Table 1 Open in new tab Cell counts and...

Cell counts (normal range) and frequencies (%)	IgG4-RSM	HD	GPA
Neutrophil cell count (1500–7700/µl)	7990	8740	7810	5130	3930
% of SLAMF7+ neutrophils	61	16	10	10	54
SLAMF7+ neutrophil cell count/µl	4874	1404	781	513	2122
Monocyte cell count (100–1000/µl)	900	1230	860	780	980
% of SLAMF7+ monocytes	86	43	49	38	73
SLAMF7+ monocyte cell count/µl	774	529	421	296	715
Lymphocyte cell count (1100–4000/µl)	1280	1560	1230	2890	1900
% of SLAMF7+ lymphocytes	36	60	78	35	10
SLAMF7+ lymphocyte cell count/µl	461	936	959	1011	190
CD3+ T cell count (700–2100/µl)	1.097	995	1174	863	1177
% of SLAMF7+ cells within CD3+ T cell population	65	69	81	24	4
CD3+SLAMF7+ cell count/µl	713	687	950	207	47
CD4+ T cell count (300–1400/µl)	714	697	815	649	472
% of SLAMF7+ cells within CD4+ T cell population	47	30	63	4	22
CD4+SLAMF7+ cell count/µl	336	209	513	26	104
% of CD28+ cells within CD4+ T cell population	71	89	59	97	87
% of CD27– cells within CD4+CD28+ T cell population	23	23	36	4	9
% of SLAMF7+ cells within CD4+CD28+ T cell population	24	21	40	4	13
% of CD28– cells within CD4+ T cell population	29	11	41	3	13
% of CD27– cells within CD4+CD28– T cell population	99	99	99	5	96
% of SLAMF7+ cells within CD4+CD28– T cell population	99	91	96	13	91
CD8+ T cell cell count (200–900/µl)	391	329	399	216	683
% of SLAMF7+ cells within CD8+ T cell population	96	96	98	65	92
CD8+SLAMF7+ cell count/µl	375	315	391	140	638
% of CD28+ cells within CD8+ T cell population	27	33	21	86	15
% of CD27– cells within CD8+CD28+ T cell population	14	18	20	5	11
% of SLAMF7+ cells within CD8+CD28+ T cell population	82	89	94	60	47
% of CD28– cells within CD8+ T cell population	73	67	79	14	85
% of CD27– cells within CD8+CD28– T cell population	86	83	83	40	91
% of SLAMF7+ cells within CD8+CD28– T cell population	100	99	98	96	99
% of CD4+CD8+ DP cells within CD3+ T cell population	6	23	13	1	2
% of SLAMF7+ cells within CD4+CD8+ DP T cell population	98	99	99	22	70
% of CD56+ cells within CD3+ T cell population	19	26	30	5	18
% of SLAMF7+ cells within CD3+CD56+ NKT cell population	99	99	99	97	99
CD3+CD56+SLAMF7+ cell count/µl	206	256	350	40	209
CD19+ B cell cell count (100–500/µl)	7	8	10	128	1
CD3-CD56+ NK cells cell count (90–600/µl)	101	57	97	150	156
% of CD56+ cells within CD3– cell population	8	31	59	52	50
% of SLAMF7+ cells within CD3–CD56+ NK cell population	98	99	98	98	99
CD3–CD56+SLAMF7+ cell count/µl	7	16	56	77	76

Cell counts (normal range) and frequencies (%)

IgG4-RSM

GPA

Baseline

Week 6

Week 12

Neutrophil cell count (1500–7700/µl)

7990

8740

7810

5130

3930

% of SLAMF7+ neutrophils

SLAMF7+ neutrophil cell count/µl

4874

1404

781

513

2122

Monocyte cell count (100–1000/µl)

900

1230

860

780

980

% of SLAMF7+ monocytes

SLAMF7+ monocyte cell count/µl

774

529

421

296

715

Lymphocyte cell count (1100–4000/µl)

1280

1560

1230

2890

1900

% of SLAMF7+ lymphocytes

SLAMF7+ lymphocyte cell count/µl

461

936

959

1011

190

CD3+ T cell count (700–2100/µl)

1.097

995

1174

863

1177

% of SLAMF7+ cells within CD3+ T cell population

CD3+SLAMF7+ cell count/µl

713

687

950

207

CD4+ T cell count (300–1400/µl)

714

697

815

649

472

% of SLAMF7+ cells within CD4+ T cell population

CD4+SLAMF7+ cell count/µl

336

209

513

104

% of CD28+ cells within CD4+ T cell population

% of CD27– cells within CD4+CD28+ T cell population

% of SLAMF7+ cells within CD4+CD28+ T cell population

% of CD28– cells within CD4+ T cell population

% of CD27– cells within CD4+CD28– T cell population

% of SLAMF7+ cells within CD4+CD28– T cell population

CD8+ T cell cell count (200–900/µl)

391

329

399

216

683

% of SLAMF7+ cells within CD8+ T cell population

CD8+SLAMF7+ cell count/µl

375

315

391

140

638

% of CD28+ cells within CD8+ T cell population

% of CD27– cells within CD8+CD28+ T cell population

% of SLAMF7+ cells within CD8+CD28+ T cell population

% of CD28– cells within CD8+ T cell population

% of CD27– cells within CD8+CD28– T cell population

% of SLAMF7+ cells within CD8+CD28– T cell population

100

% of CD4+CD8+ DP cells within CD3+ T cell population

% of SLAMF7+ cells within CD4+CD8+ DP T cell population

% of CD56+ cells within CD3+ T cell population

% of SLAMF7+ cells within CD3+CD56+ NKT cell population

CD3+CD56+SLAMF7+ cell count/µl

206

256

350

209

CD19+ B cell cell count (100–500/µl)

128

CD3-CD56+ NK cells cell count (90–600/µl)

101

150

156

% of CD56+ cells within CD3– cell population

% of SLAMF7+ cells within CD3–CD56+ NK cell population

CD3–CD56+SLAMF7+ cell count/µl

Cell counts (normal range) and frequencies (%)	IgG4-RSM	HD	GPA
Neutrophil cell count (1500–7700/µl)	7990	8740	7810	5130	3930
% of SLAMF7+ neutrophils	61	16	10	10	54
SLAMF7+ neutrophil cell count/µl	4874	1404	781	513	2122
Monocyte cell count (100–1000/µl)	900	1230	860	780	980
% of SLAMF7+ monocytes	86	43	49	38	73
SLAMF7+ monocyte cell count/µl	774	529	421	296	715
Lymphocyte cell count (1100–4000/µl)	1280	1560	1230	2890	1900
% of SLAMF7+ lymphocytes	36	60	78	35	10
SLAMF7+ lymphocyte cell count/µl	461	936	959	1011	190
CD3+ T cell count (700–2100/µl)	1.097	995	1174	863	1177
% of SLAMF7+ cells within CD3+ T cell population	65	69	81	24	4
CD3+SLAMF7+ cell count/µl	713	687	950	207	47
CD4+ T cell count (300–1400/µl)	714	697	815	649	472
% of SLAMF7+ cells within CD4+ T cell population	47	30	63	4	22
CD4+SLAMF7+ cell count/µl	336	209	513	26	104
% of CD28+ cells within CD4+ T cell population	71	89	59	97	87
% of CD27– cells within CD4+CD28+ T cell population	23	23	36	4	9
% of SLAMF7+ cells within CD4+CD28+ T cell population	24	21	40	4	13
% of CD28– cells within CD4+ T cell population	29	11	41	3	13
% of CD27– cells within CD4+CD28– T cell population	99	99	99	5	96
% of SLAMF7+ cells within CD4+CD28– T cell population	99	91	96	13	91
CD8+ T cell cell count (200–900/µl)	391	329	399	216	683
% of SLAMF7+ cells within CD8+ T cell population	96	96	98	65	92
CD8+SLAMF7+ cell count/µl	375	315	391	140	638
% of CD28+ cells within CD8+ T cell population	27	33	21	86	15
% of CD27– cells within CD8+CD28+ T cell population	14	18	20	5	11
% of SLAMF7+ cells within CD8+CD28+ T cell population	82	89	94	60	47
% of CD28– cells within CD8+ T cell population	73	67	79	14	85
% of CD27– cells within CD8+CD28– T cell population	86	83	83	40	91
% of SLAMF7+ cells within CD8+CD28– T cell population	100	99	98	96	99
% of CD4+CD8+ DP cells within CD3+ T cell population	6	23	13	1	2
% of SLAMF7+ cells within CD4+CD8+ DP T cell population	98	99	99	22	70
% of CD56+ cells within CD3+ T cell population	19	26	30	5	18
% of SLAMF7+ cells within CD3+CD56+ NKT cell population	99	99	99	97	99
CD3+CD56+SLAMF7+ cell count/µl	206	256	350	40	209
CD19+ B cell cell count (100–500/µl)	7	8	10	128	1
CD3-CD56+ NK cells cell count (90–600/µl)	101	57	97	150	156
% of CD56+ cells within CD3– cell population	8	31	59	52	50
% of SLAMF7+ cells within CD3–CD56+ NK cell population	98	99	98	98	99
CD3–CD56+SLAMF7+ cell count/µl	7	16	56	77	76

Table 1

Open in new tab

Cell counts and frequencies of cellular subsets in peripheral blood in the patient and controls

Cell counts (normal range) and frequencies (%)	IgG4-RSM			HD	GPA
Cell counts (normal range) and frequencies (%)	Baseline	Week 6	Week 12	HD	GPA
Neutrophil cell count (1500–7700/µl)	7990	8740	7810	5130	3930
% of SLAMF7+ neutrophils	61	16	10	10	54
SLAMF7+ neutrophil cell count/µl	4874	1404	781	513	2122
Monocyte cell count (100–1000/µl)	900	1230	860	780	980
% of SLAMF7+ monocytes	86	43	49	38	73
SLAMF7+ monocyte cell count/µl	774	529	421	296	715
Lymphocyte cell count (1100–4000/µl)	1280	1560	1230	2890	1900
% of SLAMF7+ lymphocytes	36	60	78	35	10
SLAMF7+ lymphocyte cell count/µl	461	936	959	1011	190
CD3+ T cell count (700–2100/µl)	1.097	995	1174	863	1177
% of SLAMF7+ cells within CD3+ T cell population	65	69	81	24	4
CD3+SLAMF7+ cell count/µl	713	687	950	207	47
CD4+ T cell count (300–1400/µl)	714	697	815	649	472
% of SLAMF7+ cells within CD4+ T cell population	47	30	63	4	22
CD4+SLAMF7+ cell count/µl	336	209	513	26	104
% of CD28+ cells within CD4+ T cell population	71	89	59	97	87
% of CD27– cells within CD4+CD28+ T cell population	23	23	36	4	9
% of SLAMF7+ cells within CD4+CD28+ T cell population	24	21	40	4	13
% of CD28– cells within CD4+ T cell population	29	11	41	3	13
% of CD27– cells within CD4+CD28– T cell population	99	99	99	5	96
% of SLAMF7+ cells within CD4+CD28– T cell population	99	91	96	13	91
CD8+ T cell cell count (200–900/µl)	391	329	399	216	683
% of SLAMF7+ cells within CD8+ T cell population	96	96	98	65	92
CD8+SLAMF7+ cell count/µl	375	315	391	140	638
% of CD28+ cells within CD8+ T cell population	27	33	21	86	15
% of CD27– cells within CD8+CD28+ T cell population	14	18	20	5	11
% of SLAMF7+ cells within CD8+CD28+ T cell population	82	89	94	60	47
% of CD28– cells within CD8+ T cell population	73	67	79	14	85
% of CD27– cells within CD8+CD28– T cell population	86	83	83	40	91
% of SLAMF7+ cells within CD8+CD28– T cell population	100	99	98	96	99
% of CD4+CD8+ DP cells within CD3+ T cell population	6	23	13	1	2
% of SLAMF7+ cells within CD4+CD8+ DP T cell population	98	99	99	22	70
% of CD56+ cells within CD3+ T cell population	19	26	30	5	18
% of SLAMF7+ cells within CD3+CD56+ NKT cell population	99	99	99	97	99
CD3+CD56+SLAMF7+ cell count/µl	206	256	350	40	209
CD19+ B cell cell count (100–500/µl)	7	8	10	128	1
CD3-CD56+ NK cells cell count (90–600/µl)	101	57	97	150	156
% of CD56+ cells within CD3– cell population	8	31	59	52	50
% of SLAMF7+ cells within CD3–CD56+ NK cell population	98	99	98	98	99
CD3–CD56+SLAMF7+ cell count/µl	7	16	56	77	76

Cell counts (normal range) and frequencies (%)	IgG4-RSM			HD	GPA
Cell counts (normal range) and frequencies (%)	Baseline	Week 6	Week 12	HD	GPA
Neutrophil cell count (1500–7700/µl)	7990	8740	7810	5130	3930
% of SLAMF7+ neutrophils	61	16	10	10	54
SLAMF7+ neutrophil cell count/µl	4874	1404	781	513	2122
Monocyte cell count (100–1000/µl)	900	1230	860	780	980
% of SLAMF7+ monocytes	86	43	49	38	73
SLAMF7+ monocyte cell count/µl	774	529	421	296	715
Lymphocyte cell count (1100–4000/µl)	1280	1560	1230	2890	1900
% of SLAMF7+ lymphocytes	36	60	78	35	10
SLAMF7+ lymphocyte cell count/µl	461	936	959	1011	190
CD3+ T cell count (700–2100/µl)	1.097	995	1174	863	1177
% of SLAMF7+ cells within CD3+ T cell population	65	69	81	24	4
CD3+SLAMF7+ cell count/µl	713	687	950	207	47
CD4+ T cell count (300–1400/µl)	714	697	815	649	472
% of SLAMF7+ cells within CD4+ T cell population	47	30	63	4	22
CD4+SLAMF7+ cell count/µl	336	209	513	26	104
% of CD28+ cells within CD4+ T cell population	71	89	59	97	87
% of CD27– cells within CD4+CD28+ T cell population	23	23	36	4	9
% of SLAMF7+ cells within CD4+CD28+ T cell population	24	21	40	4	13
% of CD28– cells within CD4+ T cell population	29	11	41	3	13
% of CD27– cells within CD4+CD28– T cell population	99	99	99	5	96
% of SLAMF7+ cells within CD4+CD28– T cell population	99	91	96	13	91
CD8+ T cell cell count (200–900/µl)	391	329	399	216	683
% of SLAMF7+ cells within CD8+ T cell population	96	96	98	65	92
CD8+SLAMF7+ cell count/µl	375	315	391	140	638
% of CD28+ cells within CD8+ T cell population	27	33	21	86	15
% of CD27– cells within CD8+CD28+ T cell population	14	18	20	5	11
% of SLAMF7+ cells within CD8+CD28+ T cell population	82	89	94	60	47
% of CD28– cells within CD8+ T cell population	73	67	79	14	85
% of CD27– cells within CD8+CD28– T cell population	86	83	83	40	91
% of SLAMF7+ cells within CD8+CD28– T cell population	100	99	98	96	99
% of CD4+CD8+ DP cells within CD3+ T cell population	6	23	13	1	2
% of SLAMF7+ cells within CD4+CD8+ DP T cell population	98	99	99	22	70
% of CD56+ cells within CD3+ T cell population	19	26	30	5	18
% of SLAMF7+ cells within CD3+CD56+ NKT cell population	99	99	99	97	99
CD3+CD56+SLAMF7+ cell count/µl	206	256	350	40	209
CD19+ B cell cell count (100–500/µl)	7	8	10	128	1
CD3-CD56+ NK cells cell count (90–600/µl)	101	57	97	150	156
% of CD56+ cells within CD3– cell population	8	31	59	52	50
% of SLAMF7+ cells within CD3–CD56+ NK cell population	98	99	98	98	99
CD3–CD56+SLAMF7+ cell count/µl	7	16	56	77	76

IgG4-RSM: IgG4-related sclerosing mesenteritis; GPA: granulomatosis with polyangiitis; HD: healthy donor.

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