Adjusted incident cardiovascular disease events based on change of SBP and hs-cTnT
Change in systolic blood pressure categorization (events; total N) | Change in hs-cTnT categorization (events; N) | Risk of cardiovascular event hazard ratio (confidence interval) |
SBP increased group (224; 510) | Decreased (25; 56) | 0.83 (0.54–1.30) |
Stable (154; 367) | 1.00 | |
Increased (45; 87) | 1.28 (0.90–1.81) | |
SBP stable group (555; 1,279) | Decreased (52; 128) | 0.86 (0.64–1.15) |
Stable (368; 899) | 1.00 | |
Increased (135; 252) | 1.27 (1.04–1.57) ǂ | |
SBP decreased group (183; 430) | Decreased (23; 47) | 1.15 (0.71–1.85) |
Stable (122; 311) | 1.00 | |
Increased (38; 72) | 1.57 (1.08–2.28) ǂ |
Change in systolic blood pressure categorization (events; total N) | Change in hs-cTnT categorization (events; N) | Risk of cardiovascular event hazard ratio (confidence interval) |
SBP increased group (224; 510) | Decreased (25; 56) | 0.83 (0.54–1.30) |
Stable (154; 367) | 1.00 | |
Increased (45; 87) | 1.28 (0.90–1.81) | |
SBP stable group (555; 1,279) | Decreased (52; 128) | 0.86 (0.64–1.15) |
Stable (368; 899) | 1.00 | |
Increased (135; 252) | 1.27 (1.04–1.57) ǂ | |
SBP decreased group (183; 430) | Decreased (23; 47) | 1.15 (0.71–1.85) |
Stable (122; 311) | 1.00 | |
Increased (38; 72) | 1.57 (1.08–2.28) ǂ |
Adjusted for baseline high-sensitivity cardiac troponin T (hs-cTnT), baseline SBP, age, body mass index, sex, race, smoking status, diabetes status, baseline lipids, use of lipid-lowering medication, and use of blood pressure medication. Similar results were seen with the excluded adjustment for blood pressure medication use. Change in systolic blood pressure (SBP) definitions. SBP increased: Baseline SBP at optimal (SBP < 120 mm Hg) or intermediate (SBP 120–139 mm Hg), increased to intermediate or elevated (SBP ≥ 140 mm Hg) at follow-up after 2–3 years; SBP stable: Baseline and follow-up SBP remained in the same group; SBP decreased: Baseline SBP at intermediate or elevated, decreased to optimal or intermediate at a follow-up after 2–3 years. Change in hs-cTnT definitions. Increased hs-cTnT: Baseline hs-cTnT at undetectable (<5 ng/l) or detectable (5–14 ng/l), increased to detectable or elevated (≥14 ng/l) at second troponin follow-up (2–3 years later); stable hs-cTnT: Baseline and follow-up. hs-cTnT remained in the same group; decreased hs-cTnT: Baseline hs-cTnT at detectable or elevated, decreased to undetectable or detectable at second troponin follow-up.
ǂP < 0.05.
Adjusted incident cardiovascular disease events based on change of SBP and hs-cTnT
Change in systolic blood pressure categorization (events; total N) | Change in hs-cTnT categorization (events; N) | Risk of cardiovascular event hazard ratio (confidence interval) |
SBP increased group (224; 510) | Decreased (25; 56) | 0.83 (0.54–1.30) |
Stable (154; 367) | 1.00 | |
Increased (45; 87) | 1.28 (0.90–1.81) | |
SBP stable group (555; 1,279) | Decreased (52; 128) | 0.86 (0.64–1.15) |
Stable (368; 899) | 1.00 | |
Increased (135; 252) | 1.27 (1.04–1.57) ǂ | |
SBP decreased group (183; 430) | Decreased (23; 47) | 1.15 (0.71–1.85) |
Stable (122; 311) | 1.00 | |
Increased (38; 72) | 1.57 (1.08–2.28) ǂ |
Change in systolic blood pressure categorization (events; total N) | Change in hs-cTnT categorization (events; N) | Risk of cardiovascular event hazard ratio (confidence interval) |
SBP increased group (224; 510) | Decreased (25; 56) | 0.83 (0.54–1.30) |
Stable (154; 367) | 1.00 | |
Increased (45; 87) | 1.28 (0.90–1.81) | |
SBP stable group (555; 1,279) | Decreased (52; 128) | 0.86 (0.64–1.15) |
Stable (368; 899) | 1.00 | |
Increased (135; 252) | 1.27 (1.04–1.57) ǂ | |
SBP decreased group (183; 430) | Decreased (23; 47) | 1.15 (0.71–1.85) |
Stable (122; 311) | 1.00 | |
Increased (38; 72) | 1.57 (1.08–2.28) ǂ |
Adjusted for baseline high-sensitivity cardiac troponin T (hs-cTnT), baseline SBP, age, body mass index, sex, race, smoking status, diabetes status, baseline lipids, use of lipid-lowering medication, and use of blood pressure medication. Similar results were seen with the excluded adjustment for blood pressure medication use. Change in systolic blood pressure (SBP) definitions. SBP increased: Baseline SBP at optimal (SBP < 120 mm Hg) or intermediate (SBP 120–139 mm Hg), increased to intermediate or elevated (SBP ≥ 140 mm Hg) at follow-up after 2–3 years; SBP stable: Baseline and follow-up SBP remained in the same group; SBP decreased: Baseline SBP at intermediate or elevated, decreased to optimal or intermediate at a follow-up after 2–3 years. Change in hs-cTnT definitions. Increased hs-cTnT: Baseline hs-cTnT at undetectable (<5 ng/l) or detectable (5–14 ng/l), increased to detectable or elevated (≥14 ng/l) at second troponin follow-up (2–3 years later); stable hs-cTnT: Baseline and follow-up. hs-cTnT remained in the same group; decreased hs-cTnT: Baseline hs-cTnT at detectable or elevated, decreased to undetectable or detectable at second troponin follow-up.
ǂP < 0.05.
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