Table 2.

Adjusted incident cardiovascular disease events based on change of SBP and hs-cTnT

Change in systolic blood pressure categorization (events; total N)Change in hs-cTnT categorization (events; N)Risk of cardiovascular event hazard ratio (confidence interval)
SBP increased group (224; 510)Decreased (25; 56)0.83 (0.54–1.30)
Stable (154; 367)1.00
Increased (45; 87)1.28 (0.90–1.81)
SBP stable group (555; 1,279)Decreased (52; 128)0.86 (0.64–1.15)
Stable (368; 899)1.00
Increased (135; 252)1.27 (1.04–1.57) ǂ
SBP decreased group (183; 430)Decreased (23; 47)1.15 (0.71–1.85)
Stable (122; 311)1.00
Increased (38; 72)1.57 (1.08–2.28) ǂ
Change in systolic blood pressure categorization (events; total N)Change in hs-cTnT categorization (events; N)Risk of cardiovascular event hazard ratio (confidence interval)
SBP increased group (224; 510)Decreased (25; 56)0.83 (0.54–1.30)
Stable (154; 367)1.00
Increased (45; 87)1.28 (0.90–1.81)
SBP stable group (555; 1,279)Decreased (52; 128)0.86 (0.64–1.15)
Stable (368; 899)1.00
Increased (135; 252)1.27 (1.04–1.57) ǂ
SBP decreased group (183; 430)Decreased (23; 47)1.15 (0.71–1.85)
Stable (122; 311)1.00
Increased (38; 72)1.57 (1.08–2.28) ǂ

Adjusted for baseline high-sensitivity cardiac troponin T (hs-cTnT), baseline SBP, age, body mass index, sex, race, smoking status, diabetes status, baseline lipids, use of lipid-lowering medication, and use of blood pressure medication. Similar results were seen with the excluded adjustment for blood pressure medication use. Change in systolic blood pressure (SBP) definitions. SBP increased: Baseline SBP at optimal (SBP < 120 mm Hg) or intermediate (SBP 120–139 mm Hg), increased to intermediate or elevated (SBP ≥ 140 mm Hg) at follow-up after 2–3 years; SBP stable: Baseline and follow-up SBP remained in the same group; SBP decreased: Baseline SBP at intermediate or elevated, decreased to optimal or intermediate at a follow-up after 2–3 years. Change in hs-cTnT definitions. Increased hs-cTnT: Baseline hs-cTnT at undetectable (<5 ng/l) or detectable (5–14 ng/l), increased to detectable or elevated (≥14 ng/l) at second troponin follow-up (2–3 years later); stable hs-cTnT: Baseline and follow-up. hs-cTnT remained in the same group; decreased hs-cTnT: Baseline hs-cTnT at detectable or elevated, decreased to undetectable or detectable at second troponin follow-up.

ǂP < 0.05.

Table 2.

Adjusted incident cardiovascular disease events based on change of SBP and hs-cTnT

Change in systolic blood pressure categorization (events; total N)Change in hs-cTnT categorization (events; N)Risk of cardiovascular event hazard ratio (confidence interval)
SBP increased group (224; 510)Decreased (25; 56)0.83 (0.54–1.30)
Stable (154; 367)1.00
Increased (45; 87)1.28 (0.90–1.81)
SBP stable group (555; 1,279)Decreased (52; 128)0.86 (0.64–1.15)
Stable (368; 899)1.00
Increased (135; 252)1.27 (1.04–1.57) ǂ
SBP decreased group (183; 430)Decreased (23; 47)1.15 (0.71–1.85)
Stable (122; 311)1.00
Increased (38; 72)1.57 (1.08–2.28) ǂ
Change in systolic blood pressure categorization (events; total N)Change in hs-cTnT categorization (events; N)Risk of cardiovascular event hazard ratio (confidence interval)
SBP increased group (224; 510)Decreased (25; 56)0.83 (0.54–1.30)
Stable (154; 367)1.00
Increased (45; 87)1.28 (0.90–1.81)
SBP stable group (555; 1,279)Decreased (52; 128)0.86 (0.64–1.15)
Stable (368; 899)1.00
Increased (135; 252)1.27 (1.04–1.57) ǂ
SBP decreased group (183; 430)Decreased (23; 47)1.15 (0.71–1.85)
Stable (122; 311)1.00
Increased (38; 72)1.57 (1.08–2.28) ǂ

Adjusted for baseline high-sensitivity cardiac troponin T (hs-cTnT), baseline SBP, age, body mass index, sex, race, smoking status, diabetes status, baseline lipids, use of lipid-lowering medication, and use of blood pressure medication. Similar results were seen with the excluded adjustment for blood pressure medication use. Change in systolic blood pressure (SBP) definitions. SBP increased: Baseline SBP at optimal (SBP < 120 mm Hg) or intermediate (SBP 120–139 mm Hg), increased to intermediate or elevated (SBP ≥ 140 mm Hg) at follow-up after 2–3 years; SBP stable: Baseline and follow-up SBP remained in the same group; SBP decreased: Baseline SBP at intermediate or elevated, decreased to optimal or intermediate at a follow-up after 2–3 years. Change in hs-cTnT definitions. Increased hs-cTnT: Baseline hs-cTnT at undetectable (<5 ng/l) or detectable (5–14 ng/l), increased to detectable or elevated (≥14 ng/l) at second troponin follow-up (2–3 years later); stable hs-cTnT: Baseline and follow-up. hs-cTnT remained in the same group; decreased hs-cTnT: Baseline hs-cTnT at detectable or elevated, decreased to undetectable or detectable at second troponin follow-up.

ǂP < 0.05.

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