Table 2
Open in new tab

The pre-test probability models diagnostic accuracy at cut-offs of 5% and 15%, with coronary stenosis at coronary computed tomography angiography and combined endpoint of computed tomography angiography and invasive coronary angiography as reference standard

2019-ESC-PTP model2013-ESC-PTP modelCAD Consortium basic model
Pre-test probability cut-off <5%
 Number of patients below cut-off8245 (19.5%)178 (0.4%)10 265 (24.3%)
 Coronary CTA
  Number of diseased patients below cut-off6257856
  Sensitivity93.8% (93.3–94.2)99.9% (99.9–100)91.5% (90.9–92.0)
  Specificity23.6% (23.1–24.0)0.5% (0.5–0.6)29.1% (28.6–29.6)
  Positive predictive value27.6% (27.1–28.0)23.7% (23.3–24.2)28.6% (28.1–29.1)
  Negative predictive value92.4% (91.8–93.0)96.1% (92.1–98.4)91.7% (91.1–92.2)
  Positive likelihood ratio1.23 (1.22–1.24)1.00 (1.00–1.01)1.29 (1.28–1.30)
  Negative likelihood ratio0.26 (0.24–0.29)0.13 (0.06–0.28)0.29 (0.27–0.31)
 Combined endpoint of CTA and ICA
  Number of diseased patients below cut-off1320151
  Sensitivity96.4% (95.8–97.0)100% (99.9–100)95.9% (95.3–96.6)
  Specificity21.0% (20.6–21.4)0.5% (0.4–0.5)26.2% (25.8–26.6)
  Positive predictive value10.5% (10.2–10.9)8.8% (8.6–9.1)11.1% (10.8–11.5)
  Negative predictive value98.4% (98.1–98.7)100% (97.9–100)98.5% (98.3–98.8)
  Positive likelihood ratio1.22 (1.21–1.23)1.00 (1.00–1.01)1.30 (1.29–1.31)
  Negative likelihood ratio0.17 (0.14–0.20)Na0.29 (0.27–0.31)
Pre-test probability cut-off <15%
 Number of patients below cut-off27 280 (64.5%)7062 (16.7%)27 625 (65.3%)
 Coronary CTA
  Number of diseased patients below cut-off40375584156
  Sensitivity59.7% (58.7–60.7)94.4% (94.0–94.9)58.5% (57.5–59.5)
  Specificity71.9% (71.4–72.4)20.1% (19.7–20.6)72.6% (72.1–73.1)
  Positive predictive value39.7% (38.9–40.5)26.8% (26.4–27.3)39.8% (39.1–40.6)
  Negative predictive value85.2% (84.8–85.6)92.1% (91.4–92.7)85.0% (84.5–85.4)
  Positive likelihood ratio2.13 (2.08–2.18)1.18 (1.17–1.19)2.14 (2.09–2.19)
  Negative likelihood ratio0.56 (0.55–0.57)0.28 (0.25–0.30)0.57 (0.56–0.59)
 Combined endpoint of CTA and ICA
  Number of diseased patients below cut-off1070971120
  Sensitivity71.2% (69.7–72.7)97.4% (96.8–97.9)69.9% (68.4–71.3)
  Specificity67.9% (67.4–68.3)18.0% (17.7–18.4)68.6% (68.2–69.1)
  Positive predictive value17.6% (17.0–18.2)10.3% (10.0–10.6)17.7% (17.1–18.3)
  Negative predictive value96.1% (95.8–96.3)98.6% (98.3–98.9)95.9% (95.7–96.2)
  Positive likelihood ratio2.22 (2.16–2.27)1.19 (1.18–1.20)2.234 (2.17–2.29)
  Negative likelihood ratio0.42 (0.40–0.45)0.14 (0.12–0.18)0.44 (0.42–0.46)
2019-ESC-PTP model2013-ESC-PTP modelCAD Consortium basic model
Pre-test probability cut-off <5%
 Number of patients below cut-off8245 (19.5%)178 (0.4%)10 265 (24.3%)
 Coronary CTA
  Number of diseased patients below cut-off6257856
  Sensitivity93.8% (93.3–94.2)99.9% (99.9–100)91.5% (90.9–92.0)
  Specificity23.6% (23.1–24.0)0.5% (0.5–0.6)29.1% (28.6–29.6)
  Positive predictive value27.6% (27.1–28.0)23.7% (23.3–24.2)28.6% (28.1–29.1)
  Negative predictive value92.4% (91.8–93.0)96.1% (92.1–98.4)91.7% (91.1–92.2)
  Positive likelihood ratio1.23 (1.22–1.24)1.00 (1.00–1.01)1.29 (1.28–1.30)
  Negative likelihood ratio0.26 (0.24–0.29)0.13 (0.06–0.28)0.29 (0.27–0.31)
 Combined endpoint of CTA and ICA
  Number of diseased patients below cut-off1320151
  Sensitivity96.4% (95.8–97.0)100% (99.9–100)95.9% (95.3–96.6)
  Specificity21.0% (20.6–21.4)0.5% (0.4–0.5)26.2% (25.8–26.6)
  Positive predictive value10.5% (10.2–10.9)8.8% (8.6–9.1)11.1% (10.8–11.5)
  Negative predictive value98.4% (98.1–98.7)100% (97.9–100)98.5% (98.3–98.8)
  Positive likelihood ratio1.22 (1.21–1.23)1.00 (1.00–1.01)1.30 (1.29–1.31)
  Negative likelihood ratio0.17 (0.14–0.20)Na0.29 (0.27–0.31)
Pre-test probability cut-off <15%
 Number of patients below cut-off27 280 (64.5%)7062 (16.7%)27 625 (65.3%)
 Coronary CTA
  Number of diseased patients below cut-off40375584156
  Sensitivity59.7% (58.7–60.7)94.4% (94.0–94.9)58.5% (57.5–59.5)
  Specificity71.9% (71.4–72.4)20.1% (19.7–20.6)72.6% (72.1–73.1)
  Positive predictive value39.7% (38.9–40.5)26.8% (26.4–27.3)39.8% (39.1–40.6)
  Negative predictive value85.2% (84.8–85.6)92.1% (91.4–92.7)85.0% (84.5–85.4)
  Positive likelihood ratio2.13 (2.08–2.18)1.18 (1.17–1.19)2.14 (2.09–2.19)
  Negative likelihood ratio0.56 (0.55–0.57)0.28 (0.25–0.30)0.57 (0.56–0.59)
 Combined endpoint of CTA and ICA
  Number of diseased patients below cut-off1070971120
  Sensitivity71.2% (69.7–72.7)97.4% (96.8–97.9)69.9% (68.4–71.3)
  Specificity67.9% (67.4–68.3)18.0% (17.7–18.4)68.6% (68.2–69.1)
  Positive predictive value17.6% (17.0–18.2)10.3% (10.0–10.6)17.7% (17.1–18.3)
  Negative predictive value96.1% (95.8–96.3)98.6% (98.3–98.9)95.9% (95.7–96.2)
  Positive likelihood ratio2.22 (2.16–2.27)1.19 (1.18–1.20)2.234 (2.17–2.29)
  Negative likelihood ratio0.42 (0.40–0.45)0.14 (0.12–0.18)0.44 (0.42–0.46)

Values are percentages (%) or ratios.

CTA, computed tomography angiography; ICA, invasive coronary angiography.

Table 2
Open in new tab

The pre-test probability models diagnostic accuracy at cut-offs of 5% and 15%, with coronary stenosis at coronary computed tomography angiography and combined endpoint of computed tomography angiography and invasive coronary angiography as reference standard

2019-ESC-PTP model2013-ESC-PTP modelCAD Consortium basic model
Pre-test probability cut-off <5%
 Number of patients below cut-off8245 (19.5%)178 (0.4%)10 265 (24.3%)
 Coronary CTA
  Number of diseased patients below cut-off6257856
  Sensitivity93.8% (93.3–94.2)99.9% (99.9–100)91.5% (90.9–92.0)
  Specificity23.6% (23.1–24.0)0.5% (0.5–0.6)29.1% (28.6–29.6)
  Positive predictive value27.6% (27.1–28.0)23.7% (23.3–24.2)28.6% (28.1–29.1)
  Negative predictive value92.4% (91.8–93.0)96.1% (92.1–98.4)91.7% (91.1–92.2)
  Positive likelihood ratio1.23 (1.22–1.24)1.00 (1.00–1.01)1.29 (1.28–1.30)
  Negative likelihood ratio0.26 (0.24–0.29)0.13 (0.06–0.28)0.29 (0.27–0.31)
 Combined endpoint of CTA and ICA
  Number of diseased patients below cut-off1320151
  Sensitivity96.4% (95.8–97.0)100% (99.9–100)95.9% (95.3–96.6)
  Specificity21.0% (20.6–21.4)0.5% (0.4–0.5)26.2% (25.8–26.6)
  Positive predictive value10.5% (10.2–10.9)8.8% (8.6–9.1)11.1% (10.8–11.5)
  Negative predictive value98.4% (98.1–98.7)100% (97.9–100)98.5% (98.3–98.8)
  Positive likelihood ratio1.22 (1.21–1.23)1.00 (1.00–1.01)1.30 (1.29–1.31)
  Negative likelihood ratio0.17 (0.14–0.20)Na0.29 (0.27–0.31)
Pre-test probability cut-off <15%
 Number of patients below cut-off27 280 (64.5%)7062 (16.7%)27 625 (65.3%)
 Coronary CTA
  Number of diseased patients below cut-off40375584156
  Sensitivity59.7% (58.7–60.7)94.4% (94.0–94.9)58.5% (57.5–59.5)
  Specificity71.9% (71.4–72.4)20.1% (19.7–20.6)72.6% (72.1–73.1)
  Positive predictive value39.7% (38.9–40.5)26.8% (26.4–27.3)39.8% (39.1–40.6)
  Negative predictive value85.2% (84.8–85.6)92.1% (91.4–92.7)85.0% (84.5–85.4)
  Positive likelihood ratio2.13 (2.08–2.18)1.18 (1.17–1.19)2.14 (2.09–2.19)
  Negative likelihood ratio0.56 (0.55–0.57)0.28 (0.25–0.30)0.57 (0.56–0.59)
 Combined endpoint of CTA and ICA
  Number of diseased patients below cut-off1070971120
  Sensitivity71.2% (69.7–72.7)97.4% (96.8–97.9)69.9% (68.4–71.3)
  Specificity67.9% (67.4–68.3)18.0% (17.7–18.4)68.6% (68.2–69.1)
  Positive predictive value17.6% (17.0–18.2)10.3% (10.0–10.6)17.7% (17.1–18.3)
  Negative predictive value96.1% (95.8–96.3)98.6% (98.3–98.9)95.9% (95.7–96.2)
  Positive likelihood ratio2.22 (2.16–2.27)1.19 (1.18–1.20)2.234 (2.17–2.29)
  Negative likelihood ratio0.42 (0.40–0.45)0.14 (0.12–0.18)0.44 (0.42–0.46)
2019-ESC-PTP model2013-ESC-PTP modelCAD Consortium basic model
Pre-test probability cut-off <5%
 Number of patients below cut-off8245 (19.5%)178 (0.4%)10 265 (24.3%)
 Coronary CTA
  Number of diseased patients below cut-off6257856
  Sensitivity93.8% (93.3–94.2)99.9% (99.9–100)91.5% (90.9–92.0)
  Specificity23.6% (23.1–24.0)0.5% (0.5–0.6)29.1% (28.6–29.6)
  Positive predictive value27.6% (27.1–28.0)23.7% (23.3–24.2)28.6% (28.1–29.1)
  Negative predictive value92.4% (91.8–93.0)96.1% (92.1–98.4)91.7% (91.1–92.2)
  Positive likelihood ratio1.23 (1.22–1.24)1.00 (1.00–1.01)1.29 (1.28–1.30)
  Negative likelihood ratio0.26 (0.24–0.29)0.13 (0.06–0.28)0.29 (0.27–0.31)
 Combined endpoint of CTA and ICA
  Number of diseased patients below cut-off1320151
  Sensitivity96.4% (95.8–97.0)100% (99.9–100)95.9% (95.3–96.6)
  Specificity21.0% (20.6–21.4)0.5% (0.4–0.5)26.2% (25.8–26.6)
  Positive predictive value10.5% (10.2–10.9)8.8% (8.6–9.1)11.1% (10.8–11.5)
  Negative predictive value98.4% (98.1–98.7)100% (97.9–100)98.5% (98.3–98.8)
  Positive likelihood ratio1.22 (1.21–1.23)1.00 (1.00–1.01)1.30 (1.29–1.31)
  Negative likelihood ratio0.17 (0.14–0.20)Na0.29 (0.27–0.31)
Pre-test probability cut-off <15%
 Number of patients below cut-off27 280 (64.5%)7062 (16.7%)27 625 (65.3%)
 Coronary CTA
  Number of diseased patients below cut-off40375584156
  Sensitivity59.7% (58.7–60.7)94.4% (94.0–94.9)58.5% (57.5–59.5)
  Specificity71.9% (71.4–72.4)20.1% (19.7–20.6)72.6% (72.1–73.1)
  Positive predictive value39.7% (38.9–40.5)26.8% (26.4–27.3)39.8% (39.1–40.6)
  Negative predictive value85.2% (84.8–85.6)92.1% (91.4–92.7)85.0% (84.5–85.4)
  Positive likelihood ratio2.13 (2.08–2.18)1.18 (1.17–1.19)2.14 (2.09–2.19)
  Negative likelihood ratio0.56 (0.55–0.57)0.28 (0.25–0.30)0.57 (0.56–0.59)
 Combined endpoint of CTA and ICA
  Number of diseased patients below cut-off1070971120
  Sensitivity71.2% (69.7–72.7)97.4% (96.8–97.9)69.9% (68.4–71.3)
  Specificity67.9% (67.4–68.3)18.0% (17.7–18.4)68.6% (68.2–69.1)
  Positive predictive value17.6% (17.0–18.2)10.3% (10.0–10.6)17.7% (17.1–18.3)
  Negative predictive value96.1% (95.8–96.3)98.6% (98.3–98.9)95.9% (95.7–96.2)
  Positive likelihood ratio2.22 (2.16–2.27)1.19 (1.18–1.20)2.234 (2.17–2.29)
  Negative likelihood ratio0.42 (0.40–0.45)0.14 (0.12–0.18)0.44 (0.42–0.46)

Values are percentages (%) or ratios.

CTA, computed tomography angiography; ICA, invasive coronary angiography.

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