| Group . | Treatment . | Dose . | Dosing schedule . | Administration route . | Number of mice . |
|---|---|---|---|---|---|
| 1 | Vehicle (5% mannitol in citrate buffer) | NA | QDx4/wk x 3 | i.p. | 8 |
| 2 | CBX-12 | 10 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 3 | CBX-12 | 20 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 4 | exatecan | 1.15 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 5 | exatecan | 2.3 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 1 | Vehicle (5% mannitol in citrate buffer) | NA | QDx4 | i.p. | 8 |
| 2 | CBX-12 | 5 mg/kg | QDx4 | i.p. | 8 |
| 3 | CBX-12 | 10 mg/kg | QDx4 | i.p. | 8 |
| 4 | CBX-12 | 20 mg/kg | QDx4 | i.p. | 8 |
| 5 | CBX-12 | 40 mg/kg | QDx4 | i.p. | 8 |
| 6 | CBX-12 | 80 mg/kg | QDx4 | i.p. | 8 |
| Group . | Treatment . | Dose . | Dosing schedule . | Administration route . | Number of mice . |
|---|---|---|---|---|---|
| 1 | Vehicle (5% mannitol in citrate buffer) | NA | QDx4/wk x 3 | i.p. | 8 |
| 2 | CBX-12 | 10 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 3 | CBX-12 | 20 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 4 | exatecan | 1.15 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 5 | exatecan | 2.3 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 1 | Vehicle (5% mannitol in citrate buffer) | NA | QDx4 | i.p. | 8 |
| 2 | CBX-12 | 5 mg/kg | QDx4 | i.p. | 8 |
| 3 | CBX-12 | 10 mg/kg | QDx4 | i.p. | 8 |
| 4 | CBX-12 | 20 mg/kg | QDx4 | i.p. | 8 |
| 5 | CBX-12 | 40 mg/kg | QDx4 | i.p. | 8 |
| 6 | CBX-12 | 80 mg/kg | QDx4 | i.p. | 8 |
| Group . | Treatment . | Dose . | Dosing schedule . | Administration route . | Number of mice . |
|---|---|---|---|---|---|
| 1 | Vehicle (5% mannitol in citrate buffer) | NA | QDx4/wk x 3 | i.p. | 8 |
| 2 | CBX-12 | 10 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 3 | CBX-12 | 20 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 4 | exatecan | 1.15 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 5 | exatecan | 2.3 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 1 | Vehicle (5% mannitol in citrate buffer) | NA | QDx4 | i.p. | 8 |
| 2 | CBX-12 | 5 mg/kg | QDx4 | i.p. | 8 |
| 3 | CBX-12 | 10 mg/kg | QDx4 | i.p. | 8 |
| 4 | CBX-12 | 20 mg/kg | QDx4 | i.p. | 8 |
| 5 | CBX-12 | 40 mg/kg | QDx4 | i.p. | 8 |
| 6 | CBX-12 | 80 mg/kg | QDx4 | i.p. | 8 |
| Group . | Treatment . | Dose . | Dosing schedule . | Administration route . | Number of mice . |
|---|---|---|---|---|---|
| 1 | Vehicle (5% mannitol in citrate buffer) | NA | QDx4/wk x 3 | i.p. | 8 |
| 2 | CBX-12 | 10 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 3 | CBX-12 | 20 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 4 | exatecan | 1.15 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 5 | exatecan | 2.3 mg/kg | QDx4/wk x 3 | i.p. | 8 |
| 1 | Vehicle (5% mannitol in citrate buffer) | NA | QDx4 | i.p. | 8 |
| 2 | CBX-12 | 5 mg/kg | QDx4 | i.p. | 8 |
| 3 | CBX-12 | 10 mg/kg | QDx4 | i.p. | 8 |
| 4 | CBX-12 | 20 mg/kg | QDx4 | i.p. | 8 |
| 5 | CBX-12 | 40 mg/kg | QDx4 | i.p. | 8 |
| 6 | CBX-12 | 80 mg/kg | QDx4 | i.p. | 8 |
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