Table 2.
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Risk Factors for Paradoxical TB-IRIS in HIV-Uninfected Patients [5, 6]

  • Disseminated tuberculosis

  • Extrapulmonary tuberculosis

  • Lymph node tuberculosis

  • Previous MTB exposure

  • Use of corticosteroids at the time of TB diagnosis

  • Anemia (Hb <10.5 g/dL)

  • Lymphopenia (ALC <1000 cells/mm3) at the time of TB diagnosis

  • Rapid increase in lymphocyte count during paradoxical IRIS response

  • Disseminated tuberculosis

  • Extrapulmonary tuberculosis

  • Lymph node tuberculosis

  • Previous MTB exposure

  • Use of corticosteroids at the time of TB diagnosis

  • Anemia (Hb <10.5 g/dL)

  • Lymphopenia (ALC <1000 cells/mm3) at the time of TB diagnosis

  • Rapid increase in lymphocyte count during paradoxical IRIS response

Abbreviations: ALC, absolute lymphocyte count; Hb, hemoglobin; IRIS, immune reconstitution inflammatory syndrome; MTB, Mycobacterium tuberculosis; TB, tuberculosis; TB-IRIS, immune reconstitution inflammatory syndrome to tuberculosis.

Table 2.
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Risk Factors for Paradoxical TB-IRIS in HIV-Uninfected Patients [5, 6]

  • Disseminated tuberculosis

  • Extrapulmonary tuberculosis

  • Lymph node tuberculosis

  • Previous MTB exposure

  • Use of corticosteroids at the time of TB diagnosis

  • Anemia (Hb <10.5 g/dL)

  • Lymphopenia (ALC <1000 cells/mm3) at the time of TB diagnosis

  • Rapid increase in lymphocyte count during paradoxical IRIS response

  • Disseminated tuberculosis

  • Extrapulmonary tuberculosis

  • Lymph node tuberculosis

  • Previous MTB exposure

  • Use of corticosteroids at the time of TB diagnosis

  • Anemia (Hb <10.5 g/dL)

  • Lymphopenia (ALC <1000 cells/mm3) at the time of TB diagnosis

  • Rapid increase in lymphocyte count during paradoxical IRIS response

Abbreviations: ALC, absolute lymphocyte count; Hb, hemoglobin; IRIS, immune reconstitution inflammatory syndrome; MTB, Mycobacterium tuberculosis; TB, tuberculosis; TB-IRIS, immune reconstitution inflammatory syndrome to tuberculosis.

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