Table 1 Open in new tab Differences in...

Structure	Healthy elderly versus MCI	MCI versus Alzheimer's disease
Temporal lobe	0.206	3.633	0.014	8.3	0.351	5.586	0.000006	16.1
Frontal lobe	0.197	3.175	0.064	8.9	0.252	3.730	0.0099	12.7
Parietal lobe	0.172	3.239	0.052	9.1	0.225	3.931	0.005	13.4
Occipital lobe	0.124	2.314	0.725	6.8	0.174	3.186	0.061	10.3
Inferior temporal gyrus	0.233	3.776	0.006	9.3	0.396	6.043	0.000001	18.2
Middle temporal gyrus	0.223	3.562	0.018	9.0	0.355	5.046	0.00006	16.4
Parahippocampal gyrus	0.189	3.278	0.042	8.1	0.357	5.715	0.000002	17.4
Superior temporal gyrus	0.177	2.857	0.155	7.1	0.340	5.047	0.00006	15.4
Lateral occipitotemporal gyrus	0.206	3.869	0.007	8.5	0.295	5.075	0.00004	13.6
Entorhinal cortex	0.262	3.524	0.0006	9.9	0.413	5.570	0.0000002	17.9
Medial frontal gyrus	0.197	2.878	0.156	8.1	0.296	3.876	0.006	13.6
Superior frontal gyrus	0.204	2.902	0.135	9.7	0.274	3.739	0.009	14.8
Medial fronto-orbital gyrus	0.235	3.727	0.008	9.5	0.252	3.493	0.019	11.3
Lateral fronto-orbital gyrus	0.245	3.390	0.030	10.3	0.258	3.457	0.023	12.2
Middle frontal gyrus	0.220	3.294	0.044	9.9	0.257	3.541	0.018	13.1
Inferior frontal gyrus	0.206	3.065	0.083	9.0	0.236	3.172	0.059	11.5

Structure

Healthy elderly versus MCI

MCI versus Alzheimer's disease

Difference (mm)

t-Stat

P-value

% Atrophy

Difference (mm)

t-Stat

P-value

% Atrophy

Temporal lobe

0.206

3.633

0.014

8.3

0.351

5.586

0.000006

16.1

Frontal lobe

0.197

3.175

0.064

8.9

0.252

3.730

0.0099

12.7

Parietal lobe

0.172

3.239

0.052

9.1

0.225

3.931

0.005

13.4

Occipital lobe

0.124

2.314

0.725

6.8

0.174

3.186

0.061

10.3

Inferior temporal gyrus

0.233

3.776

0.006

9.3

0.396

6.043

0.000001

18.2

Middle temporal gyrus

0.223

3.562

0.018

9.0

0.355

5.046

0.00006

16.4

Parahippocampal gyrus

0.189

3.278

0.042

8.1

0.357

5.715

0.000002

17.4

Superior temporal gyrus

0.177

2.857

0.155

7.1

0.340

5.047

0.00006

15.4

Lateral occipitotemporal gyrus

0.206

3.869

0.007

8.5

0.295

5.075

0.00004

13.6

Entorhinal cortex

0.262

3.524

0.0006

9.9

0.413

5.570

0.0000002

17.9

Medial frontal gyrus

0.197

2.878

0.156

8.1

0.296

3.876

0.006

13.6

Superior frontal gyrus

0.204

2.902

0.135

9.7

0.274

3.739

0.009

14.8

Medial fronto-orbital gyrus

0.235

3.727

0.008

9.5

0.252

3.493

0.019

11.3

Lateral fronto-orbital gyrus

0.245

3.390

0.030

10.3

0.258

3.457

0.023

12.2

Middle frontal gyrus

0.220

3.294

0.044

9.9

0.257

3.541

0.018

13.1

Inferior frontal gyrus

0.206

3.065

0.083

9.0

0.236

3.172

0.059

11.5

Structure	Healthy elderly versus MCI	MCI versus Alzheimer's disease
Temporal lobe	0.206	3.633	0.014	8.3	0.351	5.586	0.000006	16.1
Frontal lobe	0.197	3.175	0.064	8.9	0.252	3.730	0.0099	12.7
Parietal lobe	0.172	3.239	0.052	9.1	0.225	3.931	0.005	13.4
Occipital lobe	0.124	2.314	0.725	6.8	0.174	3.186	0.061	10.3
Inferior temporal gyrus	0.233	3.776	0.006	9.3	0.396	6.043	0.000001	18.2
Middle temporal gyrus	0.223	3.562	0.018	9.0	0.355	5.046	0.00006	16.4
Parahippocampal gyrus	0.189	3.278	0.042	8.1	0.357	5.715	0.000002	17.4
Superior temporal gyrus	0.177	2.857	0.155	7.1	0.340	5.047	0.00006	15.4
Lateral occipitotemporal gyrus	0.206	3.869	0.007	8.5	0.295	5.075	0.00004	13.6
Entorhinal cortex	0.262	3.524	0.0006	9.9	0.413	5.570	0.0000002	17.9
Medial frontal gyrus	0.197	2.878	0.156	8.1	0.296	3.876	0.006	13.6
Superior frontal gyrus	0.204	2.902	0.135	9.7	0.274	3.739	0.009	14.8
Medial fronto-orbital gyrus	0.235	3.727	0.008	9.5	0.252	3.493	0.019	11.3
Lateral fronto-orbital gyrus	0.245	3.390	0.030	10.3	0.258	3.457	0.023	12.2
Middle frontal gyrus	0.220	3.294	0.044	9.9	0.257	3.541	0.018	13.1
Inferior frontal gyrus	0.206	3.065	0.083	9.0	0.236	3.172	0.059	11.5

Table 1

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Differences in lobar thickness between the healthy elderly–MCI and MCI–Alzheimer's disease groups

Structure	Healthy elderly versus MCI				MCI versus Alzheimer's disease

	Difference (mm)	t-Stat	P-value	% Atrophy	Difference (mm)	t-Stat	P-value	% Atrophy
Temporal lobe	0.206	3.633	0.014	8.3	0.351	5.586	0.000006	16.1
Frontal lobe	0.197	3.175	0.064	8.9	0.252	3.730	0.0099	12.7
Parietal lobe	0.172	3.239	0.052	9.1	0.225	3.931	0.005	13.4
Occipital lobe	0.124	2.314	0.725	6.8	0.174	3.186	0.061	10.3
Inferior temporal gyrus	0.233	3.776	0.006	9.3	0.396	6.043	0.000001	18.2
Middle temporal gyrus	0.223	3.562	0.018	9.0	0.355	5.046	0.00006	16.4
Parahippocampal gyrus	0.189	3.278	0.042	8.1	0.357	5.715	0.000002	17.4
Superior temporal gyrus	0.177	2.857	0.155	7.1	0.340	5.047	0.00006	15.4
Lateral occipitotemporal gyrus	0.206	3.869	0.007	8.5	0.295	5.075	0.00004	13.6
Entorhinal cortex	0.262	3.524	0.0006	9.9	0.413	5.570	0.0000002	17.9
Medial frontal gyrus	0.197	2.878	0.156	8.1	0.296	3.876	0.006	13.6
Superior frontal gyrus	0.204	2.902	0.135	9.7	0.274	3.739	0.009	14.8
Medial fronto-orbital gyrus	0.235	3.727	0.008	9.5	0.252	3.493	0.019	11.3
Lateral fronto-orbital gyrus	0.245	3.390	0.030	10.3	0.258	3.457	0.023	12.2
Middle frontal gyrus	0.220	3.294	0.044	9.9	0.257	3.541	0.018	13.1
Inferior frontal gyrus	0.206	3.065	0.083	9.0	0.236	3.172	0.059	11.5

Structure	Healthy elderly versus MCI				MCI versus Alzheimer's disease

	Difference (mm)	t-Stat	P-value	% Atrophy	Difference (mm)	t-Stat	P-value	% Atrophy
Temporal lobe	0.206	3.633	0.014	8.3	0.351	5.586	0.000006	16.1
Frontal lobe	0.197	3.175	0.064	8.9	0.252	3.730	0.0099	12.7
Parietal lobe	0.172	3.239	0.052	9.1	0.225	3.931	0.005	13.4
Occipital lobe	0.124	2.314	0.725	6.8	0.174	3.186	0.061	10.3
Inferior temporal gyrus	0.233	3.776	0.006	9.3	0.396	6.043	0.000001	18.2
Middle temporal gyrus	0.223	3.562	0.018	9.0	0.355	5.046	0.00006	16.4
Parahippocampal gyrus	0.189	3.278	0.042	8.1	0.357	5.715	0.000002	17.4
Superior temporal gyrus	0.177	2.857	0.155	7.1	0.340	5.047	0.00006	15.4
Lateral occipitotemporal gyrus	0.206	3.869	0.007	8.5	0.295	5.075	0.00004	13.6
Entorhinal cortex	0.262	3.524	0.0006	9.9	0.413	5.570	0.0000002	17.9
Medial frontal gyrus	0.197	2.878	0.156	8.1	0.296	3.876	0.006	13.6
Superior frontal gyrus	0.204	2.902	0.135	9.7	0.274	3.739	0.009	14.8
Medial fronto-orbital gyrus	0.235	3.727	0.008	9.5	0.252	3.493	0.019	11.3
Lateral fronto-orbital gyrus	0.245	3.390	0.030	10.3	0.258	3.457	0.023	12.2
Middle frontal gyrus	0.220	3.294	0.044	9.9	0.257	3.541	0.018	13.1
Inferior frontal gyrus	0.206	3.065	0.083	9.0	0.236	3.172	0.059	11.5

Changes in specific gyri in the frontal and temporal lobes are presented as well. The thickness was always healthy elderly > MCI > Alzheimer's disease. The largest changes in both transitions occur in the temporal lobe, which also shows the greatest increase in atrophy. Interestingly, the fronto-orbital gyri show differences comparable to the temporal lobe structures in the transition from healthy elderly to MCI. A Bonferonni correction was performed on the P-values in order to account for multiple comparisons.

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