Table 2.

Patient Characteristics

AuthorIntervention GroupPatient, No. (%)Mean or Median Age (±SD or IQR), yMen, No. (%)ICU Admission, No. (%)Transplant Recipients, No. (%)Immunosuppressant User, No. (%)ESRD on Hemodialysis, No. (%)Intravascular Device, No. (%)Effective Empirical Therapy, No. (%)Days of Treatment, Median (IQR)Days of Hospital Stay, Median (IQR)Mortality, No. (%)
Amipara et al. [7]All patients766 (100)67 (55–79)328 (43)NDNDND77 (10)a116 (15)b710 (93)NDND69 (9)
FUBC219 (29)65 (52–75)96 (44)NDNDND55 (25)a60 (27)b204 (93)NDND12 (5)
No FUBC547 (71)68 (56–79)232 (42)NDNDND22 (4)a56 (10)b506 (93)NDND57 (10)
Chan et al. [19]All patients335 (100)ND186 (56)NDNDNDNDNDNDNDND32 (10)
FUBC299 (89)60 (48–71)174 (58)NDNDNDNDNDNDND8 (5–18)27 (9)
No FUBC36 (11)64 (53–72)12 (33)NDNDNDNDNDNDND4 (3–9)5 (14)
Elamin et al. [11]All patients482 (100)NDND174 (36)NDNDNDNDNDNDND13 (3)
FUBC321 (67)NDND133 (41)NDNDNDNDND14 (10–14)7 (5–11)9 (3)
No FUBC161 (33)NDND41 (26)NDNDNDNDND11 (10–14)5 (4–7)4 (3)
Giannella et al. [9]All patients1576 (100)69 (17)878 (56)126 (8)ND332 (21)cNDND1075 (68)11 (7–15)12 (7–22)164 (10)
FUBC278 (18)62 (16)171 (62)53 (19)ND89 (32)cNDND170 (61)15 (10–21)21 (13–36)38 (14)
No FUBC1298 (82)70 (16)707 (55)73 (6)ND243 (19)cNDND905 (70)10 (7–14)11 (7–19)126 (10)
Green et al. [16]All patients159 (100)57 (16)94 (59)73 (45)NDND31 (20)94 (59)bNDNDND40 (25)
FUBC127 (80)57 (17)76 (60)60 (46)NDND23 (18)77 (61)bNDNDND24 (19)
No FUBC32 (20)59 (15)18 (56)13 (41)NDND8 (25)17 (53)bNDNDND16 (50)
Jung et al. [17]All patients1481 (100)69 (14)745 (50)ND68 (5)d92 (6)e43 (3)f327 (22)NDNDND105 (7)
FUBC1276 (86)69 (14)628 (49)ND62 (5)d89 (7)e41 (3)f308 (24)1050 (82)NDND87 (7)
No FUBC205 (14)69 (14)117 (57)ND6 (3)d3 (1)e2 (1)f19 (9)NDNDND18 (9)
Maskarinec et al. [8]All patients1702 (100)61 (ND)936 (55)64 (4)232 (14)g411 (24)e172 (10)ND1075 (63)hNDND284 (17)i
FUBC1164 (68)60 (16)632 (54)41 (4)188 (16)g305 (26)e135 (12)ND729 (63)h15 (13–19)ND176 (15)ji
No FUBC538 (32)62 (16)304 (57)23 (4)44 (8)g106 (20)e37 (7)ND346 (64)h13 (8–16)ND108 (20)
i
Mitaka et al. [10]All patients376 (100)ND174 (46)138 (37)NDND43 (11)115 (31)NDNDNDND
FUBC271 (72)69 (59–82)123 (45)110 (40)NDND37 (14)93 (34)ND8 (5.5–13)j9 (6–14)j4 (5)j
No FUBC105 (28)73 (64–83)51 (49)28 (27)NDND6 (6)22 (21)ND6 (4–10)j7 (4.5–10.5)ij10 (11)ij
Wiggers et al. [18]All patients901 (100)67 (18)408 (45)240 (27)NDNDNDNDNDND14 (5–33)131 (15)k
FUBC241 (27)62 (18)94 (39)96 (40)NDNDNDNDNDND24 (11–46)35 (15)k
No FUBC660 (73)69 (18)314 (48)144 (22)NDNDNDNDNDND10 (4–29)96 (15)k
AuthorIntervention GroupPatient, No. (%)Mean or Median Age (±SD or IQR), yMen, No. (%)ICU Admission, No. (%)Transplant Recipients, No. (%)Immunosuppressant User, No. (%)ESRD on Hemodialysis, No. (%)Intravascular Device, No. (%)Effective Empirical Therapy, No. (%)Days of Treatment, Median (IQR)Days of Hospital Stay, Median (IQR)Mortality, No. (%)
Amipara et al. [7]All patients766 (100)67 (55–79)328 (43)NDNDND77 (10)a116 (15)b710 (93)NDND69 (9)
FUBC219 (29)65 (52–75)96 (44)NDNDND55 (25)a60 (27)b204 (93)NDND12 (5)
No FUBC547 (71)68 (56–79)232 (42)NDNDND22 (4)a56 (10)b506 (93)NDND57 (10)
Chan et al. [19]All patients335 (100)ND186 (56)NDNDNDNDNDNDNDND32 (10)
FUBC299 (89)60 (48–71)174 (58)NDNDNDNDNDNDND8 (5–18)27 (9)
No FUBC36 (11)64 (53–72)12 (33)NDNDNDNDNDNDND4 (3–9)5 (14)
Elamin et al. [11]All patients482 (100)NDND174 (36)NDNDNDNDNDNDND13 (3)
FUBC321 (67)NDND133 (41)NDNDNDNDND14 (10–14)7 (5–11)9 (3)
No FUBC161 (33)NDND41 (26)NDNDNDNDND11 (10–14)5 (4–7)4 (3)
Giannella et al. [9]All patients1576 (100)69 (17)878 (56)126 (8)ND332 (21)cNDND1075 (68)11 (7–15)12 (7–22)164 (10)
FUBC278 (18)62 (16)171 (62)53 (19)ND89 (32)cNDND170 (61)15 (10–21)21 (13–36)38 (14)
No FUBC1298 (82)70 (16)707 (55)73 (6)ND243 (19)cNDND905 (70)10 (7–14)11 (7–19)126 (10)
Green et al. [16]All patients159 (100)57 (16)94 (59)73 (45)NDND31 (20)94 (59)bNDNDND40 (25)
FUBC127 (80)57 (17)76 (60)60 (46)NDND23 (18)77 (61)bNDNDND24 (19)
No FUBC32 (20)59 (15)18 (56)13 (41)NDND8 (25)17 (53)bNDNDND16 (50)
Jung et al. [17]All patients1481 (100)69 (14)745 (50)ND68 (5)d92 (6)e43 (3)f327 (22)NDNDND105 (7)
FUBC1276 (86)69 (14)628 (49)ND62 (5)d89 (7)e41 (3)f308 (24)1050 (82)NDND87 (7)
No FUBC205 (14)69 (14)117 (57)ND6 (3)d3 (1)e2 (1)f19 (9)NDNDND18 (9)
Maskarinec et al. [8]All patients1702 (100)61 (ND)936 (55)64 (4)232 (14)g411 (24)e172 (10)ND1075 (63)hNDND284 (17)i
FUBC1164 (68)60 (16)632 (54)41 (4)188 (16)g305 (26)e135 (12)ND729 (63)h15 (13–19)ND176 (15)ji
No FUBC538 (32)62 (16)304 (57)23 (4)44 (8)g106 (20)e37 (7)ND346 (64)h13 (8–16)ND108 (20)
i
Mitaka et al. [10]All patients376 (100)ND174 (46)138 (37)NDND43 (11)115 (31)NDNDNDND
FUBC271 (72)69 (59–82)123 (45)110 (40)NDND37 (14)93 (34)ND8 (5.5–13)j9 (6–14)j4 (5)j
No FUBC105 (28)73 (64–83)51 (49)28 (27)NDND6 (6)22 (21)ND6 (4–10)j7 (4.5–10.5)ij10 (11)ij
Wiggers et al. [18]All patients901 (100)67 (18)408 (45)240 (27)NDNDNDNDNDND14 (5–33)131 (15)k
FUBC241 (27)62 (18)94 (39)96 (40)NDNDNDNDNDND24 (11–46)35 (15)k
No FUBC660 (73)69 (18)314 (48)144 (22)NDNDNDNDNDND10 (4–29)96 (15)k

Abbreviations: ESRD, end-stage renal disease; FUBCs, follow-up blood cultures; ICU, intensive care unit; IQR, interquartile range; ND, no date.

a

Patients with ESRD. No data existed on whether all these patients received dialysis.

b

Central venous catheter.

c

No details of immunosuppressants were given in the article.

d

The number (%) of patients with solid organ transplantation was 39 (3) in the whole study population, 34 (3) in patients with FUBCs, and 5 (2) in patients without FUBCs. The number (%) of patients with bone marrow transplantation was 29 (2) in the whole study population, 28 (2) in patients with FUBCs, and 1 (<1) in patients without FUBCs.

e

Steroid use.

f

The number (%) of patients who received hemodialysis was 37 (2) in the whole study population, 35 (3) in patients with FUBCs, and 2 (1) in patients without FUBCs. The number (%) of patients who received peritoneal dialysis was 6 (<1) in the whole study population, 6 (<1) in patients with FUBCs, and 0 (0) in patients without FUBCs. These data were extracted from the individual patient data.

g

There was no mention of specific transplant details (eg, solid organ transplant or bone marrow transplant).

h

The original article mentioned “days to effective therapy: 0 days.”

i

The number (%) of deaths from attributable causes was 176 (10) in the whole study population, 98 (8) in patients with FUBCs, and 78 (15) in patients without FUBCs.

j

Only data after propensity score matching were presented.

k

The number (%) of deaths in the hospital was 193 (21) in the whole study population, 54 (22) in patients with FUBCs, and 139 (21) in patients without FUBCs.

Table 2.

Patient Characteristics

AuthorIntervention GroupPatient, No. (%)Mean or Median Age (±SD or IQR), yMen, No. (%)ICU Admission, No. (%)Transplant Recipients, No. (%)Immunosuppressant User, No. (%)ESRD on Hemodialysis, No. (%)Intravascular Device, No. (%)Effective Empirical Therapy, No. (%)Days of Treatment, Median (IQR)Days of Hospital Stay, Median (IQR)Mortality, No. (%)
Amipara et al. [7]All patients766 (100)67 (55–79)328 (43)NDNDND77 (10)a116 (15)b710 (93)NDND69 (9)
FUBC219 (29)65 (52–75)96 (44)NDNDND55 (25)a60 (27)b204 (93)NDND12 (5)
No FUBC547 (71)68 (56–79)232 (42)NDNDND22 (4)a56 (10)b506 (93)NDND57 (10)
Chan et al. [19]All patients335 (100)ND186 (56)NDNDNDNDNDNDNDND32 (10)
FUBC299 (89)60 (48–71)174 (58)NDNDNDNDNDNDND8 (5–18)27 (9)
No FUBC36 (11)64 (53–72)12 (33)NDNDNDNDNDNDND4 (3–9)5 (14)
Elamin et al. [11]All patients482 (100)NDND174 (36)NDNDNDNDNDNDND13 (3)
FUBC321 (67)NDND133 (41)NDNDNDNDND14 (10–14)7 (5–11)9 (3)
No FUBC161 (33)NDND41 (26)NDNDNDNDND11 (10–14)5 (4–7)4 (3)
Giannella et al. [9]All patients1576 (100)69 (17)878 (56)126 (8)ND332 (21)cNDND1075 (68)11 (7–15)12 (7–22)164 (10)
FUBC278 (18)62 (16)171 (62)53 (19)ND89 (32)cNDND170 (61)15 (10–21)21 (13–36)38 (14)
No FUBC1298 (82)70 (16)707 (55)73 (6)ND243 (19)cNDND905 (70)10 (7–14)11 (7–19)126 (10)
Green et al. [16]All patients159 (100)57 (16)94 (59)73 (45)NDND31 (20)94 (59)bNDNDND40 (25)
FUBC127 (80)57 (17)76 (60)60 (46)NDND23 (18)77 (61)bNDNDND24 (19)
No FUBC32 (20)59 (15)18 (56)13 (41)NDND8 (25)17 (53)bNDNDND16 (50)
Jung et al. [17]All patients1481 (100)69 (14)745 (50)ND68 (5)d92 (6)e43 (3)f327 (22)NDNDND105 (7)
FUBC1276 (86)69 (14)628 (49)ND62 (5)d89 (7)e41 (3)f308 (24)1050 (82)NDND87 (7)
No FUBC205 (14)69 (14)117 (57)ND6 (3)d3 (1)e2 (1)f19 (9)NDNDND18 (9)
Maskarinec et al. [8]All patients1702 (100)61 (ND)936 (55)64 (4)232 (14)g411 (24)e172 (10)ND1075 (63)hNDND284 (17)i
FUBC1164 (68)60 (16)632 (54)41 (4)188 (16)g305 (26)e135 (12)ND729 (63)h15 (13–19)ND176 (15)ji
No FUBC538 (32)62 (16)304 (57)23 (4)44 (8)g106 (20)e37 (7)ND346 (64)h13 (8–16)ND108 (20)
i
Mitaka et al. [10]All patients376 (100)ND174 (46)138 (37)NDND43 (11)115 (31)NDNDNDND
FUBC271 (72)69 (59–82)123 (45)110 (40)NDND37 (14)93 (34)ND8 (5.5–13)j9 (6–14)j4 (5)j
No FUBC105 (28)73 (64–83)51 (49)28 (27)NDND6 (6)22 (21)ND6 (4–10)j7 (4.5–10.5)ij10 (11)ij
Wiggers et al. [18]All patients901 (100)67 (18)408 (45)240 (27)NDNDNDNDNDND14 (5–33)131 (15)k
FUBC241 (27)62 (18)94 (39)96 (40)NDNDNDNDNDND24 (11–46)35 (15)k
No FUBC660 (73)69 (18)314 (48)144 (22)NDNDNDNDNDND10 (4–29)96 (15)k
AuthorIntervention GroupPatient, No. (%)Mean or Median Age (±SD or IQR), yMen, No. (%)ICU Admission, No. (%)Transplant Recipients, No. (%)Immunosuppressant User, No. (%)ESRD on Hemodialysis, No. (%)Intravascular Device, No. (%)Effective Empirical Therapy, No. (%)Days of Treatment, Median (IQR)Days of Hospital Stay, Median (IQR)Mortality, No. (%)
Amipara et al. [7]All patients766 (100)67 (55–79)328 (43)NDNDND77 (10)a116 (15)b710 (93)NDND69 (9)
FUBC219 (29)65 (52–75)96 (44)NDNDND55 (25)a60 (27)b204 (93)NDND12 (5)
No FUBC547 (71)68 (56–79)232 (42)NDNDND22 (4)a56 (10)b506 (93)NDND57 (10)
Chan et al. [19]All patients335 (100)ND186 (56)NDNDNDNDNDNDNDND32 (10)
FUBC299 (89)60 (48–71)174 (58)NDNDNDNDNDNDND8 (5–18)27 (9)
No FUBC36 (11)64 (53–72)12 (33)NDNDNDNDNDNDND4 (3–9)5 (14)
Elamin et al. [11]All patients482 (100)NDND174 (36)NDNDNDNDNDNDND13 (3)
FUBC321 (67)NDND133 (41)NDNDNDNDND14 (10–14)7 (5–11)9 (3)
No FUBC161 (33)NDND41 (26)NDNDNDNDND11 (10–14)5 (4–7)4 (3)
Giannella et al. [9]All patients1576 (100)69 (17)878 (56)126 (8)ND332 (21)cNDND1075 (68)11 (7–15)12 (7–22)164 (10)
FUBC278 (18)62 (16)171 (62)53 (19)ND89 (32)cNDND170 (61)15 (10–21)21 (13–36)38 (14)
No FUBC1298 (82)70 (16)707 (55)73 (6)ND243 (19)cNDND905 (70)10 (7–14)11 (7–19)126 (10)
Green et al. [16]All patients159 (100)57 (16)94 (59)73 (45)NDND31 (20)94 (59)bNDNDND40 (25)
FUBC127 (80)57 (17)76 (60)60 (46)NDND23 (18)77 (61)bNDNDND24 (19)
No FUBC32 (20)59 (15)18 (56)13 (41)NDND8 (25)17 (53)bNDNDND16 (50)
Jung et al. [17]All patients1481 (100)69 (14)745 (50)ND68 (5)d92 (6)e43 (3)f327 (22)NDNDND105 (7)
FUBC1276 (86)69 (14)628 (49)ND62 (5)d89 (7)e41 (3)f308 (24)1050 (82)NDND87 (7)
No FUBC205 (14)69 (14)117 (57)ND6 (3)d3 (1)e2 (1)f19 (9)NDNDND18 (9)
Maskarinec et al. [8]All patients1702 (100)61 (ND)936 (55)64 (4)232 (14)g411 (24)e172 (10)ND1075 (63)hNDND284 (17)i
FUBC1164 (68)60 (16)632 (54)41 (4)188 (16)g305 (26)e135 (12)ND729 (63)h15 (13–19)ND176 (15)ji
No FUBC538 (32)62 (16)304 (57)23 (4)44 (8)g106 (20)e37 (7)ND346 (64)h13 (8–16)ND108 (20)
i
Mitaka et al. [10]All patients376 (100)ND174 (46)138 (37)NDND43 (11)115 (31)NDNDNDND
FUBC271 (72)69 (59–82)123 (45)110 (40)NDND37 (14)93 (34)ND8 (5.5–13)j9 (6–14)j4 (5)j
No FUBC105 (28)73 (64–83)51 (49)28 (27)NDND6 (6)22 (21)ND6 (4–10)j7 (4.5–10.5)ij10 (11)ij
Wiggers et al. [18]All patients901 (100)67 (18)408 (45)240 (27)NDNDNDNDNDND14 (5–33)131 (15)k
FUBC241 (27)62 (18)94 (39)96 (40)NDNDNDNDNDND24 (11–46)35 (15)k
No FUBC660 (73)69 (18)314 (48)144 (22)NDNDNDNDNDND10 (4–29)96 (15)k

Abbreviations: ESRD, end-stage renal disease; FUBCs, follow-up blood cultures; ICU, intensive care unit; IQR, interquartile range; ND, no date.

a

Patients with ESRD. No data existed on whether all these patients received dialysis.

b

Central venous catheter.

c

No details of immunosuppressants were given in the article.

d

The number (%) of patients with solid organ transplantation was 39 (3) in the whole study population, 34 (3) in patients with FUBCs, and 5 (2) in patients without FUBCs. The number (%) of patients with bone marrow transplantation was 29 (2) in the whole study population, 28 (2) in patients with FUBCs, and 1 (<1) in patients without FUBCs.

e

Steroid use.

f

The number (%) of patients who received hemodialysis was 37 (2) in the whole study population, 35 (3) in patients with FUBCs, and 2 (1) in patients without FUBCs. The number (%) of patients who received peritoneal dialysis was 6 (<1) in the whole study population, 6 (<1) in patients with FUBCs, and 0 (0) in patients without FUBCs. These data were extracted from the individual patient data.

g

There was no mention of specific transplant details (eg, solid organ transplant or bone marrow transplant).

h

The original article mentioned “days to effective therapy: 0 days.”

i

The number (%) of deaths from attributable causes was 176 (10) in the whole study population, 98 (8) in patients with FUBCs, and 78 (15) in patients without FUBCs.

j

Only data after propensity score matching were presented.

k

The number (%) of deaths in the hospital was 193 (21) in the whole study population, 54 (22) in patients with FUBCs, and 139 (21) in patients without FUBCs.

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