| Model and Baseline OP | HR | (95% CI) | P Value |
| 14-day mortality (n = 533): unadjusted model | |||
| Baseline OP | |||
| <200 mm H2O | 1.31 | (.87–1.98) | .20 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.73 | (1.18–2.55) | <.01 |
| 14-day mortality (n = 470): adjusted modela | |||
| Baseline OP | |||
| <200 mm H2O | 1.34 | (.83–2.14) | .23 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.53 | (.98–2.38) | .06 |
| 30-day mortality (n = 533): unadjusted model | |||
| Baseline OP | |||
| <200 mm H2O | 1.48 | (1.05–2.10) | .03 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.55 | (1.10–2.19) | .01 |
| 30-day mortality (n = 470): adjusted modela | |||
| Baseline OP | |||
| <200 mm H2O | 1.50 | (1.01–2.23) | .04 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.44 | (.97–2.13) | .07 |
| Model and Baseline OP | HR | (95% CI) | P Value |
| 14-day mortality (n = 533): unadjusted model | |||
| Baseline OP | |||
| <200 mm H2O | 1.31 | (.87–1.98) | .20 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.73 | (1.18–2.55) | <.01 |
| 14-day mortality (n = 470): adjusted modela | |||
| Baseline OP | |||
| <200 mm H2O | 1.34 | (.83–2.14) | .23 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.53 | (.98–2.38) | .06 |
| 30-day mortality (n = 533): unadjusted model | |||
| Baseline OP | |||
| <200 mm H2O | 1.48 | (1.05–2.10) | .03 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.55 | (1.10–2.19) | .01 |
| 30-day mortality (n = 470): adjusted modela | |||
| Baseline OP | |||
| <200 mm H2O | 1.50 | (1.01–2.23) | .04 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.44 | (.97–2.13) | .07 |
Abbreviations: CI, confidence interval; H2O, water; HR, hazard ratio; OP, opening pressure.
Model adjusted for baseline Glasgow Coma Scale (GCS) score, seizures, focal neurologic deficits, cerebrospinal fluid (CSF) white blood cell count <5 cells/mL, CSF quantitative culture (log10 CFU/mL), hemoglobin. GCS score, seizures, and focal neurologic deficits are likely all on the causal pathway of the effects of elevated intracranial pressure.
| Model and Baseline OP | HR | (95% CI) | P Value |
| 14-day mortality (n = 533): unadjusted model | |||
| Baseline OP | |||
| <200 mm H2O | 1.31 | (.87–1.98) | .20 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.73 | (1.18–2.55) | <.01 |
| 14-day mortality (n = 470): adjusted modela | |||
| Baseline OP | |||
| <200 mm H2O | 1.34 | (.83–2.14) | .23 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.53 | (.98–2.38) | .06 |
| 30-day mortality (n = 533): unadjusted model | |||
| Baseline OP | |||
| <200 mm H2O | 1.48 | (1.05–2.10) | .03 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.55 | (1.10–2.19) | .01 |
| 30-day mortality (n = 470): adjusted modela | |||
| Baseline OP | |||
| <200 mm H2O | 1.50 | (1.01–2.23) | .04 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.44 | (.97–2.13) | .07 |
| Model and Baseline OP | HR | (95% CI) | P Value |
| 14-day mortality (n = 533): unadjusted model | |||
| Baseline OP | |||
| <200 mm H2O | 1.31 | (.87–1.98) | .20 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.73 | (1.18–2.55) | <.01 |
| 14-day mortality (n = 470): adjusted modela | |||
| Baseline OP | |||
| <200 mm H2O | 1.34 | (.83–2.14) | .23 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.53 | (.98–2.38) | .06 |
| 30-day mortality (n = 533): unadjusted model | |||
| Baseline OP | |||
| <200 mm H2O | 1.48 | (1.05–2.10) | .03 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.55 | (1.10–2.19) | .01 |
| 30-day mortality (n = 470): adjusted modela | |||
| Baseline OP | |||
| <200 mm H2O | 1.50 | (1.01–2.23) | .04 |
| 200–350 mm H2O | REF | … | |
| >350 mm H2O | 1.44 | (.97–2.13) | .07 |
Abbreviations: CI, confidence interval; H2O, water; HR, hazard ratio; OP, opening pressure.
Model adjusted for baseline Glasgow Coma Scale (GCS) score, seizures, focal neurologic deficits, cerebrospinal fluid (CSF) white blood cell count <5 cells/mL, CSF quantitative culture (log10 CFU/mL), hemoglobin. GCS score, seizures, and focal neurologic deficits are likely all on the causal pathway of the effects of elevated intracranial pressure.
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