Table 2.
Open in new tab

Performance of NG-Test® CARBA 5 and NG-Test® CTX-M MULTI for rapid detection of carbapenemase and ESBL CTX-M directly from Enterobacterales positive BCs in comparison to reference methods

PositiveNegativeSensitivity [95% CI]Specificity [95% CI]PPV [95% CI]NPV [95% CI]
Carbapenemase detection according to reference methodNG-Test® CARBA 5
K. pneumoniae (n = 468)Positive1551491.7 [86.5–95.4]100 [98.8–100]10095.5 [92.8–97.2]
Negative0299
E. coli (n = 6)Positive60100 [54.1–100]100
Negative00
E. cloacae (n = 3)Positive30100 [29.2–100]100
Negative00
K. aerogenes (n = 1)Positive10100 [2.5–100]100
Negative00
Total (n = 478)Positive1651492.2 [87.2–95.7]100 [98.8–100]10095.5 [92.8–97.2]
Negative0299
ESBL detection according to reference methodNG-Test® CTX-M MULTI
E. coli (n = 756)Positive1731791 [86.1–94.7]100 [99.3–100]10097.1[95.5–98.1]
Negative0566
K. pneumoniae (n = 299)aPositive100892.6 [85.9–96.7]100 [98.1–100]10096 [92.6–97.9]
Negative0191
Total (n = 1055)Positive2732591.6 [87.9–94.5]100 [99.5–100]10096.8 [95.4–97.8]
Negative0757
PositiveNegativeSensitivity [95% CI]Specificity [95% CI]PPV [95% CI]NPV [95% CI]
Carbapenemase detection according to reference methodNG-Test® CARBA 5
K. pneumoniae (n = 468)Positive1551491.7 [86.5–95.4]100 [98.8–100]10095.5 [92.8–97.2]
Negative0299
E. coli (n = 6)Positive60100 [54.1–100]100
Negative00
E. cloacae (n = 3)Positive30100 [29.2–100]100
Negative00
K. aerogenes (n = 1)Positive10100 [2.5–100]100
Negative00
Total (n = 478)Positive1651492.2 [87.2–95.7]100 [98.8–100]10095.5 [92.8–97.2]
Negative0299
ESBL detection according to reference methodNG-Test® CTX-M MULTI
E. coli (n = 756)Positive1731791 [86.1–94.7]100 [99.3–100]10097.1[95.5–98.1]
Negative0566
K. pneumoniae (n = 299)aPositive100892.6 [85.9–96.7]100 [98.1–100]10096 [92.6–97.9]
Negative0191
Total (n = 1055)Positive2732591.6 [87.9–94.5]100 [99.5–100]10096.8 [95.4–97.8]
Negative0757
a

Carbapenemase-producing isolates were excluded.

Table 2.
Open in new tab

Performance of NG-Test® CARBA 5 and NG-Test® CTX-M MULTI for rapid detection of carbapenemase and ESBL CTX-M directly from Enterobacterales positive BCs in comparison to reference methods

PositiveNegativeSensitivity [95% CI]Specificity [95% CI]PPV [95% CI]NPV [95% CI]
Carbapenemase detection according to reference methodNG-Test® CARBA 5
K. pneumoniae (n = 468)Positive1551491.7 [86.5–95.4]100 [98.8–100]10095.5 [92.8–97.2]
Negative0299
E. coli (n = 6)Positive60100 [54.1–100]100
Negative00
E. cloacae (n = 3)Positive30100 [29.2–100]100
Negative00
K. aerogenes (n = 1)Positive10100 [2.5–100]100
Negative00
Total (n = 478)Positive1651492.2 [87.2–95.7]100 [98.8–100]10095.5 [92.8–97.2]
Negative0299
ESBL detection according to reference methodNG-Test® CTX-M MULTI
E. coli (n = 756)Positive1731791 [86.1–94.7]100 [99.3–100]10097.1[95.5–98.1]
Negative0566
K. pneumoniae (n = 299)aPositive100892.6 [85.9–96.7]100 [98.1–100]10096 [92.6–97.9]
Negative0191
Total (n = 1055)Positive2732591.6 [87.9–94.5]100 [99.5–100]10096.8 [95.4–97.8]
Negative0757
PositiveNegativeSensitivity [95% CI]Specificity [95% CI]PPV [95% CI]NPV [95% CI]
Carbapenemase detection according to reference methodNG-Test® CARBA 5
K. pneumoniae (n = 468)Positive1551491.7 [86.5–95.4]100 [98.8–100]10095.5 [92.8–97.2]
Negative0299
E. coli (n = 6)Positive60100 [54.1–100]100
Negative00
E. cloacae (n = 3)Positive30100 [29.2–100]100
Negative00
K. aerogenes (n = 1)Positive10100 [2.5–100]100
Negative00
Total (n = 478)Positive1651492.2 [87.2–95.7]100 [98.8–100]10095.5 [92.8–97.2]
Negative0299
ESBL detection according to reference methodNG-Test® CTX-M MULTI
E. coli (n = 756)Positive1731791 [86.1–94.7]100 [99.3–100]10097.1[95.5–98.1]
Negative0566
K. pneumoniae (n = 299)aPositive100892.6 [85.9–96.7]100 [98.1–100]10096 [92.6–97.9]
Negative0191
Total (n = 1055)Positive2732591.6 [87.9–94.5]100 [99.5–100]10096.8 [95.4–97.8]
Negative0757
a

Carbapenemase-producing isolates were excluded.

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