Table 1. Open in new tab Results of the...

Species (n)^a	Carbapenemase detected by PCR (n)^a	MIC, mg/L	Test results (n)^a
Non-carbapenemase producers (82)^d
Citrobacter freundii (1)	none	2	0.5	1.5	neg	neg
Enterobacter aerogenes (4)	none	0.5–24	0.06–32	0.12 to ≥32	neg	neg
Enterobacter asburiae (1)	none	0.5	0.064	0.19	neg	neg
Enterobacter cloacae (22)	none	0.19–24	0.06–16	0.25 to ≥32	neg	neg
Enterobacter spp. (1)	none	≥32	≥32	≥32	neg	neg
Escherichia coli (12)	none	0.023–6	0.012 to ≥32	0.008 to ≥32	neg	neg
Klebsiella oxytoca (1)	none	0.25	0.25	1	neg	neg
Klebsiella pneumoniae (34)	none	0.125 to ≥32	0.016–24	0.016 to ≥32	neg	neg
Morganella morganii (1)	none	2	0.12	0.25	neg	neg
Providencia stuartii (1)	none	1.5	0.12	0.5	neg	neg
Pantoea spp. (1)	none	0.38	0.047	0.19	neg	neg
Serratia marcescens (3)	none	0.75–2	0.12–0.75	0.25–1.5	neg	neg
Carbapenemase producers (100)^d
C. freundii (2)	KPC	6–12	2–6	4–6	pos	pos
E. cloacae (13)	KPC (3)	12 to ≥32	24 to ≥32	8 to ≥32	pos	pos
	NDM (2)	≥32	≥32	≥32	pos	pos
	NMC/IMI (4)	≥32	16 to ≥32	24–32	pos	pos
	VIM (4)	6–24	6–32	2–24	pos	pos
E. coli (26)	IMP-27 (1)	0.5	4	3	pos	pos
	KPC (2)	1–4	0.25–1.5	0.5–1.5	pos	pos
	NDM (4)	6 to ≥32	3 to ≥32	12 to ≥32	pos	pos
	OXA-48 (11)	0.5–6	0.25–6	0.5 to ≥32	pos (10); neg (1)	pos
	OXA-181 (4)	1–4	0.75–1	1.5–8	pos (2); neg (2)	pos
	OXA-244 (1)	3	3	16	neg	pos
	VIM (3)	2–12	0.5–24	0.125–16	pos	pos
K. oxytoca (1)	OXA-48	3	0.75	3	pos	pos
K. pneumoniae (38)	KPC (4)^e	0.5 to ≥32	0.125–32	0.19–32	pos (3); neg (1)	pos
	NDM (2)	≥32	≥32	≥32	pos	pos
	OXA-48 (15)	0.38–32	0.125–32	0.38 to ≥32	pos (13); neg (1)	pos
	OXA-181 (10)	6 to ≥32	2 to ≥32	3 to ≥32	pos	pos
	OXA-232 (7)	3–32	3 to ≥32	16 to ≥32	pos (5); neg (2)	pos
M. morganii (1)	NDM	32	2	2	pos	pos
Proteus mirabilis (1)	IMP-27	4	4	4	neg	neg
Providencia rettgeri (1)^e	NDM-1	≥32	≥32	16	neg	pos
P. stuartii (1)	NDM-1	≥32	≥32	≥32	neg	pos
Raoultella ornithinolytica (1)	KPC	2	0.75	0.75	pos	pos
S. marcescens (15)	KPC (1)	≥32	24	≥32	pos	pos
	SME (14)	≥32	12 to ≥32	3 to ≥32	pos	pos

Species (n)^a

Carbapenemase detected by PCR (n)^a

MIC, mg/L

Test results (n)^a

imipenem

meropenem

ertapenem

CNPt^b

CIM^c

Non-carbapenemase producers (82)^d

Citrobacter freundii (1)

none

0.5

1.5

neg

Enterobacter aerogenes (4)

none

0.5–24

0.06–32

0.12 to ≥32

neg

Enterobacter asburiae (1)

none

0.5

0.064

0.19

neg

Enterobacter cloacae (22)

none

0.19–24

0.06–16

0.25 to ≥32

neg

Enterobacter spp. (1)

none

≥32

neg

Escherichia coli (12)

none

0.023–6

0.012 to ≥32

0.008 to ≥32

neg

Klebsiella oxytoca (1)

none

0.25

neg

Klebsiella pneumoniae (34)

none

0.125 to ≥32

0.016–24

0.016 to ≥32

neg

Morganella morganii (1)

none

0.12

0.25

neg

Providencia stuartii (1)

none

1.5

0.12

0.5

neg

Pantoea spp. (1)

none

0.38

0.047

0.19

neg

Serratia marcescens (3)

none

0.75–2

0.12–0.75

0.25–1.5

neg

Carbapenemase producers (100)^d

C. freundii (2)

KPC

6–12

2–6

4–6

pos

E. cloacae (13)

KPC (3)

12 to ≥32

24 to ≥32

8 to ≥32

pos

NDM (2)

≥32

pos

NMC/IMI (4)

≥32

16 to ≥32

24–32

pos

VIM (4)

6–24

6–32

2–24

pos

E. coli (26)

IMP-27 (1)

0.5

pos

KPC (2)

1–4

0.25–1.5

0.5–1.5

pos

NDM (4)

6 to ≥32

3 to ≥32

12 to ≥32

pos

OXA-48 (11)

0.5–6

0.25–6

0.5 to ≥32

pos (10); neg (1)

pos

OXA-181 (4)

1–4

0.75–1

1.5–8

pos (2); neg (2)

pos

OXA-244 (1)

neg

pos

VIM (3)

2–12

0.5–24

0.125–16

pos

K. oxytoca (1)

OXA-48

0.75

pos

K. pneumoniae (38)

KPC (4)^e

0.5 to ≥32

0.125–32

0.19–32

pos (3); neg (1)

pos

NDM (2)

≥32

pos

OXA-48 (15)

0.38–32

0.125–32

0.38 to ≥32

pos (13); neg (1)

pos

OXA-181 (10)

6 to ≥32

2 to ≥32

3 to ≥32

pos

OXA-232 (7)

3–32

3 to ≥32

16 to ≥32

pos (5); neg (2)

pos

M. morganii (1)

NDM

pos

Proteus mirabilis (1)

IMP-27

neg

Providencia rettgeri (1)^e

NDM-1

≥32

neg

pos

P. stuartii (1)

NDM-1

≥32

neg

pos

Raoultella ornithinolytica (1)

KPC

0.75

pos

S. marcescens (15)

KPC (1)

≥32

pos

SME (14)

≥32

12 to ≥32

3 to ≥32

pos

Species (n)^a	Carbapenemase detected by PCR (n)^a	MIC, mg/L	Test results (n)^a
Non-carbapenemase producers (82)^d
Citrobacter freundii (1)	none	2	0.5	1.5	neg	neg
Enterobacter aerogenes (4)	none	0.5–24	0.06–32	0.12 to ≥32	neg	neg
Enterobacter asburiae (1)	none	0.5	0.064	0.19	neg	neg
Enterobacter cloacae (22)	none	0.19–24	0.06–16	0.25 to ≥32	neg	neg
Enterobacter spp. (1)	none	≥32	≥32	≥32	neg	neg
Escherichia coli (12)	none	0.023–6	0.012 to ≥32	0.008 to ≥32	neg	neg
Klebsiella oxytoca (1)	none	0.25	0.25	1	neg	neg
Klebsiella pneumoniae (34)	none	0.125 to ≥32	0.016–24	0.016 to ≥32	neg	neg
Morganella morganii (1)	none	2	0.12	0.25	neg	neg
Providencia stuartii (1)	none	1.5	0.12	0.5	neg	neg
Pantoea spp. (1)	none	0.38	0.047	0.19	neg	neg
Serratia marcescens (3)	none	0.75–2	0.12–0.75	0.25–1.5	neg	neg
Carbapenemase producers (100)^d
C. freundii (2)	KPC	6–12	2–6	4–6	pos	pos
E. cloacae (13)	KPC (3)	12 to ≥32	24 to ≥32	8 to ≥32	pos	pos
	NDM (2)	≥32	≥32	≥32	pos	pos
	NMC/IMI (4)	≥32	16 to ≥32	24–32	pos	pos
	VIM (4)	6–24	6–32	2–24	pos	pos
E. coli (26)	IMP-27 (1)	0.5	4	3	pos	pos
	KPC (2)	1–4	0.25–1.5	0.5–1.5	pos	pos
	NDM (4)	6 to ≥32	3 to ≥32	12 to ≥32	pos	pos
	OXA-48 (11)	0.5–6	0.25–6	0.5 to ≥32	pos (10); neg (1)	pos
	OXA-181 (4)	1–4	0.75–1	1.5–8	pos (2); neg (2)	pos
	OXA-244 (1)	3	3	16	neg	pos
	VIM (3)	2–12	0.5–24	0.125–16	pos	pos
K. oxytoca (1)	OXA-48	3	0.75	3	pos	pos
K. pneumoniae (38)	KPC (4)^e	0.5 to ≥32	0.125–32	0.19–32	pos (3); neg (1)	pos
	NDM (2)	≥32	≥32	≥32	pos	pos
	OXA-48 (15)	0.38–32	0.125–32	0.38 to ≥32	pos (13); neg (1)	pos
	OXA-181 (10)	6 to ≥32	2 to ≥32	3 to ≥32	pos	pos
	OXA-232 (7)	3–32	3 to ≥32	16 to ≥32	pos (5); neg (2)	pos
M. morganii (1)	NDM	32	2	2	pos	pos
Proteus mirabilis (1)	IMP-27	4	4	4	neg	neg
Providencia rettgeri (1)^e	NDM-1	≥32	≥32	16	neg	pos
P. stuartii (1)	NDM-1	≥32	≥32	≥32	neg	pos
Raoultella ornithinolytica (1)	KPC	2	0.75	0.75	pos	pos
S. marcescens (15)	KPC (1)	≥32	24	≥32	pos	pos
	SME (14)	≥32	12 to ≥32	3 to ≥32	pos	pos

Table 1.

Open in new tab

Results of the CIM and CNPt

Species (n)^a	Carbapenemase detected by PCR (n)^a	MIC, mg/L			Test results (n)^a
Species (n)^a	Carbapenemase detected by PCR (n)^a	imipenem	meropenem	ertapenem	CNPt^b	CIM^c
Non-carbapenemase producers (82)^d
Citrobacter freundii (1)	none	2	0.5	1.5	neg	neg
Enterobacter aerogenes (4)	none	0.5–24	0.06–32	0.12 to ≥32	neg	neg
Enterobacter asburiae (1)	none	0.5	0.064	0.19	neg	neg
Enterobacter cloacae (22)	none	0.19–24	0.06–16	0.25 to ≥32	neg	neg
Enterobacter spp. (1)	none	≥32	≥32	≥32	neg	neg
Escherichia coli (12)	none	0.023–6	0.012 to ≥32	0.008 to ≥32	neg	neg
Klebsiella oxytoca (1)	none	0.25	0.25	1	neg	neg
Klebsiella pneumoniae (34)	none	0.125 to ≥32	0.016–24	0.016 to ≥32	neg	neg
Morganella morganii (1)	none	2	0.12	0.25	neg	neg
Providencia stuartii (1)	none	1.5	0.12	0.5	neg	neg
Pantoea spp. (1)	none	0.38	0.047	0.19	neg	neg
Serratia marcescens (3)	none	0.75–2	0.12–0.75	0.25–1.5	neg	neg
Carbapenemase producers (100)^d
C. freundii (2)	KPC	6–12	2–6	4–6	pos	pos
E. cloacae (13)	KPC (3)	12 to ≥32	24 to ≥32	8 to ≥32	pos	pos
	NDM (2)	≥32	≥32	≥32	pos	pos
	NMC/IMI (4)	≥32	16 to ≥32	24–32	pos	pos
	VIM (4)	6–24	6–32	2–24	pos	pos
E. coli (26)	IMP-27 (1)	0.5	4	3	pos	pos
	KPC (2)	1–4	0.25–1.5	0.5–1.5	pos	pos
	NDM (4)	6 to ≥32	3 to ≥32	12 to ≥32	pos	pos
	OXA-48 (11)	0.5–6	0.25–6	0.5 to ≥32	pos (10); neg (1)	pos
	OXA-181 (4)	1–4	0.75–1	1.5–8	pos (2); neg (2)	pos
	OXA-244 (1)	3	3	16	neg	pos
	VIM (3)	2–12	0.5–24	0.125–16	pos	pos
K. oxytoca (1)	OXA-48	3	0.75	3	pos	pos
K. pneumoniae (38)	KPC (4)^e	0.5 to ≥32	0.125–32	0.19–32	pos (3); neg (1)	pos
	NDM (2)	≥32	≥32	≥32	pos	pos
	OXA-48 (15)	0.38–32	0.125–32	0.38 to ≥32	pos (13); neg (1)	pos
	OXA-181 (10)	6 to ≥32	2 to ≥32	3 to ≥32	pos	pos
	OXA-232 (7)	3–32	3 to ≥32	16 to ≥32	pos (5); neg (2)	pos
M. morganii (1)	NDM	32	2	2	pos	pos
Proteus mirabilis (1)	IMP-27	4	4	4	neg	neg
Providencia rettgeri (1)^e	NDM-1	≥32	≥32	16	neg	pos
P. stuartii (1)	NDM-1	≥32	≥32	≥32	neg	pos
Raoultella ornithinolytica (1)	KPC	2	0.75	0.75	pos	pos
S. marcescens (15)	KPC (1)	≥32	24	≥32	pos	pos
	SME (14)	≥32	12 to ≥32	3 to ≥32	pos	pos

Species (n)^a	Carbapenemase detected by PCR (n)^a	MIC, mg/L			Test results (n)^a
Species (n)^a	Carbapenemase detected by PCR (n)^a	imipenem	meropenem	ertapenem	CNPt^b	CIM^c
Non-carbapenemase producers (82)^d
Citrobacter freundii (1)	none	2	0.5	1.5	neg	neg
Enterobacter aerogenes (4)	none	0.5–24	0.06–32	0.12 to ≥32	neg	neg
Enterobacter asburiae (1)	none	0.5	0.064	0.19	neg	neg
Enterobacter cloacae (22)	none	0.19–24	0.06–16	0.25 to ≥32	neg	neg
Enterobacter spp. (1)	none	≥32	≥32	≥32	neg	neg
Escherichia coli (12)	none	0.023–6	0.012 to ≥32	0.008 to ≥32	neg	neg
Klebsiella oxytoca (1)	none	0.25	0.25	1	neg	neg
Klebsiella pneumoniae (34)	none	0.125 to ≥32	0.016–24	0.016 to ≥32	neg	neg
Morganella morganii (1)	none	2	0.12	0.25	neg	neg
Providencia stuartii (1)	none	1.5	0.12	0.5	neg	neg
Pantoea spp. (1)	none	0.38	0.047	0.19	neg	neg
Serratia marcescens (3)	none	0.75–2	0.12–0.75	0.25–1.5	neg	neg
Carbapenemase producers (100)^d
C. freundii (2)	KPC	6–12	2–6	4–6	pos	pos
E. cloacae (13)	KPC (3)	12 to ≥32	24 to ≥32	8 to ≥32	pos	pos
	NDM (2)	≥32	≥32	≥32	pos	pos
	NMC/IMI (4)	≥32	16 to ≥32	24–32	pos	pos
	VIM (4)	6–24	6–32	2–24	pos	pos
E. coli (26)	IMP-27 (1)	0.5	4	3	pos	pos
	KPC (2)	1–4	0.25–1.5	0.5–1.5	pos	pos
	NDM (4)	6 to ≥32	3 to ≥32	12 to ≥32	pos	pos
	OXA-48 (11)	0.5–6	0.25–6	0.5 to ≥32	pos (10); neg (1)	pos
	OXA-181 (4)	1–4	0.75–1	1.5–8	pos (2); neg (2)	pos
	OXA-244 (1)	3	3	16	neg	pos
	VIM (3)	2–12	0.5–24	0.125–16	pos	pos
K. oxytoca (1)	OXA-48	3	0.75	3	pos	pos
K. pneumoniae (38)	KPC (4)^e	0.5 to ≥32	0.125–32	0.19–32	pos (3); neg (1)	pos
	NDM (2)	≥32	≥32	≥32	pos	pos
	OXA-48 (15)	0.38–32	0.125–32	0.38 to ≥32	pos (13); neg (1)	pos
	OXA-181 (10)	6 to ≥32	2 to ≥32	3 to ≥32	pos	pos
	OXA-232 (7)	3–32	3 to ≥32	16 to ≥32	pos (5); neg (2)	pos
M. morganii (1)	NDM	32	2	2	pos	pos
Proteus mirabilis (1)	IMP-27	4	4	4	neg	neg
Providencia rettgeri (1)^e	NDM-1	≥32	≥32	16	neg	pos
P. stuartii (1)	NDM-1	≥32	≥32	≥32	neg	pos
Raoultella ornithinolytica (1)	KPC	2	0.75	0.75	pos	pos
S. marcescens (15)	KPC (1)	≥32	24	≥32	pos	pos
	SME (14)	≥32	12 to ≥32	3 to ≥32	pos	pos

^an, number of isolates.

^bCNPt results: neg, negative (red); and pos, positive (yellow/orange). All the results shown in this table were obtained following the CLSI guidelines.³ False-negative results are shown in bold.

^cCIM results: neg, negative (inhibition zone ≥20 mm); and pos, positive (no inhibition zone).³ False-negative results are shown in bold.

^dPCR analysis was performed for the following carbapenemase genes: bla_KPC, bla_NDM, bla_OXA-48-like, bla_VIM, bla_IMP, bla_GES,^7,8bla_SME and bla_NMC/IMI.⁹

^eIncludes one mucoid isolate.

This Feature Is Available To Subscribers Only