Table 4.
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Summary of pharmacokinetic parameters of ceftazidime and avibactam

ParameterCeftazidime, 2 g every 8 hAvibactam, 500 mg every 8 h
Cmax, mg/L90.414.6
t1/2, h2.72.7
V, L1722.2
AUC0–tau, mg·h/L29138.2
Protein binding, %218
Elimination (urine), %83>97
ParameterCeftazidime, 2 g every 8 hAvibactam, 500 mg every 8 h
Cmax, mg/L90.414.6
t1/2, h2.72.7
V, L1722.2
AUC0–tau, mg·h/L29138.2
Protein binding, %218
Elimination (urine), %83>97

Cmax, peak serum concentration; t1/2, half-life; V, volume of distribution; AUC0–tau, area under the curve over the dosing interval.

Table 4.
Open in new tab

Summary of pharmacokinetic parameters of ceftazidime and avibactam

ParameterCeftazidime, 2 g every 8 hAvibactam, 500 mg every 8 h
Cmax, mg/L90.414.6
t1/2, h2.72.7
V, L1722.2
AUC0–tau, mg·h/L29138.2
Protein binding, %218
Elimination (urine), %83>97
ParameterCeftazidime, 2 g every 8 hAvibactam, 500 mg every 8 h
Cmax, mg/L90.414.6
t1/2, h2.72.7
V, L1722.2
AUC0–tau, mg·h/L29138.2
Protein binding, %218
Elimination (urine), %83>97

Cmax, peak serum concentration; t1/2, half-life; V, volume of distribution; AUC0–tau, area under the curve over the dosing interval.

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