Table 2 Open in new tab Classification...

Method	Modal	NC versus AD	EMCI versus LMCI	LMCI versus AD
RF	fMRI	60.64	55.56	70.97	63.26	60.00	56.45	72.22	64.34	59.38	57.81	65.63	61.72
SNP	59.57	52.63	70.27	61.45	57.50	57.14	58.82	57.98	58.33	57.38	60.00	58.69
Dual	64.89	70.59	58.14	64.36	63.75	59.32	76.19	67.76	63.54	62.07	65.79	63.93
SVM	fMRI	65.96	50.00	80.00	65.00	62.50	62.07	63.64	62.85	64.58	59.02	74.29	66.65
SNP	63.83	60.00	70.59	65.29	60.00	60.34	59.09	59.72	61.46	57.14	69.70	63.42
Dual	68.08	65.52	69.23	67.37	71.25	66.67	80.77	73.72	67.71	66.67	69.24	67.95
CNN	fMRI	74.47	72.92	76.09	74.50	67.50	75.51	58.06	66.79	70.83	71.15	70.45	70.80
SNP	69.15	63.16	77.78	70.47	66.25	62.50	75.00	68.75	68.75	79.17	58.33	68.75
Dual	75.53	72.92	78.26	75.59	70.00	66.04	77.79	71.91	72.94	72.00	73.91	72.96
GCN	fMRI	74.47	70.00	79.55	74.77	68.75	64.29	79.17	71.73	70.83	64.29	80.00	72.14
SNP	72.34	67.31	78.57	72.94	67.50	77.27	55.56	66.41	66.67	61.02	75.68	68.35
Dual	76.60	70.00	84.09	77.05	72.50	70.59	75.86	73.23	73.96	73.47	74.47	73.97
CNN-GAN	fMRI	77.66	74.47	82.98	78.72	73.75	72.92	75.00	73.96	75.00	84.91	62.79	73.85
SNP	74.47	71.42	77.78	74.60	72.50	67.92	81.48	74.70	72.92	67.92	79.07	73.50
Dual	80.85	83.33	80.23	83.87	77.50	72.92	84.38	78.65	78.13	78.57	77.78	78.17
GCN-GAN	fMRI	78.72	76.09	81.25	78.67	75.00	60.00	81.82	70.91	76.04	72.92	79.17	76.04
SNP	75.53	67.65	80.00	73.82	73.75	71.43	77.42	74.42	73.96	75.47	72.09	73.78
Dual	81.91	89.47	80.00	84.74	78.75	75.00	84.38	79.69	79.17	78.26	80.00	79.13
FIAD-GAN	fMRI	87.23	77.27	90.28	83.38	85.00	85.71	84.21	84.96	84.38	85.37	83.64	84.50
SNP	84.48	87.50	81.48	84.49	83.75	88.37	78.38	83.38	83.33	81.40	84.91	83.15
Dual	93.62	95.35	92.16	93.75	91.25	91.67	90.63	91.15	91.95	92.11	91.84	91.97

Method

Modal

NC versus AD

EMCI versus LMCI

LMCI versus AD

ACC (%)

SEN (%)

SPE (%)

BAC (%)

ACC (%)

SEN (%)

SPE (%)

BAC (%)

ACC (%)

SEN (%)

SPE (%)

BAC (%)

fMRI

60.64

55.56

70.97

63.26

60.00

56.45

72.22

64.34

59.38

57.81

65.63

61.72

SNP

59.57

52.63

70.27

61.45

57.50

57.14

58.82

57.98

58.33

57.38

60.00

58.69

Dual

64.89

70.59

58.14

64.36

63.75

59.32

76.19

67.76

63.54

62.07

65.79

63.93

SVM

fMRI

65.96

50.00

80.00

65.00

62.50

62.07

63.64

62.85

64.58

59.02

74.29

66.65

SNP

63.83

60.00

70.59

65.29

60.00

60.34

59.09

59.72

61.46

57.14

69.70

63.42

Dual

68.08

65.52

69.23

67.37

71.25

66.67

80.77

73.72

67.71

66.67

69.24

67.95

CNN

fMRI

74.47

72.92

76.09

74.50

67.50

75.51

58.06

66.79

70.83

71.15

70.45

70.80

SNP

69.15

63.16

77.78

70.47

66.25

62.50

75.00

68.75

79.17

58.33

68.75

Dual

75.53

72.92

78.26

75.59

70.00

66.04

77.79

71.91

72.94

72.00

73.91

72.96

GCN

fMRI

74.47

70.00

79.55

74.77

68.75

64.29

79.17

71.73

70.83

64.29

80.00

72.14

SNP

72.34

67.31

78.57

72.94

67.50

77.27

55.56

66.41

66.67

61.02

75.68

68.35

Dual

76.60

70.00

84.09

77.05

72.50

70.59

75.86

73.23

73.96

73.47

74.47

73.97

CNN-GAN

fMRI

77.66

74.47

82.98

78.72

73.75

72.92

75.00

73.96

75.00

84.91

62.79

73.85

SNP

74.47

71.42

77.78

74.60

72.50

67.92

81.48

74.70

72.92

67.92

79.07

73.50

Dual

80.85

83.33

80.23

83.87

77.50

72.92

84.38

78.65

78.13

78.57

77.78

78.17

GCN-GAN

fMRI

78.72

76.09

81.25

78.67

75.00

60.00

81.82

70.91

76.04

72.92

79.17

76.04

SNP

75.53

67.65

80.00

73.82

73.75

71.43

77.42

74.42

73.96

75.47

72.09

73.78

Dual

81.91

89.47

80.00

84.74

78.75

75.00

84.38

79.69

79.17

78.26

80.00

79.13

FIAD-GAN

fMRI

87.23

77.27

90.28

83.38

85.00

85.71

84.21

84.96

84.38

85.37

83.64

84.50

SNP

84.48

87.50

81.48

84.49

83.75

88.37

78.38

83.38

83.33

81.40

84.91

83.15

Dual

93.62

95.35

92.16

93.75

91.25

91.67

90.63

91.15

91.95

92.11

91.84

91.97

Method	Modal	NC versus AD	EMCI versus LMCI	LMCI versus AD
RF	fMRI	60.64	55.56	70.97	63.26	60.00	56.45	72.22	64.34	59.38	57.81	65.63	61.72
SNP	59.57	52.63	70.27	61.45	57.50	57.14	58.82	57.98	58.33	57.38	60.00	58.69
Dual	64.89	70.59	58.14	64.36	63.75	59.32	76.19	67.76	63.54	62.07	65.79	63.93
SVM	fMRI	65.96	50.00	80.00	65.00	62.50	62.07	63.64	62.85	64.58	59.02	74.29	66.65
SNP	63.83	60.00	70.59	65.29	60.00	60.34	59.09	59.72	61.46	57.14	69.70	63.42
Dual	68.08	65.52	69.23	67.37	71.25	66.67	80.77	73.72	67.71	66.67	69.24	67.95
CNN	fMRI	74.47	72.92	76.09	74.50	67.50	75.51	58.06	66.79	70.83	71.15	70.45	70.80
SNP	69.15	63.16	77.78	70.47	66.25	62.50	75.00	68.75	68.75	79.17	58.33	68.75
Dual	75.53	72.92	78.26	75.59	70.00	66.04	77.79	71.91	72.94	72.00	73.91	72.96
GCN	fMRI	74.47	70.00	79.55	74.77	68.75	64.29	79.17	71.73	70.83	64.29	80.00	72.14
SNP	72.34	67.31	78.57	72.94	67.50	77.27	55.56	66.41	66.67	61.02	75.68	68.35
Dual	76.60	70.00	84.09	77.05	72.50	70.59	75.86	73.23	73.96	73.47	74.47	73.97
CNN-GAN	fMRI	77.66	74.47	82.98	78.72	73.75	72.92	75.00	73.96	75.00	84.91	62.79	73.85
SNP	74.47	71.42	77.78	74.60	72.50	67.92	81.48	74.70	72.92	67.92	79.07	73.50
Dual	80.85	83.33	80.23	83.87	77.50	72.92	84.38	78.65	78.13	78.57	77.78	78.17
GCN-GAN	fMRI	78.72	76.09	81.25	78.67	75.00	60.00	81.82	70.91	76.04	72.92	79.17	76.04
SNP	75.53	67.65	80.00	73.82	73.75	71.43	77.42	74.42	73.96	75.47	72.09	73.78
Dual	81.91	89.47	80.00	84.74	78.75	75.00	84.38	79.69	79.17	78.26	80.00	79.13
FIAD-GAN	fMRI	87.23	77.27	90.28	83.38	85.00	85.71	84.21	84.96	84.38	85.37	83.64	84.50
SNP	84.48	87.50	81.48	84.49	83.75	88.37	78.38	83.38	83.33	81.40	84.91	83.15
Dual	93.62	95.35	92.16	93.75	91.25	91.67	90.63	91.15	91.95	92.11	91.84	91.97

Table 2

Open in new tab

Classification performance results of different methods on three tasks under different modal data

Method	Modal	NC versus AD				EMCI versus LMCI				LMCI versus AD
Method	Modal	ACC (%)	SEN (%)	SPE (%)	BAC (%)	ACC (%)	SEN (%)	SPE (%)	BAC (%)	ACC (%)	SEN (%)	SPE (%)	BAC (%)
RF	fMRI	60.64	55.56	70.97	63.26	60.00	56.45	72.22	64.34	59.38	57.81	65.63	61.72
	SNP	59.57	52.63	70.27	61.45	57.50	57.14	58.82	57.98	58.33	57.38	60.00	58.69
	Dual	64.89	70.59	58.14	64.36	63.75	59.32	76.19	67.76	63.54	62.07	65.79	63.93
SVM	fMRI	65.96	50.00	80.00	65.00	62.50	62.07	63.64	62.85	64.58	59.02	74.29	66.65
	SNP	63.83	60.00	70.59	65.29	60.00	60.34	59.09	59.72	61.46	57.14	69.70	63.42
	Dual	68.08	65.52	69.23	67.37	71.25	66.67	80.77	73.72	67.71	66.67	69.24	67.95
CNN	fMRI	74.47	72.92	76.09	74.50	67.50	75.51	58.06	66.79	70.83	71.15	70.45	70.80
	SNP	69.15	63.16	77.78	70.47	66.25	62.50	75.00	68.75	68.75	79.17	58.33	68.75
	Dual	75.53	72.92	78.26	75.59	70.00	66.04	77.79	71.91	72.94	72.00	73.91	72.96
GCN	fMRI	74.47	70.00	79.55	74.77	68.75	64.29	79.17	71.73	70.83	64.29	80.00	72.14
	SNP	72.34	67.31	78.57	72.94	67.50	77.27	55.56	66.41	66.67	61.02	75.68	68.35
	Dual	76.60	70.00	84.09	77.05	72.50	70.59	75.86	73.23	73.96	73.47	74.47	73.97
CNN-GAN	fMRI	77.66	74.47	82.98	78.72	73.75	72.92	75.00	73.96	75.00	84.91	62.79	73.85
	SNP	74.47	71.42	77.78	74.60	72.50	67.92	81.48	74.70	72.92	67.92	79.07	73.50
	Dual	80.85	83.33	80.23	83.87	77.50	72.92	84.38	78.65	78.13	78.57	77.78	78.17
GCN-GAN	fMRI	78.72	76.09	81.25	78.67	75.00	60.00	81.82	70.91	76.04	72.92	79.17	76.04
	SNP	75.53	67.65	80.00	73.82	73.75	71.43	77.42	74.42	73.96	75.47	72.09	73.78
	Dual	81.91	89.47	80.00	84.74	78.75	75.00	84.38	79.69	79.17	78.26	80.00	79.13
FIAD-GAN	fMRI	87.23	77.27	90.28	83.38	85.00	85.71	84.21	84.96	84.38	85.37	83.64	84.50
	SNP	84.48	87.50	81.48	84.49	83.75	88.37	78.38	83.38	83.33	81.40	84.91	83.15
	Dual	93.62	95.35	92.16	93.75	91.25	91.67	90.63	91.15	91.95	92.11	91.84	91.97

Method	Modal	NC versus AD				EMCI versus LMCI				LMCI versus AD
Method	Modal	ACC (%)	SEN (%)	SPE (%)	BAC (%)	ACC (%)	SEN (%)	SPE (%)	BAC (%)	ACC (%)	SEN (%)	SPE (%)	BAC (%)
RF	fMRI	60.64	55.56	70.97	63.26	60.00	56.45	72.22	64.34	59.38	57.81	65.63	61.72
	SNP	59.57	52.63	70.27	61.45	57.50	57.14	58.82	57.98	58.33	57.38	60.00	58.69
	Dual	64.89	70.59	58.14	64.36	63.75	59.32	76.19	67.76	63.54	62.07	65.79	63.93
SVM	fMRI	65.96	50.00	80.00	65.00	62.50	62.07	63.64	62.85	64.58	59.02	74.29	66.65
	SNP	63.83	60.00	70.59	65.29	60.00	60.34	59.09	59.72	61.46	57.14	69.70	63.42
	Dual	68.08	65.52	69.23	67.37	71.25	66.67	80.77	73.72	67.71	66.67	69.24	67.95
CNN	fMRI	74.47	72.92	76.09	74.50	67.50	75.51	58.06	66.79	70.83	71.15	70.45	70.80
	SNP	69.15	63.16	77.78	70.47	66.25	62.50	75.00	68.75	68.75	79.17	58.33	68.75
	Dual	75.53	72.92	78.26	75.59	70.00	66.04	77.79	71.91	72.94	72.00	73.91	72.96
GCN	fMRI	74.47	70.00	79.55	74.77	68.75	64.29	79.17	71.73	70.83	64.29	80.00	72.14
	SNP	72.34	67.31	78.57	72.94	67.50	77.27	55.56	66.41	66.67	61.02	75.68	68.35
	Dual	76.60	70.00	84.09	77.05	72.50	70.59	75.86	73.23	73.96	73.47	74.47	73.97
CNN-GAN	fMRI	77.66	74.47	82.98	78.72	73.75	72.92	75.00	73.96	75.00	84.91	62.79	73.85
	SNP	74.47	71.42	77.78	74.60	72.50	67.92	81.48	74.70	72.92	67.92	79.07	73.50
	Dual	80.85	83.33	80.23	83.87	77.50	72.92	84.38	78.65	78.13	78.57	77.78	78.17
GCN-GAN	fMRI	78.72	76.09	81.25	78.67	75.00	60.00	81.82	70.91	76.04	72.92	79.17	76.04
	SNP	75.53	67.65	80.00	73.82	73.75	71.43	77.42	74.42	73.96	75.47	72.09	73.78
	Dual	81.91	89.47	80.00	84.74	78.75	75.00	84.38	79.69	79.17	78.26	80.00	79.13
FIAD-GAN	fMRI	87.23	77.27	90.28	83.38	85.00	85.71	84.21	84.96	84.38	85.37	83.64	84.50
	SNP	84.48	87.50	81.48	84.49	83.75	88.37	78.38	83.38	83.33	81.40	84.91	83.15
	Dual	93.62	95.35	92.16	93.75	91.25	91.67	90.63	91.15	91.95	92.11	91.84	91.97

The bold values indicate the highest results of each indicator in each group of experiments, and the proposed approach always performs the best.

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