Table 2

Effect sizes of blockbuster drugs and a recent nudge

AuthorInterventionEffect size compared with standard of care at time
McMurray et al.22Sacubitril/valsartan novel drug in patients with heart failure20% relative improvement
Keeley et al.23Primary angioplasty in acute MI22% relative improvement
RECOVERY Collaborative Group24Dexamethasone in severe COVID-19 pneumonia18–36% relative improvement depending on illness severity
Piazza et al.4CDSS alert to increase anticoagulation in high-risk hospitalized AF patients55% relative improvementa
AuthorInterventionEffect size compared with standard of care at time
McMurray et al.22Sacubitril/valsartan novel drug in patients with heart failure20% relative improvement
Keeley et al.23Primary angioplasty in acute MI22% relative improvement
RECOVERY Collaborative Group24Dexamethasone in severe COVID-19 pneumonia18–36% relative improvement depending on illness severity
Piazza et al.4CDSS alert to increase anticoagulation in high-risk hospitalized AF patients55% relative improvementa

AF, atrial fibrillation; CDSS, clinical decision support system; COVID-9, coronavirus disease 2019; MI, myocardial infarction.

a

Event rates and outcomes measured are omitted. These papers have been discussed at length in the literature and the focus of this comparison is to highlight the possibilities of nudges being equal in relative effect to any blockbuster, depending on the research context.

Table 2

Effect sizes of blockbuster drugs and a recent nudge

AuthorInterventionEffect size compared with standard of care at time
McMurray et al.22Sacubitril/valsartan novel drug in patients with heart failure20% relative improvement
Keeley et al.23Primary angioplasty in acute MI22% relative improvement
RECOVERY Collaborative Group24Dexamethasone in severe COVID-19 pneumonia18–36% relative improvement depending on illness severity
Piazza et al.4CDSS alert to increase anticoagulation in high-risk hospitalized AF patients55% relative improvementa
AuthorInterventionEffect size compared with standard of care at time
McMurray et al.22Sacubitril/valsartan novel drug in patients with heart failure20% relative improvement
Keeley et al.23Primary angioplasty in acute MI22% relative improvement
RECOVERY Collaborative Group24Dexamethasone in severe COVID-19 pneumonia18–36% relative improvement depending on illness severity
Piazza et al.4CDSS alert to increase anticoagulation in high-risk hospitalized AF patients55% relative improvementa

AF, atrial fibrillation; CDSS, clinical decision support system; COVID-9, coronavirus disease 2019; MI, myocardial infarction.

a

Event rates and outcomes measured are omitted. These papers have been discussed at length in the literature and the focus of this comparison is to highlight the possibilities of nudges being equal in relative effect to any blockbuster, depending on the research context.

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