Table 2
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Network meta-analysis results of five-node analysis, including confidence assessments

ComparisonTrials with direct comparisons (n)Direct estimate (95% CI)Indirect estimate (95% CrI)NMA estimate (95% CrI)Overall certainty
Acute restoration of sinus rhythm
 Class Ia vs. no treatment or rate control31.04 (0.38, 2.89)8.10 (1.22, 55.69)1.65 (0.65, 4.24)High
 Class Ic vs. no treatment or rate control41.54 (0.60, 4.02)0.81 (0.17, 3.88)1.30 (0.59, 2.96)High
 Class III vs. no treatment or rate control102.41 (1.37, 4.62)N/A*2.41 (1.37, 4.62)High
 Amiodarone vs. no treatment or rate control132.82 (1.61, 4.98)0.80 (0.07, 8.89)2.58 (1.54, 4.37)High
 Class Ic vs. Class Ia10.21 (0.04, 1.22)1.67 (0.47, 6.46)0.79 (0.26, 2.38)High
 Amiodarone vs. Class Ic10.74 (0.08, 6.94)2.40 (0.88, 6.76)1.97 (0.79, 5.02)High
 Amiodarone vs. Class III40.75 (0.25, 2.11)1.45 (0.43, 4.01)1.07 (0.50, 2.12)High
Long-term maintenance of sinus rhythm
 Class Ia vs. no treatment or rate control13.52 (0.94, 14.08)N/A*3.52 (0.94, 14.08)High
 Class Ic vs. no treatment or rate control31.91 (0.96, 4.08)4.71 (2.03, 11.03)2.83 (1.60, 5.10)Moderate
 Class III vs. no treatment or rate control52.50 (1.70, 3.79)N/A*2.50 (1.70, 3.79)High
 Amiodarone vs. no treatment or rate control115.86 (4.09, 8.42)2.37 (0.68, 8.33)5.37 (4.00, 7.39)High
 Amiodarone vs. Class Ic11.22 (0.55, 2.81)3.08 (1.38, 6.48)1.89 (1.05, 3.45)Moderate
 Amiodarone vs. Class III32.31 (1.21, 4.18)1.97 (0.88, 4.46)2.19 (1.39, 3.26)High
ComparisonTrials with direct comparisons (n)Direct estimate (95% CI)Indirect estimate (95% CrI)NMA estimate (95% CrI)Overall certainty
Acute restoration of sinus rhythm
 Class Ia vs. no treatment or rate control31.04 (0.38, 2.89)8.10 (1.22, 55.69)1.65 (0.65, 4.24)High
 Class Ic vs. no treatment or rate control41.54 (0.60, 4.02)0.81 (0.17, 3.88)1.30 (0.59, 2.96)High
 Class III vs. no treatment or rate control102.41 (1.37, 4.62)N/A*2.41 (1.37, 4.62)High
 Amiodarone vs. no treatment or rate control132.82 (1.61, 4.98)0.80 (0.07, 8.89)2.58 (1.54, 4.37)High
 Class Ic vs. Class Ia10.21 (0.04, 1.22)1.67 (0.47, 6.46)0.79 (0.26, 2.38)High
 Amiodarone vs. Class Ic10.74 (0.08, 6.94)2.40 (0.88, 6.76)1.97 (0.79, 5.02)High
 Amiodarone vs. Class III40.75 (0.25, 2.11)1.45 (0.43, 4.01)1.07 (0.50, 2.12)High
Long-term maintenance of sinus rhythm
 Class Ia vs. no treatment or rate control13.52 (0.94, 14.08)N/A*3.52 (0.94, 14.08)High
 Class Ic vs. no treatment or rate control31.91 (0.96, 4.08)4.71 (2.03, 11.03)2.83 (1.60, 5.10)Moderate
 Class III vs. no treatment or rate control52.50 (1.70, 3.79)N/A*2.50 (1.70, 3.79)High
 Amiodarone vs. no treatment or rate control115.86 (4.09, 8.42)2.37 (0.68, 8.33)5.37 (4.00, 7.39)High
 Amiodarone vs. Class Ic11.22 (0.55, 2.81)3.08 (1.38, 6.48)1.89 (1.05, 3.45)Moderate
 Amiodarone vs. Class III32.31 (1.21, 4.18)1.97 (0.88, 4.46)2.19 (1.39, 3.26)High

CI, confidence interval; CrI, credible interval; N/A, not applicable.

Table 2
Open in new tab

Network meta-analysis results of five-node analysis, including confidence assessments

ComparisonTrials with direct comparisons (n)Direct estimate (95% CI)Indirect estimate (95% CrI)NMA estimate (95% CrI)Overall certainty
Acute restoration of sinus rhythm
 Class Ia vs. no treatment or rate control31.04 (0.38, 2.89)8.10 (1.22, 55.69)1.65 (0.65, 4.24)High
 Class Ic vs. no treatment or rate control41.54 (0.60, 4.02)0.81 (0.17, 3.88)1.30 (0.59, 2.96)High
 Class III vs. no treatment or rate control102.41 (1.37, 4.62)N/A*2.41 (1.37, 4.62)High
 Amiodarone vs. no treatment or rate control132.82 (1.61, 4.98)0.80 (0.07, 8.89)2.58 (1.54, 4.37)High
 Class Ic vs. Class Ia10.21 (0.04, 1.22)1.67 (0.47, 6.46)0.79 (0.26, 2.38)High
 Amiodarone vs. Class Ic10.74 (0.08, 6.94)2.40 (0.88, 6.76)1.97 (0.79, 5.02)High
 Amiodarone vs. Class III40.75 (0.25, 2.11)1.45 (0.43, 4.01)1.07 (0.50, 2.12)High
Long-term maintenance of sinus rhythm
 Class Ia vs. no treatment or rate control13.52 (0.94, 14.08)N/A*3.52 (0.94, 14.08)High
 Class Ic vs. no treatment or rate control31.91 (0.96, 4.08)4.71 (2.03, 11.03)2.83 (1.60, 5.10)Moderate
 Class III vs. no treatment or rate control52.50 (1.70, 3.79)N/A*2.50 (1.70, 3.79)High
 Amiodarone vs. no treatment or rate control115.86 (4.09, 8.42)2.37 (0.68, 8.33)5.37 (4.00, 7.39)High
 Amiodarone vs. Class Ic11.22 (0.55, 2.81)3.08 (1.38, 6.48)1.89 (1.05, 3.45)Moderate
 Amiodarone vs. Class III32.31 (1.21, 4.18)1.97 (0.88, 4.46)2.19 (1.39, 3.26)High
ComparisonTrials with direct comparisons (n)Direct estimate (95% CI)Indirect estimate (95% CrI)NMA estimate (95% CrI)Overall certainty
Acute restoration of sinus rhythm
 Class Ia vs. no treatment or rate control31.04 (0.38, 2.89)8.10 (1.22, 55.69)1.65 (0.65, 4.24)High
 Class Ic vs. no treatment or rate control41.54 (0.60, 4.02)0.81 (0.17, 3.88)1.30 (0.59, 2.96)High
 Class III vs. no treatment or rate control102.41 (1.37, 4.62)N/A*2.41 (1.37, 4.62)High
 Amiodarone vs. no treatment or rate control132.82 (1.61, 4.98)0.80 (0.07, 8.89)2.58 (1.54, 4.37)High
 Class Ic vs. Class Ia10.21 (0.04, 1.22)1.67 (0.47, 6.46)0.79 (0.26, 2.38)High
 Amiodarone vs. Class Ic10.74 (0.08, 6.94)2.40 (0.88, 6.76)1.97 (0.79, 5.02)High
 Amiodarone vs. Class III40.75 (0.25, 2.11)1.45 (0.43, 4.01)1.07 (0.50, 2.12)High
Long-term maintenance of sinus rhythm
 Class Ia vs. no treatment or rate control13.52 (0.94, 14.08)N/A*3.52 (0.94, 14.08)High
 Class Ic vs. no treatment or rate control31.91 (0.96, 4.08)4.71 (2.03, 11.03)2.83 (1.60, 5.10)Moderate
 Class III vs. no treatment or rate control52.50 (1.70, 3.79)N/A*2.50 (1.70, 3.79)High
 Amiodarone vs. no treatment or rate control115.86 (4.09, 8.42)2.37 (0.68, 8.33)5.37 (4.00, 7.39)High
 Amiodarone vs. Class Ic11.22 (0.55, 2.81)3.08 (1.38, 6.48)1.89 (1.05, 3.45)Moderate
 Amiodarone vs. Class III32.31 (1.21, 4.18)1.97 (0.88, 4.46)2.19 (1.39, 3.26)High

CI, confidence interval; CrI, credible interval; N/A, not applicable.

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