| . | Healthy controls (n = 28) . | Bicuspid aortic valve patients (n = 32) . | P-value . |
|---|---|---|---|
| Age (years) | 33 (28–48) | 34 (25–40) | 0.656 |
| Male | 15 (54%) | 23 (72%) | 0.148 |
| Weight (kg) | 72 (66–84) | 79 (71–85) | 0.112 |
| Body surface area (m2) | 1.9 (1.8–2.1) | 2.0 (1.9–2.1) | 0.110 |
| Height (cm) | 179 (174–184) | 183 (177–191) | 0.112 |
| Heart rate (bpm) | 59 (54–66) | 67 (60–78) | 0.008 |
| Systolic blood pressure (mmHg) | 110 (104–118) | 120 (113–131) | 0.005 |
| Diastolic blood pressure (mmHg) | 70 (65–76) | 80 (73–86) | <0.001 |
| Coarctation | 6 (18%) | ||
| Aortic valve morphology | |||
| BAV type 0 | 8 (25%) | ||
| BAV type 1 RL | 16 (50%) | ||
| BAV type 1 RN | 4 (13%) | ||
| BAV type 1 NL | 0 (0%) | ||
| BAV type 2 | 4 (13%) | ||
| Left ventricular ejection fraction (%) | 58 (53–62) | 54 (49–58) | 0.013 |
| Forward flow (mL/beat) | 95 (87–112) | 113 (99–129) | 0.009 |
| Aortic valve regurgitation | |||
| None | 28 (100%) | 15 (47%) | |
| Mild | 14 (44%) | ||
| Moderate | 3 (9%) | ||
| Severe | 0 (0%) | ||
| Peak aortic valve velocity (m/s) | 0.6 (0.5–0.6) | 2.6 (1.9–3.4) | <0.001 |
| Aortic valve stenosis | |||
| None | 28 (100%) | 15 (47%) | |
| Mild | 4 (13%) | ||
| Moderate | 10 (31%) | ||
| Severe | 3 (9%) | ||
| Aortic root diameter (mm) | 32.0 (30.8–34.3) | 39.5 (36.8–42.5) | <0.001 |
| Aortic root diameter (mm/m)a | 17.7 (17.2–19.4) | 22.0 (19.7–23.4) | <0.001 |
| Aortic root diameter (mm/m2)b | 16.6 (15.9–18.1) | 20.4 (17.7–21.6) | <0.001 |
| Sinotubular junction diameter (mm) | 27.0 (25.0–30.0) | 34.5 (31.0–38.3) | <0.001 |
| Sinotubular junction diameter (mm/m)a | 15.3 (14.5–16.3) | 19.3 (16.8–20.9) | <0.001 |
| Sinotubular junction diameter (mm/m2)b | 14.4 (13.6–15.1) | 16.8 (15.5–18.9) | <0.001 |
| Ascending aorta diameter (mm) | 28.0 (27.0–30.0) | 43.5 (37.0–46.0) | <0.001 |
| Ascending aorta diameter (mm/m)a | 15.7 (14.9–16.7) | 23.6 (20.1–25.4) | <0.001 |
| Ascending aorta diameter (mm/m2)b | 14.8 (13.9–15.7) | 20.7 (18.7–23.4) | <0.001 |
| . | Healthy controls (n = 28) . | Bicuspid aortic valve patients (n = 32) . | P-value . |
|---|---|---|---|
| Age (years) | 33 (28–48) | 34 (25–40) | 0.656 |
| Male | 15 (54%) | 23 (72%) | 0.148 |
| Weight (kg) | 72 (66–84) | 79 (71–85) | 0.112 |
| Body surface area (m2) | 1.9 (1.8–2.1) | 2.0 (1.9–2.1) | 0.110 |
| Height (cm) | 179 (174–184) | 183 (177–191) | 0.112 |
| Heart rate (bpm) | 59 (54–66) | 67 (60–78) | 0.008 |
| Systolic blood pressure (mmHg) | 110 (104–118) | 120 (113–131) | 0.005 |
| Diastolic blood pressure (mmHg) | 70 (65–76) | 80 (73–86) | <0.001 |
| Coarctation | 6 (18%) | ||
| Aortic valve morphology | |||
| BAV type 0 | 8 (25%) | ||
| BAV type 1 RL | 16 (50%) | ||
| BAV type 1 RN | 4 (13%) | ||
| BAV type 1 NL | 0 (0%) | ||
| BAV type 2 | 4 (13%) | ||
| Left ventricular ejection fraction (%) | 58 (53–62) | 54 (49–58) | 0.013 |
| Forward flow (mL/beat) | 95 (87–112) | 113 (99–129) | 0.009 |
| Aortic valve regurgitation | |||
| None | 28 (100%) | 15 (47%) | |
| Mild | 14 (44%) | ||
| Moderate | 3 (9%) | ||
| Severe | 0 (0%) | ||
| Peak aortic valve velocity (m/s) | 0.6 (0.5–0.6) | 2.6 (1.9–3.4) | <0.001 |
| Aortic valve stenosis | |||
| None | 28 (100%) | 15 (47%) | |
| Mild | 4 (13%) | ||
| Moderate | 10 (31%) | ||
| Severe | 3 (9%) | ||
| Aortic root diameter (mm) | 32.0 (30.8–34.3) | 39.5 (36.8–42.5) | <0.001 |
| Aortic root diameter (mm/m)a | 17.7 (17.2–19.4) | 22.0 (19.7–23.4) | <0.001 |
| Aortic root diameter (mm/m2)b | 16.6 (15.9–18.1) | 20.4 (17.7–21.6) | <0.001 |
| Sinotubular junction diameter (mm) | 27.0 (25.0–30.0) | 34.5 (31.0–38.3) | <0.001 |
| Sinotubular junction diameter (mm/m)a | 15.3 (14.5–16.3) | 19.3 (16.8–20.9) | <0.001 |
| Sinotubular junction diameter (mm/m2)b | 14.4 (13.6–15.1) | 16.8 (15.5–18.9) | <0.001 |
| Ascending aorta diameter (mm) | 28.0 (27.0–30.0) | 43.5 (37.0–46.0) | <0.001 |
| Ascending aorta diameter (mm/m)a | 15.7 (14.9–16.7) | 23.6 (20.1–25.4) | <0.001 |
| Ascending aorta diameter (mm/m2)b | 14.8 (13.9–15.7) | 20.7 (18.7–23.4) | <0.001 |
Values are presented as numbers (percentages) or median (interquartile range). Aortic diameter measurements in healthy controls are cardiovascular magnetic resonance based, aortic diameter measurements in patients are computed tomography angiography based.
Diameters are corrected for height.
Diameters are corrected for body surface area.
| . | Healthy controls (n = 28) . | Bicuspid aortic valve patients (n = 32) . | P-value . |
|---|---|---|---|
| Age (years) | 33 (28–48) | 34 (25–40) | 0.656 |
| Male | 15 (54%) | 23 (72%) | 0.148 |
| Weight (kg) | 72 (66–84) | 79 (71–85) | 0.112 |
| Body surface area (m2) | 1.9 (1.8–2.1) | 2.0 (1.9–2.1) | 0.110 |
| Height (cm) | 179 (174–184) | 183 (177–191) | 0.112 |
| Heart rate (bpm) | 59 (54–66) | 67 (60–78) | 0.008 |
| Systolic blood pressure (mmHg) | 110 (104–118) | 120 (113–131) | 0.005 |
| Diastolic blood pressure (mmHg) | 70 (65–76) | 80 (73–86) | <0.001 |
| Coarctation | 6 (18%) | ||
| Aortic valve morphology | |||
| BAV type 0 | 8 (25%) | ||
| BAV type 1 RL | 16 (50%) | ||
| BAV type 1 RN | 4 (13%) | ||
| BAV type 1 NL | 0 (0%) | ||
| BAV type 2 | 4 (13%) | ||
| Left ventricular ejection fraction (%) | 58 (53–62) | 54 (49–58) | 0.013 |
| Forward flow (mL/beat) | 95 (87–112) | 113 (99–129) | 0.009 |
| Aortic valve regurgitation | |||
| None | 28 (100%) | 15 (47%) | |
| Mild | 14 (44%) | ||
| Moderate | 3 (9%) | ||
| Severe | 0 (0%) | ||
| Peak aortic valve velocity (m/s) | 0.6 (0.5–0.6) | 2.6 (1.9–3.4) | <0.001 |
| Aortic valve stenosis | |||
| None | 28 (100%) | 15 (47%) | |
| Mild | 4 (13%) | ||
| Moderate | 10 (31%) | ||
| Severe | 3 (9%) | ||
| Aortic root diameter (mm) | 32.0 (30.8–34.3) | 39.5 (36.8–42.5) | <0.001 |
| Aortic root diameter (mm/m)a | 17.7 (17.2–19.4) | 22.0 (19.7–23.4) | <0.001 |
| Aortic root diameter (mm/m2)b | 16.6 (15.9–18.1) | 20.4 (17.7–21.6) | <0.001 |
| Sinotubular junction diameter (mm) | 27.0 (25.0–30.0) | 34.5 (31.0–38.3) | <0.001 |
| Sinotubular junction diameter (mm/m)a | 15.3 (14.5–16.3) | 19.3 (16.8–20.9) | <0.001 |
| Sinotubular junction diameter (mm/m2)b | 14.4 (13.6–15.1) | 16.8 (15.5–18.9) | <0.001 |
| Ascending aorta diameter (mm) | 28.0 (27.0–30.0) | 43.5 (37.0–46.0) | <0.001 |
| Ascending aorta diameter (mm/m)a | 15.7 (14.9–16.7) | 23.6 (20.1–25.4) | <0.001 |
| Ascending aorta diameter (mm/m2)b | 14.8 (13.9–15.7) | 20.7 (18.7–23.4) | <0.001 |
| . | Healthy controls (n = 28) . | Bicuspid aortic valve patients (n = 32) . | P-value . |
|---|---|---|---|
| Age (years) | 33 (28–48) | 34 (25–40) | 0.656 |
| Male | 15 (54%) | 23 (72%) | 0.148 |
| Weight (kg) | 72 (66–84) | 79 (71–85) | 0.112 |
| Body surface area (m2) | 1.9 (1.8–2.1) | 2.0 (1.9–2.1) | 0.110 |
| Height (cm) | 179 (174–184) | 183 (177–191) | 0.112 |
| Heart rate (bpm) | 59 (54–66) | 67 (60–78) | 0.008 |
| Systolic blood pressure (mmHg) | 110 (104–118) | 120 (113–131) | 0.005 |
| Diastolic blood pressure (mmHg) | 70 (65–76) | 80 (73–86) | <0.001 |
| Coarctation | 6 (18%) | ||
| Aortic valve morphology | |||
| BAV type 0 | 8 (25%) | ||
| BAV type 1 RL | 16 (50%) | ||
| BAV type 1 RN | 4 (13%) | ||
| BAV type 1 NL | 0 (0%) | ||
| BAV type 2 | 4 (13%) | ||
| Left ventricular ejection fraction (%) | 58 (53–62) | 54 (49–58) | 0.013 |
| Forward flow (mL/beat) | 95 (87–112) | 113 (99–129) | 0.009 |
| Aortic valve regurgitation | |||
| None | 28 (100%) | 15 (47%) | |
| Mild | 14 (44%) | ||
| Moderate | 3 (9%) | ||
| Severe | 0 (0%) | ||
| Peak aortic valve velocity (m/s) | 0.6 (0.5–0.6) | 2.6 (1.9–3.4) | <0.001 |
| Aortic valve stenosis | |||
| None | 28 (100%) | 15 (47%) | |
| Mild | 4 (13%) | ||
| Moderate | 10 (31%) | ||
| Severe | 3 (9%) | ||
| Aortic root diameter (mm) | 32.0 (30.8–34.3) | 39.5 (36.8–42.5) | <0.001 |
| Aortic root diameter (mm/m)a | 17.7 (17.2–19.4) | 22.0 (19.7–23.4) | <0.001 |
| Aortic root diameter (mm/m2)b | 16.6 (15.9–18.1) | 20.4 (17.7–21.6) | <0.001 |
| Sinotubular junction diameter (mm) | 27.0 (25.0–30.0) | 34.5 (31.0–38.3) | <0.001 |
| Sinotubular junction diameter (mm/m)a | 15.3 (14.5–16.3) | 19.3 (16.8–20.9) | <0.001 |
| Sinotubular junction diameter (mm/m2)b | 14.4 (13.6–15.1) | 16.8 (15.5–18.9) | <0.001 |
| Ascending aorta diameter (mm) | 28.0 (27.0–30.0) | 43.5 (37.0–46.0) | <0.001 |
| Ascending aorta diameter (mm/m)a | 15.7 (14.9–16.7) | 23.6 (20.1–25.4) | <0.001 |
| Ascending aorta diameter (mm/m2)b | 14.8 (13.9–15.7) | 20.7 (18.7–23.4) | <0.001 |
Values are presented as numbers (percentages) or median (interquartile range). Aortic diameter measurements in healthy controls are cardiovascular magnetic resonance based, aortic diameter measurements in patients are computed tomography angiography based.
Diameters are corrected for height.
Diameters are corrected for body surface area.
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