Endocrinological and biochemical evaluation of the study population. Data are presented as mean ± s.d.
| . | Control (n = 30) . | CO AGHD (n = 20) . | P value . |
|---|---|---|---|
| IGF-1 (ng/mL) | 231.2 ± 66.9 | 51.0 ± 29.9 | <0.001 |
| IGF-1 SDS | 0.32 ± 0.80 | −4.62 ± 2.07 | <0.001 |
| ACTH (pg/mL) | 28.2 ± 16.6 | 29.2 ± 14.8 | 0.057 |
| Cortisol (μg/dL) | 13.2 ± 4.0 | 8.4 ± 5.6 | 0.003 |
| LH (IU/L) | 3.69 ± 1.44 | 0.45 ± 0.66 | <0.001 |
| FSH (IU/L) | 4.24 ± 1.76 | 0.88 ± 0.93 | <0.001 |
| T (ng/mL) | 4.66 ± 1.35 | 5.08 ± 1.73 | 0.334 |
| TSH (μIU/mL) | 1.947 ± 0.810 | 1.875 ± 1.027 | 0.783 |
| FT3 (pg/mL) | 3.30 ± 0.33 | 2.61 ± 0.57 | <0.001 |
| FT4 (ng/dL) | 1.39 ± 0.19 | 0.96 ± 0.25 | <0.001 |
| Glu (mmol/L) | 5.29 ± 0.40 | 4.94 ± 0.47 | 0.006 |
| HbA1c (%) | 5.14 ± 0.25 | 5.30 ± 0.15 | 0.106 |
| Hb (g/L) | 155.6 ± 12.3 | 141.5 ± 12.1 | <0.001 |
| ALT (U/L) | 26.2 ± 11.7 | 19.7 ± 9.7 | 0.038 |
| AST(U/L) | 21.6 ± 4.8 | 26.3 ± 8.6 | 0.005 |
| ALP (U/L) | 66.7 ± 13.3 | 148.7 ± 65.6 | <0.001 |
| Alb (g/L) | 48.5 ± 2.0 | 47.3 ± 2.9 | 0.083 |
| PA (mg/L) | 301.3 ± 40.1 | 229.8 ± 69.6 | <0.001 |
| Tbil (μmol/L) | 16.2 ± 6.3 | 12.8 ± 6.4 | 0.074 |
| Dbil (μmol/L) | 5.2 ± 2.1 | 4.2 ± 2.4 | 0.090 |
| Ca (mmol/L) | 2.36 ± 0.07 | 2.39 ± 0.07 | 0.115 |
| P (mmol/L) | 1.12 ± 0.12 | 1.43 ± 0.23 | <0.001 |
| 25 OHD (ng/mL) | 23.28 ± 8.03 | 21.58 ± 8.41 | 0.532 |
| PTH (pg/mL) | 41.63 ± 12.93 | 48.54 ± 25.95 | 0.275 |
| β-CTX (ng/mL) | 0.29 ± 0.13 | 0.72 ± 0.28 | <0.001 |
| Cr (μmol/L) | 82.6 ± 9.1 | 68.1 ± 14.8 | 0.001 |
| UA (μmol/L) | 360.9 ± 69.3 | 380.9 ± 78.6 | 0.350 |
| . | Control (n = 30) . | CO AGHD (n = 20) . | P value . |
|---|---|---|---|
| IGF-1 (ng/mL) | 231.2 ± 66.9 | 51.0 ± 29.9 | <0.001 |
| IGF-1 SDS | 0.32 ± 0.80 | −4.62 ± 2.07 | <0.001 |
| ACTH (pg/mL) | 28.2 ± 16.6 | 29.2 ± 14.8 | 0.057 |
| Cortisol (μg/dL) | 13.2 ± 4.0 | 8.4 ± 5.6 | 0.003 |
| LH (IU/L) | 3.69 ± 1.44 | 0.45 ± 0.66 | <0.001 |
| FSH (IU/L) | 4.24 ± 1.76 | 0.88 ± 0.93 | <0.001 |
| T (ng/mL) | 4.66 ± 1.35 | 5.08 ± 1.73 | 0.334 |
| TSH (μIU/mL) | 1.947 ± 0.810 | 1.875 ± 1.027 | 0.783 |
| FT3 (pg/mL) | 3.30 ± 0.33 | 2.61 ± 0.57 | <0.001 |
| FT4 (ng/dL) | 1.39 ± 0.19 | 0.96 ± 0.25 | <0.001 |
| Glu (mmol/L) | 5.29 ± 0.40 | 4.94 ± 0.47 | 0.006 |
| HbA1c (%) | 5.14 ± 0.25 | 5.30 ± 0.15 | 0.106 |
| Hb (g/L) | 155.6 ± 12.3 | 141.5 ± 12.1 | <0.001 |
| ALT (U/L) | 26.2 ± 11.7 | 19.7 ± 9.7 | 0.038 |
| AST(U/L) | 21.6 ± 4.8 | 26.3 ± 8.6 | 0.005 |
| ALP (U/L) | 66.7 ± 13.3 | 148.7 ± 65.6 | <0.001 |
| Alb (g/L) | 48.5 ± 2.0 | 47.3 ± 2.9 | 0.083 |
| PA (mg/L) | 301.3 ± 40.1 | 229.8 ± 69.6 | <0.001 |
| Tbil (μmol/L) | 16.2 ± 6.3 | 12.8 ± 6.4 | 0.074 |
| Dbil (μmol/L) | 5.2 ± 2.1 | 4.2 ± 2.4 | 0.090 |
| Ca (mmol/L) | 2.36 ± 0.07 | 2.39 ± 0.07 | 0.115 |
| P (mmol/L) | 1.12 ± 0.12 | 1.43 ± 0.23 | <0.001 |
| 25 OHD (ng/mL) | 23.28 ± 8.03 | 21.58 ± 8.41 | 0.532 |
| PTH (pg/mL) | 41.63 ± 12.93 | 48.54 ± 25.95 | 0.275 |
| β-CTX (ng/mL) | 0.29 ± 0.13 | 0.72 ± 0.28 | <0.001 |
| Cr (μmol/L) | 82.6 ± 9.1 | 68.1 ± 14.8 | 0.001 |
| UA (μmol/L) | 360.9 ± 69.3 | 380.9 ± 78.6 | 0.350 |
25 OHD, 25 hydroxyvitamin D; ACTH, adrenocorticotropic hormone; Alb, albumin; ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate aminotransferase; Ca, calcium; Cr, creatinine; Dbil, direct bilirubin; FSH, follicle stimulating hormone; FT3, free triiodothyronine; FT4, free thyroxine; Glu, glucose; Hb, hemoglobin; HbA1c, glycosylated hemoglobin; IGF-1, insulin like growth factor 1; LH, luteinizing hormone; P, phosphate; PA, prealbumin; PTH, parathyroid hormone; T, testosterone; Tbil, total bilirubin; TSH, thyroid stimulating hormone; UA, uric acid; β-CTX, β-C-terminal telopeptide region of collagen type 1.
Endocrinological and biochemical evaluation of the study population. Data are presented as mean ± s.d.
| . | Control (n = 30) . | CO AGHD (n = 20) . | P value . |
|---|---|---|---|
| IGF-1 (ng/mL) | 231.2 ± 66.9 | 51.0 ± 29.9 | <0.001 |
| IGF-1 SDS | 0.32 ± 0.80 | −4.62 ± 2.07 | <0.001 |
| ACTH (pg/mL) | 28.2 ± 16.6 | 29.2 ± 14.8 | 0.057 |
| Cortisol (μg/dL) | 13.2 ± 4.0 | 8.4 ± 5.6 | 0.003 |
| LH (IU/L) | 3.69 ± 1.44 | 0.45 ± 0.66 | <0.001 |
| FSH (IU/L) | 4.24 ± 1.76 | 0.88 ± 0.93 | <0.001 |
| T (ng/mL) | 4.66 ± 1.35 | 5.08 ± 1.73 | 0.334 |
| TSH (μIU/mL) | 1.947 ± 0.810 | 1.875 ± 1.027 | 0.783 |
| FT3 (pg/mL) | 3.30 ± 0.33 | 2.61 ± 0.57 | <0.001 |
| FT4 (ng/dL) | 1.39 ± 0.19 | 0.96 ± 0.25 | <0.001 |
| Glu (mmol/L) | 5.29 ± 0.40 | 4.94 ± 0.47 | 0.006 |
| HbA1c (%) | 5.14 ± 0.25 | 5.30 ± 0.15 | 0.106 |
| Hb (g/L) | 155.6 ± 12.3 | 141.5 ± 12.1 | <0.001 |
| ALT (U/L) | 26.2 ± 11.7 | 19.7 ± 9.7 | 0.038 |
| AST(U/L) | 21.6 ± 4.8 | 26.3 ± 8.6 | 0.005 |
| ALP (U/L) | 66.7 ± 13.3 | 148.7 ± 65.6 | <0.001 |
| Alb (g/L) | 48.5 ± 2.0 | 47.3 ± 2.9 | 0.083 |
| PA (mg/L) | 301.3 ± 40.1 | 229.8 ± 69.6 | <0.001 |
| Tbil (μmol/L) | 16.2 ± 6.3 | 12.8 ± 6.4 | 0.074 |
| Dbil (μmol/L) | 5.2 ± 2.1 | 4.2 ± 2.4 | 0.090 |
| Ca (mmol/L) | 2.36 ± 0.07 | 2.39 ± 0.07 | 0.115 |
| P (mmol/L) | 1.12 ± 0.12 | 1.43 ± 0.23 | <0.001 |
| 25 OHD (ng/mL) | 23.28 ± 8.03 | 21.58 ± 8.41 | 0.532 |
| PTH (pg/mL) | 41.63 ± 12.93 | 48.54 ± 25.95 | 0.275 |
| β-CTX (ng/mL) | 0.29 ± 0.13 | 0.72 ± 0.28 | <0.001 |
| Cr (μmol/L) | 82.6 ± 9.1 | 68.1 ± 14.8 | 0.001 |
| UA (μmol/L) | 360.9 ± 69.3 | 380.9 ± 78.6 | 0.350 |
| . | Control (n = 30) . | CO AGHD (n = 20) . | P value . |
|---|---|---|---|
| IGF-1 (ng/mL) | 231.2 ± 66.9 | 51.0 ± 29.9 | <0.001 |
| IGF-1 SDS | 0.32 ± 0.80 | −4.62 ± 2.07 | <0.001 |
| ACTH (pg/mL) | 28.2 ± 16.6 | 29.2 ± 14.8 | 0.057 |
| Cortisol (μg/dL) | 13.2 ± 4.0 | 8.4 ± 5.6 | 0.003 |
| LH (IU/L) | 3.69 ± 1.44 | 0.45 ± 0.66 | <0.001 |
| FSH (IU/L) | 4.24 ± 1.76 | 0.88 ± 0.93 | <0.001 |
| T (ng/mL) | 4.66 ± 1.35 | 5.08 ± 1.73 | 0.334 |
| TSH (μIU/mL) | 1.947 ± 0.810 | 1.875 ± 1.027 | 0.783 |
| FT3 (pg/mL) | 3.30 ± 0.33 | 2.61 ± 0.57 | <0.001 |
| FT4 (ng/dL) | 1.39 ± 0.19 | 0.96 ± 0.25 | <0.001 |
| Glu (mmol/L) | 5.29 ± 0.40 | 4.94 ± 0.47 | 0.006 |
| HbA1c (%) | 5.14 ± 0.25 | 5.30 ± 0.15 | 0.106 |
| Hb (g/L) | 155.6 ± 12.3 | 141.5 ± 12.1 | <0.001 |
| ALT (U/L) | 26.2 ± 11.7 | 19.7 ± 9.7 | 0.038 |
| AST(U/L) | 21.6 ± 4.8 | 26.3 ± 8.6 | 0.005 |
| ALP (U/L) | 66.7 ± 13.3 | 148.7 ± 65.6 | <0.001 |
| Alb (g/L) | 48.5 ± 2.0 | 47.3 ± 2.9 | 0.083 |
| PA (mg/L) | 301.3 ± 40.1 | 229.8 ± 69.6 | <0.001 |
| Tbil (μmol/L) | 16.2 ± 6.3 | 12.8 ± 6.4 | 0.074 |
| Dbil (μmol/L) | 5.2 ± 2.1 | 4.2 ± 2.4 | 0.090 |
| Ca (mmol/L) | 2.36 ± 0.07 | 2.39 ± 0.07 | 0.115 |
| P (mmol/L) | 1.12 ± 0.12 | 1.43 ± 0.23 | <0.001 |
| 25 OHD (ng/mL) | 23.28 ± 8.03 | 21.58 ± 8.41 | 0.532 |
| PTH (pg/mL) | 41.63 ± 12.93 | 48.54 ± 25.95 | 0.275 |
| β-CTX (ng/mL) | 0.29 ± 0.13 | 0.72 ± 0.28 | <0.001 |
| Cr (μmol/L) | 82.6 ± 9.1 | 68.1 ± 14.8 | 0.001 |
| UA (μmol/L) | 360.9 ± 69.3 | 380.9 ± 78.6 | 0.350 |
25 OHD, 25 hydroxyvitamin D; ACTH, adrenocorticotropic hormone; Alb, albumin; ALP, alkaline phosphatase; ALT, alanine transaminase; AST, aspartate aminotransferase; Ca, calcium; Cr, creatinine; Dbil, direct bilirubin; FSH, follicle stimulating hormone; FT3, free triiodothyronine; FT4, free thyroxine; Glu, glucose; Hb, hemoglobin; HbA1c, glycosylated hemoglobin; IGF-1, insulin like growth factor 1; LH, luteinizing hormone; P, phosphate; PA, prealbumin; PTH, parathyroid hormone; T, testosterone; Tbil, total bilirubin; TSH, thyroid stimulating hormone; UA, uric acid; β-CTX, β-C-terminal telopeptide region of collagen type 1.
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