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Table 1.

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Details of homology and AlphaFold models used in this study

		Phyre2 homology models — templates					S. cerevisiae AlphaFold model
Protein name	Model extent	PDB accession code	Protein	Species	Chain	Method^c	Identifier
Nse1	Full-length	3NW0	Nse1	H. sapiens	A	X-ray	AF-Q07913-F1
Nse2	Full-length^a	3HTK	Nse2	S. cerevisiae	C	X-ray	AF-P38632-F1
Nse3	Full-length	3NW0	Nse3	H. sapiens	B	X-ray	AF-Q05541-F1
Nse4	N-terminal domain^b	6YVU	Brn1	S. cerevisiae	C	EM	AF-P43124-F1
Nse4	C-terminal domain^b	6YVU	Brn1	S. cerevisiae	C	EM	AF-P43124-F1
Nse4	Middle section	7DG2	Nse4	X. laevis	D	X-ray	AF-P43124-F1
Smc5	Head (N-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc5	Head (C-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc6	Head (N-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc6	Head (C-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc5	Full-length	6YVU	Smc4	S. cerevisiae	B	EM	AF-Q08204-F1
Smc6	Full-length	6YVU	Smc2	S. cerevisiae	A	EM	AF-Q12749-F1

		Phyre2 homology models — templates					S. cerevisiae AlphaFold model
Protein name	Model extent	PDB accession code	Protein	Species	Chain	Method^c	Identifier
Nse1	Full-length	3NW0	Nse1	H. sapiens	A	X-ray	AF-Q07913-F1
Nse2	Full-length^a	3HTK	Nse2	S. cerevisiae	C	X-ray	AF-P38632-F1
Nse3	Full-length	3NW0	Nse3	H. sapiens	B	X-ray	AF-Q05541-F1
Nse4	N-terminal domain^b	6YVU	Brn1	S. cerevisiae	C	EM	AF-P43124-F1
Nse4	C-terminal domain^b	6YVU	Brn1	S. cerevisiae	C	EM	AF-P43124-F1
Nse4	Middle section	7DG2	Nse4	X. laevis	D	X-ray	AF-P43124-F1
Smc5	Head (N-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc5	Head (C-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc6	Head (N-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc6	Head (C-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc5	Full-length	6YVU	Smc4	S. cerevisiae	B	EM	AF-Q08204-F1
Smc6	Full-length	6YVU	Smc2	S. cerevisiae	A	EM	AF-Q12749-F1

^aUsed directly as model.

^bGenerated by one-to-one threading (expert mode of Phyre2).

^cX-ray = X-ray crystallography; EM = cryo-electron microscopy.

Table 1.

Open in new tab

Details of homology and AlphaFold models used in this study

		Phyre2 homology models — templates					S. cerevisiae AlphaFold model
Protein name	Model extent	PDB accession code	Protein	Species	Chain	Method^c	Identifier
Nse1	Full-length	3NW0	Nse1	H. sapiens	A	X-ray	AF-Q07913-F1
Nse2	Full-length^a	3HTK	Nse2	S. cerevisiae	C	X-ray	AF-P38632-F1
Nse3	Full-length	3NW0	Nse3	H. sapiens	B	X-ray	AF-Q05541-F1
Nse4	N-terminal domain^b	6YVU	Brn1	S. cerevisiae	C	EM	AF-P43124-F1
Nse4	C-terminal domain^b	6YVU	Brn1	S. cerevisiae	C	EM	AF-P43124-F1
Nse4	Middle section	7DG2	Nse4	X. laevis	D	X-ray	AF-P43124-F1
Smc5	Head (N-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc5	Head (C-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc6	Head (N-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc6	Head (C-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc5	Full-length	6YVU	Smc4	S. cerevisiae	B	EM	AF-Q08204-F1
Smc6	Full-length	6YVU	Smc2	S. cerevisiae	A	EM	AF-Q12749-F1

		Phyre2 homology models — templates					S. cerevisiae AlphaFold model
Protein name	Model extent	PDB accession code	Protein	Species	Chain	Method^c	Identifier
Nse1	Full-length	3NW0	Nse1	H. sapiens	A	X-ray	AF-Q07913-F1
Nse2	Full-length^a	3HTK	Nse2	S. cerevisiae	C	X-ray	AF-P38632-F1
Nse3	Full-length	3NW0	Nse3	H. sapiens	B	X-ray	AF-Q05541-F1
Nse4	N-terminal domain^b	6YVU	Brn1	S. cerevisiae	C	EM	AF-P43124-F1
Nse4	C-terminal domain^b	6YVU	Brn1	S. cerevisiae	C	EM	AF-P43124-F1
Nse4	Middle section	7DG2	Nse4	X. laevis	D	X-ray	AF-P43124-F1
Smc5	Head (N-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc5	Head (C-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc6	Head (N-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc6	Head (C-terminal)	5XEI	Smc	P. yayanosii	A	X-ray	-
Smc5	Full-length	6YVU	Smc4	S. cerevisiae	B	EM	AF-Q08204-F1
Smc6	Full-length	6YVU	Smc2	S. cerevisiae	A	EM	AF-Q12749-F1

^aUsed directly as model.

^bGenerated by one-to-one threading (expert mode of Phyre2).

^cX-ray = X-ray crystallography; EM = cryo-electron microscopy.