Differences and Similarities in BA Changes Between Patients With CD and Patients with UC
| Study . | Sample . | Comparison . | Similarities . | Differences . |
|---|---|---|---|---|
| Weng et al42 | Feces | CD/UC vs HC | CDCA↓, LCA↓, TLCA↓ | GCDCA↓, GLCA↓ only in UC |
| Das et al35 | Feces | CA↑, TCA↑, DCA↓ | CD: GCA↑, TCDCA↑, TDCA↑, LCA↓, UDCA↓; UC: GUDCA↑, keto-DCA↑ | |
| Murakami et al48 | Serum | DCA/(DCA+CA)↓ in remission state | DCA/(DCA+CA)↓ in exacerbation state (only in UC) | |
| Kruis et al37 | Feces | CA↑, DCA↓, LCA↓ | CD: total BAs↑, CDCA↑, UDCA↑; UC: total BAs↓ | |
| Roda et al65 | Serum | CD/UC (conventional treatments) vs HC | / | CD: serum BA level↓, PBAs/SBAs↑; UC: serum BA profiles similar |
| CD/UC (anti-TNFs) vs CD/UC (conventional treatments) | CD (anti-TNFs): serum BA level↑, SBAs↑, PBAs/SBAs↓; UC: serum BA profiles similar | |||
| Martin et al38 | Urine | UC vs CD | / | DCA↑, 7-keto-LCA↑, β-UCA↑ in UC |
| Study . | Sample . | Comparison . | Similarities . | Differences . |
|---|---|---|---|---|
| Weng et al42 | Feces | CD/UC vs HC | CDCA↓, LCA↓, TLCA↓ | GCDCA↓, GLCA↓ only in UC |
| Das et al35 | Feces | CA↑, TCA↑, DCA↓ | CD: GCA↑, TCDCA↑, TDCA↑, LCA↓, UDCA↓; UC: GUDCA↑, keto-DCA↑ | |
| Murakami et al48 | Serum | DCA/(DCA+CA)↓ in remission state | DCA/(DCA+CA)↓ in exacerbation state (only in UC) | |
| Kruis et al37 | Feces | CA↑, DCA↓, LCA↓ | CD: total BAs↑, CDCA↑, UDCA↑; UC: total BAs↓ | |
| Roda et al65 | Serum | CD/UC (conventional treatments) vs HC | / | CD: serum BA level↓, PBAs/SBAs↑; UC: serum BA profiles similar |
| CD/UC (anti-TNFs) vs CD/UC (conventional treatments) | CD (anti-TNFs): serum BA level↑, SBAs↑, PBAs/SBAs↓; UC: serum BA profiles similar | |||
| Martin et al38 | Urine | UC vs CD | / | DCA↑, 7-keto-LCA↑, β-UCA↑ in UC |
↑ = higher level; ↓ = lower level; / = no information available.
BA, bile acid; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; GLCA, glycolithocholic acid; GUDCA, glycoursodeoxycholic acid; LCA, lithocholic acid; PBAs, primary bile acids; SBAs, second bile acids; TCA, taurocholic acid; TCDCA, taurochenodeoxycholic acid; TDCA, taurodeoxycholic acid; TLCA, taurolithocholic acid; UCA, ursocholic acid; UDCA, ursodeoxycholic acid.
Differences and Similarities in BA Changes Between Patients With CD and Patients with UC
| Study . | Sample . | Comparison . | Similarities . | Differences . |
|---|---|---|---|---|
| Weng et al42 | Feces | CD/UC vs HC | CDCA↓, LCA↓, TLCA↓ | GCDCA↓, GLCA↓ only in UC |
| Das et al35 | Feces | CA↑, TCA↑, DCA↓ | CD: GCA↑, TCDCA↑, TDCA↑, LCA↓, UDCA↓; UC: GUDCA↑, keto-DCA↑ | |
| Murakami et al48 | Serum | DCA/(DCA+CA)↓ in remission state | DCA/(DCA+CA)↓ in exacerbation state (only in UC) | |
| Kruis et al37 | Feces | CA↑, DCA↓, LCA↓ | CD: total BAs↑, CDCA↑, UDCA↑; UC: total BAs↓ | |
| Roda et al65 | Serum | CD/UC (conventional treatments) vs HC | / | CD: serum BA level↓, PBAs/SBAs↑; UC: serum BA profiles similar |
| CD/UC (anti-TNFs) vs CD/UC (conventional treatments) | CD (anti-TNFs): serum BA level↑, SBAs↑, PBAs/SBAs↓; UC: serum BA profiles similar | |||
| Martin et al38 | Urine | UC vs CD | / | DCA↑, 7-keto-LCA↑, β-UCA↑ in UC |
| Study . | Sample . | Comparison . | Similarities . | Differences . |
|---|---|---|---|---|
| Weng et al42 | Feces | CD/UC vs HC | CDCA↓, LCA↓, TLCA↓ | GCDCA↓, GLCA↓ only in UC |
| Das et al35 | Feces | CA↑, TCA↑, DCA↓ | CD: GCA↑, TCDCA↑, TDCA↑, LCA↓, UDCA↓; UC: GUDCA↑, keto-DCA↑ | |
| Murakami et al48 | Serum | DCA/(DCA+CA)↓ in remission state | DCA/(DCA+CA)↓ in exacerbation state (only in UC) | |
| Kruis et al37 | Feces | CA↑, DCA↓, LCA↓ | CD: total BAs↑, CDCA↑, UDCA↑; UC: total BAs↓ | |
| Roda et al65 | Serum | CD/UC (conventional treatments) vs HC | / | CD: serum BA level↓, PBAs/SBAs↑; UC: serum BA profiles similar |
| CD/UC (anti-TNFs) vs CD/UC (conventional treatments) | CD (anti-TNFs): serum BA level↑, SBAs↑, PBAs/SBAs↓; UC: serum BA profiles similar | |||
| Martin et al38 | Urine | UC vs CD | / | DCA↑, 7-keto-LCA↑, β-UCA↑ in UC |
↑ = higher level; ↓ = lower level; / = no information available.
BA, bile acid; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; GLCA, glycolithocholic acid; GUDCA, glycoursodeoxycholic acid; LCA, lithocholic acid; PBAs, primary bile acids; SBAs, second bile acids; TCA, taurocholic acid; TCDCA, taurochenodeoxycholic acid; TDCA, taurodeoxycholic acid; TLCA, taurolithocholic acid; UCA, ursocholic acid; UDCA, ursodeoxycholic acid.
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