Table 2
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Overall Concordance Rates of the Change of the Different Single Items and Overall Response Using Simple Kappa Coefficient: Median (Lower-Upper Quartile) Between Baseline and Follow-Up MRI

MRI findingsAll raters
(N = 35)		Neuroradiologists and neurologists (N = 26)Neurologists only (N = 17)Neuroradiologists only (N = 9)P-value between neurologists and neuroradiologists
Number of Kappa analysisN = 595N = 325N = 153N = 136
LM-related items
Brain nodules0.32
(0.14–0.5)		0.29
(0.12–0.48)		0.29
(0.14–0.48)		0.31
(–0.07 to 0.57)		.3702
Brain linear disease0.18
(–0.08 to 0.37)		0.18
(–0.07 to 0.35)		0.15
(–0.07 to 0.35)		0.22
(–0.07 to 0.35)		.3050
Hydrocephalus0.64
(0.44–0.77)		0.64
(0.45–0.77)		0.64
(0.45–0.77)		0.69
(0.54–0.83)		.0259
Spinal nodules0.58
(0.38–0.74)		0.58
(0.34–0.73)		0.61
(0.36–0.77)		0.46
(0.31–0.65)		.0511
Spinal linear disease0.44
(0.22–0.63)		0.52
(0.31–0.65)		0.45
(0.29–0.6)		0.66
(0.45–0.84)		.0004
Overall response0.44
(0.29–0.58)		0.46
(0.31–0.6)		0.46
(0.34–0.61)		0.4
(0.29–0.6)		.2174
Non-LM-related items
Brain parenchymal metastases0
(–0.09 to 0.49)		0
(–0.09 to 0.45)		0.21
(–0.09 to 0.48)		–0.08
(–0.08 to 0.38)		.1093
MRI findingsAll raters
(N = 35)		Neuroradiologists and neurologists (N = 26)Neurologists only (N = 17)Neuroradiologists only (N = 9)P-value between neurologists and neuroradiologists
Number of Kappa analysisN = 595N = 325N = 153N = 136
LM-related items
Brain nodules0.32
(0.14–0.5)		0.29
(0.12–0.48)		0.29
(0.14–0.48)		0.31
(–0.07 to 0.57)		.3702
Brain linear disease0.18
(–0.08 to 0.37)		0.18
(–0.07 to 0.35)		0.15
(–0.07 to 0.35)		0.22
(–0.07 to 0.35)		.3050
Hydrocephalus0.64
(0.44–0.77)		0.64
(0.45–0.77)		0.64
(0.45–0.77)		0.69
(0.54–0.83)		.0259
Spinal nodules0.58
(0.38–0.74)		0.58
(0.34–0.73)		0.61
(0.36–0.77)		0.46
(0.31–0.65)		.0511
Spinal linear disease0.44
(0.22–0.63)		0.52
(0.31–0.65)		0.45
(0.29–0.6)		0.66
(0.45–0.84)		.0004
Overall response0.44
(0.29–0.58)		0.46
(0.31–0.6)		0.46
(0.34–0.61)		0.4
(0.29–0.6)		.2174
Non-LM-related items
Brain parenchymal metastases0
(–0.09 to 0.49)		0
(–0.09 to 0.45)		0.21
(–0.09 to 0.48)		–0.08
(–0.08 to 0.38)		.1093

LM, leptomeningeal metastasis; N, number

Table 2
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Overall Concordance Rates of the Change of the Different Single Items and Overall Response Using Simple Kappa Coefficient: Median (Lower-Upper Quartile) Between Baseline and Follow-Up MRI

MRI findingsAll raters
(N = 35)		Neuroradiologists and neurologists (N = 26)Neurologists only (N = 17)Neuroradiologists only (N = 9)P-value between neurologists and neuroradiologists
Number of Kappa analysisN = 595N = 325N = 153N = 136
LM-related items
Brain nodules0.32
(0.14–0.5)		0.29
(0.12–0.48)		0.29
(0.14–0.48)		0.31
(–0.07 to 0.57)		.3702
Brain linear disease0.18
(–0.08 to 0.37)		0.18
(–0.07 to 0.35)		0.15
(–0.07 to 0.35)		0.22
(–0.07 to 0.35)		.3050
Hydrocephalus0.64
(0.44–0.77)		0.64
(0.45–0.77)		0.64
(0.45–0.77)		0.69
(0.54–0.83)		.0259
Spinal nodules0.58
(0.38–0.74)		0.58
(0.34–0.73)		0.61
(0.36–0.77)		0.46
(0.31–0.65)		.0511
Spinal linear disease0.44
(0.22–0.63)		0.52
(0.31–0.65)		0.45
(0.29–0.6)		0.66
(0.45–0.84)		.0004
Overall response0.44
(0.29–0.58)		0.46
(0.31–0.6)		0.46
(0.34–0.61)		0.4
(0.29–0.6)		.2174
Non-LM-related items
Brain parenchymal metastases0
(–0.09 to 0.49)		0
(–0.09 to 0.45)		0.21
(–0.09 to 0.48)		–0.08
(–0.08 to 0.38)		.1093
MRI findingsAll raters
(N = 35)		Neuroradiologists and neurologists (N = 26)Neurologists only (N = 17)Neuroradiologists only (N = 9)P-value between neurologists and neuroradiologists
Number of Kappa analysisN = 595N = 325N = 153N = 136
LM-related items
Brain nodules0.32
(0.14–0.5)		0.29
(0.12–0.48)		0.29
(0.14–0.48)		0.31
(–0.07 to 0.57)		.3702
Brain linear disease0.18
(–0.08 to 0.37)		0.18
(–0.07 to 0.35)		0.15
(–0.07 to 0.35)		0.22
(–0.07 to 0.35)		.3050
Hydrocephalus0.64
(0.44–0.77)		0.64
(0.45–0.77)		0.64
(0.45–0.77)		0.69
(0.54–0.83)		.0259
Spinal nodules0.58
(0.38–0.74)		0.58
(0.34–0.73)		0.61
(0.36–0.77)		0.46
(0.31–0.65)		.0511
Spinal linear disease0.44
(0.22–0.63)		0.52
(0.31–0.65)		0.45
(0.29–0.6)		0.66
(0.45–0.84)		.0004
Overall response0.44
(0.29–0.58)		0.46
(0.31–0.6)		0.46
(0.34–0.61)		0.4
(0.29–0.6)		.2174
Non-LM-related items
Brain parenchymal metastases0
(–0.09 to 0.49)		0
(–0.09 to 0.45)		0.21
(–0.09 to 0.48)		–0.08
(–0.08 to 0.38)		.1093

LM, leptomeningeal metastasis; N, number

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