 13 (93) | 15 (83) | 26 (70) | 0·14 | 0·34 |
| Continuous | 1 (7) | 3 (17) | 11 (30) | ||
| Palmoplantar pustular psoriasis | |||||
| Yes | 3 (20) | 5 (25) | 4 (10) | 0·36 | 0·13 |
| No | 12 (80) | 15 (75) | 37 (90) | ||
| Tongue affectedb | |||||
| Yes | 4 (27) | 5 (25) | 8 (21) | 0·71 | 0·74 |
| No | 11 (73) | 15 (75) | 31 (79) | ||
| Psoriasis vulgarisc | |||||
| Yes | 3 (20) | 5 (25) | 20 (50) | 0·066 | 0·095 |
| No | 12 (80) | 15 (75) | 20 (50) | ||
| Nails affected | |||||
| Yes | 5 (33) | 5 (25) | 11 (27) | 0·74 | 1 |
| No | 10 (67) | 15 (75) | 30 (73) | ||
| Joints affected | |||||
| Yes | 4 (27) | 6 (30) | 12 (29) | 1 | 1 |
| No | 11 (73) | 14 (70) | 29 (71) | ||
| Cholangitis | |||||
| Yes | 1 (7) | 1 (5) | 1 (2) | 0·46 | 1 |
| No | 14 (93) | 19 (95) | 40 (98) | ||
| Family history positived | |||||
| Yes | 9 (60) | 11 (58) | 17 (43) | 0·36 | 0·4 |
| No | 6 (40) | 8 (42) | 23 (58) | ||
| Consanguinity | |||||
| Yes | 3 (20) | 3 (15) | 0 (0) | 0·016 | 0·032 |
| No | 12 (80) | 17 (85) | 41 (100) | ||
| Category and subcategory | Group A, carriers of two IL36RN mutations (n =15) | Group B, carriers of one to two IL36RN mutations (n =20) | Group C, noncarriers of IL36RN mutation (n =41) | P‐value (A vs. C) | P‐value (B vs. C) |
| Sex | |||||
| Male | 4 (27) | 5 (25) | 13 (32) | 1 | 0·76 |
| Female | 11 (73) | 15 (75) | 28 (68) | ||
| Course of diseasea | |||||
| Episodic | 13 (93) | 15 (83) | 26 (70) | 0·14 | 0·34 |
| Continuous | 1 (7) | 3 (17) | 11 (30) | ||
| Palmoplantar pustular psoriasis | |||||
| Yes | 3 (20) | 5 (25) | 4 (10) | 0·36 | 0·13 |
| No | 12 (80) | 15 (75) | 37 (90) | ||
| Tongue affectedb | |||||
| Yes | 4 (27) | 5 (25) | 8 (21) | 0·71 | 0·74 |
| No | 11 (73) | 15 (75) | 31 (79) | ||
| Psoriasis vulgarisc | |||||
| Yes | 3 (20) | 5 (25) | 20 (50) | 0·066 | 0·095 |
| No | 12 (80) | 15 (75) | 20 (50) | ||
| Nails affected | |||||
| Yes | 5 (33) | 5 (25) | 11 (27) | 0·74 | 1 |
| No | 10 (67) | 15 (75) | 30 (73) | ||
| Joints affected | |||||
| Yes | 4 (27) | 6 (30) | 12 (29) | 1 | 1 |
| No | 11 (73) | 14 (70) | 29 (71) | ||
| Cholangitis | |||||
| Yes | 1 (7) | 1 (5) | 1 (2) | 0·46 | 1 |
| No | 14 (93) | 19 (95) | 40 (98) | ||
| Family history positived | |||||
| Yes | 9 (60) | 11 (58) | 17 (43) | 0·36 | 0·4 |
| No | 6 (40) | 8 (42) | 23 (58) | ||
| Consanguinity | |||||
| Yes | 3 (20) | 3 (15) | 0 (0) | 0·016 | 0·032 |
| No | 12 (80) | 17 (85) | 41 (100) | ||
Data are n (%). aGroup A, n =14; group B, n =18 and group C, n =37; bgroup C, n =39; cgroup C, n =40; dgroup B, n =19 and group C, n =40.
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