Table 1.
Open in new tab

Proteins dysregulated in the CSF of patients versus controls (unmatched and matched)

Unmatched
KLS (n = 23); controls (n = 80)		Matched
KLS (n = 20); controls (n = 20)		Association with time of collection
ProteinlogFCFDRplogFCFDRpFDR
DKK4−1.432.5E−072.2E−10−1.443.8E−051.3E−072.7E−04
VWF−0.745.0E−071.1E−09−0.781.3E−041.1E−065.7E−02
GPI−1.735.0E−071.3E−09−1.916.1E−065.4E−091.6E−02
PGF−1.269.5E−073.4E−09−1.185.7E−041.6E−054.8E−02
C9−0.841.3E−065.7E−09−0.871.1E−047.6E−074.4E−02
IL17B−1.132.3E−061.2E−08−1.188.1E−055.0E−073.2E−02
TFPI−0.934.0E−062.8E−08−0.771.4E−037.9E−051.1E−02
TGFB20.784.0E−063.0E−080.962.3E−043.1E−062.4E−02
DKK1−0.644.0E−063.2E−08−0.696.5E−042.5E−051.6E−02
CCDC80−0.689.5E−068.5E−08−0.733.3E−045.8E−062.7E−03
IL340.599.8E−069.6E−080.727.4E−053.3E−071.7E−01
HGF−0.831.0E−051.3E−07−0.823.8E−048.2E−063.6E−02
PLA2G2A−1.201.0E−051.3E−07−1.253.8E−049.6E−062.7E−02
IGF10.681.0E−051.4E−070.851.3E−052.3E−086.7E−02
JAM20.351.0E−051.4E−070.283.8E−033.3E−045.2E−01
FABP3−0.571.5E−052.2E−07−0.668.1E−055.0E−074.4E−03
IL1RL1−1.351.9E−052.9E−07−1.458.2E−043.4E−051.1E−01
NXPH1−0.851.9E−053.1E−07−0.983.3E−045.8E−061.6E−02
INHBA−0.712.0E−053.5E−07−0.833.3E−045.8E−061.7E−01
LBP−1.492.0E−053.5E−07−1.653.0E−032.3E−042.4E−02
ITGAV ITGB5−0.492.6E−054.8E−07−0.585.7E−041.8E−055.1E−02
BGN−1.013.0E−055.9E−07−1.061.0E−035.2E−051.1E−01
IL27 EBI30.173.3E−056.7E−070.193.2E−044.9E−064.8E−02
TNFRSF6B−0.543.8E−058.1E−07−0.613.2E−032.5E−044.5E−02
CASP100.524.0E−058.9E−070.606.5E−042.3E−057.7E−02
GNLY−1.456.2E−051.4E−06−1.295.8E−036.0E−042.4E−02
SPARC0.666.5E−051.6E−060.843.8E−051.3E−071.6E−02
CD163−0.499.3E−052.3E−06−0.608.9E−043.9E−053.1E−02
Unmatched
KLS (n = 23); controls (n = 80)		Matched
KLS (n = 20); controls (n = 20)		Association with time of collection
ProteinlogFCFDRplogFCFDRpFDR
DKK4−1.432.5E−072.2E−10−1.443.8E−051.3E−072.7E−04
VWF−0.745.0E−071.1E−09−0.781.3E−041.1E−065.7E−02
GPI−1.735.0E−071.3E−09−1.916.1E−065.4E−091.6E−02
PGF−1.269.5E−073.4E−09−1.185.7E−041.6E−054.8E−02
C9−0.841.3E−065.7E−09−0.871.1E−047.6E−074.4E−02
IL17B−1.132.3E−061.2E−08−1.188.1E−055.0E−073.2E−02
TFPI−0.934.0E−062.8E−08−0.771.4E−037.9E−051.1E−02
TGFB20.784.0E−063.0E−080.962.3E−043.1E−062.4E−02
DKK1−0.644.0E−063.2E−08−0.696.5E−042.5E−051.6E−02
CCDC80−0.689.5E−068.5E−08−0.733.3E−045.8E−062.7E−03
IL340.599.8E−069.6E−080.727.4E−053.3E−071.7E−01
HGF−0.831.0E−051.3E−07−0.823.8E−048.2E−063.6E−02
PLA2G2A−1.201.0E−051.3E−07−1.253.8E−049.6E−062.7E−02
IGF10.681.0E−051.4E−070.851.3E−052.3E−086.7E−02
JAM20.351.0E−051.4E−070.283.8E−033.3E−045.2E−01
FABP3−0.571.5E−052.2E−07−0.668.1E−055.0E−074.4E−03
IL1RL1−1.351.9E−052.9E−07−1.458.2E−043.4E−051.1E−01
NXPH1−0.851.9E−053.1E−07−0.983.3E−045.8E−061.6E−02
INHBA−0.712.0E−053.5E−07−0.833.3E−045.8E−061.7E−01
LBP−1.492.0E−053.5E−07−1.653.0E−032.3E−042.4E−02
ITGAV ITGB5−0.492.6E−054.8E−07−0.585.7E−041.8E−055.1E−02
BGN−1.013.0E−055.9E−07−1.061.0E−035.2E−051.1E−01
IL27 EBI30.173.3E−056.7E−070.193.2E−044.9E−064.8E−02
TNFRSF6B−0.543.8E−058.1E−07−0.613.2E−032.5E−044.5E−02
CASP100.524.0E−058.9E−070.606.5E−042.3E−057.7E−02
GNLY−1.456.2E−051.4E−06−1.295.8E−036.0E−042.4E−02
SPARC0.666.5E−051.6E−060.843.8E−051.3E−071.6E−02
CD163−0.499.3E−052.3E−06−0.608.9E−043.9E−053.1E−02

LogFC is log fold change, FDR is false discovery rate.

Table 1.
Open in new tab

Proteins dysregulated in the CSF of patients versus controls (unmatched and matched)

Unmatched
KLS (n = 23); controls (n = 80)		Matched
KLS (n = 20); controls (n = 20)		Association with time of collection
ProteinlogFCFDRplogFCFDRpFDR
DKK4−1.432.5E−072.2E−10−1.443.8E−051.3E−072.7E−04
VWF−0.745.0E−071.1E−09−0.781.3E−041.1E−065.7E−02
GPI−1.735.0E−071.3E−09−1.916.1E−065.4E−091.6E−02
PGF−1.269.5E−073.4E−09−1.185.7E−041.6E−054.8E−02
C9−0.841.3E−065.7E−09−0.871.1E−047.6E−074.4E−02
IL17B−1.132.3E−061.2E−08−1.188.1E−055.0E−073.2E−02
TFPI−0.934.0E−062.8E−08−0.771.4E−037.9E−051.1E−02
TGFB20.784.0E−063.0E−080.962.3E−043.1E−062.4E−02
DKK1−0.644.0E−063.2E−08−0.696.5E−042.5E−051.6E−02
CCDC80−0.689.5E−068.5E−08−0.733.3E−045.8E−062.7E−03
IL340.599.8E−069.6E−080.727.4E−053.3E−071.7E−01
HGF−0.831.0E−051.3E−07−0.823.8E−048.2E−063.6E−02
PLA2G2A−1.201.0E−051.3E−07−1.253.8E−049.6E−062.7E−02
IGF10.681.0E−051.4E−070.851.3E−052.3E−086.7E−02
JAM20.351.0E−051.4E−070.283.8E−033.3E−045.2E−01
FABP3−0.571.5E−052.2E−07−0.668.1E−055.0E−074.4E−03
IL1RL1−1.351.9E−052.9E−07−1.458.2E−043.4E−051.1E−01
NXPH1−0.851.9E−053.1E−07−0.983.3E−045.8E−061.6E−02
INHBA−0.712.0E−053.5E−07−0.833.3E−045.8E−061.7E−01
LBP−1.492.0E−053.5E−07−1.653.0E−032.3E−042.4E−02
ITGAV ITGB5−0.492.6E−054.8E−07−0.585.7E−041.8E−055.1E−02
BGN−1.013.0E−055.9E−07−1.061.0E−035.2E−051.1E−01
IL27 EBI30.173.3E−056.7E−070.193.2E−044.9E−064.8E−02
TNFRSF6B−0.543.8E−058.1E−07−0.613.2E−032.5E−044.5E−02
CASP100.524.0E−058.9E−070.606.5E−042.3E−057.7E−02
GNLY−1.456.2E−051.4E−06−1.295.8E−036.0E−042.4E−02
SPARC0.666.5E−051.6E−060.843.8E−051.3E−071.6E−02
CD163−0.499.3E−052.3E−06−0.608.9E−043.9E−053.1E−02
Unmatched
KLS (n = 23); controls (n = 80)		Matched
KLS (n = 20); controls (n = 20)		Association with time of collection
ProteinlogFCFDRplogFCFDRpFDR
DKK4−1.432.5E−072.2E−10−1.443.8E−051.3E−072.7E−04
VWF−0.745.0E−071.1E−09−0.781.3E−041.1E−065.7E−02
GPI−1.735.0E−071.3E−09−1.916.1E−065.4E−091.6E−02
PGF−1.269.5E−073.4E−09−1.185.7E−041.6E−054.8E−02
C9−0.841.3E−065.7E−09−0.871.1E−047.6E−074.4E−02
IL17B−1.132.3E−061.2E−08−1.188.1E−055.0E−073.2E−02
TFPI−0.934.0E−062.8E−08−0.771.4E−037.9E−051.1E−02
TGFB20.784.0E−063.0E−080.962.3E−043.1E−062.4E−02
DKK1−0.644.0E−063.2E−08−0.696.5E−042.5E−051.6E−02
CCDC80−0.689.5E−068.5E−08−0.733.3E−045.8E−062.7E−03
IL340.599.8E−069.6E−080.727.4E−053.3E−071.7E−01
HGF−0.831.0E−051.3E−07−0.823.8E−048.2E−063.6E−02
PLA2G2A−1.201.0E−051.3E−07−1.253.8E−049.6E−062.7E−02
IGF10.681.0E−051.4E−070.851.3E−052.3E−086.7E−02
JAM20.351.0E−051.4E−070.283.8E−033.3E−045.2E−01
FABP3−0.571.5E−052.2E−07−0.668.1E−055.0E−074.4E−03
IL1RL1−1.351.9E−052.9E−07−1.458.2E−043.4E−051.1E−01
NXPH1−0.851.9E−053.1E−07−0.983.3E−045.8E−061.6E−02
INHBA−0.712.0E−053.5E−07−0.833.3E−045.8E−061.7E−01
LBP−1.492.0E−053.5E−07−1.653.0E−032.3E−042.4E−02
ITGAV ITGB5−0.492.6E−054.8E−07−0.585.7E−041.8E−055.1E−02
BGN−1.013.0E−055.9E−07−1.061.0E−035.2E−051.1E−01
IL27 EBI30.173.3E−056.7E−070.193.2E−044.9E−064.8E−02
TNFRSF6B−0.543.8E−058.1E−07−0.613.2E−032.5E−044.5E−02
CASP100.524.0E−058.9E−070.606.5E−042.3E−057.7E−02
GNLY−1.456.2E−051.4E−06−1.295.8E−036.0E−042.4E−02
SPARC0.666.5E−051.6E−060.843.8E−051.3E−071.6E−02
CD163−0.499.3E−052.3E−06−0.608.9E−043.9E−053.1E−02

LogFC is log fold change, FDR is false discovery rate.

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