| Number of strains . | MIC (mg/L) . | Amino acid substitutions in gyrA (sequencing) . | WT band missing (MTBDRsl) . | Resistance mutation (MTBDRsl) . | |
|---|---|---|---|---|---|
| Ofloxacin . | Levofloxacin . | ||||
| 19 | 0.25 | 0.125 | no | no | no |
| 6 | 0.25 | 0.25 | no | no | no |
| 1 | 0.25 | 1 | no | no | no |
| 4 | 0.5 | 0.125 | no | no | no |
| 14 | 0.5 | 0.25 | no | no | no |
| 1 | 0.5 | 0.25 | Thr80Ala | no | no |
| 1 | 1 | 0.25 | Ala90Val | WT 2 | mut 1 |
| 1 | 1 | 0.5 | Ala74Ser | no | mut 3c |
| 4 | 2 | 1 | Ala90Val | WT 2 | mut 1 |
| 1 | 2 | 1 | no | no | no |
| 1 | 2 | 2 | Ala90Val | WT 2 | mut 1 |
| 1 | 4 | 1 | Ala90Val | WT 2 | mut 1 |
| 1 | 4 | 1 | no | no | no |
| 1 | 4 | 2 | Asp94Gly | no | mut 3c |
| 1 | 4 | 2 | Asp89Asn | WT 1 | no |
| 2 | 4 | 2 | Ala90Val | WT 2 | mut 1 |
| 1 | 4 | 2 | Asp94Tyr | no | no |
| 1 | 4 | 2 | Asp94Asn | no | mut 3b |
| 5 | 8 | 4 | Asp94Gly | WT 3 | mut 3c |
| 1 | 8 | 4 | Asp94Tyr | no | mut 3b |
| 1 | 8 | 4 | Asp94Asn | WT 3 | mut 3b |
| 1 | 8 | 4 | Asp94Ala | WT 3 | mut 3a |
| 1 | 8 | 4 | Asp94Gly | no | mut 3c |
| 2 | 8 | 4 | Ser91Pro Asp94Tyr | no | mut 3b |
| 1 | 8 | 8 | no | no | no |
| 1 | 16 | 8 | Asp94Gly | WT 3 | mut 3c |
| 1 | 32 | 16 | Ala90Val Asp94Asn | WT 2, 3 | mut 1, 3b |
| Number of strains . | MIC (mg/L) . | Amino acid substitutions in gyrA (sequencing) . | WT band missing (MTBDRsl) . | Resistance mutation (MTBDRsl) . | |
|---|---|---|---|---|---|
| Ofloxacin . | Levofloxacin . | ||||
| 19 | 0.25 | 0.125 | no | no | no |
| 6 | 0.25 | 0.25 | no | no | no |
| 1 | 0.25 | 1 | no | no | no |
| 4 | 0.5 | 0.125 | no | no | no |
| 14 | 0.5 | 0.25 | no | no | no |
| 1 | 0.5 | 0.25 | Thr80Ala | no | no |
| 1 | 1 | 0.25 | Ala90Val | WT 2 | mut 1 |
| 1 | 1 | 0.5 | Ala74Ser | no | mut 3c |
| 4 | 2 | 1 | Ala90Val | WT 2 | mut 1 |
| 1 | 2 | 1 | no | no | no |
| 1 | 2 | 2 | Ala90Val | WT 2 | mut 1 |
| 1 | 4 | 1 | Ala90Val | WT 2 | mut 1 |
| 1 | 4 | 1 | no | no | no |
| 1 | 4 | 2 | Asp94Gly | no | mut 3c |
| 1 | 4 | 2 | Asp89Asn | WT 1 | no |
| 2 | 4 | 2 | Ala90Val | WT 2 | mut 1 |
| 1 | 4 | 2 | Asp94Tyr | no | no |
| 1 | 4 | 2 | Asp94Asn | no | mut 3b |
| 5 | 8 | 4 | Asp94Gly | WT 3 | mut 3c |
| 1 | 8 | 4 | Asp94Tyr | no | mut 3b |
| 1 | 8 | 4 | Asp94Asn | WT 3 | mut 3b |
| 1 | 8 | 4 | Asp94Ala | WT 3 | mut 3a |
| 1 | 8 | 4 | Asp94Gly | no | mut 3c |
| 2 | 8 | 4 | Ser91Pro Asp94Tyr | no | mut 3b |
| 1 | 8 | 8 | no | no | no |
| 1 | 16 | 8 | Asp94Gly | WT 3 | mut 3c |
| 1 | 32 | 16 | Ala90Val Asp94Asn | WT 2, 3 | mut 1, 3b |
mut, mutation.
| Number of strains . | MIC (mg/L) . | Amino acid substitutions in gyrA (sequencing) . | WT band missing (MTBDRsl) . | Resistance mutation (MTBDRsl) . | |
|---|---|---|---|---|---|
| Ofloxacin . | Levofloxacin . | ||||
| 19 | 0.25 | 0.125 | no | no | no |
| 6 | 0.25 | 0.25 | no | no | no |
| 1 | 0.25 | 1 | no | no | no |
| 4 | 0.5 | 0.125 | no | no | no |
| 14 | 0.5 | 0.25 | no | no | no |
| 1 | 0.5 | 0.25 | Thr80Ala | no | no |
| 1 | 1 | 0.25 | Ala90Val | WT 2 | mut 1 |
| 1 | 1 | 0.5 | Ala74Ser | no | mut 3c |
| 4 | 2 | 1 | Ala90Val | WT 2 | mut 1 |
| 1 | 2 | 1 | no | no | no |
| 1 | 2 | 2 | Ala90Val | WT 2 | mut 1 |
| 1 | 4 | 1 | Ala90Val | WT 2 | mut 1 |
| 1 | 4 | 1 | no | no | no |
| 1 | 4 | 2 | Asp94Gly | no | mut 3c |
| 1 | 4 | 2 | Asp89Asn | WT 1 | no |
| 2 | 4 | 2 | Ala90Val | WT 2 | mut 1 |
| 1 | 4 | 2 | Asp94Tyr | no | no |
| 1 | 4 | 2 | Asp94Asn | no | mut 3b |
| 5 | 8 | 4 | Asp94Gly | WT 3 | mut 3c |
| 1 | 8 | 4 | Asp94Tyr | no | mut 3b |
| 1 | 8 | 4 | Asp94Asn | WT 3 | mut 3b |
| 1 | 8 | 4 | Asp94Ala | WT 3 | mut 3a |
| 1 | 8 | 4 | Asp94Gly | no | mut 3c |
| 2 | 8 | 4 | Ser91Pro Asp94Tyr | no | mut 3b |
| 1 | 8 | 8 | no | no | no |
| 1 | 16 | 8 | Asp94Gly | WT 3 | mut 3c |
| 1 | 32 | 16 | Ala90Val Asp94Asn | WT 2, 3 | mut 1, 3b |
| Number of strains . | MIC (mg/L) . | Amino acid substitutions in gyrA (sequencing) . | WT band missing (MTBDRsl) . | Resistance mutation (MTBDRsl) . | |
|---|---|---|---|---|---|
| Ofloxacin . | Levofloxacin . | ||||
| 19 | 0.25 | 0.125 | no | no | no |
| 6 | 0.25 | 0.25 | no | no | no |
| 1 | 0.25 | 1 | no | no | no |
| 4 | 0.5 | 0.125 | no | no | no |
| 14 | 0.5 | 0.25 | no | no | no |
| 1 | 0.5 | 0.25 | Thr80Ala | no | no |
| 1 | 1 | 0.25 | Ala90Val | WT 2 | mut 1 |
| 1 | 1 | 0.5 | Ala74Ser | no | mut 3c |
| 4 | 2 | 1 | Ala90Val | WT 2 | mut 1 |
| 1 | 2 | 1 | no | no | no |
| 1 | 2 | 2 | Ala90Val | WT 2 | mut 1 |
| 1 | 4 | 1 | Ala90Val | WT 2 | mut 1 |
| 1 | 4 | 1 | no | no | no |
| 1 | 4 | 2 | Asp94Gly | no | mut 3c |
| 1 | 4 | 2 | Asp89Asn | WT 1 | no |
| 2 | 4 | 2 | Ala90Val | WT 2 | mut 1 |
| 1 | 4 | 2 | Asp94Tyr | no | no |
| 1 | 4 | 2 | Asp94Asn | no | mut 3b |
| 5 | 8 | 4 | Asp94Gly | WT 3 | mut 3c |
| 1 | 8 | 4 | Asp94Tyr | no | mut 3b |
| 1 | 8 | 4 | Asp94Asn | WT 3 | mut 3b |
| 1 | 8 | 4 | Asp94Ala | WT 3 | mut 3a |
| 1 | 8 | 4 | Asp94Gly | no | mut 3c |
| 2 | 8 | 4 | Ser91Pro Asp94Tyr | no | mut 3b |
| 1 | 8 | 8 | no | no | no |
| 1 | 16 | 8 | Asp94Gly | WT 3 | mut 3c |
| 1 | 32 | 16 | Ala90Val Asp94Asn | WT 2, 3 | mut 1, 3b |
mut, mutation.
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