Clinical features of the 836 patients who were examined at ≥60 years according to age at first syncope
| Clinical features . | First syncope . | P-value . | ||||
|---|---|---|---|---|---|---|
| <30 years (n = 100) . | 30–59 years (n = 151) . | ≥60 years (n = 585) . | <30 vs. 30–59 years . | <30 vs. ≥60 years . | 30–59 vs. ≥60 years . | |
| Female sex, n (%) | 71 (71) | 83 (55) | 276 (47) | 0.011 | <0.001 | 0.088 |
| Age at investigation, median (IQR) | 70 (65–75) | 64 (61–70) | 74 (69–80) | <0.001 | <0.001 | <0.001 |
| Years between first syncope and investigation, median (IQR) | 54 (46–60) | 11 (5–20) | 2 (1–5) | <0.001 | <0.001 | <0.001 |
| Total no. of syncopes, median (IQR) | 8 (3–20) | 6 (3–10) | 3 (2–6) | 0.001 | <0.001 | 0.003 |
| Supine SBP, mean ± SD | 145 ± 19 | 141 ± 22 | 144 ± 23 | 0.256 | 0.910 | 0.143 |
| Supine DBP, mean ± SD | 77 ± 11 | 75 ± 12 | 74 ± 12 | 0.316 | 0.026 | 0.222 |
| Supine HR, mean ± SD | 70 ± 12 | 70 ± 12 | 70 ± 12 | 0.804 | 0.689 | 0.902 |
| Prodromes, n (%) | 51 (52) | 52 (34) | 149 (26) | 0.020 | <0.001 | 0.113 |
| Palpitations, n (%) | 13 (13) | 28 (19) | 71 (12) | 0.146 | 0.186 | 0.136 |
| Dizziness upon standing, n (%) | 69 (69) | 98 (65) | 398 (68) | 0.500 | 0.884 | 0.431 |
| Hypertension, n (%) | 40 (40) | 70 (47) | 341 (59) | 0.307 | 0.001 | 0.009 |
| History of CAD, n (%) | 8 (8) | 15 (10) | 79 (14) | 0.609 | 0.129 | 0.241 |
| Heart failure, n (%) | 2 (2) | 8 (5) | 50 (9) | 0.198 | 0.024 | 0.186 |
| Atrial fibrillation, n (%) | 9 (9) | 13 (9) | 113 (20) | 0.921 | 0.013 | 0.002 |
| VVS, n (%) | 39 (39) | 47 (31) | 108 (19) | 0.198 | <0.001 | 0.001 |
| OH, n (%) | 7 (7) | 21 (14) | 133 (23) | 0.089 | <0.001 | 0.017 |
| CSS/CSH, n (%) | 4 (4) | 8 (5) | 54 (9) | 0.637 | 0.082 | 0.120 |
| Complex syncope, n (%) | 37 (37) | 45 (30) | 152 (26) | 0.234 | 0.023 | 0.351 |
| PPS, n (%) | 0 (0) | 1 (1) | 1 (0.2) | 0.415 | 0.697 | 0.302 |
| No diagnosis, n (%) | 13 (13) | 29 (19) | 135 (23) | 0.197 | 0.023 | 0.299 |
| Clinical features . | First syncope . | P-value . | ||||
|---|---|---|---|---|---|---|
| <30 years (n = 100) . | 30–59 years (n = 151) . | ≥60 years (n = 585) . | <30 vs. 30–59 years . | <30 vs. ≥60 years . | 30–59 vs. ≥60 years . | |
| Female sex, n (%) | 71 (71) | 83 (55) | 276 (47) | 0.011 | <0.001 | 0.088 |
| Age at investigation, median (IQR) | 70 (65–75) | 64 (61–70) | 74 (69–80) | <0.001 | <0.001 | <0.001 |
| Years between first syncope and investigation, median (IQR) | 54 (46–60) | 11 (5–20) | 2 (1–5) | <0.001 | <0.001 | <0.001 |
| Total no. of syncopes, median (IQR) | 8 (3–20) | 6 (3–10) | 3 (2–6) | 0.001 | <0.001 | 0.003 |
| Supine SBP, mean ± SD | 145 ± 19 | 141 ± 22 | 144 ± 23 | 0.256 | 0.910 | 0.143 |
| Supine DBP, mean ± SD | 77 ± 11 | 75 ± 12 | 74 ± 12 | 0.316 | 0.026 | 0.222 |
| Supine HR, mean ± SD | 70 ± 12 | 70 ± 12 | 70 ± 12 | 0.804 | 0.689 | 0.902 |
| Prodromes, n (%) | 51 (52) | 52 (34) | 149 (26) | 0.020 | <0.001 | 0.113 |
| Palpitations, n (%) | 13 (13) | 28 (19) | 71 (12) | 0.146 | 0.186 | 0.136 |
| Dizziness upon standing, n (%) | 69 (69) | 98 (65) | 398 (68) | 0.500 | 0.884 | 0.431 |
| Hypertension, n (%) | 40 (40) | 70 (47) | 341 (59) | 0.307 | 0.001 | 0.009 |
| History of CAD, n (%) | 8 (8) | 15 (10) | 79 (14) | 0.609 | 0.129 | 0.241 |
| Heart failure, n (%) | 2 (2) | 8 (5) | 50 (9) | 0.198 | 0.024 | 0.186 |
| Atrial fibrillation, n (%) | 9 (9) | 13 (9) | 113 (20) | 0.921 | 0.013 | 0.002 |
| VVS, n (%) | 39 (39) | 47 (31) | 108 (19) | 0.198 | <0.001 | 0.001 |
| OH, n (%) | 7 (7) | 21 (14) | 133 (23) | 0.089 | <0.001 | 0.017 |
| CSS/CSH, n (%) | 4 (4) | 8 (5) | 54 (9) | 0.637 | 0.082 | 0.120 |
| Complex syncope, n (%) | 37 (37) | 45 (30) | 152 (26) | 0.234 | 0.023 | 0.351 |
| PPS, n (%) | 0 (0) | 1 (1) | 1 (0.2) | 0.415 | 0.697 | 0.302 |
| No diagnosis, n (%) | 13 (13) | 29 (19) | 135 (23) | 0.197 | 0.023 | 0.299 |
The Bonferroni-adjusted significance level was set at P = 0.017.
SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; CAD, coronary artery disease; VVS, vasovagal syncope; OH, orthostatic hypotension; CSH, carotid sinus hypersensitivity; CSS, carotid sinus syndrome; PPS, psychogenic pseudosyncope; SD, standard deviation; IQR, interquartile range.
Clinical features of the 836 patients who were examined at ≥60 years according to age at first syncope
| Clinical features . | First syncope . | P-value . | ||||
|---|---|---|---|---|---|---|
| <30 years (n = 100) . | 30–59 years (n = 151) . | ≥60 years (n = 585) . | <30 vs. 30–59 years . | <30 vs. ≥60 years . | 30–59 vs. ≥60 years . | |
| Female sex, n (%) | 71 (71) | 83 (55) | 276 (47) | 0.011 | <0.001 | 0.088 |
| Age at investigation, median (IQR) | 70 (65–75) | 64 (61–70) | 74 (69–80) | <0.001 | <0.001 | <0.001 |
| Years between first syncope and investigation, median (IQR) | 54 (46–60) | 11 (5–20) | 2 (1–5) | <0.001 | <0.001 | <0.001 |
| Total no. of syncopes, median (IQR) | 8 (3–20) | 6 (3–10) | 3 (2–6) | 0.001 | <0.001 | 0.003 |
| Supine SBP, mean ± SD | 145 ± 19 | 141 ± 22 | 144 ± 23 | 0.256 | 0.910 | 0.143 |
| Supine DBP, mean ± SD | 77 ± 11 | 75 ± 12 | 74 ± 12 | 0.316 | 0.026 | 0.222 |
| Supine HR, mean ± SD | 70 ± 12 | 70 ± 12 | 70 ± 12 | 0.804 | 0.689 | 0.902 |
| Prodromes, n (%) | 51 (52) | 52 (34) | 149 (26) | 0.020 | <0.001 | 0.113 |
| Palpitations, n (%) | 13 (13) | 28 (19) | 71 (12) | 0.146 | 0.186 | 0.136 |
| Dizziness upon standing, n (%) | 69 (69) | 98 (65) | 398 (68) | 0.500 | 0.884 | 0.431 |
| Hypertension, n (%) | 40 (40) | 70 (47) | 341 (59) | 0.307 | 0.001 | 0.009 |
| History of CAD, n (%) | 8 (8) | 15 (10) | 79 (14) | 0.609 | 0.129 | 0.241 |
| Heart failure, n (%) | 2 (2) | 8 (5) | 50 (9) | 0.198 | 0.024 | 0.186 |
| Atrial fibrillation, n (%) | 9 (9) | 13 (9) | 113 (20) | 0.921 | 0.013 | 0.002 |
| VVS, n (%) | 39 (39) | 47 (31) | 108 (19) | 0.198 | <0.001 | 0.001 |
| OH, n (%) | 7 (7) | 21 (14) | 133 (23) | 0.089 | <0.001 | 0.017 |
| CSS/CSH, n (%) | 4 (4) | 8 (5) | 54 (9) | 0.637 | 0.082 | 0.120 |
| Complex syncope, n (%) | 37 (37) | 45 (30) | 152 (26) | 0.234 | 0.023 | 0.351 |
| PPS, n (%) | 0 (0) | 1 (1) | 1 (0.2) | 0.415 | 0.697 | 0.302 |
| No diagnosis, n (%) | 13 (13) | 29 (19) | 135 (23) | 0.197 | 0.023 | 0.299 |
| Clinical features . | First syncope . | P-value . | ||||
|---|---|---|---|---|---|---|
| <30 years (n = 100) . | 30–59 years (n = 151) . | ≥60 years (n = 585) . | <30 vs. 30–59 years . | <30 vs. ≥60 years . | 30–59 vs. ≥60 years . | |
| Female sex, n (%) | 71 (71) | 83 (55) | 276 (47) | 0.011 | <0.001 | 0.088 |
| Age at investigation, median (IQR) | 70 (65–75) | 64 (61–70) | 74 (69–80) | <0.001 | <0.001 | <0.001 |
| Years between first syncope and investigation, median (IQR) | 54 (46–60) | 11 (5–20) | 2 (1–5) | <0.001 | <0.001 | <0.001 |
| Total no. of syncopes, median (IQR) | 8 (3–20) | 6 (3–10) | 3 (2–6) | 0.001 | <0.001 | 0.003 |
| Supine SBP, mean ± SD | 145 ± 19 | 141 ± 22 | 144 ± 23 | 0.256 | 0.910 | 0.143 |
| Supine DBP, mean ± SD | 77 ± 11 | 75 ± 12 | 74 ± 12 | 0.316 | 0.026 | 0.222 |
| Supine HR, mean ± SD | 70 ± 12 | 70 ± 12 | 70 ± 12 | 0.804 | 0.689 | 0.902 |
| Prodromes, n (%) | 51 (52) | 52 (34) | 149 (26) | 0.020 | <0.001 | 0.113 |
| Palpitations, n (%) | 13 (13) | 28 (19) | 71 (12) | 0.146 | 0.186 | 0.136 |
| Dizziness upon standing, n (%) | 69 (69) | 98 (65) | 398 (68) | 0.500 | 0.884 | 0.431 |
| Hypertension, n (%) | 40 (40) | 70 (47) | 341 (59) | 0.307 | 0.001 | 0.009 |
| History of CAD, n (%) | 8 (8) | 15 (10) | 79 (14) | 0.609 | 0.129 | 0.241 |
| Heart failure, n (%) | 2 (2) | 8 (5) | 50 (9) | 0.198 | 0.024 | 0.186 |
| Atrial fibrillation, n (%) | 9 (9) | 13 (9) | 113 (20) | 0.921 | 0.013 | 0.002 |
| VVS, n (%) | 39 (39) | 47 (31) | 108 (19) | 0.198 | <0.001 | 0.001 |
| OH, n (%) | 7 (7) | 21 (14) | 133 (23) | 0.089 | <0.001 | 0.017 |
| CSS/CSH, n (%) | 4 (4) | 8 (5) | 54 (9) | 0.637 | 0.082 | 0.120 |
| Complex syncope, n (%) | 37 (37) | 45 (30) | 152 (26) | 0.234 | 0.023 | 0.351 |
| PPS, n (%) | 0 (0) | 1 (1) | 1 (0.2) | 0.415 | 0.697 | 0.302 |
| No diagnosis, n (%) | 13 (13) | 29 (19) | 135 (23) | 0.197 | 0.023 | 0.299 |
The Bonferroni-adjusted significance level was set at P = 0.017.
SBP, systolic blood pressure; DBP, diastolic blood pressure; HR, heart rate; CAD, coronary artery disease; VVS, vasovagal syncope; OH, orthostatic hypotension; CSH, carotid sinus hypersensitivity; CSS, carotid sinus syndrome; PPS, psychogenic pseudosyncope; SD, standard deviation; IQR, interquartile range.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
