Table 1.
Open in new tab

Criteria for Diagnosing Paradoxical TB-IRIS [1]

  • Initial improvement in TB symptoms and/or radiographic findings after initiation of TB treatment

AND

  • Recrudescence of TB symptoms and/or radiographic findings OR development of new lesions during or after TB treatment

AND

  • Exclusion of other potential causes of clinical worsening:

    • Poor medication adherence

    • Medication reaction

    • Inadequate treatment course

    • Re-infection with TB

    • Relapsed infection with TB

    • Secondary infection

    • Malabsorption

    • Drug resistance

  • Initial improvement in TB symptoms and/or radiographic findings after initiation of TB treatment

AND

  • Recrudescence of TB symptoms and/or radiographic findings OR development of new lesions during or after TB treatment

AND

  • Exclusion of other potential causes of clinical worsening:

    • Poor medication adherence

    • Medication reaction

    • Inadequate treatment course

    • Re-infection with TB

    • Relapsed infection with TB

    • Secondary infection

    • Malabsorption

    • Drug resistance

Abbreviations: TB, tuberculosis; TB-IRIS, immune reconstitution inflammatory syndrome to tuberculosis.

Table 1.
Open in new tab

Criteria for Diagnosing Paradoxical TB-IRIS [1]

  • Initial improvement in TB symptoms and/or radiographic findings after initiation of TB treatment

AND

  • Recrudescence of TB symptoms and/or radiographic findings OR development of new lesions during or after TB treatment

AND

  • Exclusion of other potential causes of clinical worsening:

    • Poor medication adherence

    • Medication reaction

    • Inadequate treatment course

    • Re-infection with TB

    • Relapsed infection with TB

    • Secondary infection

    • Malabsorption

    • Drug resistance

  • Initial improvement in TB symptoms and/or radiographic findings after initiation of TB treatment

AND

  • Recrudescence of TB symptoms and/or radiographic findings OR development of new lesions during or after TB treatment

AND

  • Exclusion of other potential causes of clinical worsening:

    • Poor medication adherence

    • Medication reaction

    • Inadequate treatment course

    • Re-infection with TB

    • Relapsed infection with TB

    • Secondary infection

    • Malabsorption

    • Drug resistance

Abbreviations: TB, tuberculosis; TB-IRIS, immune reconstitution inflammatory syndrome to tuberculosis.

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