Table 1 Open in new tab Mendelian...

		Inverse-variance weighted method	Maximum likelihood	MR-Egger regression	Median-based method
SBP	266	1.018	1.012–1.024	1E−08	<0.0001	1.019	1.012–1.025	<0.001	<0.0001	1.006	1.002–1.010	0.006	0.998	0.982–0.013	0.763	1.016	1.009–1.023	<0.001
DBP	345	1.026	1.016–1.035	1.5E−<0	<0.0001	1.027	1.016–1.037	<0.001	<0.0001	1.001	0.997–1.005	0.597	1.02	0.997–1.043	0.083	1.021	1.012–1.030	<0.001
PP	283	1.014	1.001–1.028	0.033	<0.0001	1.016	1.000–1.031	0.05	<0.0001	0.998	0.993–1.004	0.533	1.024	0.991–1.058	0.158	1.015	1.005–1.025	0.004

Inverse-variance weighted method

Maximum likelihood

MR-Egger regression

Median-based method

Intercept

Slope

BP trait

95% CI

P-value

P-value for heterogeneity

95% CI

P-value

P-value for heterogeneity

95% CI

P-value

95% CI

P-value

95% CI

P-value

SBP

266

1.018

1.012–1.024

1E−08

<0.0001

1.019

1.012–1.025

<0.001

<0.0001

1.006

1.002–1.010

0.006

0.998

0.982–0.013

0.763

1.016

1.009–1.023

<0.001

DBP

345

1.026

1.016–1.035

1.5E−<0

<0.0001

1.027

1.016–1.037

<0.001

<0.0001

1.001

0.997–1.005

0.597

1.02

0.997–1.043

0.083

1.021

1.012–1.030

<0.001

283

1.014

1.001–1.028

0.033

<0.0001

1.016

1.000–1.031

0.05

<0.0001

0.998

0.993–1.004

0.533

1.024

0.991–1.058

0.158

1.015

1.005–1.025

0.004

		Inverse-variance weighted method	Maximum likelihood	MR-Egger regression	Median-based method
SBP	266	1.018	1.012–1.024	1E−08	<0.0001	1.019	1.012–1.025	<0.001	<0.0001	1.006	1.002–1.010	0.006	0.998	0.982–0.013	0.763	1.016	1.009–1.023	<0.001
DBP	345	1.026	1.016–1.035	1.5E−<0	<0.0001	1.027	1.016–1.037	<0.001	<0.0001	1.001	0.997–1.005	0.597	1.02	0.997–1.043	0.083	1.021	1.012–1.030	<0.001
PP	283	1.014	1.001–1.028	0.033	<0.0001	1.016	1.000–1.031	0.05	<0.0001	0.998	0.993–1.004	0.533	1.024	0.991–1.058	0.158	1.015	1.005–1.025	0.004

Table 1

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Mendelian randomization estimates between blood pressure traits and atrial fibrillation

		Inverse-variance weighted method				Maximum likelihood				MR-Egger regression						Median-based method
										Intercept			Slope
BP trait	Ν	OR	95% CI	P-value	P-value for heterogeneity	OR	95% CI	P-value	P-value for heterogeneity	OR	95% CI	P-value	OR	95% CI	P-value	OR	95% CI	P-value
SBP	266	1.018	1.012–1.024	1E−08	<0.0001	1.019	1.012–1.025	<0.001	<0.0001	1.006	1.002–1.010	0.006	0.998	0.982–0.013	0.763	1.016	1.009–1.023	<0.001
DBP	345	1.026	1.016–1.035	1.5E−<0	<0.0001	1.027	1.016–1.037	<0.001	<0.0001	1.001	0.997–1.005	0.597	1.02	0.997–1.043	0.083	1.021	1.012–1.030	<0.001
PP	283	1.014	1.001–1.028	0.033	<0.0001	1.016	1.000–1.031	0.05	<0.0001	0.998	0.993–1.004	0.533	1.024	0.991–1.058	0.158	1.015	1.005–1.025	0.004

		Inverse-variance weighted method				Maximum likelihood				MR-Egger regression						Median-based method
										Intercept			Slope
BP trait	Ν	OR	95% CI	P-value	P-value for heterogeneity	OR	95% CI	P-value	P-value for heterogeneity	OR	95% CI	P-value	OR	95% CI	P-value	OR	95% CI	P-value
SBP	266	1.018	1.012–1.024	1E−08	<0.0001	1.019	1.012–1.025	<0.001	<0.0001	1.006	1.002–1.010	0.006	0.998	0.982–0.013	0.763	1.016	1.009–1.023	<0.001
DBP	345	1.026	1.016–1.035	1.5E−<0	<0.0001	1.027	1.016–1.037	<0.001	<0.0001	1.001	0.997–1.005	0.597	1.02	0.997–1.043	0.083	1.021	1.012–1.030	<0.001
PP	283	1.014	1.001–1.028	0.033	<0.0001	1.016	1.000–1.031	0.05	<0.0001	0.998	0.993–1.004	0.533	1.024	0.991–1.058	0.158	1.015	1.005–1.025	0.004

BP, blood pressure; CI, confidence interval; DBP, diastolic blood pressure; MR, mendelian randomization; OR, odds ratio; PP, pulse pressure; SBP, systolic blood pressure; SNPs, single-nucleotide polymorphisms; Ν, # of SNPs used in MR.

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