Differential expression analysis of Alzheimer’s disease candidate miRNAs in brain samples of Parkinson’s disease patients and controls
| Alzheimer’s disease candidate miRNA . | Relative quantity (95% CI) . | Effect size (±SE) . | P-value . | N (Parkinson’s disease cases, controls) . |
|---|---|---|---|---|
| hsa-miR-125b-5p | 1.021 (0.975, 1.069) | 0.0309 (±0.155) | 0.842 | 244 (200, 44) |
| hsa-miR-501-3p | 0.880 (0.806, 0.960) | −0.186 (±0.183) | 0.312 | 197 (162, 35) |
| hsa-miR-132-5p | 0.659 (0.609, 0.714) | −0.705 (±0.15) | 4.52E−06 | 255 (209, 46) |
| hsa-miR-138-5p | 1.014 (0.971, 1.059) | 0.0474 (±0.161) | 0.769 | 254 (208, 46) |
| hsa-miR-195-5p | 1.003 (0.871, 1.155) | −0.0875 (±0.152) | 0.565 | 244 (198, 46) |
| hsa-miR-129-5p | 0.868 (0.821, 0.917) | −0.333 (±0.159) | 0.0379 | 249 (203, 46) |
| Alzheimer’s disease candidate miRNA . | Relative quantity (95% CI) . | Effect size (±SE) . | P-value . | N (Parkinson’s disease cases, controls) . |
|---|---|---|---|---|
| hsa-miR-125b-5p | 1.021 (0.975, 1.069) | 0.0309 (±0.155) | 0.842 | 244 (200, 44) |
| hsa-miR-501-3p | 0.880 (0.806, 0.960) | −0.186 (±0.183) | 0.312 | 197 (162, 35) |
| hsa-miR-132-5p | 0.659 (0.609, 0.714) | −0.705 (±0.15) | 4.52E−06 | 255 (209, 46) |
| hsa-miR-138-5p | 1.014 (0.971, 1.059) | 0.0474 (±0.161) | 0.769 | 254 (208, 46) |
| hsa-miR-195-5p | 1.003 (0.871, 1.155) | −0.0875 (±0.152) | 0.565 | 244 (198, 46) |
| hsa-miR-129-5p | 0.868 (0.821, 0.917) | −0.333 (±0.159) | 0.0379 | 249 (203, 46) |
This table displays the statistical results of the differential gene expression analyses of Alzheimer’s disease candidate miRNAs in post-mortem brain samples of 214 Parkinson’s disease patients and 47 controls. P-values displayed in bold highlight nominally significant (α = 0.05) differential expression results. SE, standard error; N, number.
Differential expression analysis of Alzheimer’s disease candidate miRNAs in brain samples of Parkinson’s disease patients and controls
| Alzheimer’s disease candidate miRNA . | Relative quantity (95% CI) . | Effect size (±SE) . | P-value . | N (Parkinson’s disease cases, controls) . |
|---|---|---|---|---|
| hsa-miR-125b-5p | 1.021 (0.975, 1.069) | 0.0309 (±0.155) | 0.842 | 244 (200, 44) |
| hsa-miR-501-3p | 0.880 (0.806, 0.960) | −0.186 (±0.183) | 0.312 | 197 (162, 35) |
| hsa-miR-132-5p | 0.659 (0.609, 0.714) | −0.705 (±0.15) | 4.52E−06 | 255 (209, 46) |
| hsa-miR-138-5p | 1.014 (0.971, 1.059) | 0.0474 (±0.161) | 0.769 | 254 (208, 46) |
| hsa-miR-195-5p | 1.003 (0.871, 1.155) | −0.0875 (±0.152) | 0.565 | 244 (198, 46) |
| hsa-miR-129-5p | 0.868 (0.821, 0.917) | −0.333 (±0.159) | 0.0379 | 249 (203, 46) |
| Alzheimer’s disease candidate miRNA . | Relative quantity (95% CI) . | Effect size (±SE) . | P-value . | N (Parkinson’s disease cases, controls) . |
|---|---|---|---|---|
| hsa-miR-125b-5p | 1.021 (0.975, 1.069) | 0.0309 (±0.155) | 0.842 | 244 (200, 44) |
| hsa-miR-501-3p | 0.880 (0.806, 0.960) | −0.186 (±0.183) | 0.312 | 197 (162, 35) |
| hsa-miR-132-5p | 0.659 (0.609, 0.714) | −0.705 (±0.15) | 4.52E−06 | 255 (209, 46) |
| hsa-miR-138-5p | 1.014 (0.971, 1.059) | 0.0474 (±0.161) | 0.769 | 254 (208, 46) |
| hsa-miR-195-5p | 1.003 (0.871, 1.155) | −0.0875 (±0.152) | 0.565 | 244 (198, 46) |
| hsa-miR-129-5p | 0.868 (0.821, 0.917) | −0.333 (±0.159) | 0.0379 | 249 (203, 46) |
This table displays the statistical results of the differential gene expression analyses of Alzheimer’s disease candidate miRNAs in post-mortem brain samples of 214 Parkinson’s disease patients and 47 controls. P-values displayed in bold highlight nominally significant (α = 0.05) differential expression results. SE, standard error; N, number.
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