Patient-Reported Presenting Symptoms Associated With Height z Score Differences
| Presenting Symptoms . | Sex . | n (%)‡ . | β . | 95% CI . | P . |
|---|---|---|---|---|---|
| Anorexia* | F (n = 39) | 7 (17.9) | 0.34 | –0.30 to 0.97 | 0.299 |
| M (n = 72) | 15 (20.8) | 0.70 | 0.22 to 1.19 | 0.005§ | |
| Sex difference† | M:F | 0.28 | –0.54 to 1.10 | 0.500 | |
| Arthralgia* | F (n = 39) | 4 (10.3) | 0.93 | 0.17 to 1.70 | 0.016¶ |
| M (n = 72) | 9 (12.5) | 0.20 | –0.44 to 0.84 | 0.537 | |
| Sex difference† | M:F | –0.77 | –1.82 to 0.29 | 0.153 | |
| Poor growth/decreased height velocity* | F (n = 39) | 11 (28.2) | –0.24 | –0.79 to 0.31 | 0.390 |
| M (n = 72) | 15 (20.8) | –0.84 | –1.35 to –0.33 | 0.001‖ | |
| Sex difference† | M:F | –0.52 | –1.26 to 0.23 | 0.173 | |
| Mouth sore* | F (n = 38) | 9 (23.7) | –0.59 | –1.20 to 0.02 | 0.058 |
| M (n = 72) | 17 (23.6) | 0.68 | 0.21 to 1.14 | 0.004§ | |
| Sex difference† | M:F | 1.10 | 0.34 to 1.87 | 0.005** |
| Presenting Symptoms . | Sex . | n (%)‡ . | β . | 95% CI . | P . |
|---|---|---|---|---|---|
| Anorexia* | F (n = 39) | 7 (17.9) | 0.34 | –0.30 to 0.97 | 0.299 |
| M (n = 72) | 15 (20.8) | 0.70 | 0.22 to 1.19 | 0.005§ | |
| Sex difference† | M:F | 0.28 | –0.54 to 1.10 | 0.500 | |
| Arthralgia* | F (n = 39) | 4 (10.3) | 0.93 | 0.17 to 1.70 | 0.016¶ |
| M (n = 72) | 9 (12.5) | 0.20 | –0.44 to 0.84 | 0.537 | |
| Sex difference† | M:F | –0.77 | –1.82 to 0.29 | 0.153 | |
| Poor growth/decreased height velocity* | F (n = 39) | 11 (28.2) | –0.24 | –0.79 to 0.31 | 0.390 |
| M (n = 72) | 15 (20.8) | –0.84 | –1.35 to –0.33 | 0.001‖ | |
| Sex difference† | M:F | –0.52 | –1.26 to 0.23 | 0.173 | |
| Mouth sore* | F (n = 38) | 9 (23.7) | –0.59 | –1.20 to 0.02 | 0.058 |
| M (n = 72) | 17 (23.6) | 0.68 | 0.21 to 1.14 | 0.004§ | |
| Sex difference† | M:F | 1.10 | 0.34 to 1.87 | 0.005** |
*β in each of these rows is the regression coefficient (adjusting for CA, race, and number of years since IBD diagnosis) corresponding to the presenting symptom and represents the strength of the association between each presenting symptom and the height z score difference (height CA-z score minus height BA-z score). Negative β reflects higher standardized height gain with BA progression; positive β reflects lower standardized height gain with BA progression.
†β in each of these rows is the regression coefficient (adjusting for CA, race, and number of years since IBD diagnosis) corresponding to the presenting symptom-by-sex interaction, which represents the sex difference in the strength of the association between presenting symptom at diagnosis and height z score difference (height CA-z score minus height BA-z score).
‡n= 39 for female patients for the variables anorexia, arthralgia, and poor growth/decreased height velocity; n = 38 for female patients for the variable mouth sore; n = 72 for male patients.
§Anorexia and mouth sores were associated with lower standardized height gain with BA progression in male patients.
¶Arthralgia was associated with lower standardized height gain with BA progression in female patients.
‖Poor growth/decreased height velocity was associated with higher standardized height gain with BA progression in male patients.
**The strength of the association between mouth sores and height z score difference differs by sex.
Patient-Reported Presenting Symptoms Associated With Height z Score Differences
| Presenting Symptoms . | Sex . | n (%)‡ . | β . | 95% CI . | P . |
|---|---|---|---|---|---|
| Anorexia* | F (n = 39) | 7 (17.9) | 0.34 | –0.30 to 0.97 | 0.299 |
| M (n = 72) | 15 (20.8) | 0.70 | 0.22 to 1.19 | 0.005§ | |
| Sex difference† | M:F | 0.28 | –0.54 to 1.10 | 0.500 | |
| Arthralgia* | F (n = 39) | 4 (10.3) | 0.93 | 0.17 to 1.70 | 0.016¶ |
| M (n = 72) | 9 (12.5) | 0.20 | –0.44 to 0.84 | 0.537 | |
| Sex difference† | M:F | –0.77 | –1.82 to 0.29 | 0.153 | |
| Poor growth/decreased height velocity* | F (n = 39) | 11 (28.2) | –0.24 | –0.79 to 0.31 | 0.390 |
| M (n = 72) | 15 (20.8) | –0.84 | –1.35 to –0.33 | 0.001‖ | |
| Sex difference† | M:F | –0.52 | –1.26 to 0.23 | 0.173 | |
| Mouth sore* | F (n = 38) | 9 (23.7) | –0.59 | –1.20 to 0.02 | 0.058 |
| M (n = 72) | 17 (23.6) | 0.68 | 0.21 to 1.14 | 0.004§ | |
| Sex difference† | M:F | 1.10 | 0.34 to 1.87 | 0.005** |
| Presenting Symptoms . | Sex . | n (%)‡ . | β . | 95% CI . | P . |
|---|---|---|---|---|---|
| Anorexia* | F (n = 39) | 7 (17.9) | 0.34 | –0.30 to 0.97 | 0.299 |
| M (n = 72) | 15 (20.8) | 0.70 | 0.22 to 1.19 | 0.005§ | |
| Sex difference† | M:F | 0.28 | –0.54 to 1.10 | 0.500 | |
| Arthralgia* | F (n = 39) | 4 (10.3) | 0.93 | 0.17 to 1.70 | 0.016¶ |
| M (n = 72) | 9 (12.5) | 0.20 | –0.44 to 0.84 | 0.537 | |
| Sex difference† | M:F | –0.77 | –1.82 to 0.29 | 0.153 | |
| Poor growth/decreased height velocity* | F (n = 39) | 11 (28.2) | –0.24 | –0.79 to 0.31 | 0.390 |
| M (n = 72) | 15 (20.8) | –0.84 | –1.35 to –0.33 | 0.001‖ | |
| Sex difference† | M:F | –0.52 | –1.26 to 0.23 | 0.173 | |
| Mouth sore* | F (n = 38) | 9 (23.7) | –0.59 | –1.20 to 0.02 | 0.058 |
| M (n = 72) | 17 (23.6) | 0.68 | 0.21 to 1.14 | 0.004§ | |
| Sex difference† | M:F | 1.10 | 0.34 to 1.87 | 0.005** |
*β in each of these rows is the regression coefficient (adjusting for CA, race, and number of years since IBD diagnosis) corresponding to the presenting symptom and represents the strength of the association between each presenting symptom and the height z score difference (height CA-z score minus height BA-z score). Negative β reflects higher standardized height gain with BA progression; positive β reflects lower standardized height gain with BA progression.
†β in each of these rows is the regression coefficient (adjusting for CA, race, and number of years since IBD diagnosis) corresponding to the presenting symptom-by-sex interaction, which represents the sex difference in the strength of the association between presenting symptom at diagnosis and height z score difference (height CA-z score minus height BA-z score).
‡n= 39 for female patients for the variables anorexia, arthralgia, and poor growth/decreased height velocity; n = 38 for female patients for the variable mouth sore; n = 72 for male patients.
§Anorexia and mouth sores were associated with lower standardized height gain with BA progression in male patients.
¶Arthralgia was associated with lower standardized height gain with BA progression in female patients.
‖Poor growth/decreased height velocity was associated with higher standardized height gain with BA progression in male patients.
**The strength of the association between mouth sores and height z score difference differs by sex.
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