Table 3. Open in new tab Generalized...

	Univariate LHV	Model A LHV	Univariate RHV	Model B RHV
Age	−0.090	−0.240 to 0.059	0.235	−0.028	−0.173 to 0.117	0.701	0.022	−0.128 to 0.173	0.773	0.091	−0.060 to 0.242	0.235
Sex	−0.471	−0.604 to −0.338	<0.001	−0.455	−0.589 to −0.321	<0.001	−0.408	-0.545 to -0.270	<0.001	−0.386	−0.524 to −0.248	<0.001
White non-Hispanic race/ethnicity	0.119	−0.030 to 0.269	0.117	0.027	−0.111 to 0.165	0.700	0.113	−0.037 to 0.262	0.139	0.037	−0.106 to 0.180	0.608
Family history of mental illnesses	0.052	−0.099 to 0.202	0.497	0.075	−0.059 to 0.208	0.270	0.034	−0.116 to 0.185	0.653	0.058	−0.079 to 0.196	0.404
Childhood poverty	0.003	−0.147 to 0.154	0.963	0.094	−0.045 to 0.233	0.185	0.039	−0.112 to 0.189	0.614	0.127	−0.017 to 0.271	0.084
Parental education	0.067	−0.084 to 0.217	0.384	0.071	−0.063 to 0.205	0.300	0.088	−0.062 to 0.238	0.249	0.092	−0.046 to 0.230	0.190
Life event stress	−0.261	−0.386 to −0.135	<0.001	−0.129	−0.276 to 0.018	0.084	−0.126	−0.276 to 0.023	0.097	−0.157	−0.311 to −0.003	0.045
Neighborhood poverty	−0.191	−0.339 to −0.043	0.011	−0.180	−0.327 to −0.034	0.016	−0.174	−0.322 to −0.026	0.022	−0.185	−0.335 to −0.035	0.016

Univariate LHV

Model A LHV

Univariate RHV

Model B RHV

95% CI

Age

−0.090

−0.240 to 0.059

0.235

−0.028

−0.173 to 0.117

0.701

0.022

−0.128 to 0.173

0.773

0.091

−0.060 to 0.242

0.235

Sex

−0.471

−0.604 to −0.338

<0.001

−0.455

−0.589 to −0.321

<0.001

−0.408

-0.545 to -0.270

<0.001

−0.386

−0.524 to −0.248

<0.001

White non-Hispanic race/ethnicity

0.119

−0.030 to 0.269

0.117

0.027

−0.111 to 0.165

0.700

0.113

−0.037 to 0.262

0.139

0.037

−0.106 to 0.180

0.608

Family history of mental illnesses

0.052

−0.099 to 0.202

0.497

0.075

−0.059 to 0.208

0.270

0.034

−0.116 to 0.185

0.653

0.058

−0.079 to 0.196

0.404

Childhood poverty

0.003

−0.147 to 0.154

0.963

0.094

−0.045 to 0.233

0.185

0.039

−0.112 to 0.189

0.614

0.127

−0.017 to 0.271

0.084

Parental education

0.067

−0.084 to 0.217

0.384

0.071

−0.063 to 0.205

0.300

0.088

−0.062 to 0.238

0.249

0.092

−0.046 to 0.230

0.190

Life event stress

−0.261

−0.386 to −0.135

<0.001

−0.129

−0.276 to 0.018

0.084

−0.126

−0.276 to 0.023

0.097

−0.157

−0.311 to −0.003

0.045

Neighborhood poverty

−0.191

−0.339 to −0.043

0.011

−0.180

−0.327 to −0.034

0.016

−0.174

−0.322 to −0.026

0.022

−0.185

−0.335 to −0.035

0.016

	Univariate LHV	Model A LHV	Univariate RHV	Model B RHV
Age	−0.090	−0.240 to 0.059	0.235	−0.028	−0.173 to 0.117	0.701	0.022	−0.128 to 0.173	0.773	0.091	−0.060 to 0.242	0.235
Sex	−0.471	−0.604 to −0.338	<0.001	−0.455	−0.589 to −0.321	<0.001	−0.408	-0.545 to -0.270	<0.001	−0.386	−0.524 to −0.248	<0.001
White non-Hispanic race/ethnicity	0.119	−0.030 to 0.269	0.117	0.027	−0.111 to 0.165	0.700	0.113	−0.037 to 0.262	0.139	0.037	−0.106 to 0.180	0.608
Family history of mental illnesses	0.052	−0.099 to 0.202	0.497	0.075	−0.059 to 0.208	0.270	0.034	−0.116 to 0.185	0.653	0.058	−0.079 to 0.196	0.404
Childhood poverty	0.003	−0.147 to 0.154	0.963	0.094	−0.045 to 0.233	0.185	0.039	−0.112 to 0.189	0.614	0.127	−0.017 to 0.271	0.084
Parental education	0.067	−0.084 to 0.217	0.384	0.071	−0.063 to 0.205	0.300	0.088	−0.062 to 0.238	0.249	0.092	−0.046 to 0.230	0.190
Life event stress	−0.261	−0.386 to −0.135	<0.001	−0.129	−0.276 to 0.018	0.084	−0.126	−0.276 to 0.023	0.097	−0.157	−0.311 to −0.003	0.045
Neighborhood poverty	−0.191	−0.339 to −0.043	0.011	−0.180	−0.327 to −0.034	0.016	−0.174	−0.322 to −0.026	0.022	−0.185	−0.335 to −0.035	0.016

Table 3.

Open in new tab

Generalized Linear Mixed Univariate and Multivariate Models Predicting Hippocampal Volumes of Both Hemispheres

	Univariate LHV			Model A LHV			Univariate RHV			Model B RHV
	β	95% CI	P	β	95% CI	P	β	95% CI	P	β	95% CI	P
Age	−0.090	−0.240 to 0.059	0.235	−0.028	−0.173 to 0.117	0.701	0.022	−0.128 to 0.173	0.773	0.091	−0.060 to 0.242	0.235
Sex	−0.471	−0.604 to −0.338	<0.001	−0.455	−0.589 to −0.321	<0.001	−0.408	-0.545 to -0.270	<0.001	−0.386	−0.524 to −0.248	<0.001
White non-Hispanic race/ethnicity	0.119	−0.030 to 0.269	0.117	0.027	−0.111 to 0.165	0.700	0.113	−0.037 to 0.262	0.139	0.037	−0.106 to 0.180	0.608
Family history of mental illnesses	0.052	−0.099 to 0.202	0.497	0.075	−0.059 to 0.208	0.270	0.034	−0.116 to 0.185	0.653	0.058	−0.079 to 0.196	0.404
Childhood poverty	0.003	−0.147 to 0.154	0.963	0.094	−0.045 to 0.233	0.185	0.039	−0.112 to 0.189	0.614	0.127	−0.017 to 0.271	0.084
Parental education	0.067	−0.084 to 0.217	0.384	0.071	−0.063 to 0.205	0.300	0.088	−0.062 to 0.238	0.249	0.092	−0.046 to 0.230	0.190
Life event stress	−0.261	−0.386 to −0.135	<0.001	−0.129	−0.276 to 0.018	0.084	−0.126	−0.276 to 0.023	0.097	−0.157	−0.311 to −0.003	0.045
Neighborhood poverty	−0.191	−0.339 to −0.043	0.011	−0.180	−0.327 to −0.034	0.016	−0.174	−0.322 to −0.026	0.022	−0.185	−0.335 to −0.035	0.016

	Univariate LHV			Model A LHV			Univariate RHV			Model B RHV
	β	95% CI	P	β	95% CI	P	β	95% CI	P	β	95% CI	P
Age	−0.090	−0.240 to 0.059	0.235	−0.028	−0.173 to 0.117	0.701	0.022	−0.128 to 0.173	0.773	0.091	−0.060 to 0.242	0.235
Sex	−0.471	−0.604 to −0.338	<0.001	−0.455	−0.589 to −0.321	<0.001	−0.408	-0.545 to -0.270	<0.001	−0.386	−0.524 to −0.248	<0.001
White non-Hispanic race/ethnicity	0.119	−0.030 to 0.269	0.117	0.027	−0.111 to 0.165	0.700	0.113	−0.037 to 0.262	0.139	0.037	−0.106 to 0.180	0.608
Family history of mental illnesses	0.052	−0.099 to 0.202	0.497	0.075	−0.059 to 0.208	0.270	0.034	−0.116 to 0.185	0.653	0.058	−0.079 to 0.196	0.404
Childhood poverty	0.003	−0.147 to 0.154	0.963	0.094	−0.045 to 0.233	0.185	0.039	−0.112 to 0.189	0.614	0.127	−0.017 to 0.271	0.084
Parental education	0.067	−0.084 to 0.217	0.384	0.071	−0.063 to 0.205	0.300	0.088	−0.062 to 0.238	0.249	0.092	−0.046 to 0.230	0.190
Life event stress	−0.261	−0.386 to −0.135	<0.001	−0.129	−0.276 to 0.018	0.084	−0.126	−0.276 to 0.023	0.097	−0.157	−0.311 to −0.003	0.045
Neighborhood poverty	−0.191	−0.339 to −0.043	0.011	−0.180	−0.327 to −0.034	0.016	−0.174	−0.322 to −0.026	0.022	−0.185	−0.335 to −0.035	0.016

All models used generalized linear mixed models with census tracts as the random intercept.

Univariate LHV tested associations between individual predictor variables and left hippocampal volume.

Model A LHV tested the multivariable associations between all variables shown and left hippocampal volume.

Univariate RHV tested associations between individual predictor variables and right hippocampal volume.

Model B RHV tested the multivariable associations between all variables shown and right hippocampal volume.

All significant associations (P < .025) are shown in bold.

This Feature Is Available To Subscribers Only