Hazard ratios of non-fatal or fatal coronary heart disease events according to physical activity levels
| Physical activity level . | HRa . | (95% CI) . | N total . | N cases . | I2b . | (95% CI) . |
|---|---|---|---|---|---|---|
| Model 1c | ||||||
| Inactive | 1 | REF | 5754 | 2546 | ||
| Moderately inactive | 0.81 | (0.75–0.89) | 7635 | 2822 | 11% | (0%, 46%) |
| Moderately active | 0.70 | (0.62–0.78) | 5058 | 1815 | 28% | (0%, 58%) |
| Active | 0.72 | (0.65–0.79) | 4609 | 1730 | 0% | (0%, 47%) |
| Model 2d | ||||||
| Inactive | 1 | REF | 5754 | 2546 | ||
| Moderately inactive | 0.88 | (0.80–0.96) | 7635 | 2822 | 0% | (0%, 47%) |
| Moderately active | 0.76 | (0.67–0.86) | 5058 | 1815 | 29% | (0%, 58%) |
| Active | 0.78 | (0.70–0.86) | 4609 | 1730 | 0% | (0%, 47%) |
| Model 2, excluding first 2 years of follow-up | ||||||
| Inactive | 1 | REF | 5478 | 2290 | ||
| Moderately inactive | 0.87 | (0.79–0.96) | 7284 | 2505 | 13% | (0%, 47%) |
| Moderately active | 0.76 | (0.67–0.86) | 4852 | 1637 | 30% | (0%, 59%) |
| Active | 0.76 | (0.68–0.84) | 4382 | 1526 | 0% | (0%, 47%) |
| Model 3,e including intermediaries | ||||||
| Inactive | 1 | REF | 5754 | 2546 | ||
| Moderately in active | 0.91 | (0.82–1.01) | 7635 | 2822 | 0% | (0%, 47%) |
| Moderately active | 0.83 | (0.73–0.94) | 5058 | 1815 | 0% | (0%, 47%) |
| Active | 0.83 | (0.74–0.94) | 4609 | 1730 | 0% | (0%, 47%) |
| Physical activity level . | HRa . | (95% CI) . | N total . | N cases . | I2b . | (95% CI) . |
|---|---|---|---|---|---|---|
| Model 1c | ||||||
| Inactive | 1 | REF | 5754 | 2546 | ||
| Moderately inactive | 0.81 | (0.75–0.89) | 7635 | 2822 | 11% | (0%, 46%) |
| Moderately active | 0.70 | (0.62–0.78) | 5058 | 1815 | 28% | (0%, 58%) |
| Active | 0.72 | (0.65–0.79) | 4609 | 1730 | 0% | (0%, 47%) |
| Model 2d | ||||||
| Inactive | 1 | REF | 5754 | 2546 | ||
| Moderately inactive | 0.88 | (0.80–0.96) | 7635 | 2822 | 0% | (0%, 47%) |
| Moderately active | 0.76 | (0.67–0.86) | 5058 | 1815 | 29% | (0%, 58%) |
| Active | 0.78 | (0.70–0.86) | 4609 | 1730 | 0% | (0%, 47%) |
| Model 2, excluding first 2 years of follow-up | ||||||
| Inactive | 1 | REF | 5478 | 2290 | ||
| Moderately inactive | 0.87 | (0.79–0.96) | 7284 | 2505 | 13% | (0%, 47%) |
| Moderately active | 0.76 | (0.67–0.86) | 4852 | 1637 | 30% | (0%, 59%) |
| Active | 0.76 | (0.68–0.84) | 4382 | 1526 | 0% | (0%, 47%) |
| Model 3,e including intermediaries | ||||||
| Inactive | 1 | REF | 5754 | 2546 | ||
| Moderately in active | 0.91 | (0.82–1.01) | 7635 | 2822 | 0% | (0%, 47%) |
| Moderately active | 0.83 | (0.73–0.94) | 5058 | 1815 | 0% | (0%, 47%) |
| Active | 0.83 | (0.74–0.94) | 4609 | 1730 | 0% | (0%, 47%) |
Hazard ratio (HR) and 95% confidence intervals (CI) estimated from Prentice-weighted Cox proportional hazard models. HRs from each study centre were combined using random effects meta-analysis.
I2 describes the heterogeneity across 21 study centres (eight countries)
Model 1: adjusted for age at baseline, stratified by sex, and study centre.
Model 2: Model 1 and additionally adjusted for educational level (none, primary, secondary, or vocational/university), alcohol consumption (0, 0.1–5, 5.1–10, 11–40, >40 g/day), smoking status (never, former, and current), fruit, and vegetable intake.
Model 3: Model 2 and additionally adjusted for BMI, cholesterol, hypertension, and diabetes.
Hazard ratios of non-fatal or fatal coronary heart disease events according to physical activity levels
| Physical activity level . | HRa . | (95% CI) . | N total . | N cases . | I2b . | (95% CI) . |
|---|---|---|---|---|---|---|
| Model 1c | ||||||
| Inactive | 1 | REF | 5754 | 2546 | ||
| Moderately inactive | 0.81 | (0.75–0.89) | 7635 | 2822 | 11% | (0%, 46%) |
| Moderately active | 0.70 | (0.62–0.78) | 5058 | 1815 | 28% | (0%, 58%) |
| Active | 0.72 | (0.65–0.79) | 4609 | 1730 | 0% | (0%, 47%) |
| Model 2d | ||||||
| Inactive | 1 | REF | 5754 | 2546 | ||
| Moderately inactive | 0.88 | (0.80–0.96) | 7635 | 2822 | 0% | (0%, 47%) |
| Moderately active | 0.76 | (0.67–0.86) | 5058 | 1815 | 29% | (0%, 58%) |
| Active | 0.78 | (0.70–0.86) | 4609 | 1730 | 0% | (0%, 47%) |
| Model 2, excluding first 2 years of follow-up | ||||||
| Inactive | 1 | REF | 5478 | 2290 | ||
| Moderately inactive | 0.87 | (0.79–0.96) | 7284 | 2505 | 13% | (0%, 47%) |
| Moderately active | 0.76 | (0.67–0.86) | 4852 | 1637 | 30% | (0%, 59%) |
| Active | 0.76 | (0.68–0.84) | 4382 | 1526 | 0% | (0%, 47%) |
| Model 3,e including intermediaries | ||||||
| Inactive | 1 | REF | 5754 | 2546 | ||
| Moderately in active | 0.91 | (0.82–1.01) | 7635 | 2822 | 0% | (0%, 47%) |
| Moderately active | 0.83 | (0.73–0.94) | 5058 | 1815 | 0% | (0%, 47%) |
| Active | 0.83 | (0.74–0.94) | 4609 | 1730 | 0% | (0%, 47%) |
| Physical activity level . | HRa . | (95% CI) . | N total . | N cases . | I2b . | (95% CI) . |
|---|---|---|---|---|---|---|
| Model 1c | ||||||
| Inactive | 1 | REF | 5754 | 2546 | ||
| Moderately inactive | 0.81 | (0.75–0.89) | 7635 | 2822 | 11% | (0%, 46%) |
| Moderately active | 0.70 | (0.62–0.78) | 5058 | 1815 | 28% | (0%, 58%) |
| Active | 0.72 | (0.65–0.79) | 4609 | 1730 | 0% | (0%, 47%) |
| Model 2d | ||||||
| Inactive | 1 | REF | 5754 | 2546 | ||
| Moderately inactive | 0.88 | (0.80–0.96) | 7635 | 2822 | 0% | (0%, 47%) |
| Moderately active | 0.76 | (0.67–0.86) | 5058 | 1815 | 29% | (0%, 58%) |
| Active | 0.78 | (0.70–0.86) | 4609 | 1730 | 0% | (0%, 47%) |
| Model 2, excluding first 2 years of follow-up | ||||||
| Inactive | 1 | REF | 5478 | 2290 | ||
| Moderately inactive | 0.87 | (0.79–0.96) | 7284 | 2505 | 13% | (0%, 47%) |
| Moderately active | 0.76 | (0.67–0.86) | 4852 | 1637 | 30% | (0%, 59%) |
| Active | 0.76 | (0.68–0.84) | 4382 | 1526 | 0% | (0%, 47%) |
| Model 3,e including intermediaries | ||||||
| Inactive | 1 | REF | 5754 | 2546 | ||
| Moderately in active | 0.91 | (0.82–1.01) | 7635 | 2822 | 0% | (0%, 47%) |
| Moderately active | 0.83 | (0.73–0.94) | 5058 | 1815 | 0% | (0%, 47%) |
| Active | 0.83 | (0.74–0.94) | 4609 | 1730 | 0% | (0%, 47%) |
Hazard ratio (HR) and 95% confidence intervals (CI) estimated from Prentice-weighted Cox proportional hazard models. HRs from each study centre were combined using random effects meta-analysis.
I2 describes the heterogeneity across 21 study centres (eight countries)
Model 1: adjusted for age at baseline, stratified by sex, and study centre.
Model 2: Model 1 and additionally adjusted for educational level (none, primary, secondary, or vocational/university), alcohol consumption (0, 0.1–5, 5.1–10, 11–40, >40 g/day), smoking status (never, former, and current), fruit, and vegetable intake.
Model 3: Model 2 and additionally adjusted for BMI, cholesterol, hypertension, and diabetes.
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