The Correlation Coefficients (r, Spearman Correlation) and Mean Maximum SOFA Score Changes Associated With 1-Unit Increase in HCoV anti-S IgG Within the COVID-19 Cohort
| Spike Strain or Subunit . | Spearman Correlation . | Maximum SOFA Change . | ||
|---|---|---|---|---|
| r . | P Value . | Mean . | P Value . | |
| SARS-CoV-2 S | 0.2249 | .0041 | 0.26 | .0112 |
| OC43 | 0.2326 | .0030 | 0.40 | .0465 |
| HKU1 | 0.2453 | .0017 | 0.33 | .1312 |
| 229E | −0.0136 | .8644 | −0.48 | .1268 |
| MNL63 | 0.0663 | .4036 | −0.07 | .7989 |
| SARS-CoV-2 S1 | 0.2679 | .0006 | 0.18 | .0504 |
| SARS-CoV-2 RBD | 0.2415 | .0020 | 0.23 | .0777 |
| SARS-CoV-2 S2 | 0.2301 | .0033 | 0.27 | .0125 |
| Spike Strain or Subunit . | Spearman Correlation . | Maximum SOFA Change . | ||
|---|---|---|---|---|
| r . | P Value . | Mean . | P Value . | |
| SARS-CoV-2 S | 0.2249 | .0041 | 0.26 | .0112 |
| OC43 | 0.2326 | .0030 | 0.40 | .0465 |
| HKU1 | 0.2453 | .0017 | 0.33 | .1312 |
| 229E | −0.0136 | .8644 | −0.48 | .1268 |
| MNL63 | 0.0663 | .4036 | −0.07 | .7989 |
| SARS-CoV-2 S1 | 0.2679 | .0006 | 0.18 | .0504 |
| SARS-CoV-2 RBD | 0.2415 | .0020 | 0.23 | .0777 |
| SARS-CoV-2 S2 | 0.2301 | .0033 | 0.27 | .0125 |
Abbreviations: COVID-19, coronavirus disease 2019; HCoV, human coronavirus; IgG, immunoglobulin G; RBD, receptor-binding domain; S, spike; SARS-CoV-2, severe acute respiratory syndrome 2; SOFA, sequential organ failure assessment. Values in bold are statistically significant with P < .05.
The Correlation Coefficients (r, Spearman Correlation) and Mean Maximum SOFA Score Changes Associated With 1-Unit Increase in HCoV anti-S IgG Within the COVID-19 Cohort
| Spike Strain or Subunit . | Spearman Correlation . | Maximum SOFA Change . | ||
|---|---|---|---|---|
| r . | P Value . | Mean . | P Value . | |
| SARS-CoV-2 S | 0.2249 | .0041 | 0.26 | .0112 |
| OC43 | 0.2326 | .0030 | 0.40 | .0465 |
| HKU1 | 0.2453 | .0017 | 0.33 | .1312 |
| 229E | −0.0136 | .8644 | −0.48 | .1268 |
| MNL63 | 0.0663 | .4036 | −0.07 | .7989 |
| SARS-CoV-2 S1 | 0.2679 | .0006 | 0.18 | .0504 |
| SARS-CoV-2 RBD | 0.2415 | .0020 | 0.23 | .0777 |
| SARS-CoV-2 S2 | 0.2301 | .0033 | 0.27 | .0125 |
| Spike Strain or Subunit . | Spearman Correlation . | Maximum SOFA Change . | ||
|---|---|---|---|---|
| r . | P Value . | Mean . | P Value . | |
| SARS-CoV-2 S | 0.2249 | .0041 | 0.26 | .0112 |
| OC43 | 0.2326 | .0030 | 0.40 | .0465 |
| HKU1 | 0.2453 | .0017 | 0.33 | .1312 |
| 229E | −0.0136 | .8644 | −0.48 | .1268 |
| MNL63 | 0.0663 | .4036 | −0.07 | .7989 |
| SARS-CoV-2 S1 | 0.2679 | .0006 | 0.18 | .0504 |
| SARS-CoV-2 RBD | 0.2415 | .0020 | 0.23 | .0777 |
| SARS-CoV-2 S2 | 0.2301 | .0033 | 0.27 | .0125 |
Abbreviations: COVID-19, coronavirus disease 2019; HCoV, human coronavirus; IgG, immunoglobulin G; RBD, receptor-binding domain; S, spike; SARS-CoV-2, severe acute respiratory syndrome 2; SOFA, sequential organ failure assessment. Values in bold are statistically significant with P < .05.
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