Table 3 Open in new tab Logistic...

Variable	Odds ratio	95% confidence interval	P-value
Post-operative hs-cTnI quartiles			<0.001
2nd quartile	0.76	0.42–1.4	0.38
3rd quartile	0.97	0.49–1.9	0.93
4th quartile	17.7	11.9–26.4	<0.001
hs-cTnI >13 000 ng/L	21.2	15.1–29.7	<0.001
Age	1.03	1.01–1.05	0.001
EuroSCORE II	1.11	1.07–1.15	<0.001
Statin use	0.57	0.41–0.81	0.001
CPB use	3.27	2.29–4.67	<0.001
Time on CPB	1.01	1.009–1.02	<0.001
LVEF	0.98	0.97–0.99	0.004
History of AF	2.0	1.1–3.7	0.02

Variable

Odds ratio

95% confidence interval

P-value

A. Univariate logistic regression analysis

Post-operative hs-cTnI quartiles

<0.001

2nd quartile

0.76

0.42–1.4

0.38

3rd quartile

0.97

0.49–1.9

0.93

4th quartile

17.7

11.9–26.4

<0.001

hs-cTnI >13 000 ng/L

21.2

15.1–29.7

<0.001

Age

1.03

1.01–1.05

0.001

EuroSCORE II

1.11

1.07–1.15

<0.001

Statin use

0.57

0.41–0.81

0.001

CPB use

3.27

2.29–4.67

<0.001

Time on CPB

1.01

1.009–1.02

<0.001

LVEF

0.98

0.97–0.99

0.004

History of AF

2.0

1.1–3.7

0.02

Variable	Odds ratio	95% confidence interval	P-value
Post-operative hs-cTnI quartiles			<0.001
2nd quartile	0.76	0.42–1.4	0.38
3rd quartile	0.97	0.49–1.9	0.93
4th quartile	17.7	11.9–26.4	<0.001
hs-cTnI >13 000 ng/L	21.2	15.1–29.7	<0.001
Age	1.03	1.01–1.05	0.001
EuroSCORE II	1.11	1.07–1.15	<0.001
Statin use	0.57	0.41–0.81	0.001
CPB use	3.27	2.29–4.67	<0.001
Time on CPB	1.01	1.009–1.02	<0.001
LVEF	0.98	0.97–0.99	0.004
History of AF	2.0	1.1–3.7	0.02

B. Multivariate logistic regression analysis for CV outcomes (females and males)

hs-cTnI >13 000 ng/L

21.9

15.5–30.8

<0.001

EuroSCORE II

1.10

1.05–1.14

0.001

Statin use

0.65

0.46–0.93

0.02

C. Multivariate analysis for 30-day MACE applying gender-specific cut-off values

Females (>9400 ng/L)
Males (>13 300 ng/L)

20.1

14.3–28.2

<0.001

EuroSCORE II

1.1

1.05–1.13

<0.001

Statin use

0.66

0.46–0.93

0.007

D. Logistic regression analysis of different hs-cTnI thresholds to predict 30-day MACE in the study cohort
<10×URL	1/131	1.0	Reference
≥10–<35× URL	7/572	1.4	0.17–11.7	0.74
≥35–<70×URL	17/1053	1.9	0.25–14.3	0.54
≥70–<500×URL	40/2541	1.8	0.24–13.0	0.58
≥500×URL	94/387	34.5	4.6–250.8	<0.001

D. Logistic regression analysis of different hs-cTnI thresholds to predict 30-day MACE in the study cohort

Threshold

Events/total

Adjusted odds ratio^a

95% confidence interval

P-value

<10×URL

1/131

1.0

Reference

≥10–<35× URL

7/572

1.4

0.17–11.7

0.74

≥35–<70×URL

17/1053

1.9

0.25–14.3

0.54

≥70–<500×URL

40/2541

1.8

0.24–13.0

0.58

≥500×URL

94/387

34.5

4.6–250.8

<0.001

D. Logistic regression analysis of different hs-cTnI thresholds to predict 30-day MACE in the study cohort
<10×URL	1/131	1.0	Reference
≥10–<35× URL	7/572	1.4	0.17–11.7	0.74
≥35–<70×URL	17/1053	1.9	0.25–14.3	0.54
≥70–<500×URL	40/2541	1.8	0.24–13.0	0.58
≥500×URL	94/387	34.5	4.6–250.8	<0.001

E. Univariate logistic regression analysis of derived hs-cTnI thresholds to predict 30-day MACE in the external validation cohort from The Alfred Hospital
hs-cTnI > 13 000 ng/L	17.5	6.0–51.2	<0.001
Gender-specific cut-off values	5.97	1.21–29.4	0.013

E. Univariate logistic regression analysis of derived hs-cTnI thresholds to predict 30-day MACE in the external validation cohort from The Alfred Hospital

Variable

Odds ratio

95% confidence interval

P-value

hs-cTnI > 13 000 ng/L

17.5

6.0–51.2

<0.001

Gender-specific cut-off values

5.97

1.21–29.4

0.013

E. Univariate logistic regression analysis of derived hs-cTnI thresholds to predict 30-day MACE in the external validation cohort from The Alfred Hospital
hs-cTnI > 13 000 ng/L	17.5	6.0–51.2	<0.001
Gender-specific cut-off values	5.97	1.21–29.4	0.013

F. Logistic regression analysis of different hs-cTnI thresholds to predict 30-day MACE in the external validation cohort from The Alfred Hospital
<35×URL^b	3/184 (1.6)	1.0	—	1.0 (reference)	—
≥35–<70× URL	3/186 (1.6)	1.26 (0.30–5.35)	0.75	1.35 (0.31–5.82)	0.69
≥70–<500× URL	10/240 (4.2)	2.17 (0.61–7.80)	0.22	2.43 (0.64–9.12)	0.19
≥500× URL	6/18 (33)	26.2 (6.73–102)	<0.001	37.9 (8.85–163)	<0.001

F. Logistic regression analysis of different hs-cTnI thresholds to predict 30-day MACE in the external validation cohort from The Alfred Hospital

Threshold

Events/total

Univariate OR (95% CI)

Univariate P-value

Adjusted^a OR (95% CI)

P-value

<35×URL^b

3/184 (1.6)

1.0

—

1.0 (reference)

—

≥35–<70× URL

3/186 (1.6)

1.26 (0.30–5.35)

0.75

1.35 (0.31–5.82)

0.69

≥70–<500× URL

10/240 (4.2)

2.17 (0.61–7.80)

0.22

2.43 (0.64–9.12)

0.19

≥500× URL

6/18 (33)

26.2 (6.73–102)

<0.001

37.9 (8.85–163)

<0.001

F. Logistic regression analysis of different hs-cTnI thresholds to predict 30-day MACE in the external validation cohort from The Alfred Hospital
<35×URL^b	3/184 (1.6)	1.0	—	1.0 (reference)	—
≥35–<70× URL	3/186 (1.6)	1.26 (0.30–5.35)	0.75	1.35 (0.31–5.82)	0.69
≥70–<500× URL	10/240 (4.2)	2.17 (0.61–7.80)	0.22	2.43 (0.64–9.12)	0.19
≥500× URL	6/18 (33)	26.2 (6.73–102)	<0.001	37.9 (8.85–163)	<0.001

Table 3

Open in new tab

Logistic regression analyses for predictors of 30-day major adverse cardiovascular event rate

Variable	Odds ratio	95% confidence interval	P-value
A. Univariate logistic regression analysis
Post-operative hs-cTnI quartiles			<0.001
2nd quartile	0.76	0.42–1.4	0.38
3rd quartile	0.97	0.49–1.9	0.93
4th quartile	17.7	11.9–26.4	<0.001
hs-cTnI >13 000 ng/L	21.2	15.1–29.7	<0.001
Age	1.03	1.01–1.05	0.001
EuroSCORE II	1.11	1.07–1.15	<0.001
Statin use	0.57	0.41–0.81	0.001
CPB use	3.27	2.29–4.67	<0.001
Time on CPB	1.01	1.009–1.02	<0.001
LVEF	0.98	0.97–0.99	0.004
History of AF	2.0	1.1–3.7	0.02

Variable	Odds ratio	95% confidence interval	P-value
A. Univariate logistic regression analysis
Post-operative hs-cTnI quartiles			<0.001
2nd quartile	0.76	0.42–1.4	0.38
3rd quartile	0.97	0.49–1.9	0.93
4th quartile	17.7	11.9–26.4	<0.001
hs-cTnI >13 000 ng/L	21.2	15.1–29.7	<0.001
Age	1.03	1.01–1.05	0.001
EuroSCORE II	1.11	1.07–1.15	<0.001
Statin use	0.57	0.41–0.81	0.001
CPB use	3.27	2.29–4.67	<0.001
Time on CPB	1.01	1.009–1.02	<0.001
LVEF	0.98	0.97–0.99	0.004
History of AF	2.0	1.1–3.7	0.02

B. Multivariate logistic regression analysis for CV outcomes (females and males)
hs-cTnI >13 000 ng/L	21.9	15.5–30.8	<0.001
EuroSCORE II	1.10	1.05–1.14	0.001
Statin use	0.65	0.46–0.93	0.02

B. Multivariate logistic regression analysis for CV outcomes (females and males)
hs-cTnI >13 000 ng/L	21.9	15.5–30.8	<0.001
EuroSCORE II	1.10	1.05–1.14	0.001
Statin use	0.65	0.46–0.93	0.02

C. Multivariate analysis for 30-day MACE applying gender-specific cut-off values
Females (>9400 ng/L) Males (>13 300 ng/L)	20.1	14.3–28.2	<0.001
EuroSCORE II	1.1	1.05–1.13	<0.001
Statin use	0.66	0.46–0.93	0.007

C. Multivariate analysis for 30-day MACE applying gender-specific cut-off values
Females (>9400 ng/L) Males (>13 300 ng/L)	20.1	14.3–28.2	<0.001
EuroSCORE II	1.1	1.05–1.13	<0.001
Statin use	0.66	0.46–0.93	0.007

D. Logistic regression analysis of different hs-cTnI thresholds to predict 30-day MACE in the study cohort
Threshold	Events/total	Adjusted odds ratio^a	95% confidence interval	P-value
<10×URL	1/131	1.0	Reference
≥10–<35× URL	7/572	1.4	0.17–11.7	0.74
≥35–<70×URL	17/1053	1.9	0.25–14.3	0.54
≥70–<500×URL	40/2541	1.8	0.24–13.0	0.58
≥500×URL	94/387	34.5	4.6–250.8	<0.001

D. Logistic regression analysis of different hs-cTnI thresholds to predict 30-day MACE in the study cohort
Threshold	Events/total	Adjusted odds ratio^a	95% confidence interval	P-value
<10×URL	1/131	1.0	Reference
≥10–<35× URL	7/572	1.4	0.17–11.7	0.74
≥35–<70×URL	17/1053	1.9	0.25–14.3	0.54
≥70–<500×URL	40/2541	1.8	0.24–13.0	0.58
≥500×URL	94/387	34.5	4.6–250.8	<0.001

E. Univariate logistic regression analysis of derived hs-cTnI thresholds to predict 30-day MACE in the external validation cohort from The Alfred Hospital
Variable	Odds ratio	95% confidence interval	P-value
hs-cTnI > 13 000 ng/L	17.5	6.0–51.2	<0.001
Gender-specific cut-off values	5.97	1.21–29.4	0.013

E. Univariate logistic regression analysis of derived hs-cTnI thresholds to predict 30-day MACE in the external validation cohort from The Alfred Hospital
Variable	Odds ratio	95% confidence interval	P-value
hs-cTnI > 13 000 ng/L	17.5	6.0–51.2	<0.001
Gender-specific cut-off values	5.97	1.21–29.4	0.013

F. Logistic regression analysis of different hs-cTnI thresholds to predict 30-day MACE in the external validation cohort from The Alfred Hospital
Threshold	Events/total	Univariate OR (95% CI)	Univariate P-value	Adjusted^a OR (95% CI)	P-value
<35×URL^b	3/184 (1.6)	1.0	—	1.0 (reference)	—
≥35–<70× URL	3/186 (1.6)	1.26 (0.30–5.35)	0.75	1.35 (0.31–5.82)	0.69
≥70–<500× URL	10/240 (4.2)	2.17 (0.61–7.80)	0.22	2.43 (0.64–9.12)	0.19
≥500× URL	6/18 (33)	26.2 (6.73–102)	<0.001	37.9 (8.85–163)	<0.001

F. Logistic regression analysis of different hs-cTnI thresholds to predict 30-day MACE in the external validation cohort from The Alfred Hospital
Threshold	Events/total	Univariate OR (95% CI)	Univariate P-value	Adjusted^a OR (95% CI)	P-value
<35×URL^b	3/184 (1.6)	1.0	—	1.0 (reference)	—
≥35–<70× URL	3/186 (1.6)	1.26 (0.30–5.35)	0.75	1.35 (0.31–5.82)	0.69
≥70–<500× URL	10/240 (4.2)	2.17 (0.61–7.80)	0.22	2.43 (0.64–9.12)	0.19
≥500× URL	6/18 (33)	26.2 (6.73–102)	<0.001	37.9 (8.85–163)	<0.001

Refer also to Supplementary material online, Section XVII for further details.

hs-cTnI, high-sensitivity cardiac troponin I; MACE, major adverse cardiovascular events; CPB, cardiopulmonary bypass; LVEF, left ventricular ejection fraction; AF, atrial fibrillation; URL, upper reference limit.

Adjusted for EuroSCORE II and statin use.

Zero outcomes for the group of <10×URL (0/22), so group combined with 10–<35× URL as reference.

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