| Gene . | Mutations, n . | Mutated samples, n (%) . | Mutations in COSMIC Cancer Gene Census . | Mutations in OncoKB . |
|---|---|---|---|---|
| TP53 | 10 | 13 (68) | 10/10 pathogenic | 6/10 likely oncogenic, 2/10 oncogenic |
| NOTCH1 | 3 | 4 (21) | - | - |
| ATM | 3 | 3 (16) | 2/3 pathogenic, 1/3 SNP | - |
| FBXW7 | 2 | 3 (16) | 1/2 pathogenic | 1/2 likely oncogenic |
| ERBB2 | 2 | 2 (11) | 2/2 pathogenic | 1/2 oncogenic |
| PIK3CA | 2 | 2 (11) | 2/2 pathogenic | 1/2 oncogenic |
| PDGFRA | 2 | 2 (11) | - | - |
| KDR | 2 | 2 (11) | 1/2 pathogenic | - |
| CDKN2A | 2 | 2 (11) | 2/2 neutral | - |
| MPL | 1 | 1 (5) | - | - |
| KRAS | 1 | 1 (5) | 1/1 pathogenic | 1/1 oncogenic |
| FLT3 | 1 | 1 (5) | 1/1 pathogenic | - |
| CDH1 | 1 | 1 (5) | - | - |
| SMAD4 | 1 | 1 (5) | 1/1 pathogenic | - |
| STK11 | 1 | 1 (5) | 1/1 pathogenic | - |
| ALK | 1 | 1 (5) | - | - |
| IDH1 | 1 | 1 (5) | - | - |
| GNAS | 3 | 1 (5) | - | - |
| MLH1 | 1 | 1 (5) | - | - |
| CTNNB1 | 1 | 1 (5) | - | - |
| APC | 1 | 1 (5) | - | - |
| CSF1R | 1 | 1 (5) | - | - |
| EGFR | 1 | 1 (5) | 1/1 pathogenic | - |
| JAK2 | 2 | 1 (5) | 1/1 pathogenic | - |
| Gene . | Mutations, n . | Mutated samples, n (%) . | Mutations in COSMIC Cancer Gene Census . | Mutations in OncoKB . |
|---|---|---|---|---|
| TP53 | 10 | 13 (68) | 10/10 pathogenic | 6/10 likely oncogenic, 2/10 oncogenic |
| NOTCH1 | 3 | 4 (21) | - | - |
| ATM | 3 | 3 (16) | 2/3 pathogenic, 1/3 SNP | - |
| FBXW7 | 2 | 3 (16) | 1/2 pathogenic | 1/2 likely oncogenic |
| ERBB2 | 2 | 2 (11) | 2/2 pathogenic | 1/2 oncogenic |
| PIK3CA | 2 | 2 (11) | 2/2 pathogenic | 1/2 oncogenic |
| PDGFRA | 2 | 2 (11) | - | - |
| KDR | 2 | 2 (11) | 1/2 pathogenic | - |
| CDKN2A | 2 | 2 (11) | 2/2 neutral | - |
| MPL | 1 | 1 (5) | - | - |
| KRAS | 1 | 1 (5) | 1/1 pathogenic | 1/1 oncogenic |
| FLT3 | 1 | 1 (5) | 1/1 pathogenic | - |
| CDH1 | 1 | 1 (5) | - | - |
| SMAD4 | 1 | 1 (5) | 1/1 pathogenic | - |
| STK11 | 1 | 1 (5) | 1/1 pathogenic | - |
| ALK | 1 | 1 (5) | - | - |
| IDH1 | 1 | 1 (5) | - | - |
| GNAS | 3 | 1 (5) | - | - |
| MLH1 | 1 | 1 (5) | - | - |
| CTNNB1 | 1 | 1 (5) | - | - |
| APC | 1 | 1 (5) | - | - |
| CSF1R | 1 | 1 (5) | - | - |
| EGFR | 1 | 1 (5) | 1/1 pathogenic | - |
| JAK2 | 2 | 1 (5) | 1/1 pathogenic | - |
A hyphen (-) indicates that the value is not present in the database. Abbreviations: COSMIC, catalogue of somatic mutations in cancer; PSC-IBD-CRC, colorectal cancer associated with primary sclerosing cholangitis and inflammatory bowel disease; SNP, single nucleotide polymorphism.
| Gene . | Mutations, n . | Mutated samples, n (%) . | Mutations in COSMIC Cancer Gene Census . | Mutations in OncoKB . |
|---|---|---|---|---|
| TP53 | 10 | 13 (68) | 10/10 pathogenic | 6/10 likely oncogenic, 2/10 oncogenic |
| NOTCH1 | 3 | 4 (21) | - | - |
| ATM | 3 | 3 (16) | 2/3 pathogenic, 1/3 SNP | - |
| FBXW7 | 2 | 3 (16) | 1/2 pathogenic | 1/2 likely oncogenic |
| ERBB2 | 2 | 2 (11) | 2/2 pathogenic | 1/2 oncogenic |
| PIK3CA | 2 | 2 (11) | 2/2 pathogenic | 1/2 oncogenic |
| PDGFRA | 2 | 2 (11) | - | - |
| KDR | 2 | 2 (11) | 1/2 pathogenic | - |
| CDKN2A | 2 | 2 (11) | 2/2 neutral | - |
| MPL | 1 | 1 (5) | - | - |
| KRAS | 1 | 1 (5) | 1/1 pathogenic | 1/1 oncogenic |
| FLT3 | 1 | 1 (5) | 1/1 pathogenic | - |
| CDH1 | 1 | 1 (5) | - | - |
| SMAD4 | 1 | 1 (5) | 1/1 pathogenic | - |
| STK11 | 1 | 1 (5) | 1/1 pathogenic | - |
| ALK | 1 | 1 (5) | - | - |
| IDH1 | 1 | 1 (5) | - | - |
| GNAS | 3 | 1 (5) | - | - |
| MLH1 | 1 | 1 (5) | - | - |
| CTNNB1 | 1 | 1 (5) | - | - |
| APC | 1 | 1 (5) | - | - |
| CSF1R | 1 | 1 (5) | - | - |
| EGFR | 1 | 1 (5) | 1/1 pathogenic | - |
| JAK2 | 2 | 1 (5) | 1/1 pathogenic | - |
| Gene . | Mutations, n . | Mutated samples, n (%) . | Mutations in COSMIC Cancer Gene Census . | Mutations in OncoKB . |
|---|---|---|---|---|
| TP53 | 10 | 13 (68) | 10/10 pathogenic | 6/10 likely oncogenic, 2/10 oncogenic |
| NOTCH1 | 3 | 4 (21) | - | - |
| ATM | 3 | 3 (16) | 2/3 pathogenic, 1/3 SNP | - |
| FBXW7 | 2 | 3 (16) | 1/2 pathogenic | 1/2 likely oncogenic |
| ERBB2 | 2 | 2 (11) | 2/2 pathogenic | 1/2 oncogenic |
| PIK3CA | 2 | 2 (11) | 2/2 pathogenic | 1/2 oncogenic |
| PDGFRA | 2 | 2 (11) | - | - |
| KDR | 2 | 2 (11) | 1/2 pathogenic | - |
| CDKN2A | 2 | 2 (11) | 2/2 neutral | - |
| MPL | 1 | 1 (5) | - | - |
| KRAS | 1 | 1 (5) | 1/1 pathogenic | 1/1 oncogenic |
| FLT3 | 1 | 1 (5) | 1/1 pathogenic | - |
| CDH1 | 1 | 1 (5) | - | - |
| SMAD4 | 1 | 1 (5) | 1/1 pathogenic | - |
| STK11 | 1 | 1 (5) | 1/1 pathogenic | - |
| ALK | 1 | 1 (5) | - | - |
| IDH1 | 1 | 1 (5) | - | - |
| GNAS | 3 | 1 (5) | - | - |
| MLH1 | 1 | 1 (5) | - | - |
| CTNNB1 | 1 | 1 (5) | - | - |
| APC | 1 | 1 (5) | - | - |
| CSF1R | 1 | 1 (5) | - | - |
| EGFR | 1 | 1 (5) | 1/1 pathogenic | - |
| JAK2 | 2 | 1 (5) | 1/1 pathogenic | - |
A hyphen (-) indicates that the value is not present in the database. Abbreviations: COSMIC, catalogue of somatic mutations in cancer; PSC-IBD-CRC, colorectal cancer associated with primary sclerosing cholangitis and inflammatory bowel disease; SNP, single nucleotide polymorphism.
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