Table 2. Open in new tab Correlation...

gyrAB QRDRs	Gatifloxacin MIC (mg/L)
Total	162	40	32	32	39	8	14	327
WT	160	33	4	3	8	0	0	208
gyrB mutation	6
535Met	0	1	1	0	0	0	0	2
538Ser	0	0	0	0	0	0	1	1
539Asn	0	0	1	0	0	0	0	1
539Ala	0	1	0	0	0	0	0	1
539Ile	0	0	0	1	0	0	0	1
Heterogeneous WT + gyrB mutation	1
WT + 539Asn	0	0	0	1	0	0	0	1
gyrA mutation	96
74Ser	0	2	0	0	0	0	0	2
88Cys	0	0	0	1	0	1	0	2
89Asn	0	0	0	1	0	0	2	3
89Gly	0	0	1	0	0	0	0	1
90Val	1	2	14	12	0	0	1	30
91Pro	0	0	0	2	6	0	0	8
94Ala	0	1	7	5	1	0	0	14
94Asn	0	0	0	0	1	1	0	2
94Gly	0	0	0	5	16	5	2	28
94His	0	0	0	0	1	0	0	1
94Tyr	0	0	0	0	1	1	0	2
94Ala + 37Val	0	0	0	0	1	0	0	1
94Asn + 94Gly	0	0	0	0	1	0	0	1
90Val + 91Pro	0	0	0	0	0	0	1	1
gyrA + B mutation	6
94Gly + 540Arg	0	0	0	0	0	0	1	1
90Val + 539Ala	0	0	0	0	1	0	0	1
94Tyr + 538Ser	0	0	0	0	0	0	4	4
Heterogeneous WT + gyrA mutation	10
WT + 89Asn	0	0	0	0	0	0	1	1
WT + 90Val	0	0	1	1	0	0	0	2
WT + 94Ala	1	0	2	0	0	0	0	3
WT + 94Gly^a	0	0	1	0	2	0	1	4

gyrAB QRDRs	Gatifloxacin MIC (mg/L)
Total	162	40	32	32	39	8	14	327
WT	160	33	4	3	8	0	0	208
gyrB mutation	6
535Met	0	1	1	0	0	0	0	2
538Ser	0	0	0	0	0	0	1	1
539Asn	0	0	1	0	0	0	0	1
539Ala	0	1	0	0	0	0	0	1
539Ile	0	0	0	1	0	0	0	1
Heterogeneous WT + gyrB mutation	1
WT + 539Asn	0	0	0	1	0	0	0	1
gyrA mutation	96
74Ser	0	2	0	0	0	0	0	2
88Cys	0	0	0	1	0	1	0	2
89Asn	0	0	0	1	0	0	2	3
89Gly	0	0	1	0	0	0	0	1
90Val	1	2	14	12	0	0	1	30
91Pro	0	0	0	2	6	0	0	8
94Ala	0	1	7	5	1	0	0	14
94Asn	0	0	0	0	1	1	0	2
94Gly	0	0	0	5	16	5	2	28
94His	0	0	0	0	1	0	0	1
94Tyr	0	0	0	0	1	1	0	2
94Ala + 37Val	0	0	0	0	1	0	0	1
94Asn + 94Gly	0	0	0	0	1	0	0	1
90Val + 91Pro	0	0	0	0	0	0	1	1
gyrA + B mutation	6
94Gly + 540Arg	0	0	0	0	0	0	1	1
90Val + 539Ala	0	0	0	0	1	0	0	1
94Tyr + 538Ser	0	0	0	0	0	0	4	4
Heterogeneous WT + gyrA mutation	10
WT + 89Asn	0	0	0	0	0	0	1	1
WT + 90Val	0	0	1	1	0	0	0	2
WT + 94Ala	1	0	2	0	0	0	0	3
WT + 94Gly^a	0	0	1	0	2	0	1	4

Table 2.

Correlation between observed mutations in the QRDRs of gyrA and gyrB genes and gatifloxacin MICs for 327 M. tuberculosis isolates from patients prior to initiation and during follow-up of MDR treatment; this table includes all isolates for which gatifloxacin MICs were determined

gyrAB QRDRs	Gatifloxacin MIC (mg/L)
gyrAB QRDRs	≤0.25	0.5	1	2	4	8	>8	total
Total	162	40	32	32	39	8	14	327
WT	160	33	4	3	8	0	0	208
gyrB mutation								6
535Met	0	1	1	0	0	0	0	2
538Ser	0	0	0	0	0	0	1	1
539Asn	0	0	1	0	0	0	0	1
539Ala	0	1	0	0	0	0	0	1
539Ile	0	0	0	1	0	0	0	1
Heterogeneous WT + gyrB mutation								1
WT + 539Asn	0	0	0	1	0	0	0	1
gyrA mutation								96
74Ser	0	2	0	0	0	0	0	2
88Cys	0	0	0	1	0	1	0	2
89Asn	0	0	0	1	0	0	2	3
89Gly	0	0	1	0	0	0	0	1
90Val	1	2	14	12	0	0	1	30
91Pro	0	0	0	2	6	0	0	8
94Ala	0	1	7	5	1	0	0	14
94Asn	0	0	0	0	1	1	0	2
94Gly	0	0	0	5	16	5	2	28
94His	0	0	0	0	1	0	0	1
94Tyr	0	0	0	0	1	1	0	2
94Ala + 37Val	0	0	0	0	1	0	0	1
94Asn + 94Gly	0	0	0	0	1	0	0	1
90Val + 91Pro	0	0	0	0	0	0	1	1
gyrA + B mutation								6
94Gly + 540Arg	0	0	0	0	0	0	1	1
90Val + 539Ala	0	0	0	0	1	0	0	1
94Tyr + 538Ser	0	0	0	0	0	0	4	4
Heterogeneous WT + gyrA mutation								10
WT + 89Asn	0	0	0	0	0	0	1	1
WT + 90Val	0	0	1	1	0	0	0	2
WT + 94Ala	1	0	2	0	0	0	0	3
WT + 94Gly^a	0	0	1	0	2	0	1	4

gyrAB QRDRs	Gatifloxacin MIC (mg/L)
gyrAB QRDRs	≤0.25	0.5	1	2	4	8	>8	total
Total	162	40	32	32	39	8	14	327
WT	160	33	4	3	8	0	0	208
gyrB mutation								6
535Met	0	1	1	0	0	0	0	2
538Ser	0	0	0	0	0	0	1	1
539Asn	0	0	1	0	0	0	0	1
539Ala	0	1	0	0	0	0	0	1
539Ile	0	0	0	1	0	0	0	1
Heterogeneous WT + gyrB mutation								1
WT + 539Asn	0	0	0	1	0	0	0	1
gyrA mutation								96
74Ser	0	2	0	0	0	0	0	2
88Cys	0	0	0	1	0	1	0	2
89Asn	0	0	0	1	0	0	2	3
89Gly	0	0	1	0	0	0	0	1
90Val	1	2	14	12	0	0	1	30
91Pro	0	0	0	2	6	0	0	8
94Ala	0	1	7	5	1	0	0	14
94Asn	0	0	0	0	1	1	0	2
94Gly	0	0	0	5	16	5	2	28
94His	0	0	0	0	1	0	0	1
94Tyr	0	0	0	0	1	1	0	2
94Ala + 37Val	0	0	0	0	1	0	0	1
94Asn + 94Gly	0	0	0	0	1	0	0	1
90Val + 91Pro	0	0	0	0	0	0	1	1
gyrA + B mutation								6
94Gly + 540Arg	0	0	0	0	0	0	1	1
90Val + 539Ala	0	0	0	0	1	0	0	1
94Tyr + 538Ser	0	0	0	0	0	0	4	4
Heterogeneous WT + gyrA mutation								10
WT + 89Asn	0	0	0	0	0	0	1	1
WT + 90Val	0	0	1	1	0	0	0	2
WT + 94Ala	1	0	2	0	0	0	0	3
WT + 94Gly^a	0	0	1	0	2	0	1	4

^aOne patient had an additional 538Asp mutation.

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