Proteins dysregulated in the serum of patients versus controls (unmatched and matched)
| . | Unmatched KLS (n = 20); controls (n = 54) . | Matched KLS (n = 20); controls (n = 20) . | Association with time of collection . | ||||
|---|---|---|---|---|---|---|---|
| Protein . | logFC . | FDR . | p . | logFC . | FDR . | p . | FDR . |
| FYN | 2.5 | 1.3E−06 | 1.2E−09 | 2.3 | 1.7E−05 | 3.0E−08 | 8.0E−05 |
| CSK | 2.7 | 5.4E−06 | 1.8E−08 | 2.3 | 6.0E−05 | 7.6E−07 | 2.7E−04 |
| DUSP3 | 2.0 | 5.4E−06 | 2.5E−08 | 1.9 | 6.0E−05 | 9.3E−07 | 3.6E−04 |
| HIST3H2A | 3.4 | 5.4E−06 | 1.9E−08 | 3.4 | 1.8E−04 | 5.8E−06 | 6.9E−04 |
| METAP1 | 2.3 | 5.4E−06 | 2.2E−08 | 2.2 | 1.9E−05 | 5.1E−08 | 3.6E−03 |
| PTPN11 | 1.9 | 5.4E−06 | 2.9E−08 | 1.7 | 7.4E−05 | 2.0E−06 | 4.1E−05 |
| TBP | 0.7 | 5.7E−06 | 3.6E−08 | 0.6 | 2.8E−04 | 1.6E−05 | 7.3E−07 |
| BTK | 1.9 | 6.1E−06 | 7.7E−08 | 1.7 | 6.0E−05 | 9.3E−07 | 7.3E−03 |
| EIF4G2 | 2.4 | 6.1E−06 | 8.8E−08 | 2.4 | 5.7E−05 | 4.1E−07 | 4.9E−03 |
| ENPP7 | −1.6 | 6.1E−06 | 7.2E−08 | −1.2 | 4.5E−04 | 2.9E−05 | 4.7E−04 |
| HIST1H1C | 2.7 | 6.1E−06 | 6.3E−08 | 2.5 | 7.4E−05 | 2.0E−06 | 8.1E−05 |
| HSD17B1 | 0.8 | 6.1E−06 | 8.8E−08 | 0.7 | 2.5E−04 | 1.1E−05 | 7.3E−07 |
| ICOSLG | 2.8 | 6.1E−06 | 5.8E−08 | 2.5 | 2.0E−04 | 6.9E−06 | 3.1E−05 |
| PTPN6 | 1.9 | 6.1E−06 | 8.2E−08 | 1.5 | 1.0E−03 | 1.4E−04 | 1.4E−05 |
| TPT1 | 1.9 | 6.1E−06 | 5.8E−08 | 1.9 | 6.9E−05 | 1.4E−06 | 7.3E−03 |
| VTA1 | 2.4 | 6.1E−06 | 7.2E−08 | 2.0 | 1.4E−04 | 4.1E−06 | 3.6E−04 |
| AIF1 | 0.9 | 6.2E−06 | 9.5E−08 | 0.7 | 1.0E−03 | 1.2E−04 | 5.8E−06 |
| TIMP2 | 0.6 | 6.5E−06 | 1.1E−07 | 0.6 | 6.0E−05 | 8.5E−07 | 7.6E−04 |
| AKT2 | 1.4 | 7.2E−06 | 1.5E−07 | 1.4 | 6.0E−05 | 7.6E−07 | 6.3E−06 |
| CD226 | 0.9 | 7.2E−06 | 1.4E−07 | 1.0 | 2.3E−04 | 8.6E−06 | 6.0E−02 |
| CMA1 | 0.8 | 7.2E−06 | 1.6E−07 | 0.8 | 2.8E−04 | 1.6E−05 | 7.3E−07 |
| PRKAA2 PRKAB2 PRKAG1 | 1.2 | 7.2E−06 | 1.5E−07 | 1.1 | 2.3E−04 | 9.7E−06 | 6.3E−06 |
| TOP1 | 1.1 | 7.2E−06 | 1.6E−07 | 1.1 | 2.5E−04 | 1.1E−05 | 3.6E−06 |
| TPM4 | 2.2 | 7.2E−06 | 1.6E−07 | 2.1 | 6.6E−05 | 1.1E−06 | 1.3E−02 |
| VAV1 | 2.2 | 7.2E−06 | 1.2E−07 | 1.8 | 8.4E−04 | 9.1E−05 | 2.5E−03 |
| EFNB3 | 0.4 | 7.4E−06 | 2.1E−07 | 0.4 | 6.0E−05 | 9.3E−07 | 1.3E−04 |
| EPS15L1 | 1.2 | 7.4E−06 | 1.7E−07 | 1.3 | 6.0E−05 | 7.6E−07 | 7.7E−03 |
| FER | 2.4 | 7.4E−06 | 2.1E−07 | 2.5 | 6.0E−05 | 9.3E−07 | 1.2E−02 |
| IL13RA1 | −0.8 | 7.4E−06 | 2.1E−07 | −0.6 | 4.9E−04 | 3.9E−05 | 1.8E−03 |
| IL16 | 0.7 | 7.4E−06 | 2.0E−07 | 0.5 | 7.0E−04 | 6.9E−05 | 1.9E−06 |
| IL1R1 | −0.9 | 7.4E−06 | 2.1E−07 | −0.8 | 2.3E−04 | 9.7E−06 | 1.4E−03 |
| SFTPD | 3.0 | 7.4E−06 | 1.9E−07 | 3.0 | 2.2E−03 | 3.3E−04 | 6.0E−05 |
| CEBPB | 0.8 | 7.4E−06 | 2.3E−07 | 0.7 | 2.6E−04 | 1.3E−05 | 4.4E−05 |
| STAT6 | 0.8 | 7.4E−06 | 2.3E−07 | 0.7 | 4.9E−04 | 3.7E−05 | 1.4E−05 |
| STIP1 | 1.6 | 7.7E−06 | 2.4E−07 | 1.4 | 5.9E−04 | 5.2E−05 | 5.1E−05 |
| CAMK2A | 1.2 | 7.8E−06 | 2.6E−07 | 1.1 | 4.7E−04 | 3.4E−05 | 1.1E−06 |
| RPS6KA3 | 1.4 | 7.8E−06 | 2.6E−07 | 1.3 | 5.9E−04 | 5.2E−05 | 4.1E−04 |
| UBE2I | 1.5 | 8.6E−06 | 3.0E−07 | 1.4 | 7.7E−04 | 7.9E−05 | 1.9E−03 |
| HNRNPAB | 2.0 | 9.0E−06 | 3.2E−07 | 1.8 | 4.7E−04 | 3.4E−05 | 8.5E−06 |
| CTSG | 0.8 | 9.1E−06 | 3.4E−07 | 0.7 | 2.6E−04 | 1.3E−05 | 1.9E−05 |
| SUMO3 | 1.6 | 9.1E−06 | 3.4E−07 | 1.4 | 4.0E−04 | 2.5E−05 | 1.0E−02 |
| HMGB1 | 1.1 | 9.7E−06 | 3.8E−07 | 1.0 | 8.4E−04 | 9.1E−05 | 2.3E−07 |
| IDS | −0.9 | 9.7E−06 | 4.1E−07 | −0.7 | 7.0E−04 | 6.9E−05 | 7.2E−03 |
| MAPK14 | 0.9 | 9.7E−06 | 4.1E−07 | 0.9 | 1.0E−03 | 1.2E−04 | 7.5E−05 |
| NUDCD3 | 1.1 | 9.7E−06 | 4.1E−07 | 1.2 | 7.1E−05 | 1.7E−06 | 1.1E−02 |
| TEC | 0.8 | 9.7E−06 | 3.8E−07 | 0.8 | 7.1E−05 | 1.7E−06 | 1.1E−02 |
| TIE1 | −0.4 | 9.7E−06 | 4.1E−07 | −0.4 | 3.6E−04 | 2.1E−05 | 3.1E−02 |
| PRKCD | 0.5 | 1.0E−05 | 4.4E−07 | 0.4 | 5.9E−04 | 5.2E−05 | 1.4E−05 |
| GFRA3 | 0.4 | 1.1E−05 | 4.7E−07 | 0.4 | 2.6E−04 | 1.3E−05 | 9.7E−06 |
| CAMK2B | 1.6 | 1.1E−05 | 5.3E−07 | 1.3 | 1.0E−03 | 1.4E−04 | 1.2E−06 |
| CAMK2D | 1.6 | 1.1E−05 | 5.3E−07 | 1.4 | 6.5E−04 | 6.0E−05 | 1.2E−06 |
| CDH1 | −0.6 | 1.1E−05 | 5.3E−07 | −0.5 | 2.5E−04 | 1.1E−05 | 5.1E−05 |
| KAT6A | 0.4 | 1.1E−05 | 5.0E−07 | 0.4 | 8.6E−05 | 2.4E−06 | 3.1E−06 |
| LBP | −0.9 | 1.1E−05 | 5.3E−07 | −0.8 | 2.8E−04 | 1.6E−05 | 1.5E−02 |
| MMP17 | 0.8 | 1.1E−05 | 5.3E−07 | 0.7 | 2.2E−04 | 8.2E−06 | 1.6E−05 |
| CCL13 | 0.7 | 1.1E−05 | 5.6E−07 | 0.7 | 7.4E−05 | 2.0E−06 | 1.1E−03 |
| DDX19B | 1.4 | 1.1E−05 | 5.6E−07 | 1.2 | 1.0E−03 | 1.2E−04 | 9.6E−04 |
| XRCC6 | 1.3 | 1.1E−05 | 5.6E−07 | 1.0 | 6.7E−03 | 1.4E−03 | 3.6E−07 |
| CYP3A4 | 0.8 | 1.1E−05 | 6.0E−07 | 0.7 | 7.0E−04 | 6.9E−05 | 1.8E−03 |
| HNRNPA2B1 | 2.0 | 1.2E−05 | 6.4E−07 | 1.9 | 2.4E−03 | 3.7E−04 | 8.0E−05 |
| GDF15 | −0.6 | 1.2E−05 | 6.6E−07 | −0.4 | 1.3E−03 | 1.7E−04 | 1.2E−01 |
| TAGLN2 | 1.5 | 1.2E−05 | 6.8E−07 | 1.6 | 5.7E−05 | 4.1E−07 | 1.2E−02 |
| CXCL8 | 3.4 | 1.3E−05 | 7.3E−07 | 3.9 | 5.7E−05 | 3.3E−07 | 7.6E−02 |
| CLIC1 | 1.0 | 1.5E−05 | 8.8E−07 | 0.8 | 4.9E−04 | 3.9E−05 | 6.3E−06 |
| SNX4 | 1.0 | 1.6E−05 | 9.4E−07 | 0.8 | 7.7E−04 | 7.9E−05 | 2.6E−04 |
| YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ SFN | 0.9 | 1.6E−05 | 9.4E−07 | 0.8 | 2.8E−04 | 1.6E−05 | 2.2E−05 |
| IMPDH1 | 2.1 | 1.7E−05 | 1.0E−06 | 2.0 | 2.6E−03 | 4.2E−04 | 4.2E−05 |
| H2AFZ | 2.3 | 1.7E−05 | 1.1E−06 | 2.2 | 4.7E−04 | 3.4E−05 | 6.3E−06 |
| IGF1 | 0.5 | 1.7E−05 | 1.1E−06 | 0.6 | 3.7E−05 | 1.3E−07 | 9.3E−03 |
| PRKCZ | 0.7 | 1.8E−05 | 1.1E−06 | 0.6 | 9.2E−04 | 1.0E−04 | 1.4E−05 |
| LAMA1 LAMB1 LAMC1 | −0.5 | 1.8E−05 | 1.2E−06 | −0.5 | 3.2E−04 | 1.8E−05 | 2.2E−02 |
| LYN (Duplicate 1/2) | 1.6 | 1.8E−05 | 1.2E−06 | 1.2 | 2.4E−03 | 3.7E−04 | 2.0E−05 |
| SBDS | 1.3 | 1.8E−05 | 1.2E−06 | 1.1 | 4.0E−04 | 2.5E−05 | 7.5E−05 |
| BPI | 2.4 | 1.9E−05 | 1.3E−06 | 2.7 | 6.9E−05 | 1.4E−06 | 6.4E−02 |
| NAGK | 1.1 | 1.9E−05 | 1.3E−06 | 1.0 | 9.2E−04 | 1.0E−04 | 1.9E−06 |
| RPS7 | 1.4 | 1.9E−05 | 1.3E−06 | 1.2 | 4.8E−03 | 9.3E−04 | 1.2E−05 |
| FCGR1A | 0.5 | 1.9E−05 | 1.4E−06 | 0.5 | 5.1E−04 | 4.2E−05 | 2.3E−04 |
| FSTL3 | −0.5 | 1.9E−05 | 1.4E−06 | −0.4 | 6.2E−03 | 1.3E−03 | 4.2E−02 |
| SSRP1 | 0.8 | 1.9E−05 | 1.4E−06 | 0.7 | 1.3E−03 | 1.8E−04 | 1.3E−04 |
| EIF4A3 | 0.4 | 2.1E−05 | 1.6E−06 | 0.4 | 1.0E−03 | 1.2E−04 | 1.9E−05 |
| PDPK1 | 1.9 | 2.1E−05 | 1.6E−06 | 1.4 | 1.1E−02 | 2.9E−03 | 2.2E−04 |
| CTSE | 0.4 | 2.2E−05 | 1.6E−06 | 0.5 | 1.8E−04 | 5.8E−06 | 2.3E−02 |
| PRSS2 | −0.9 | 2.2E−05 | 1.6E−06 | −0.7 | 3.2E−03 | 5.3E−04 | 4.1E−02 |
| ESR1 | 0.5 | 2.3E−05 | 1.8E−06 | 0.5 | 2.2E−04 | 8.2E−06 | 5.9E−05 |
| PDXK | 1.1 | 2.3E−05 | 1.8E−06 | 0.9 | 4.8E−03 | 9.3E−04 | 2.8E−05 |
| INSR | −0.6 | 2.5E−05 | 2.0E−06 | −0.4 | 4.5E−03 | 8.4E−04 | 6.1E−02 |
| TNFRSF25 | −0.7 | 2.5E−05 | 2.0E−06 | −0.6 | 2.0E−03 | 2.9E−04 | 2.1E−03 |
| HDGFRP2 | 0.3 | 2.7E−05 | 2.1E−06 | 0.2 | 6.2E−03 | 1.3E−03 | 7.3E−07 |
| MAPK12 | 0.5 | 2.7E−05 | 2.2E−06 | 0.6 | 2.3E−04 | 9.7E−06 | 3.8E−03 |
| LCK | 0.4 | 2.7E−05 | 2.2E−06 | 0.3 | 1.1E−02 | 2.9E−03 | 7.3E−07 |
| TPI1 | 1.4 | 2.7E−05 | 2.2E−06 | 1.4 | 8.4E−04 | 9.1E−05 | 3.0E−03 |
| S100A12 | 1.7 | 2.8E−05 | 2.4E−06 | 1.7 | 1.0E−03 | 1.4E−04 | 3.0E−03 |
| TFPI | −0.9 | 2.8E−05 | 2.4E−06 | −0.9 | 4.7E−04 | 3.4E−05 | 2.3E−03 |
| SELL | 0.4 | 3.0E−05 | 2.5E−06 | 0.3 | 1.0E−03 | 1.4E−04 | 1.3E−04 |
| TNFSF14 | 1.1 | 3.0E−05 | 2.5E−06 | 1.1 | 6.6E−05 | 1.1E−06 | 2.6E−02 |
| DAPK2 | 0.7 | 3.1E−05 | 2.7E−06 | 0.5 | 1.1E−02 | 2.9E−03 | 3.9E−07 |
| PRKCI | 0.8 | 3.1E−05 | 2.7E−06 | 0.6 | 2.9E−03 | 4.7E−04 | 2.7E−05 |
| CSNK2A1 | 0.3 | 3.2E−05 | 2.9E−06 | 0.3 | 4.9E−04 | 3.7E−05 | 1.5E−04 |
| CLEC1B | 0.7 | 3.4E−05 | 3.0E−06 | 0.5 | 1.2E−03 | 1.6E−04 | 5.2E−02 |
| MAPK13 | 0.6 | 3.5E−05 | 3.1E−06 | 0.4 | 1.5E−02 | 4.3E−03 | 1.3E−03 |
| HMOX2 | 0.6 | 3.5E−05 | 3.2E−06 | 0.5 | 9.2E−03 | 2.2E−03 | 6.2E−06 |
| MATN3 | 0.5 | 3.7E−05 | 3.4E−06 | 0.5 | 4.5E−04 | 2.9E−05 | 6.2E−06 |
| UBE2N | 1.4 | 3.9E−05 | 3.6E−06 | 1.4 | 1.4E−03 | 2.0E−04 | 1.0E−02 |
| CFL1 | 0.9 | 4.1E−05 | 3.8E−06 | 0.8 | 2.9E−03 | 4.7E−04 | 1.3E−03 |
| RBM39 | 1.3 | 4.1E−05 | 3.8E−06 | 1.1 | 1.3E−02 | 3.5E−03 | 3.4E−04 |
| LGALS3 | −0.4 | 4.5E−05 | 4.3E−06 | −0.3 | 6.2E−03 | 1.3E−03 | 9.5E−03 |
| UFM1 | 1.2 | 4.5E−05 | 4.3E−06 | 1.2 | 6.5E−04 | 6.0E−05 | 2.1E−03 |
| DSC2 | −0.4 | 4.7E−05 | 4.6E−06 | −0.3 | 1.3E−02 | 3.5E−03 | 6.8E−04 |
| PAFAH1B2 | 1.0 | 4.7E−05 | 4.6E−06 | 1.0 | 1.0E−03 | 1.4E−04 | 4.9E−05 |
| TP53 | 0.7 | 4.9E−05 | 4.9E−06 | 0.5 | 9.2E−04 | 1.0E−04 | 5.0E−03 |
| BMPER | 0.4 | 5.4E−05 | 5.5E−06 | 0.5 | 7.1E−05 | 1.7E−06 | 6.1E−04 |
| EFNB2 | −0.5 | 5.4E−05 | 5.5E−06 | −0.4 | 4.1E−03 | 7.5E−04 | 3.8E−02 |
| IDUA | 0.7 | 6.0E−05 | 6.2E−06 | 0.7 | 2.3E−04 | 9.7E−06 | 1.1E−03 |
| SFRP1 | −1.0 | 6.0E−05 | 6.2E−06 | −1.0 | 4.7E−04 | 3.4E−05 | 3.0E−02 |
| BMP6 | −1.1 | 6.3E−05 | 6.5E−06 | −0.9 | 2.6E−03 | 4.2E−04 | 1.8E−03 |
| LYN (Duplicate 2/2) | 1.5 | 6.3E−05 | 6.5E−06 | 1.0 | 1.5E−02 | 4.3E−03 | 9.4E−05 |
| CA13 | 2.1 | 6.5E−05 | 6.9E−06 | 2.2 | 2.2E−04 | 8.2E−06 | 5.3E−02 |
| RAC3 | 0.9 | 6.5E−05 | 6.9E−06 | 0.9 | 1.4E−03 | 2.0E−04 | 9.4E−06 |
| TKT | 1.2 | 6.5E−05 | 6.9E−06 | 1.2 | 1.6E−03 | 2.3E−04 | 6.3E−03 |
| NCK1 | 0.5 | 6.8E−05 | 7.3E−06 | 0.4 | 1.5E−02 | 4.3E−03 | 1.1E−01 |
| MDM2 | 0.3 | 7.1E−05 | 7.8E−06 | 0.3 | 3.8E−04 | 2.3E−05 | 2.4E−04 |
| SIGLEC7 | −0.4 | 7.2E−05 | 8.0E−06 | −0.4 | 3.6E−04 | 2.1E−05 | 1.3E−01 |
| TGFB3 | 0.4 | 7.2E−05 | 8.0E−06 | 0.5 | 3.6E−04 | 2.1E−05 | 9.9E−04 |
| PLXNB2 | −0.5 | 7.3E−05 | 8.2E−06 | −0.3 | 4.2E−02 | 1.5E−02 | 4.1E−03 |
| RPS27A | 1.3 | 7.3E−05 | 8.2E−06 | 1.2 | 3.4E−03 | 6.0E−04 | 3.0E−03 |
| BCL2 | 0.6 | 7.5E−05 | 8.7E−06 | 0.6 | 8.4E−04 | 9.1E−05 | 1.9E−05 |
| CASP3 | 1.0 | 7.5E−05 | 8.7E−06 | 0.8 | 2.4E−03 | 3.7E−04 | 2.0E−04 |
| COL23A1 | 0.4 | 7.5E−05 | 8.7E−06 | 0.6 | 5.7E−05 | 2.6E−07 | 4.4E−02 |
| F2 (Duplicate 1/2) | −0.9 | 7.5E−05 | 8.7E−06 | −0.9 | 4.9E−04 | 3.9E−05 | 1.3E−04 |
| DSG2 | −0.5 | 7.8E−05 | 9.2E−06 | −0.5 | 2.5E−04 | 1.1E−05 | 4.3E−04 |
| HK2 | 1.7 | 7.8E−05 | 9.2E−06 | 1.4 | 9.2E−03 | 2.2E−03 | 6.7E−06 |
| PTPN1 | 0.8 | 7.8E−05 | 9.2E−06 | 0.5 | 4.8E−03 | 9.3E−04 | 6.8E−03 |
| CHST2 | 0.5 | 8.0E−05 | 9.8E−06 | 0.5 | 1.0E−03 | 1.4E−04 | 3.5E−05 |
| CLEC7A | 0.3 | 8.0E−05 | 9.8E−06 | 0.3 | 6.9E−05 | 1.4E−06 | 1.1E−03 |
| F2 (Duplicate 2/2) | −1.1 | 8.0E−05 | 9.8E−06 | −1.1 | 7.7E−04 | 7.9E−05 | 2.9E−03 |
| PPIA | 0.9 | 8.0E−05 | 9.8E−06 | 0.8 | 3.4E−03 | 6.0E−04 | 3.5E−02 |
| DNAJB1 | 0.3 | 8.4E−05 | 1.0E−05 | 0.2 | 6.9E−03 | 1.5E−03 | 6.7E−06 |
| IL3 | 0.5 | 8.8E−05 | 1.1E−05 | 0.4 | 2.9E−03 | 4.7E−04 | 8.2E−01 |
| SLAMF7 | −0.8 | 8.8E−05 | 1.1E−05 | −0.9 | 2.3E−04 | 9.7E−06 | 3.0E−02 |
| ACP1 | 1.4 | 9.2E−05 | 1.2E−05 | 1.3 | 1.2E−03 | 1.6E−04 | 3.5E−04 |
| SELP | 1.0 | 9.7E−05 | 1.2E−05 | 1.0 | 4.7E−04 | 3.4E−05 | 2.0E−01 |
| . | Unmatched KLS (n = 20); controls (n = 54) . | Matched KLS (n = 20); controls (n = 20) . | Association with time of collection . | ||||
|---|---|---|---|---|---|---|---|
| Protein . | logFC . | FDR . | p . | logFC . | FDR . | p . | FDR . |
| FYN | 2.5 | 1.3E−06 | 1.2E−09 | 2.3 | 1.7E−05 | 3.0E−08 | 8.0E−05 |
| CSK | 2.7 | 5.4E−06 | 1.8E−08 | 2.3 | 6.0E−05 | 7.6E−07 | 2.7E−04 |
| DUSP3 | 2.0 | 5.4E−06 | 2.5E−08 | 1.9 | 6.0E−05 | 9.3E−07 | 3.6E−04 |
| HIST3H2A | 3.4 | 5.4E−06 | 1.9E−08 | 3.4 | 1.8E−04 | 5.8E−06 | 6.9E−04 |
| METAP1 | 2.3 | 5.4E−06 | 2.2E−08 | 2.2 | 1.9E−05 | 5.1E−08 | 3.6E−03 |
| PTPN11 | 1.9 | 5.4E−06 | 2.9E−08 | 1.7 | 7.4E−05 | 2.0E−06 | 4.1E−05 |
| TBP | 0.7 | 5.7E−06 | 3.6E−08 | 0.6 | 2.8E−04 | 1.6E−05 | 7.3E−07 |
| BTK | 1.9 | 6.1E−06 | 7.7E−08 | 1.7 | 6.0E−05 | 9.3E−07 | 7.3E−03 |
| EIF4G2 | 2.4 | 6.1E−06 | 8.8E−08 | 2.4 | 5.7E−05 | 4.1E−07 | 4.9E−03 |
| ENPP7 | −1.6 | 6.1E−06 | 7.2E−08 | −1.2 | 4.5E−04 | 2.9E−05 | 4.7E−04 |
| HIST1H1C | 2.7 | 6.1E−06 | 6.3E−08 | 2.5 | 7.4E−05 | 2.0E−06 | 8.1E−05 |
| HSD17B1 | 0.8 | 6.1E−06 | 8.8E−08 | 0.7 | 2.5E−04 | 1.1E−05 | 7.3E−07 |
| ICOSLG | 2.8 | 6.1E−06 | 5.8E−08 | 2.5 | 2.0E−04 | 6.9E−06 | 3.1E−05 |
| PTPN6 | 1.9 | 6.1E−06 | 8.2E−08 | 1.5 | 1.0E−03 | 1.4E−04 | 1.4E−05 |
| TPT1 | 1.9 | 6.1E−06 | 5.8E−08 | 1.9 | 6.9E−05 | 1.4E−06 | 7.3E−03 |
| VTA1 | 2.4 | 6.1E−06 | 7.2E−08 | 2.0 | 1.4E−04 | 4.1E−06 | 3.6E−04 |
| AIF1 | 0.9 | 6.2E−06 | 9.5E−08 | 0.7 | 1.0E−03 | 1.2E−04 | 5.8E−06 |
| TIMP2 | 0.6 | 6.5E−06 | 1.1E−07 | 0.6 | 6.0E−05 | 8.5E−07 | 7.6E−04 |
| AKT2 | 1.4 | 7.2E−06 | 1.5E−07 | 1.4 | 6.0E−05 | 7.6E−07 | 6.3E−06 |
| CD226 | 0.9 | 7.2E−06 | 1.4E−07 | 1.0 | 2.3E−04 | 8.6E−06 | 6.0E−02 |
| CMA1 | 0.8 | 7.2E−06 | 1.6E−07 | 0.8 | 2.8E−04 | 1.6E−05 | 7.3E−07 |
| PRKAA2 PRKAB2 PRKAG1 | 1.2 | 7.2E−06 | 1.5E−07 | 1.1 | 2.3E−04 | 9.7E−06 | 6.3E−06 |
| TOP1 | 1.1 | 7.2E−06 | 1.6E−07 | 1.1 | 2.5E−04 | 1.1E−05 | 3.6E−06 |
| TPM4 | 2.2 | 7.2E−06 | 1.6E−07 | 2.1 | 6.6E−05 | 1.1E−06 | 1.3E−02 |
| VAV1 | 2.2 | 7.2E−06 | 1.2E−07 | 1.8 | 8.4E−04 | 9.1E−05 | 2.5E−03 |
| EFNB3 | 0.4 | 7.4E−06 | 2.1E−07 | 0.4 | 6.0E−05 | 9.3E−07 | 1.3E−04 |
| EPS15L1 | 1.2 | 7.4E−06 | 1.7E−07 | 1.3 | 6.0E−05 | 7.6E−07 | 7.7E−03 |
| FER | 2.4 | 7.4E−06 | 2.1E−07 | 2.5 | 6.0E−05 | 9.3E−07 | 1.2E−02 |
| IL13RA1 | −0.8 | 7.4E−06 | 2.1E−07 | −0.6 | 4.9E−04 | 3.9E−05 | 1.8E−03 |
| IL16 | 0.7 | 7.4E−06 | 2.0E−07 | 0.5 | 7.0E−04 | 6.9E−05 | 1.9E−06 |
| IL1R1 | −0.9 | 7.4E−06 | 2.1E−07 | −0.8 | 2.3E−04 | 9.7E−06 | 1.4E−03 |
| SFTPD | 3.0 | 7.4E−06 | 1.9E−07 | 3.0 | 2.2E−03 | 3.3E−04 | 6.0E−05 |
| CEBPB | 0.8 | 7.4E−06 | 2.3E−07 | 0.7 | 2.6E−04 | 1.3E−05 | 4.4E−05 |
| STAT6 | 0.8 | 7.4E−06 | 2.3E−07 | 0.7 | 4.9E−04 | 3.7E−05 | 1.4E−05 |
| STIP1 | 1.6 | 7.7E−06 | 2.4E−07 | 1.4 | 5.9E−04 | 5.2E−05 | 5.1E−05 |
| CAMK2A | 1.2 | 7.8E−06 | 2.6E−07 | 1.1 | 4.7E−04 | 3.4E−05 | 1.1E−06 |
| RPS6KA3 | 1.4 | 7.8E−06 | 2.6E−07 | 1.3 | 5.9E−04 | 5.2E−05 | 4.1E−04 |
| UBE2I | 1.5 | 8.6E−06 | 3.0E−07 | 1.4 | 7.7E−04 | 7.9E−05 | 1.9E−03 |
| HNRNPAB | 2.0 | 9.0E−06 | 3.2E−07 | 1.8 | 4.7E−04 | 3.4E−05 | 8.5E−06 |
| CTSG | 0.8 | 9.1E−06 | 3.4E−07 | 0.7 | 2.6E−04 | 1.3E−05 | 1.9E−05 |
| SUMO3 | 1.6 | 9.1E−06 | 3.4E−07 | 1.4 | 4.0E−04 | 2.5E−05 | 1.0E−02 |
| HMGB1 | 1.1 | 9.7E−06 | 3.8E−07 | 1.0 | 8.4E−04 | 9.1E−05 | 2.3E−07 |
| IDS | −0.9 | 9.7E−06 | 4.1E−07 | −0.7 | 7.0E−04 | 6.9E−05 | 7.2E−03 |
| MAPK14 | 0.9 | 9.7E−06 | 4.1E−07 | 0.9 | 1.0E−03 | 1.2E−04 | 7.5E−05 |
| NUDCD3 | 1.1 | 9.7E−06 | 4.1E−07 | 1.2 | 7.1E−05 | 1.7E−06 | 1.1E−02 |
| TEC | 0.8 | 9.7E−06 | 3.8E−07 | 0.8 | 7.1E−05 | 1.7E−06 | 1.1E−02 |
| TIE1 | −0.4 | 9.7E−06 | 4.1E−07 | −0.4 | 3.6E−04 | 2.1E−05 | 3.1E−02 |
| PRKCD | 0.5 | 1.0E−05 | 4.4E−07 | 0.4 | 5.9E−04 | 5.2E−05 | 1.4E−05 |
| GFRA3 | 0.4 | 1.1E−05 | 4.7E−07 | 0.4 | 2.6E−04 | 1.3E−05 | 9.7E−06 |
| CAMK2B | 1.6 | 1.1E−05 | 5.3E−07 | 1.3 | 1.0E−03 | 1.4E−04 | 1.2E−06 |
| CAMK2D | 1.6 | 1.1E−05 | 5.3E−07 | 1.4 | 6.5E−04 | 6.0E−05 | 1.2E−06 |
| CDH1 | −0.6 | 1.1E−05 | 5.3E−07 | −0.5 | 2.5E−04 | 1.1E−05 | 5.1E−05 |
| KAT6A | 0.4 | 1.1E−05 | 5.0E−07 | 0.4 | 8.6E−05 | 2.4E−06 | 3.1E−06 |
| LBP | −0.9 | 1.1E−05 | 5.3E−07 | −0.8 | 2.8E−04 | 1.6E−05 | 1.5E−02 |
| MMP17 | 0.8 | 1.1E−05 | 5.3E−07 | 0.7 | 2.2E−04 | 8.2E−06 | 1.6E−05 |
| CCL13 | 0.7 | 1.1E−05 | 5.6E−07 | 0.7 | 7.4E−05 | 2.0E−06 | 1.1E−03 |
| DDX19B | 1.4 | 1.1E−05 | 5.6E−07 | 1.2 | 1.0E−03 | 1.2E−04 | 9.6E−04 |
| XRCC6 | 1.3 | 1.1E−05 | 5.6E−07 | 1.0 | 6.7E−03 | 1.4E−03 | 3.6E−07 |
| CYP3A4 | 0.8 | 1.1E−05 | 6.0E−07 | 0.7 | 7.0E−04 | 6.9E−05 | 1.8E−03 |
| HNRNPA2B1 | 2.0 | 1.2E−05 | 6.4E−07 | 1.9 | 2.4E−03 | 3.7E−04 | 8.0E−05 |
| GDF15 | −0.6 | 1.2E−05 | 6.6E−07 | −0.4 | 1.3E−03 | 1.7E−04 | 1.2E−01 |
| TAGLN2 | 1.5 | 1.2E−05 | 6.8E−07 | 1.6 | 5.7E−05 | 4.1E−07 | 1.2E−02 |
| CXCL8 | 3.4 | 1.3E−05 | 7.3E−07 | 3.9 | 5.7E−05 | 3.3E−07 | 7.6E−02 |
| CLIC1 | 1.0 | 1.5E−05 | 8.8E−07 | 0.8 | 4.9E−04 | 3.9E−05 | 6.3E−06 |
| SNX4 | 1.0 | 1.6E−05 | 9.4E−07 | 0.8 | 7.7E−04 | 7.9E−05 | 2.6E−04 |
| YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ SFN | 0.9 | 1.6E−05 | 9.4E−07 | 0.8 | 2.8E−04 | 1.6E−05 | 2.2E−05 |
| IMPDH1 | 2.1 | 1.7E−05 | 1.0E−06 | 2.0 | 2.6E−03 | 4.2E−04 | 4.2E−05 |
| H2AFZ | 2.3 | 1.7E−05 | 1.1E−06 | 2.2 | 4.7E−04 | 3.4E−05 | 6.3E−06 |
| IGF1 | 0.5 | 1.7E−05 | 1.1E−06 | 0.6 | 3.7E−05 | 1.3E−07 | 9.3E−03 |
| PRKCZ | 0.7 | 1.8E−05 | 1.1E−06 | 0.6 | 9.2E−04 | 1.0E−04 | 1.4E−05 |
| LAMA1 LAMB1 LAMC1 | −0.5 | 1.8E−05 | 1.2E−06 | −0.5 | 3.2E−04 | 1.8E−05 | 2.2E−02 |
| LYN (Duplicate 1/2) | 1.6 | 1.8E−05 | 1.2E−06 | 1.2 | 2.4E−03 | 3.7E−04 | 2.0E−05 |
| SBDS | 1.3 | 1.8E−05 | 1.2E−06 | 1.1 | 4.0E−04 | 2.5E−05 | 7.5E−05 |
| BPI | 2.4 | 1.9E−05 | 1.3E−06 | 2.7 | 6.9E−05 | 1.4E−06 | 6.4E−02 |
| NAGK | 1.1 | 1.9E−05 | 1.3E−06 | 1.0 | 9.2E−04 | 1.0E−04 | 1.9E−06 |
| RPS7 | 1.4 | 1.9E−05 | 1.3E−06 | 1.2 | 4.8E−03 | 9.3E−04 | 1.2E−05 |
| FCGR1A | 0.5 | 1.9E−05 | 1.4E−06 | 0.5 | 5.1E−04 | 4.2E−05 | 2.3E−04 |
| FSTL3 | −0.5 | 1.9E−05 | 1.4E−06 | −0.4 | 6.2E−03 | 1.3E−03 | 4.2E−02 |
| SSRP1 | 0.8 | 1.9E−05 | 1.4E−06 | 0.7 | 1.3E−03 | 1.8E−04 | 1.3E−04 |
| EIF4A3 | 0.4 | 2.1E−05 | 1.6E−06 | 0.4 | 1.0E−03 | 1.2E−04 | 1.9E−05 |
| PDPK1 | 1.9 | 2.1E−05 | 1.6E−06 | 1.4 | 1.1E−02 | 2.9E−03 | 2.2E−04 |
| CTSE | 0.4 | 2.2E−05 | 1.6E−06 | 0.5 | 1.8E−04 | 5.8E−06 | 2.3E−02 |
| PRSS2 | −0.9 | 2.2E−05 | 1.6E−06 | −0.7 | 3.2E−03 | 5.3E−04 | 4.1E−02 |
| ESR1 | 0.5 | 2.3E−05 | 1.8E−06 | 0.5 | 2.2E−04 | 8.2E−06 | 5.9E−05 |
| PDXK | 1.1 | 2.3E−05 | 1.8E−06 | 0.9 | 4.8E−03 | 9.3E−04 | 2.8E−05 |
| INSR | −0.6 | 2.5E−05 | 2.0E−06 | −0.4 | 4.5E−03 | 8.4E−04 | 6.1E−02 |
| TNFRSF25 | −0.7 | 2.5E−05 | 2.0E−06 | −0.6 | 2.0E−03 | 2.9E−04 | 2.1E−03 |
| HDGFRP2 | 0.3 | 2.7E−05 | 2.1E−06 | 0.2 | 6.2E−03 | 1.3E−03 | 7.3E−07 |
| MAPK12 | 0.5 | 2.7E−05 | 2.2E−06 | 0.6 | 2.3E−04 | 9.7E−06 | 3.8E−03 |
| LCK | 0.4 | 2.7E−05 | 2.2E−06 | 0.3 | 1.1E−02 | 2.9E−03 | 7.3E−07 |
| TPI1 | 1.4 | 2.7E−05 | 2.2E−06 | 1.4 | 8.4E−04 | 9.1E−05 | 3.0E−03 |
| S100A12 | 1.7 | 2.8E−05 | 2.4E−06 | 1.7 | 1.0E−03 | 1.4E−04 | 3.0E−03 |
| TFPI | −0.9 | 2.8E−05 | 2.4E−06 | −0.9 | 4.7E−04 | 3.4E−05 | 2.3E−03 |
| SELL | 0.4 | 3.0E−05 | 2.5E−06 | 0.3 | 1.0E−03 | 1.4E−04 | 1.3E−04 |
| TNFSF14 | 1.1 | 3.0E−05 | 2.5E−06 | 1.1 | 6.6E−05 | 1.1E−06 | 2.6E−02 |
| DAPK2 | 0.7 | 3.1E−05 | 2.7E−06 | 0.5 | 1.1E−02 | 2.9E−03 | 3.9E−07 |
| PRKCI | 0.8 | 3.1E−05 | 2.7E−06 | 0.6 | 2.9E−03 | 4.7E−04 | 2.7E−05 |
| CSNK2A1 | 0.3 | 3.2E−05 | 2.9E−06 | 0.3 | 4.9E−04 | 3.7E−05 | 1.5E−04 |
| CLEC1B | 0.7 | 3.4E−05 | 3.0E−06 | 0.5 | 1.2E−03 | 1.6E−04 | 5.2E−02 |
| MAPK13 | 0.6 | 3.5E−05 | 3.1E−06 | 0.4 | 1.5E−02 | 4.3E−03 | 1.3E−03 |
| HMOX2 | 0.6 | 3.5E−05 | 3.2E−06 | 0.5 | 9.2E−03 | 2.2E−03 | 6.2E−06 |
| MATN3 | 0.5 | 3.7E−05 | 3.4E−06 | 0.5 | 4.5E−04 | 2.9E−05 | 6.2E−06 |
| UBE2N | 1.4 | 3.9E−05 | 3.6E−06 | 1.4 | 1.4E−03 | 2.0E−04 | 1.0E−02 |
| CFL1 | 0.9 | 4.1E−05 | 3.8E−06 | 0.8 | 2.9E−03 | 4.7E−04 | 1.3E−03 |
| RBM39 | 1.3 | 4.1E−05 | 3.8E−06 | 1.1 | 1.3E−02 | 3.5E−03 | 3.4E−04 |
| LGALS3 | −0.4 | 4.5E−05 | 4.3E−06 | −0.3 | 6.2E−03 | 1.3E−03 | 9.5E−03 |
| UFM1 | 1.2 | 4.5E−05 | 4.3E−06 | 1.2 | 6.5E−04 | 6.0E−05 | 2.1E−03 |
| DSC2 | −0.4 | 4.7E−05 | 4.6E−06 | −0.3 | 1.3E−02 | 3.5E−03 | 6.8E−04 |
| PAFAH1B2 | 1.0 | 4.7E−05 | 4.6E−06 | 1.0 | 1.0E−03 | 1.4E−04 | 4.9E−05 |
| TP53 | 0.7 | 4.9E−05 | 4.9E−06 | 0.5 | 9.2E−04 | 1.0E−04 | 5.0E−03 |
| BMPER | 0.4 | 5.4E−05 | 5.5E−06 | 0.5 | 7.1E−05 | 1.7E−06 | 6.1E−04 |
| EFNB2 | −0.5 | 5.4E−05 | 5.5E−06 | −0.4 | 4.1E−03 | 7.5E−04 | 3.8E−02 |
| IDUA | 0.7 | 6.0E−05 | 6.2E−06 | 0.7 | 2.3E−04 | 9.7E−06 | 1.1E−03 |
| SFRP1 | −1.0 | 6.0E−05 | 6.2E−06 | −1.0 | 4.7E−04 | 3.4E−05 | 3.0E−02 |
| BMP6 | −1.1 | 6.3E−05 | 6.5E−06 | −0.9 | 2.6E−03 | 4.2E−04 | 1.8E−03 |
| LYN (Duplicate 2/2) | 1.5 | 6.3E−05 | 6.5E−06 | 1.0 | 1.5E−02 | 4.3E−03 | 9.4E−05 |
| CA13 | 2.1 | 6.5E−05 | 6.9E−06 | 2.2 | 2.2E−04 | 8.2E−06 | 5.3E−02 |
| RAC3 | 0.9 | 6.5E−05 | 6.9E−06 | 0.9 | 1.4E−03 | 2.0E−04 | 9.4E−06 |
| TKT | 1.2 | 6.5E−05 | 6.9E−06 | 1.2 | 1.6E−03 | 2.3E−04 | 6.3E−03 |
| NCK1 | 0.5 | 6.8E−05 | 7.3E−06 | 0.4 | 1.5E−02 | 4.3E−03 | 1.1E−01 |
| MDM2 | 0.3 | 7.1E−05 | 7.8E−06 | 0.3 | 3.8E−04 | 2.3E−05 | 2.4E−04 |
| SIGLEC7 | −0.4 | 7.2E−05 | 8.0E−06 | −0.4 | 3.6E−04 | 2.1E−05 | 1.3E−01 |
| TGFB3 | 0.4 | 7.2E−05 | 8.0E−06 | 0.5 | 3.6E−04 | 2.1E−05 | 9.9E−04 |
| PLXNB2 | −0.5 | 7.3E−05 | 8.2E−06 | −0.3 | 4.2E−02 | 1.5E−02 | 4.1E−03 |
| RPS27A | 1.3 | 7.3E−05 | 8.2E−06 | 1.2 | 3.4E−03 | 6.0E−04 | 3.0E−03 |
| BCL2 | 0.6 | 7.5E−05 | 8.7E−06 | 0.6 | 8.4E−04 | 9.1E−05 | 1.9E−05 |
| CASP3 | 1.0 | 7.5E−05 | 8.7E−06 | 0.8 | 2.4E−03 | 3.7E−04 | 2.0E−04 |
| COL23A1 | 0.4 | 7.5E−05 | 8.7E−06 | 0.6 | 5.7E−05 | 2.6E−07 | 4.4E−02 |
| F2 (Duplicate 1/2) | −0.9 | 7.5E−05 | 8.7E−06 | −0.9 | 4.9E−04 | 3.9E−05 | 1.3E−04 |
| DSG2 | −0.5 | 7.8E−05 | 9.2E−06 | −0.5 | 2.5E−04 | 1.1E−05 | 4.3E−04 |
| HK2 | 1.7 | 7.8E−05 | 9.2E−06 | 1.4 | 9.2E−03 | 2.2E−03 | 6.7E−06 |
| PTPN1 | 0.8 | 7.8E−05 | 9.2E−06 | 0.5 | 4.8E−03 | 9.3E−04 | 6.8E−03 |
| CHST2 | 0.5 | 8.0E−05 | 9.8E−06 | 0.5 | 1.0E−03 | 1.4E−04 | 3.5E−05 |
| CLEC7A | 0.3 | 8.0E−05 | 9.8E−06 | 0.3 | 6.9E−05 | 1.4E−06 | 1.1E−03 |
| F2 (Duplicate 2/2) | −1.1 | 8.0E−05 | 9.8E−06 | −1.1 | 7.7E−04 | 7.9E−05 | 2.9E−03 |
| PPIA | 0.9 | 8.0E−05 | 9.8E−06 | 0.8 | 3.4E−03 | 6.0E−04 | 3.5E−02 |
| DNAJB1 | 0.3 | 8.4E−05 | 1.0E−05 | 0.2 | 6.9E−03 | 1.5E−03 | 6.7E−06 |
| IL3 | 0.5 | 8.8E−05 | 1.1E−05 | 0.4 | 2.9E−03 | 4.7E−04 | 8.2E−01 |
| SLAMF7 | −0.8 | 8.8E−05 | 1.1E−05 | −0.9 | 2.3E−04 | 9.7E−06 | 3.0E−02 |
| ACP1 | 1.4 | 9.2E−05 | 1.2E−05 | 1.3 | 1.2E−03 | 1.6E−04 | 3.5E−04 |
| SELP | 1.0 | 9.7E−05 | 1.2E−05 | 1.0 | 4.7E−04 | 3.4E−05 | 2.0E−01 |
LogFC is log fold change, FDR is false discovery rate.
Proteins dysregulated in the serum of patients versus controls (unmatched and matched)
| . | Unmatched KLS (n = 20); controls (n = 54) . | Matched KLS (n = 20); controls (n = 20) . | Association with time of collection . | ||||
|---|---|---|---|---|---|---|---|
| Protein . | logFC . | FDR . | p . | logFC . | FDR . | p . | FDR . |
| FYN | 2.5 | 1.3E−06 | 1.2E−09 | 2.3 | 1.7E−05 | 3.0E−08 | 8.0E−05 |
| CSK | 2.7 | 5.4E−06 | 1.8E−08 | 2.3 | 6.0E−05 | 7.6E−07 | 2.7E−04 |
| DUSP3 | 2.0 | 5.4E−06 | 2.5E−08 | 1.9 | 6.0E−05 | 9.3E−07 | 3.6E−04 |
| HIST3H2A | 3.4 | 5.4E−06 | 1.9E−08 | 3.4 | 1.8E−04 | 5.8E−06 | 6.9E−04 |
| METAP1 | 2.3 | 5.4E−06 | 2.2E−08 | 2.2 | 1.9E−05 | 5.1E−08 | 3.6E−03 |
| PTPN11 | 1.9 | 5.4E−06 | 2.9E−08 | 1.7 | 7.4E−05 | 2.0E−06 | 4.1E−05 |
| TBP | 0.7 | 5.7E−06 | 3.6E−08 | 0.6 | 2.8E−04 | 1.6E−05 | 7.3E−07 |
| BTK | 1.9 | 6.1E−06 | 7.7E−08 | 1.7 | 6.0E−05 | 9.3E−07 | 7.3E−03 |
| EIF4G2 | 2.4 | 6.1E−06 | 8.8E−08 | 2.4 | 5.7E−05 | 4.1E−07 | 4.9E−03 |
| ENPP7 | −1.6 | 6.1E−06 | 7.2E−08 | −1.2 | 4.5E−04 | 2.9E−05 | 4.7E−04 |
| HIST1H1C | 2.7 | 6.1E−06 | 6.3E−08 | 2.5 | 7.4E−05 | 2.0E−06 | 8.1E−05 |
| HSD17B1 | 0.8 | 6.1E−06 | 8.8E−08 | 0.7 | 2.5E−04 | 1.1E−05 | 7.3E−07 |
| ICOSLG | 2.8 | 6.1E−06 | 5.8E−08 | 2.5 | 2.0E−04 | 6.9E−06 | 3.1E−05 |
| PTPN6 | 1.9 | 6.1E−06 | 8.2E−08 | 1.5 | 1.0E−03 | 1.4E−04 | 1.4E−05 |
| TPT1 | 1.9 | 6.1E−06 | 5.8E−08 | 1.9 | 6.9E−05 | 1.4E−06 | 7.3E−03 |
| VTA1 | 2.4 | 6.1E−06 | 7.2E−08 | 2.0 | 1.4E−04 | 4.1E−06 | 3.6E−04 |
| AIF1 | 0.9 | 6.2E−06 | 9.5E−08 | 0.7 | 1.0E−03 | 1.2E−04 | 5.8E−06 |
| TIMP2 | 0.6 | 6.5E−06 | 1.1E−07 | 0.6 | 6.0E−05 | 8.5E−07 | 7.6E−04 |
| AKT2 | 1.4 | 7.2E−06 | 1.5E−07 | 1.4 | 6.0E−05 | 7.6E−07 | 6.3E−06 |
| CD226 | 0.9 | 7.2E−06 | 1.4E−07 | 1.0 | 2.3E−04 | 8.6E−06 | 6.0E−02 |
| CMA1 | 0.8 | 7.2E−06 | 1.6E−07 | 0.8 | 2.8E−04 | 1.6E−05 | 7.3E−07 |
| PRKAA2 PRKAB2 PRKAG1 | 1.2 | 7.2E−06 | 1.5E−07 | 1.1 | 2.3E−04 | 9.7E−06 | 6.3E−06 |
| TOP1 | 1.1 | 7.2E−06 | 1.6E−07 | 1.1 | 2.5E−04 | 1.1E−05 | 3.6E−06 |
| TPM4 | 2.2 | 7.2E−06 | 1.6E−07 | 2.1 | 6.6E−05 | 1.1E−06 | 1.3E−02 |
| VAV1 | 2.2 | 7.2E−06 | 1.2E−07 | 1.8 | 8.4E−04 | 9.1E−05 | 2.5E−03 |
| EFNB3 | 0.4 | 7.4E−06 | 2.1E−07 | 0.4 | 6.0E−05 | 9.3E−07 | 1.3E−04 |
| EPS15L1 | 1.2 | 7.4E−06 | 1.7E−07 | 1.3 | 6.0E−05 | 7.6E−07 | 7.7E−03 |
| FER | 2.4 | 7.4E−06 | 2.1E−07 | 2.5 | 6.0E−05 | 9.3E−07 | 1.2E−02 |
| IL13RA1 | −0.8 | 7.4E−06 | 2.1E−07 | −0.6 | 4.9E−04 | 3.9E−05 | 1.8E−03 |
| IL16 | 0.7 | 7.4E−06 | 2.0E−07 | 0.5 | 7.0E−04 | 6.9E−05 | 1.9E−06 |
| IL1R1 | −0.9 | 7.4E−06 | 2.1E−07 | −0.8 | 2.3E−04 | 9.7E−06 | 1.4E−03 |
| SFTPD | 3.0 | 7.4E−06 | 1.9E−07 | 3.0 | 2.2E−03 | 3.3E−04 | 6.0E−05 |
| CEBPB | 0.8 | 7.4E−06 | 2.3E−07 | 0.7 | 2.6E−04 | 1.3E−05 | 4.4E−05 |
| STAT6 | 0.8 | 7.4E−06 | 2.3E−07 | 0.7 | 4.9E−04 | 3.7E−05 | 1.4E−05 |
| STIP1 | 1.6 | 7.7E−06 | 2.4E−07 | 1.4 | 5.9E−04 | 5.2E−05 | 5.1E−05 |
| CAMK2A | 1.2 | 7.8E−06 | 2.6E−07 | 1.1 | 4.7E−04 | 3.4E−05 | 1.1E−06 |
| RPS6KA3 | 1.4 | 7.8E−06 | 2.6E−07 | 1.3 | 5.9E−04 | 5.2E−05 | 4.1E−04 |
| UBE2I | 1.5 | 8.6E−06 | 3.0E−07 | 1.4 | 7.7E−04 | 7.9E−05 | 1.9E−03 |
| HNRNPAB | 2.0 | 9.0E−06 | 3.2E−07 | 1.8 | 4.7E−04 | 3.4E−05 | 8.5E−06 |
| CTSG | 0.8 | 9.1E−06 | 3.4E−07 | 0.7 | 2.6E−04 | 1.3E−05 | 1.9E−05 |
| SUMO3 | 1.6 | 9.1E−06 | 3.4E−07 | 1.4 | 4.0E−04 | 2.5E−05 | 1.0E−02 |
| HMGB1 | 1.1 | 9.7E−06 | 3.8E−07 | 1.0 | 8.4E−04 | 9.1E−05 | 2.3E−07 |
| IDS | −0.9 | 9.7E−06 | 4.1E−07 | −0.7 | 7.0E−04 | 6.9E−05 | 7.2E−03 |
| MAPK14 | 0.9 | 9.7E−06 | 4.1E−07 | 0.9 | 1.0E−03 | 1.2E−04 | 7.5E−05 |
| NUDCD3 | 1.1 | 9.7E−06 | 4.1E−07 | 1.2 | 7.1E−05 | 1.7E−06 | 1.1E−02 |
| TEC | 0.8 | 9.7E−06 | 3.8E−07 | 0.8 | 7.1E−05 | 1.7E−06 | 1.1E−02 |
| TIE1 | −0.4 | 9.7E−06 | 4.1E−07 | −0.4 | 3.6E−04 | 2.1E−05 | 3.1E−02 |
| PRKCD | 0.5 | 1.0E−05 | 4.4E−07 | 0.4 | 5.9E−04 | 5.2E−05 | 1.4E−05 |
| GFRA3 | 0.4 | 1.1E−05 | 4.7E−07 | 0.4 | 2.6E−04 | 1.3E−05 | 9.7E−06 |
| CAMK2B | 1.6 | 1.1E−05 | 5.3E−07 | 1.3 | 1.0E−03 | 1.4E−04 | 1.2E−06 |
| CAMK2D | 1.6 | 1.1E−05 | 5.3E−07 | 1.4 | 6.5E−04 | 6.0E−05 | 1.2E−06 |
| CDH1 | −0.6 | 1.1E−05 | 5.3E−07 | −0.5 | 2.5E−04 | 1.1E−05 | 5.1E−05 |
| KAT6A | 0.4 | 1.1E−05 | 5.0E−07 | 0.4 | 8.6E−05 | 2.4E−06 | 3.1E−06 |
| LBP | −0.9 | 1.1E−05 | 5.3E−07 | −0.8 | 2.8E−04 | 1.6E−05 | 1.5E−02 |
| MMP17 | 0.8 | 1.1E−05 | 5.3E−07 | 0.7 | 2.2E−04 | 8.2E−06 | 1.6E−05 |
| CCL13 | 0.7 | 1.1E−05 | 5.6E−07 | 0.7 | 7.4E−05 | 2.0E−06 | 1.1E−03 |
| DDX19B | 1.4 | 1.1E−05 | 5.6E−07 | 1.2 | 1.0E−03 | 1.2E−04 | 9.6E−04 |
| XRCC6 | 1.3 | 1.1E−05 | 5.6E−07 | 1.0 | 6.7E−03 | 1.4E−03 | 3.6E−07 |
| CYP3A4 | 0.8 | 1.1E−05 | 6.0E−07 | 0.7 | 7.0E−04 | 6.9E−05 | 1.8E−03 |
| HNRNPA2B1 | 2.0 | 1.2E−05 | 6.4E−07 | 1.9 | 2.4E−03 | 3.7E−04 | 8.0E−05 |
| GDF15 | −0.6 | 1.2E−05 | 6.6E−07 | −0.4 | 1.3E−03 | 1.7E−04 | 1.2E−01 |
| TAGLN2 | 1.5 | 1.2E−05 | 6.8E−07 | 1.6 | 5.7E−05 | 4.1E−07 | 1.2E−02 |
| CXCL8 | 3.4 | 1.3E−05 | 7.3E−07 | 3.9 | 5.7E−05 | 3.3E−07 | 7.6E−02 |
| CLIC1 | 1.0 | 1.5E−05 | 8.8E−07 | 0.8 | 4.9E−04 | 3.9E−05 | 6.3E−06 |
| SNX4 | 1.0 | 1.6E−05 | 9.4E−07 | 0.8 | 7.7E−04 | 7.9E−05 | 2.6E−04 |
| YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ SFN | 0.9 | 1.6E−05 | 9.4E−07 | 0.8 | 2.8E−04 | 1.6E−05 | 2.2E−05 |
| IMPDH1 | 2.1 | 1.7E−05 | 1.0E−06 | 2.0 | 2.6E−03 | 4.2E−04 | 4.2E−05 |
| H2AFZ | 2.3 | 1.7E−05 | 1.1E−06 | 2.2 | 4.7E−04 | 3.4E−05 | 6.3E−06 |
| IGF1 | 0.5 | 1.7E−05 | 1.1E−06 | 0.6 | 3.7E−05 | 1.3E−07 | 9.3E−03 |
| PRKCZ | 0.7 | 1.8E−05 | 1.1E−06 | 0.6 | 9.2E−04 | 1.0E−04 | 1.4E−05 |
| LAMA1 LAMB1 LAMC1 | −0.5 | 1.8E−05 | 1.2E−06 | −0.5 | 3.2E−04 | 1.8E−05 | 2.2E−02 |
| LYN (Duplicate 1/2) | 1.6 | 1.8E−05 | 1.2E−06 | 1.2 | 2.4E−03 | 3.7E−04 | 2.0E−05 |
| SBDS | 1.3 | 1.8E−05 | 1.2E−06 | 1.1 | 4.0E−04 | 2.5E−05 | 7.5E−05 |
| BPI | 2.4 | 1.9E−05 | 1.3E−06 | 2.7 | 6.9E−05 | 1.4E−06 | 6.4E−02 |
| NAGK | 1.1 | 1.9E−05 | 1.3E−06 | 1.0 | 9.2E−04 | 1.0E−04 | 1.9E−06 |
| RPS7 | 1.4 | 1.9E−05 | 1.3E−06 | 1.2 | 4.8E−03 | 9.3E−04 | 1.2E−05 |
| FCGR1A | 0.5 | 1.9E−05 | 1.4E−06 | 0.5 | 5.1E−04 | 4.2E−05 | 2.3E−04 |
| FSTL3 | −0.5 | 1.9E−05 | 1.4E−06 | −0.4 | 6.2E−03 | 1.3E−03 | 4.2E−02 |
| SSRP1 | 0.8 | 1.9E−05 | 1.4E−06 | 0.7 | 1.3E−03 | 1.8E−04 | 1.3E−04 |
| EIF4A3 | 0.4 | 2.1E−05 | 1.6E−06 | 0.4 | 1.0E−03 | 1.2E−04 | 1.9E−05 |
| PDPK1 | 1.9 | 2.1E−05 | 1.6E−06 | 1.4 | 1.1E−02 | 2.9E−03 | 2.2E−04 |
| CTSE | 0.4 | 2.2E−05 | 1.6E−06 | 0.5 | 1.8E−04 | 5.8E−06 | 2.3E−02 |
| PRSS2 | −0.9 | 2.2E−05 | 1.6E−06 | −0.7 | 3.2E−03 | 5.3E−04 | 4.1E−02 |
| ESR1 | 0.5 | 2.3E−05 | 1.8E−06 | 0.5 | 2.2E−04 | 8.2E−06 | 5.9E−05 |
| PDXK | 1.1 | 2.3E−05 | 1.8E−06 | 0.9 | 4.8E−03 | 9.3E−04 | 2.8E−05 |
| INSR | −0.6 | 2.5E−05 | 2.0E−06 | −0.4 | 4.5E−03 | 8.4E−04 | 6.1E−02 |
| TNFRSF25 | −0.7 | 2.5E−05 | 2.0E−06 | −0.6 | 2.0E−03 | 2.9E−04 | 2.1E−03 |
| HDGFRP2 | 0.3 | 2.7E−05 | 2.1E−06 | 0.2 | 6.2E−03 | 1.3E−03 | 7.3E−07 |
| MAPK12 | 0.5 | 2.7E−05 | 2.2E−06 | 0.6 | 2.3E−04 | 9.7E−06 | 3.8E−03 |
| LCK | 0.4 | 2.7E−05 | 2.2E−06 | 0.3 | 1.1E−02 | 2.9E−03 | 7.3E−07 |
| TPI1 | 1.4 | 2.7E−05 | 2.2E−06 | 1.4 | 8.4E−04 | 9.1E−05 | 3.0E−03 |
| S100A12 | 1.7 | 2.8E−05 | 2.4E−06 | 1.7 | 1.0E−03 | 1.4E−04 | 3.0E−03 |
| TFPI | −0.9 | 2.8E−05 | 2.4E−06 | −0.9 | 4.7E−04 | 3.4E−05 | 2.3E−03 |
| SELL | 0.4 | 3.0E−05 | 2.5E−06 | 0.3 | 1.0E−03 | 1.4E−04 | 1.3E−04 |
| TNFSF14 | 1.1 | 3.0E−05 | 2.5E−06 | 1.1 | 6.6E−05 | 1.1E−06 | 2.6E−02 |
| DAPK2 | 0.7 | 3.1E−05 | 2.7E−06 | 0.5 | 1.1E−02 | 2.9E−03 | 3.9E−07 |
| PRKCI | 0.8 | 3.1E−05 | 2.7E−06 | 0.6 | 2.9E−03 | 4.7E−04 | 2.7E−05 |
| CSNK2A1 | 0.3 | 3.2E−05 | 2.9E−06 | 0.3 | 4.9E−04 | 3.7E−05 | 1.5E−04 |
| CLEC1B | 0.7 | 3.4E−05 | 3.0E−06 | 0.5 | 1.2E−03 | 1.6E−04 | 5.2E−02 |
| MAPK13 | 0.6 | 3.5E−05 | 3.1E−06 | 0.4 | 1.5E−02 | 4.3E−03 | 1.3E−03 |
| HMOX2 | 0.6 | 3.5E−05 | 3.2E−06 | 0.5 | 9.2E−03 | 2.2E−03 | 6.2E−06 |
| MATN3 | 0.5 | 3.7E−05 | 3.4E−06 | 0.5 | 4.5E−04 | 2.9E−05 | 6.2E−06 |
| UBE2N | 1.4 | 3.9E−05 | 3.6E−06 | 1.4 | 1.4E−03 | 2.0E−04 | 1.0E−02 |
| CFL1 | 0.9 | 4.1E−05 | 3.8E−06 | 0.8 | 2.9E−03 | 4.7E−04 | 1.3E−03 |
| RBM39 | 1.3 | 4.1E−05 | 3.8E−06 | 1.1 | 1.3E−02 | 3.5E−03 | 3.4E−04 |
| LGALS3 | −0.4 | 4.5E−05 | 4.3E−06 | −0.3 | 6.2E−03 | 1.3E−03 | 9.5E−03 |
| UFM1 | 1.2 | 4.5E−05 | 4.3E−06 | 1.2 | 6.5E−04 | 6.0E−05 | 2.1E−03 |
| DSC2 | −0.4 | 4.7E−05 | 4.6E−06 | −0.3 | 1.3E−02 | 3.5E−03 | 6.8E−04 |
| PAFAH1B2 | 1.0 | 4.7E−05 | 4.6E−06 | 1.0 | 1.0E−03 | 1.4E−04 | 4.9E−05 |
| TP53 | 0.7 | 4.9E−05 | 4.9E−06 | 0.5 | 9.2E−04 | 1.0E−04 | 5.0E−03 |
| BMPER | 0.4 | 5.4E−05 | 5.5E−06 | 0.5 | 7.1E−05 | 1.7E−06 | 6.1E−04 |
| EFNB2 | −0.5 | 5.4E−05 | 5.5E−06 | −0.4 | 4.1E−03 | 7.5E−04 | 3.8E−02 |
| IDUA | 0.7 | 6.0E−05 | 6.2E−06 | 0.7 | 2.3E−04 | 9.7E−06 | 1.1E−03 |
| SFRP1 | −1.0 | 6.0E−05 | 6.2E−06 | −1.0 | 4.7E−04 | 3.4E−05 | 3.0E−02 |
| BMP6 | −1.1 | 6.3E−05 | 6.5E−06 | −0.9 | 2.6E−03 | 4.2E−04 | 1.8E−03 |
| LYN (Duplicate 2/2) | 1.5 | 6.3E−05 | 6.5E−06 | 1.0 | 1.5E−02 | 4.3E−03 | 9.4E−05 |
| CA13 | 2.1 | 6.5E−05 | 6.9E−06 | 2.2 | 2.2E−04 | 8.2E−06 | 5.3E−02 |
| RAC3 | 0.9 | 6.5E−05 | 6.9E−06 | 0.9 | 1.4E−03 | 2.0E−04 | 9.4E−06 |
| TKT | 1.2 | 6.5E−05 | 6.9E−06 | 1.2 | 1.6E−03 | 2.3E−04 | 6.3E−03 |
| NCK1 | 0.5 | 6.8E−05 | 7.3E−06 | 0.4 | 1.5E−02 | 4.3E−03 | 1.1E−01 |
| MDM2 | 0.3 | 7.1E−05 | 7.8E−06 | 0.3 | 3.8E−04 | 2.3E−05 | 2.4E−04 |
| SIGLEC7 | −0.4 | 7.2E−05 | 8.0E−06 | −0.4 | 3.6E−04 | 2.1E−05 | 1.3E−01 |
| TGFB3 | 0.4 | 7.2E−05 | 8.0E−06 | 0.5 | 3.6E−04 | 2.1E−05 | 9.9E−04 |
| PLXNB2 | −0.5 | 7.3E−05 | 8.2E−06 | −0.3 | 4.2E−02 | 1.5E−02 | 4.1E−03 |
| RPS27A | 1.3 | 7.3E−05 | 8.2E−06 | 1.2 | 3.4E−03 | 6.0E−04 | 3.0E−03 |
| BCL2 | 0.6 | 7.5E−05 | 8.7E−06 | 0.6 | 8.4E−04 | 9.1E−05 | 1.9E−05 |
| CASP3 | 1.0 | 7.5E−05 | 8.7E−06 | 0.8 | 2.4E−03 | 3.7E−04 | 2.0E−04 |
| COL23A1 | 0.4 | 7.5E−05 | 8.7E−06 | 0.6 | 5.7E−05 | 2.6E−07 | 4.4E−02 |
| F2 (Duplicate 1/2) | −0.9 | 7.5E−05 | 8.7E−06 | −0.9 | 4.9E−04 | 3.9E−05 | 1.3E−04 |
| DSG2 | −0.5 | 7.8E−05 | 9.2E−06 | −0.5 | 2.5E−04 | 1.1E−05 | 4.3E−04 |
| HK2 | 1.7 | 7.8E−05 | 9.2E−06 | 1.4 | 9.2E−03 | 2.2E−03 | 6.7E−06 |
| PTPN1 | 0.8 | 7.8E−05 | 9.2E−06 | 0.5 | 4.8E−03 | 9.3E−04 | 6.8E−03 |
| CHST2 | 0.5 | 8.0E−05 | 9.8E−06 | 0.5 | 1.0E−03 | 1.4E−04 | 3.5E−05 |
| CLEC7A | 0.3 | 8.0E−05 | 9.8E−06 | 0.3 | 6.9E−05 | 1.4E−06 | 1.1E−03 |
| F2 (Duplicate 2/2) | −1.1 | 8.0E−05 | 9.8E−06 | −1.1 | 7.7E−04 | 7.9E−05 | 2.9E−03 |
| PPIA | 0.9 | 8.0E−05 | 9.8E−06 | 0.8 | 3.4E−03 | 6.0E−04 | 3.5E−02 |
| DNAJB1 | 0.3 | 8.4E−05 | 1.0E−05 | 0.2 | 6.9E−03 | 1.5E−03 | 6.7E−06 |
| IL3 | 0.5 | 8.8E−05 | 1.1E−05 | 0.4 | 2.9E−03 | 4.7E−04 | 8.2E−01 |
| SLAMF7 | −0.8 | 8.8E−05 | 1.1E−05 | −0.9 | 2.3E−04 | 9.7E−06 | 3.0E−02 |
| ACP1 | 1.4 | 9.2E−05 | 1.2E−05 | 1.3 | 1.2E−03 | 1.6E−04 | 3.5E−04 |
| SELP | 1.0 | 9.7E−05 | 1.2E−05 | 1.0 | 4.7E−04 | 3.4E−05 | 2.0E−01 |
| . | Unmatched KLS (n = 20); controls (n = 54) . | Matched KLS (n = 20); controls (n = 20) . | Association with time of collection . | ||||
|---|---|---|---|---|---|---|---|
| Protein . | logFC . | FDR . | p . | logFC . | FDR . | p . | FDR . |
| FYN | 2.5 | 1.3E−06 | 1.2E−09 | 2.3 | 1.7E−05 | 3.0E−08 | 8.0E−05 |
| CSK | 2.7 | 5.4E−06 | 1.8E−08 | 2.3 | 6.0E−05 | 7.6E−07 | 2.7E−04 |
| DUSP3 | 2.0 | 5.4E−06 | 2.5E−08 | 1.9 | 6.0E−05 | 9.3E−07 | 3.6E−04 |
| HIST3H2A | 3.4 | 5.4E−06 | 1.9E−08 | 3.4 | 1.8E−04 | 5.8E−06 | 6.9E−04 |
| METAP1 | 2.3 | 5.4E−06 | 2.2E−08 | 2.2 | 1.9E−05 | 5.1E−08 | 3.6E−03 |
| PTPN11 | 1.9 | 5.4E−06 | 2.9E−08 | 1.7 | 7.4E−05 | 2.0E−06 | 4.1E−05 |
| TBP | 0.7 | 5.7E−06 | 3.6E−08 | 0.6 | 2.8E−04 | 1.6E−05 | 7.3E−07 |
| BTK | 1.9 | 6.1E−06 | 7.7E−08 | 1.7 | 6.0E−05 | 9.3E−07 | 7.3E−03 |
| EIF4G2 | 2.4 | 6.1E−06 | 8.8E−08 | 2.4 | 5.7E−05 | 4.1E−07 | 4.9E−03 |
| ENPP7 | −1.6 | 6.1E−06 | 7.2E−08 | −1.2 | 4.5E−04 | 2.9E−05 | 4.7E−04 |
| HIST1H1C | 2.7 | 6.1E−06 | 6.3E−08 | 2.5 | 7.4E−05 | 2.0E−06 | 8.1E−05 |
| HSD17B1 | 0.8 | 6.1E−06 | 8.8E−08 | 0.7 | 2.5E−04 | 1.1E−05 | 7.3E−07 |
| ICOSLG | 2.8 | 6.1E−06 | 5.8E−08 | 2.5 | 2.0E−04 | 6.9E−06 | 3.1E−05 |
| PTPN6 | 1.9 | 6.1E−06 | 8.2E−08 | 1.5 | 1.0E−03 | 1.4E−04 | 1.4E−05 |
| TPT1 | 1.9 | 6.1E−06 | 5.8E−08 | 1.9 | 6.9E−05 | 1.4E−06 | 7.3E−03 |
| VTA1 | 2.4 | 6.1E−06 | 7.2E−08 | 2.0 | 1.4E−04 | 4.1E−06 | 3.6E−04 |
| AIF1 | 0.9 | 6.2E−06 | 9.5E−08 | 0.7 | 1.0E−03 | 1.2E−04 | 5.8E−06 |
| TIMP2 | 0.6 | 6.5E−06 | 1.1E−07 | 0.6 | 6.0E−05 | 8.5E−07 | 7.6E−04 |
| AKT2 | 1.4 | 7.2E−06 | 1.5E−07 | 1.4 | 6.0E−05 | 7.6E−07 | 6.3E−06 |
| CD226 | 0.9 | 7.2E−06 | 1.4E−07 | 1.0 | 2.3E−04 | 8.6E−06 | 6.0E−02 |
| CMA1 | 0.8 | 7.2E−06 | 1.6E−07 | 0.8 | 2.8E−04 | 1.6E−05 | 7.3E−07 |
| PRKAA2 PRKAB2 PRKAG1 | 1.2 | 7.2E−06 | 1.5E−07 | 1.1 | 2.3E−04 | 9.7E−06 | 6.3E−06 |
| TOP1 | 1.1 | 7.2E−06 | 1.6E−07 | 1.1 | 2.5E−04 | 1.1E−05 | 3.6E−06 |
| TPM4 | 2.2 | 7.2E−06 | 1.6E−07 | 2.1 | 6.6E−05 | 1.1E−06 | 1.3E−02 |
| VAV1 | 2.2 | 7.2E−06 | 1.2E−07 | 1.8 | 8.4E−04 | 9.1E−05 | 2.5E−03 |
| EFNB3 | 0.4 | 7.4E−06 | 2.1E−07 | 0.4 | 6.0E−05 | 9.3E−07 | 1.3E−04 |
| EPS15L1 | 1.2 | 7.4E−06 | 1.7E−07 | 1.3 | 6.0E−05 | 7.6E−07 | 7.7E−03 |
| FER | 2.4 | 7.4E−06 | 2.1E−07 | 2.5 | 6.0E−05 | 9.3E−07 | 1.2E−02 |
| IL13RA1 | −0.8 | 7.4E−06 | 2.1E−07 | −0.6 | 4.9E−04 | 3.9E−05 | 1.8E−03 |
| IL16 | 0.7 | 7.4E−06 | 2.0E−07 | 0.5 | 7.0E−04 | 6.9E−05 | 1.9E−06 |
| IL1R1 | −0.9 | 7.4E−06 | 2.1E−07 | −0.8 | 2.3E−04 | 9.7E−06 | 1.4E−03 |
| SFTPD | 3.0 | 7.4E−06 | 1.9E−07 | 3.0 | 2.2E−03 | 3.3E−04 | 6.0E−05 |
| CEBPB | 0.8 | 7.4E−06 | 2.3E−07 | 0.7 | 2.6E−04 | 1.3E−05 | 4.4E−05 |
| STAT6 | 0.8 | 7.4E−06 | 2.3E−07 | 0.7 | 4.9E−04 | 3.7E−05 | 1.4E−05 |
| STIP1 | 1.6 | 7.7E−06 | 2.4E−07 | 1.4 | 5.9E−04 | 5.2E−05 | 5.1E−05 |
| CAMK2A | 1.2 | 7.8E−06 | 2.6E−07 | 1.1 | 4.7E−04 | 3.4E−05 | 1.1E−06 |
| RPS6KA3 | 1.4 | 7.8E−06 | 2.6E−07 | 1.3 | 5.9E−04 | 5.2E−05 | 4.1E−04 |
| UBE2I | 1.5 | 8.6E−06 | 3.0E−07 | 1.4 | 7.7E−04 | 7.9E−05 | 1.9E−03 |
| HNRNPAB | 2.0 | 9.0E−06 | 3.2E−07 | 1.8 | 4.7E−04 | 3.4E−05 | 8.5E−06 |
| CTSG | 0.8 | 9.1E−06 | 3.4E−07 | 0.7 | 2.6E−04 | 1.3E−05 | 1.9E−05 |
| SUMO3 | 1.6 | 9.1E−06 | 3.4E−07 | 1.4 | 4.0E−04 | 2.5E−05 | 1.0E−02 |
| HMGB1 | 1.1 | 9.7E−06 | 3.8E−07 | 1.0 | 8.4E−04 | 9.1E−05 | 2.3E−07 |
| IDS | −0.9 | 9.7E−06 | 4.1E−07 | −0.7 | 7.0E−04 | 6.9E−05 | 7.2E−03 |
| MAPK14 | 0.9 | 9.7E−06 | 4.1E−07 | 0.9 | 1.0E−03 | 1.2E−04 | 7.5E−05 |
| NUDCD3 | 1.1 | 9.7E−06 | 4.1E−07 | 1.2 | 7.1E−05 | 1.7E−06 | 1.1E−02 |
| TEC | 0.8 | 9.7E−06 | 3.8E−07 | 0.8 | 7.1E−05 | 1.7E−06 | 1.1E−02 |
| TIE1 | −0.4 | 9.7E−06 | 4.1E−07 | −0.4 | 3.6E−04 | 2.1E−05 | 3.1E−02 |
| PRKCD | 0.5 | 1.0E−05 | 4.4E−07 | 0.4 | 5.9E−04 | 5.2E−05 | 1.4E−05 |
| GFRA3 | 0.4 | 1.1E−05 | 4.7E−07 | 0.4 | 2.6E−04 | 1.3E−05 | 9.7E−06 |
| CAMK2B | 1.6 | 1.1E−05 | 5.3E−07 | 1.3 | 1.0E−03 | 1.4E−04 | 1.2E−06 |
| CAMK2D | 1.6 | 1.1E−05 | 5.3E−07 | 1.4 | 6.5E−04 | 6.0E−05 | 1.2E−06 |
| CDH1 | −0.6 | 1.1E−05 | 5.3E−07 | −0.5 | 2.5E−04 | 1.1E−05 | 5.1E−05 |
| KAT6A | 0.4 | 1.1E−05 | 5.0E−07 | 0.4 | 8.6E−05 | 2.4E−06 | 3.1E−06 |
| LBP | −0.9 | 1.1E−05 | 5.3E−07 | −0.8 | 2.8E−04 | 1.6E−05 | 1.5E−02 |
| MMP17 | 0.8 | 1.1E−05 | 5.3E−07 | 0.7 | 2.2E−04 | 8.2E−06 | 1.6E−05 |
| CCL13 | 0.7 | 1.1E−05 | 5.6E−07 | 0.7 | 7.4E−05 | 2.0E−06 | 1.1E−03 |
| DDX19B | 1.4 | 1.1E−05 | 5.6E−07 | 1.2 | 1.0E−03 | 1.2E−04 | 9.6E−04 |
| XRCC6 | 1.3 | 1.1E−05 | 5.6E−07 | 1.0 | 6.7E−03 | 1.4E−03 | 3.6E−07 |
| CYP3A4 | 0.8 | 1.1E−05 | 6.0E−07 | 0.7 | 7.0E−04 | 6.9E−05 | 1.8E−03 |
| HNRNPA2B1 | 2.0 | 1.2E−05 | 6.4E−07 | 1.9 | 2.4E−03 | 3.7E−04 | 8.0E−05 |
| GDF15 | −0.6 | 1.2E−05 | 6.6E−07 | −0.4 | 1.3E−03 | 1.7E−04 | 1.2E−01 |
| TAGLN2 | 1.5 | 1.2E−05 | 6.8E−07 | 1.6 | 5.7E−05 | 4.1E−07 | 1.2E−02 |
| CXCL8 | 3.4 | 1.3E−05 | 7.3E−07 | 3.9 | 5.7E−05 | 3.3E−07 | 7.6E−02 |
| CLIC1 | 1.0 | 1.5E−05 | 8.8E−07 | 0.8 | 4.9E−04 | 3.9E−05 | 6.3E−06 |
| SNX4 | 1.0 | 1.6E−05 | 9.4E−07 | 0.8 | 7.7E−04 | 7.9E−05 | 2.6E−04 |
| YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ SFN | 0.9 | 1.6E−05 | 9.4E−07 | 0.8 | 2.8E−04 | 1.6E−05 | 2.2E−05 |
| IMPDH1 | 2.1 | 1.7E−05 | 1.0E−06 | 2.0 | 2.6E−03 | 4.2E−04 | 4.2E−05 |
| H2AFZ | 2.3 | 1.7E−05 | 1.1E−06 | 2.2 | 4.7E−04 | 3.4E−05 | 6.3E−06 |
| IGF1 | 0.5 | 1.7E−05 | 1.1E−06 | 0.6 | 3.7E−05 | 1.3E−07 | 9.3E−03 |
| PRKCZ | 0.7 | 1.8E−05 | 1.1E−06 | 0.6 | 9.2E−04 | 1.0E−04 | 1.4E−05 |
| LAMA1 LAMB1 LAMC1 | −0.5 | 1.8E−05 | 1.2E−06 | −0.5 | 3.2E−04 | 1.8E−05 | 2.2E−02 |
| LYN (Duplicate 1/2) | 1.6 | 1.8E−05 | 1.2E−06 | 1.2 | 2.4E−03 | 3.7E−04 | 2.0E−05 |
| SBDS | 1.3 | 1.8E−05 | 1.2E−06 | 1.1 | 4.0E−04 | 2.5E−05 | 7.5E−05 |
| BPI | 2.4 | 1.9E−05 | 1.3E−06 | 2.7 | 6.9E−05 | 1.4E−06 | 6.4E−02 |
| NAGK | 1.1 | 1.9E−05 | 1.3E−06 | 1.0 | 9.2E−04 | 1.0E−04 | 1.9E−06 |
| RPS7 | 1.4 | 1.9E−05 | 1.3E−06 | 1.2 | 4.8E−03 | 9.3E−04 | 1.2E−05 |
| FCGR1A | 0.5 | 1.9E−05 | 1.4E−06 | 0.5 | 5.1E−04 | 4.2E−05 | 2.3E−04 |
| FSTL3 | −0.5 | 1.9E−05 | 1.4E−06 | −0.4 | 6.2E−03 | 1.3E−03 | 4.2E−02 |
| SSRP1 | 0.8 | 1.9E−05 | 1.4E−06 | 0.7 | 1.3E−03 | 1.8E−04 | 1.3E−04 |
| EIF4A3 | 0.4 | 2.1E−05 | 1.6E−06 | 0.4 | 1.0E−03 | 1.2E−04 | 1.9E−05 |
| PDPK1 | 1.9 | 2.1E−05 | 1.6E−06 | 1.4 | 1.1E−02 | 2.9E−03 | 2.2E−04 |
| CTSE | 0.4 | 2.2E−05 | 1.6E−06 | 0.5 | 1.8E−04 | 5.8E−06 | 2.3E−02 |
| PRSS2 | −0.9 | 2.2E−05 | 1.6E−06 | −0.7 | 3.2E−03 | 5.3E−04 | 4.1E−02 |
| ESR1 | 0.5 | 2.3E−05 | 1.8E−06 | 0.5 | 2.2E−04 | 8.2E−06 | 5.9E−05 |
| PDXK | 1.1 | 2.3E−05 | 1.8E−06 | 0.9 | 4.8E−03 | 9.3E−04 | 2.8E−05 |
| INSR | −0.6 | 2.5E−05 | 2.0E−06 | −0.4 | 4.5E−03 | 8.4E−04 | 6.1E−02 |
| TNFRSF25 | −0.7 | 2.5E−05 | 2.0E−06 | −0.6 | 2.0E−03 | 2.9E−04 | 2.1E−03 |
| HDGFRP2 | 0.3 | 2.7E−05 | 2.1E−06 | 0.2 | 6.2E−03 | 1.3E−03 | 7.3E−07 |
| MAPK12 | 0.5 | 2.7E−05 | 2.2E−06 | 0.6 | 2.3E−04 | 9.7E−06 | 3.8E−03 |
| LCK | 0.4 | 2.7E−05 | 2.2E−06 | 0.3 | 1.1E−02 | 2.9E−03 | 7.3E−07 |
| TPI1 | 1.4 | 2.7E−05 | 2.2E−06 | 1.4 | 8.4E−04 | 9.1E−05 | 3.0E−03 |
| S100A12 | 1.7 | 2.8E−05 | 2.4E−06 | 1.7 | 1.0E−03 | 1.4E−04 | 3.0E−03 |
| TFPI | −0.9 | 2.8E−05 | 2.4E−06 | −0.9 | 4.7E−04 | 3.4E−05 | 2.3E−03 |
| SELL | 0.4 | 3.0E−05 | 2.5E−06 | 0.3 | 1.0E−03 | 1.4E−04 | 1.3E−04 |
| TNFSF14 | 1.1 | 3.0E−05 | 2.5E−06 | 1.1 | 6.6E−05 | 1.1E−06 | 2.6E−02 |
| DAPK2 | 0.7 | 3.1E−05 | 2.7E−06 | 0.5 | 1.1E−02 | 2.9E−03 | 3.9E−07 |
| PRKCI | 0.8 | 3.1E−05 | 2.7E−06 | 0.6 | 2.9E−03 | 4.7E−04 | 2.7E−05 |
| CSNK2A1 | 0.3 | 3.2E−05 | 2.9E−06 | 0.3 | 4.9E−04 | 3.7E−05 | 1.5E−04 |
| CLEC1B | 0.7 | 3.4E−05 | 3.0E−06 | 0.5 | 1.2E−03 | 1.6E−04 | 5.2E−02 |
| MAPK13 | 0.6 | 3.5E−05 | 3.1E−06 | 0.4 | 1.5E−02 | 4.3E−03 | 1.3E−03 |
| HMOX2 | 0.6 | 3.5E−05 | 3.2E−06 | 0.5 | 9.2E−03 | 2.2E−03 | 6.2E−06 |
| MATN3 | 0.5 | 3.7E−05 | 3.4E−06 | 0.5 | 4.5E−04 | 2.9E−05 | 6.2E−06 |
| UBE2N | 1.4 | 3.9E−05 | 3.6E−06 | 1.4 | 1.4E−03 | 2.0E−04 | 1.0E−02 |
| CFL1 | 0.9 | 4.1E−05 | 3.8E−06 | 0.8 | 2.9E−03 | 4.7E−04 | 1.3E−03 |
| RBM39 | 1.3 | 4.1E−05 | 3.8E−06 | 1.1 | 1.3E−02 | 3.5E−03 | 3.4E−04 |
| LGALS3 | −0.4 | 4.5E−05 | 4.3E−06 | −0.3 | 6.2E−03 | 1.3E−03 | 9.5E−03 |
| UFM1 | 1.2 | 4.5E−05 | 4.3E−06 | 1.2 | 6.5E−04 | 6.0E−05 | 2.1E−03 |
| DSC2 | −0.4 | 4.7E−05 | 4.6E−06 | −0.3 | 1.3E−02 | 3.5E−03 | 6.8E−04 |
| PAFAH1B2 | 1.0 | 4.7E−05 | 4.6E−06 | 1.0 | 1.0E−03 | 1.4E−04 | 4.9E−05 |
| TP53 | 0.7 | 4.9E−05 | 4.9E−06 | 0.5 | 9.2E−04 | 1.0E−04 | 5.0E−03 |
| BMPER | 0.4 | 5.4E−05 | 5.5E−06 | 0.5 | 7.1E−05 | 1.7E−06 | 6.1E−04 |
| EFNB2 | −0.5 | 5.4E−05 | 5.5E−06 | −0.4 | 4.1E−03 | 7.5E−04 | 3.8E−02 |
| IDUA | 0.7 | 6.0E−05 | 6.2E−06 | 0.7 | 2.3E−04 | 9.7E−06 | 1.1E−03 |
| SFRP1 | −1.0 | 6.0E−05 | 6.2E−06 | −1.0 | 4.7E−04 | 3.4E−05 | 3.0E−02 |
| BMP6 | −1.1 | 6.3E−05 | 6.5E−06 | −0.9 | 2.6E−03 | 4.2E−04 | 1.8E−03 |
| LYN (Duplicate 2/2) | 1.5 | 6.3E−05 | 6.5E−06 | 1.0 | 1.5E−02 | 4.3E−03 | 9.4E−05 |
| CA13 | 2.1 | 6.5E−05 | 6.9E−06 | 2.2 | 2.2E−04 | 8.2E−06 | 5.3E−02 |
| RAC3 | 0.9 | 6.5E−05 | 6.9E−06 | 0.9 | 1.4E−03 | 2.0E−04 | 9.4E−06 |
| TKT | 1.2 | 6.5E−05 | 6.9E−06 | 1.2 | 1.6E−03 | 2.3E−04 | 6.3E−03 |
| NCK1 | 0.5 | 6.8E−05 | 7.3E−06 | 0.4 | 1.5E−02 | 4.3E−03 | 1.1E−01 |
| MDM2 | 0.3 | 7.1E−05 | 7.8E−06 | 0.3 | 3.8E−04 | 2.3E−05 | 2.4E−04 |
| SIGLEC7 | −0.4 | 7.2E−05 | 8.0E−06 | −0.4 | 3.6E−04 | 2.1E−05 | 1.3E−01 |
| TGFB3 | 0.4 | 7.2E−05 | 8.0E−06 | 0.5 | 3.6E−04 | 2.1E−05 | 9.9E−04 |
| PLXNB2 | −0.5 | 7.3E−05 | 8.2E−06 | −0.3 | 4.2E−02 | 1.5E−02 | 4.1E−03 |
| RPS27A | 1.3 | 7.3E−05 | 8.2E−06 | 1.2 | 3.4E−03 | 6.0E−04 | 3.0E−03 |
| BCL2 | 0.6 | 7.5E−05 | 8.7E−06 | 0.6 | 8.4E−04 | 9.1E−05 | 1.9E−05 |
| CASP3 | 1.0 | 7.5E−05 | 8.7E−06 | 0.8 | 2.4E−03 | 3.7E−04 | 2.0E−04 |
| COL23A1 | 0.4 | 7.5E−05 | 8.7E−06 | 0.6 | 5.7E−05 | 2.6E−07 | 4.4E−02 |
| F2 (Duplicate 1/2) | −0.9 | 7.5E−05 | 8.7E−06 | −0.9 | 4.9E−04 | 3.9E−05 | 1.3E−04 |
| DSG2 | −0.5 | 7.8E−05 | 9.2E−06 | −0.5 | 2.5E−04 | 1.1E−05 | 4.3E−04 |
| HK2 | 1.7 | 7.8E−05 | 9.2E−06 | 1.4 | 9.2E−03 | 2.2E−03 | 6.7E−06 |
| PTPN1 | 0.8 | 7.8E−05 | 9.2E−06 | 0.5 | 4.8E−03 | 9.3E−04 | 6.8E−03 |
| CHST2 | 0.5 | 8.0E−05 | 9.8E−06 | 0.5 | 1.0E−03 | 1.4E−04 | 3.5E−05 |
| CLEC7A | 0.3 | 8.0E−05 | 9.8E−06 | 0.3 | 6.9E−05 | 1.4E−06 | 1.1E−03 |
| F2 (Duplicate 2/2) | −1.1 | 8.0E−05 | 9.8E−06 | −1.1 | 7.7E−04 | 7.9E−05 | 2.9E−03 |
| PPIA | 0.9 | 8.0E−05 | 9.8E−06 | 0.8 | 3.4E−03 | 6.0E−04 | 3.5E−02 |
| DNAJB1 | 0.3 | 8.4E−05 | 1.0E−05 | 0.2 | 6.9E−03 | 1.5E−03 | 6.7E−06 |
| IL3 | 0.5 | 8.8E−05 | 1.1E−05 | 0.4 | 2.9E−03 | 4.7E−04 | 8.2E−01 |
| SLAMF7 | −0.8 | 8.8E−05 | 1.1E−05 | −0.9 | 2.3E−04 | 9.7E−06 | 3.0E−02 |
| ACP1 | 1.4 | 9.2E−05 | 1.2E−05 | 1.3 | 1.2E−03 | 1.6E−04 | 3.5E−04 |
| SELP | 1.0 | 9.7E−05 | 1.2E−05 | 1.0 | 4.7E−04 | 3.4E−05 | 2.0E−01 |
LogFC is log fold change, FDR is false discovery rate.
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