Table 7 Open in new tab For six... | Oxford Academic

Table 7

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For six SARS-CoV-2 replication-related proteins, the antiviral drugs in top 50 drugs with better affinities predicted by MRBDTA and MATT_DTI based on KIBA score

Key proteins in SARS-CoV-2	MRBDTA			MATT_DTI
Key proteins in SARS-CoV-2	Antiviral drug	KIBA score	Rank out of 3137	Antiviral drug	KIBA score	Rank out of 3137
3C-like proteinase	Daclatasvir (BMS-790052)	13.9089	4	Peramivir	12.1797	25
3C-like proteinase	Ritonavir	13.4445	21	Lopinavir	12.0090	45
RNA-dependent RNA polymerase	Daclatasvir (BMS-790052)	13.4401	8
	Ritonavir	12.6714	29
	Entecavir	12.5049	45
Helicase	Daclatasvir (BMS-790052)	13.9021	3
Helicase	Ritonavir	13.3434	18
3′-to-5′ exonuclease	Daclatasvir (BMS-790052)	13.7957	5	Zanamivir	12.2460	30
	Ritonavir	13.3427	19	Peramivir	12.1969	33
				Saquinavir	12.1460	37
EndoRNAse	Daclatasvir (BMS-790052)	13.8885	4	Peramivir	12.0356	37
EndoRNAse	Ritonavir	13.4665	19
2’-O-ribose methyltransferase	Daclatasvir (BMS-790052)	13.9041	4	Peramivir	12.2849	21
2’-O-ribose methyltransferase	Ritonavir	13.4015	24	Zanamivir	12.0110	46

Key proteins in SARS-CoV-2	MRBDTA			MATT_DTI
Key proteins in SARS-CoV-2	Antiviral drug	KIBA score	Rank out of 3137	Antiviral drug	KIBA score	Rank out of 3137
3C-like proteinase	Daclatasvir (BMS-790052)	13.9089	4	Peramivir	12.1797	25
3C-like proteinase	Ritonavir	13.4445	21	Lopinavir	12.0090	45
RNA-dependent RNA polymerase	Daclatasvir (BMS-790052)	13.4401	8
	Ritonavir	12.6714	29
	Entecavir	12.5049	45
Helicase	Daclatasvir (BMS-790052)	13.9021	3
Helicase	Ritonavir	13.3434	18
3′-to-5′ exonuclease	Daclatasvir (BMS-790052)	13.7957	5	Zanamivir	12.2460	30
	Ritonavir	13.3427	19	Peramivir	12.1969	33
				Saquinavir	12.1460	37
EndoRNAse	Daclatasvir (BMS-790052)	13.8885	4	Peramivir	12.0356	37
EndoRNAse	Ritonavir	13.4665	19
2’-O-ribose methyltransferase	Daclatasvir (BMS-790052)	13.9041	4	Peramivir	12.2849	21
2’-O-ribose methyltransferase	Ritonavir	13.4015	24	Zanamivir	12.0110	46

Table 7

Open in new tab

For six SARS-CoV-2 replication-related proteins, the antiviral drugs in top 50 drugs with better affinities predicted by MRBDTA and MATT_DTI based on KIBA score

Key proteins in SARS-CoV-2	MRBDTA			MATT_DTI
Key proteins in SARS-CoV-2	Antiviral drug	KIBA score	Rank out of 3137	Antiviral drug	KIBA score	Rank out of 3137
3C-like proteinase	Daclatasvir (BMS-790052)	13.9089	4	Peramivir	12.1797	25
3C-like proteinase	Ritonavir	13.4445	21	Lopinavir	12.0090	45
RNA-dependent RNA polymerase	Daclatasvir (BMS-790052)	13.4401	8
	Ritonavir	12.6714	29
	Entecavir	12.5049	45
Helicase	Daclatasvir (BMS-790052)	13.9021	3
Helicase	Ritonavir	13.3434	18
3′-to-5′ exonuclease	Daclatasvir (BMS-790052)	13.7957	5	Zanamivir	12.2460	30
	Ritonavir	13.3427	19	Peramivir	12.1969	33
				Saquinavir	12.1460	37
EndoRNAse	Daclatasvir (BMS-790052)	13.8885	4	Peramivir	12.0356	37
EndoRNAse	Ritonavir	13.4665	19
2’-O-ribose methyltransferase	Daclatasvir (BMS-790052)	13.9041	4	Peramivir	12.2849	21
2’-O-ribose methyltransferase	Ritonavir	13.4015	24	Zanamivir	12.0110	46

Key proteins in SARS-CoV-2	MRBDTA			MATT_DTI
Key proteins in SARS-CoV-2	Antiviral drug	KIBA score	Rank out of 3137	Antiviral drug	KIBA score	Rank out of 3137
3C-like proteinase	Daclatasvir (BMS-790052)	13.9089	4	Peramivir	12.1797	25
3C-like proteinase	Ritonavir	13.4445	21	Lopinavir	12.0090	45
RNA-dependent RNA polymerase	Daclatasvir (BMS-790052)	13.4401	8
	Ritonavir	12.6714	29
	Entecavir	12.5049	45
Helicase	Daclatasvir (BMS-790052)	13.9021	3
Helicase	Ritonavir	13.3434	18
3′-to-5′ exonuclease	Daclatasvir (BMS-790052)	13.7957	5	Zanamivir	12.2460	30
	Ritonavir	13.3427	19	Peramivir	12.1969	33
				Saquinavir	12.1460	37
EndoRNAse	Daclatasvir (BMS-790052)	13.8885	4	Peramivir	12.0356	37
EndoRNAse	Ritonavir	13.4665	19
2’-O-ribose methyltransferase	Daclatasvir (BMS-790052)	13.9041	4	Peramivir	12.2849	21
2’-O-ribose methyltransferase	Ritonavir	13.4015	24	Zanamivir	12.0110	46