Table 3 Open in new tab Outcome...

	Univariate analysis	Multivariate analysis
Baseline parameters
WHO Class ≥ III	2.26 (1.26–4.03)	0.006	^a
6MWD	0.99 (0.99–1.00)	0.02	0.99 (0.98–1.00)	0.02
BNP	1.00 (0.99–1.00)	0.53	^a
RA area	1.05 (1.02–1.08)	0.002	^a
RA pressure	1.24 (1.11–1.38)	<0.001	1.27 (1.01–1.59)	0.04
TAPSE	0.91 (0.83–1.00)	0.04	0.85 (0.73–0.98)	0.03
LV EF	1.05 (1.00–1.12)	0.04	1.18 (1.05–1.32)	0.006
LVEDD	0.96 (0.86–1.07)	0.47	^a
RV EF	0.96 (0.91–1.01)	0.08	0.93 (0.86–1.01)	0.09
RV EDV	1.01 (1.00–1.02)	0.003	^a
RV global area strain	1.05 (0.96–1.14)	0.29	1.21 (0.99–1.47)	0.06
RV lateral area strain	1.05 (1.01–1.12)	0.03	1.18 (1.05–1.32)	0.005
RV global circumferential strain	1.07 (0.93–1.23)	0.33	1.36 (1.01–1.84)	0.04
RV global longitudinal strain	1.06 (0.92–1.22)	0.40	^a
Pericardial effusion	1.89 (0.69–5.16)	0.21	11.26 (2.72–46.55)	<0.001
Follow-up parameters
WHO Class III ≥ III	26.9 (3.6–201.2)	0.001	^a
6MWD	0.99 (0.98–0.99)	0.005	0.99 (0.98–1.00)	0.02
BNP	1.00 (1.00–1.00)	0.003	1.00 (1.00–1.00)	0.11
RA area	1.10 (1.06–1.14)	<0.001	1.18 (1.00–1.40)	0.04
RA pressure	1.29 (1.17–1.42)	<0.001	1.48 (1.03–2.12)	0.03
TAPSE	0.89 (0.81–0.97)	0.007	0.72 (0.50–1.04)	0.08
LV EF	1.07 (1.01–1.14)	0.02	^a
LV EDD	0.93 (0.83–1.04)	0.93	^a
RV EF	0.91 (0.88–0.95)	<0.001	0.38 (0.11–1.38)	0.14
RV EDV	1.02 (1.01–1.03)	<0.001	1.03 (1.00–1.05)	0.01
RV global area strain	1.16 (1.09–1.24)	<0.001	1.53 (1.13–2.07)	0.006
RV lateral area strain	1.15 (1.09–1.22)	<0.001	1.10 (1.04–1.17)	<0.001
RV global circumferential strain	1.25 (1.13–1.38)	<0.001	2.15 (0.998–4.628)	0.051
RV global longitudinal strain	1.31 (1.15–1.48)	<0.001	1.50 (1.06–2.14)	0.02
Pericardial effusion	3.4 (1.38–8.49)	0.008	34.8 (3.76–320.93)	0.002

Univariate analysis

Multivariate analysis

HR (95% CI)

P-value

HR (95% CI)

P-value

Baseline parameters

WHO Class ≥ III

2.26 (1.26–4.03)

0.006

6MWD

0.99 (0.99–1.00)

0.02

0.99 (0.98–1.00)

0.02

BNP

1.00 (0.99–1.00)

0.53

RA area

1.05 (1.02–1.08)

0.002

RA pressure

1.24 (1.11–1.38)

<0.001

1.27 (1.01–1.59)

0.04

TAPSE

0.91 (0.83–1.00)

0.04

0.85 (0.73–0.98)

0.03

LV EF

1.05 (1.00–1.12)

0.04

1.18 (1.05–1.32)

0.006

LVEDD

0.96 (0.86–1.07)

0.47

RV EF

0.96 (0.91–1.01)

0.08

0.93 (0.86–1.01)

0.09

RV EDV

1.01 (1.00–1.02)

0.003

RV global area strain

1.05 (0.96–1.14)

0.29

1.21 (0.99–1.47)

0.06

RV lateral area strain

1.05 (1.01–1.12)

0.03

1.18 (1.05–1.32)

0.005

RV global circumferential strain

1.07 (0.93–1.23)

0.33

1.36 (1.01–1.84)

0.04

RV global longitudinal strain

1.06 (0.92–1.22)

0.40

Pericardial effusion

1.89 (0.69–5.16)

0.21

11.26 (2.72–46.55)

<0.001

Follow-up parameters

WHO Class III ≥ III

26.9 (3.6–201.2)

0.001

6MWD

0.99 (0.98–0.99)

0.005

0.99 (0.98–1.00)

0.02

BNP

1.00 (1.00–1.00)

0.003

1.00 (1.00–1.00)

0.11

RA area

1.10 (1.06–1.14)

<0.001

1.18 (1.00–1.40)

0.04

RA pressure

1.29 (1.17–1.42)

<0.001

1.48 (1.03–2.12)

0.03

TAPSE

0.89 (0.81–0.97)

0.007

0.72 (0.50–1.04)

0.08

LV EF

1.07 (1.01–1.14)

0.02

LV EDD

0.93 (0.83–1.04)

0.93

RV EF

0.91 (0.88–0.95)

<0.001

0.38 (0.11–1.38)

0.14

RV EDV

1.02 (1.01–1.03)

<0.001

1.03 (1.00–1.05)

0.01

RV global area strain

1.16 (1.09–1.24)

<0.001

1.53 (1.13–2.07)

0.006

RV lateral area strain

1.15 (1.09–1.22)

<0.001

1.10 (1.04–1.17)

<0.001

RV global circumferential strain

1.25 (1.13–1.38)

<0.001

2.15 (0.998–4.628)

0.051

RV global longitudinal strain

1.31 (1.15–1.48)

<0.001

1.50 (1.06–2.14)

0.02

Pericardial effusion

3.4 (1.38–8.49)

0.008

34.8 (3.76–320.93)

0.002

	Univariate analysis	Multivariate analysis
Baseline parameters
WHO Class ≥ III	2.26 (1.26–4.03)	0.006	^a
6MWD	0.99 (0.99–1.00)	0.02	0.99 (0.98–1.00)	0.02
BNP	1.00 (0.99–1.00)	0.53	^a
RA area	1.05 (1.02–1.08)	0.002	^a
RA pressure	1.24 (1.11–1.38)	<0.001	1.27 (1.01–1.59)	0.04
TAPSE	0.91 (0.83–1.00)	0.04	0.85 (0.73–0.98)	0.03
LV EF	1.05 (1.00–1.12)	0.04	1.18 (1.05–1.32)	0.006
LVEDD	0.96 (0.86–1.07)	0.47	^a
RV EF	0.96 (0.91–1.01)	0.08	0.93 (0.86–1.01)	0.09
RV EDV	1.01 (1.00–1.02)	0.003	^a
RV global area strain	1.05 (0.96–1.14)	0.29	1.21 (0.99–1.47)	0.06
RV lateral area strain	1.05 (1.01–1.12)	0.03	1.18 (1.05–1.32)	0.005
RV global circumferential strain	1.07 (0.93–1.23)	0.33	1.36 (1.01–1.84)	0.04
RV global longitudinal strain	1.06 (0.92–1.22)	0.40	^a
Pericardial effusion	1.89 (0.69–5.16)	0.21	11.26 (2.72–46.55)	<0.001
Follow-up parameters
WHO Class III ≥ III	26.9 (3.6–201.2)	0.001	^a
6MWD	0.99 (0.98–0.99)	0.005	0.99 (0.98–1.00)	0.02
BNP	1.00 (1.00–1.00)	0.003	1.00 (1.00–1.00)	0.11
RA area	1.10 (1.06–1.14)	<0.001	1.18 (1.00–1.40)	0.04
RA pressure	1.29 (1.17–1.42)	<0.001	1.48 (1.03–2.12)	0.03
TAPSE	0.89 (0.81–0.97)	0.007	0.72 (0.50–1.04)	0.08
LV EF	1.07 (1.01–1.14)	0.02	^a
LV EDD	0.93 (0.83–1.04)	0.93	^a
RV EF	0.91 (0.88–0.95)	<0.001	0.38 (0.11–1.38)	0.14
RV EDV	1.02 (1.01–1.03)	<0.001	1.03 (1.00–1.05)	0.01
RV global area strain	1.16 (1.09–1.24)	<0.001	1.53 (1.13–2.07)	0.006
RV lateral area strain	1.15 (1.09–1.22)	<0.001	1.10 (1.04–1.17)	<0.001
RV global circumferential strain	1.25 (1.13–1.38)	<0.001	2.15 (0.998–4.628)	0.051
RV global longitudinal strain	1.31 (1.15–1.48)	<0.001	1.50 (1.06–2.14)	0.02
Pericardial effusion	3.4 (1.38–8.49)	0.008	34.8 (3.76–320.93)	0.002

Table 3

Open in new tab

Outcome analysis—predictors of death or lung transplant

	Univariate analysis		Multivariate analysis
	HR (95% CI)	P-value	HR (95% CI)	P-value
Baseline parameters
WHO Class ≥ III	2.26 (1.26–4.03)	0.006	^a
6MWD	0.99 (0.99–1.00)	0.02	0.99 (0.98–1.00)	0.02
BNP	1.00 (0.99–1.00)	0.53	^a
RA area	1.05 (1.02–1.08)	0.002	^a
RA pressure	1.24 (1.11–1.38)	<0.001	1.27 (1.01–1.59)	0.04
TAPSE	0.91 (0.83–1.00)	0.04	0.85 (0.73–0.98)	0.03
LV EF	1.05 (1.00–1.12)	0.04	1.18 (1.05–1.32)	0.006
LVEDD	0.96 (0.86–1.07)	0.47	^a
RV EF	0.96 (0.91–1.01)	0.08	0.93 (0.86–1.01)	0.09
RV EDV	1.01 (1.00–1.02)	0.003	^a
RV global area strain	1.05 (0.96–1.14)	0.29	1.21 (0.99–1.47)	0.06
RV lateral area strain	1.05 (1.01–1.12)	0.03	1.18 (1.05–1.32)	0.005
RV global circumferential strain	1.07 (0.93–1.23)	0.33	1.36 (1.01–1.84)	0.04
RV global longitudinal strain	1.06 (0.92–1.22)	0.40	^a
Pericardial effusion	1.89 (0.69–5.16)	0.21	11.26 (2.72–46.55)	<0.001
Follow-up parameters
WHO Class III ≥ III	26.9 (3.6–201.2)	0.001	^a
6MWD	0.99 (0.98–0.99)	0.005	0.99 (0.98–1.00)	0.02
BNP	1.00 (1.00–1.00)	0.003	1.00 (1.00–1.00)	0.11
RA area	1.10 (1.06–1.14)	<0.001	1.18 (1.00–1.40)	0.04
RA pressure	1.29 (1.17–1.42)	<0.001	1.48 (1.03–2.12)	0.03
TAPSE	0.89 (0.81–0.97)	0.007	0.72 (0.50–1.04)	0.08
LV EF	1.07 (1.01–1.14)	0.02	^a
LV EDD	0.93 (0.83–1.04)	0.93	^a
RV EF	0.91 (0.88–0.95)	<0.001	0.38 (0.11–1.38)	0.14
RV EDV	1.02 (1.01–1.03)	<0.001	1.03 (1.00–1.05)	0.01
RV global area strain	1.16 (1.09–1.24)	<0.001	1.53 (1.13–2.07)	0.006
RV lateral area strain	1.15 (1.09–1.22)	<0.001	1.10 (1.04–1.17)	<0.001
RV global circumferential strain	1.25 (1.13–1.38)	<0.001	2.15 (0.998–4.628)	0.051
RV global longitudinal strain	1.31 (1.15–1.48)	<0.001	1.50 (1.06–2.14)	0.02
Pericardial effusion	3.4 (1.38–8.49)	0.008	34.8 (3.76–320.93)	0.002

	Univariate analysis		Multivariate analysis
	HR (95% CI)	P-value	HR (95% CI)	P-value
Baseline parameters
WHO Class ≥ III	2.26 (1.26–4.03)	0.006	^a
6MWD	0.99 (0.99–1.00)	0.02	0.99 (0.98–1.00)	0.02
BNP	1.00 (0.99–1.00)	0.53	^a
RA area	1.05 (1.02–1.08)	0.002	^a
RA pressure	1.24 (1.11–1.38)	<0.001	1.27 (1.01–1.59)	0.04
TAPSE	0.91 (0.83–1.00)	0.04	0.85 (0.73–0.98)	0.03
LV EF	1.05 (1.00–1.12)	0.04	1.18 (1.05–1.32)	0.006
LVEDD	0.96 (0.86–1.07)	0.47	^a
RV EF	0.96 (0.91–1.01)	0.08	0.93 (0.86–1.01)	0.09
RV EDV	1.01 (1.00–1.02)	0.003	^a
RV global area strain	1.05 (0.96–1.14)	0.29	1.21 (0.99–1.47)	0.06
RV lateral area strain	1.05 (1.01–1.12)	0.03	1.18 (1.05–1.32)	0.005
RV global circumferential strain	1.07 (0.93–1.23)	0.33	1.36 (1.01–1.84)	0.04
RV global longitudinal strain	1.06 (0.92–1.22)	0.40	^a
Pericardial effusion	1.89 (0.69–5.16)	0.21	11.26 (2.72–46.55)	<0.001
Follow-up parameters
WHO Class III ≥ III	26.9 (3.6–201.2)	0.001	^a
6MWD	0.99 (0.98–0.99)	0.005	0.99 (0.98–1.00)	0.02
BNP	1.00 (1.00–1.00)	0.003	1.00 (1.00–1.00)	0.11
RA area	1.10 (1.06–1.14)	<0.001	1.18 (1.00–1.40)	0.04
RA pressure	1.29 (1.17–1.42)	<0.001	1.48 (1.03–2.12)	0.03
TAPSE	0.89 (0.81–0.97)	0.007	0.72 (0.50–1.04)	0.08
LV EF	1.07 (1.01–1.14)	0.02	^a
LV EDD	0.93 (0.83–1.04)	0.93	^a
RV EF	0.91 (0.88–0.95)	<0.001	0.38 (0.11–1.38)	0.14
RV EDV	1.02 (1.01–1.03)	<0.001	1.03 (1.00–1.05)	0.01
RV global area strain	1.16 (1.09–1.24)	<0.001	1.53 (1.13–2.07)	0.006
RV lateral area strain	1.15 (1.09–1.22)	<0.001	1.10 (1.04–1.17)	<0.001
RV global circumferential strain	1.25 (1.13–1.38)	<0.001	2.15 (0.998–4.628)	0.051
RV global longitudinal strain	1.31 (1.15–1.48)	<0.001	1.50 (1.06–2.14)	0.02
Pericardial effusion	3.4 (1.38–8.49)	0.008	34.8 (3.76–320.93)	0.002

Variables not included in the multivariate stepwise COX analysis (P-value >0.1).

6MWD, 6-minute walking distance; BNP, brain natriuretic peptide; EDD, end-diastolic diameter; EDV, end-diastolic volume; EF, ejection fraction; LV, left ventricular; RA, right atrial; RV, right ventricular; WHO, world health organization.

This Feature Is Available To Subscribers Only