Lethal arrhythmic events in Brugada syndrome cohort-I subgroups classified by different SCN5A functional properties
| Subgroups . | Patient characteristics . | Patient number . | LAE during follow-up (%) . | Annual event rate (%/year) . | Estimated mean LAE-free period (months, mean ± SE) . |
|---|---|---|---|---|---|
| All BrS | All BrS patients | 415 | 62 (14.9) | 2.5 | 206.9 ± 6.0 |
| SCN5A(−) | Rare SCN5A variants non-carriers | 355 | 49 (13.8) | 2.2 | 210.8 ± 6.0 |
| SCN5A(+) | Rare SCN5A variant carriers | 60 | 13 (21.7) | 5.1 | 136.6 ± 12.9 |
| LOF | LOF-SCN5A mutation carriers | 45 | 13 (28.9) | 7.9 | 94.5 ± 10.7 |
| Non-LOF | Non-LOF SCN5A variant carriers | 15 | 0 (0) | 0 | NA |
| Non-LOF +SCN5A(−) | Patients without LOF-SCN5A mutations | 370 | 49 (13.2) | 2.1 | 208.8 ± 5.9 |
| Subgroups . | Patient characteristics . | Patient number . | LAE during follow-up (%) . | Annual event rate (%/year) . | Estimated mean LAE-free period (months, mean ± SE) . |
|---|---|---|---|---|---|
| All BrS | All BrS patients | 415 | 62 (14.9) | 2.5 | 206.9 ± 6.0 |
| SCN5A(−) | Rare SCN5A variants non-carriers | 355 | 49 (13.8) | 2.2 | 210.8 ± 6.0 |
| SCN5A(+) | Rare SCN5A variant carriers | 60 | 13 (21.7) | 5.1 | 136.6 ± 12.9 |
| LOF | LOF-SCN5A mutation carriers | 45 | 13 (28.9) | 7.9 | 94.5 ± 10.7 |
| Non-LOF | Non-LOF SCN5A variant carriers | 15 | 0 (0) | 0 | NA |
| Non-LOF +SCN5A(−) | Patients without LOF-SCN5A mutations | 370 | 49 (13.2) | 2.1 | 208.8 ± 5.9 |
BrS, Brugada syndrome; LAE, lethal arrhythmic event; LOF, loss of function; SE, standard error; NA, not available.
Lethal arrhythmic events in Brugada syndrome cohort-I subgroups classified by different SCN5A functional properties
| Subgroups . | Patient characteristics . | Patient number . | LAE during follow-up (%) . | Annual event rate (%/year) . | Estimated mean LAE-free period (months, mean ± SE) . |
|---|---|---|---|---|---|
| All BrS | All BrS patients | 415 | 62 (14.9) | 2.5 | 206.9 ± 6.0 |
| SCN5A(−) | Rare SCN5A variants non-carriers | 355 | 49 (13.8) | 2.2 | 210.8 ± 6.0 |
| SCN5A(+) | Rare SCN5A variant carriers | 60 | 13 (21.7) | 5.1 | 136.6 ± 12.9 |
| LOF | LOF-SCN5A mutation carriers | 45 | 13 (28.9) | 7.9 | 94.5 ± 10.7 |
| Non-LOF | Non-LOF SCN5A variant carriers | 15 | 0 (0) | 0 | NA |
| Non-LOF +SCN5A(−) | Patients without LOF-SCN5A mutations | 370 | 49 (13.2) | 2.1 | 208.8 ± 5.9 |
| Subgroups . | Patient characteristics . | Patient number . | LAE during follow-up (%) . | Annual event rate (%/year) . | Estimated mean LAE-free period (months, mean ± SE) . |
|---|---|---|---|---|---|
| All BrS | All BrS patients | 415 | 62 (14.9) | 2.5 | 206.9 ± 6.0 |
| SCN5A(−) | Rare SCN5A variants non-carriers | 355 | 49 (13.8) | 2.2 | 210.8 ± 6.0 |
| SCN5A(+) | Rare SCN5A variant carriers | 60 | 13 (21.7) | 5.1 | 136.6 ± 12.9 |
| LOF | LOF-SCN5A mutation carriers | 45 | 13 (28.9) | 7.9 | 94.5 ± 10.7 |
| Non-LOF | Non-LOF SCN5A variant carriers | 15 | 0 (0) | 0 | NA |
| Non-LOF +SCN5A(−) | Patients without LOF-SCN5A mutations | 370 | 49 (13.2) | 2.1 | 208.8 ± 5.9 |
BrS, Brugada syndrome; LAE, lethal arrhythmic event; LOF, loss of function; SE, standard error; NA, not available.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
