Table 3 Open in new tab Predictors of...

	Univariate	Multivariate
6-month new SCIL volume
HALT	−0.11	−0.37–0.14	0.38
CHA₂DS₂-VASc	0.05	0.00–0.09	0.047
Atrial fibrillation	0.08	−0.07–0.23	0.27
6-month new WMH volume
HALT	0.69	0.08–1.32	0.028	0.79	0.20–1.39	0.009
CHA₂DS₂-VASc	0.09	−0.03–0.21	0.16
Atrial fibrillation	0.15	−0.03–0.34	0.11
Procedural SCIL volume	0.71	0.53–0.89	<0.001	0.58	0.18–1.00	<0.001

	Univariate	Multivariate
6-month new SCIL volume
HALT	−0.11	−0.37–0.14	0.38
CHA₂DS₂-VASc	0.05	0.00–0.09	0.047
Atrial fibrillation	0.08	−0.07–0.23	0.27
6-month new WMH volume
HALT	0.69	0.08–1.32	0.028	0.79	0.20–1.39	0.009
CHA₂DS₂-VASc	0.09	−0.03–0.21	0.16
Atrial fibrillation	0.15	−0.03–0.34	0.11
Procedural SCIL volume	0.71	0.53–0.89	<0.001	0.58	0.18–1.00	<0.001

Table 3

Predictors of subclinical brain MRI findings

	Univariate			Multivariate
	Beta	95%CI	P	Beta	95%CI	P
6-month new SCIL volume
HALT	−0.11	−0.37–0.14	0.38
CHA₂DS₂-VASc	0.05	0.00–0.09	0.047
Atrial fibrillation	0.08	−0.07–0.23	0.27
6-month new WMH volume
HALT	0.69	0.08–1.32	0.028	0.79	0.20–1.39	0.009
CHA₂DS₂-VASc	0.09	−0.03–0.21	0.16
Atrial fibrillation	0.15	−0.03–0.34	0.11
Procedural SCIL volume	0.71	0.53–0.89	<0.001	0.58	0.18–1.00	<0.001

	Univariate			Multivariate
	Beta	95%CI	P	Beta	95%CI	P
6-month new SCIL volume
HALT	−0.11	−0.37–0.14	0.38
CHA₂DS₂-VASc	0.05	0.00–0.09	0.047
Atrial fibrillation	0.08	−0.07–0.23	0.27
6-month new WMH volume
HALT	0.69	0.08–1.32	0.028	0.79	0.20–1.39	0.009
CHA₂DS₂-VASc	0.09	−0.03–0.21	0.16
Atrial fibrillation	0.15	−0.03–0.34	0.11
Procedural SCIL volume	0.71	0.53–0.89	<0.001	0.58	0.18–1.00	<0.001

HALT, hypoattenuated leaflet thickening; 6-month SCIL, silent cerebral ischaemic lesion on the 6-month MRI; 6-month new WMH, white matter hyperintensity on the 6-month MRI that was not visible at baseline.

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