| No. . | Initial Regimen . | Comment . | Duration of Therapy, d . | Treatment Failure . | Rejection After Treatment . | Outcome . |
|---|---|---|---|---|---|---|
| 1 | Clarithromycin, levofloxacin, and tigecycline | After initial treatment, tigecycline caused transaminitis and levofloxacin was stopped based on susceptibility result. But treatment was terminated in about 25 d because it was thought that M abscessus was contaminated. | 25 | No | Yes | Alive |
| 2 | Not treated | Not treated | Not treated | No | Yes | Alive |
| 3 | Azithromycin, cefoxitin, and tigecycline | Initial regimen was continued for 3 mo, and then it was stepped down to azithromycin and tigecycline. | 297 | No | Yes | Dead |
| 4 | Azithromycin, imipenem-cilastatin, and tigecycline | After the initial treatment was started, imipenem-cilastatin was switched to cefoxitin 2 d later. Then the patient was discharged to other facility and there was no further follow-up in our system. | NA | NA | NA | NA |
| 5 | Not treated | Not treated | Not treated | No | No | Alive |
| 6 | Not treated | Not treated | Not treated | No | No | Alive |
| 7 | Azithromycin, cefoxitin, and tigecycline | Initial treatment was continued without any significant side effect. | 20 | No | No | Dead |
| 8 | Azithromycin, cefoxitin, and tigecycline | Initial regimen was switched to azithromycin, imipenem-cilastatin, and cefoxitin because of transaminitis. The patient had been on the 3 medications for 8 mo and then azithromycin and imipenem-cilastatin were continued additional 10 mo for relapse. | 523 | No | Yes | Alive |
| 9 | Not treated | The patient was not treated as infection. Azithromycin was given as prophylaxis. | 202 | No | Yes | Alive |
| 10 | Not treated | Not treated | Not treated | No | Yes | Alive |
| 11 | Azithromycin, cefoxitin, and tigecycline | The initial regimen was switched to azithromycin, imipenem-cilastatin, and linezolid in 4 d. But the further information was missing. | NA | No | No | Alive |
| 12 | Azithromycin, imipenem-cilastatin, and cefoxitin | The initial regimen was switched to azithromycin, tigecycline, and amikacin. The patient died of the event not related to M abscessus infection. | 87 | Yes | No | Dead |
| 13 | Azithromycin, cefoxitin, and amikacin | After the initial treatment, amikacin was stopped in 1 mo, then the regimen was switched to azithromycin, cefoxitin, and tigecycline. The treatment was stopped in 4 mo. After the treatment, the infection relapsed. | 136 | No | Yes | Dead |
| 14 | Azithromycin, cefoxitin, and tigecycline | The initial treatment was switched to azithromycin, imipenem-cilastatin, and inhaled amikacin because tigecycline caused transaminitis and imipenem-cilastatin was started for treating Achromobacter infection. | 184 | Yes | No | Alive |
| 15 | Azithromycin, cefoxitin, and amikacin | The initial treatment was switched to azithromycin, cefoxitin, and tigecycline because amikacin caused hearing loss. After that, tigecycline caused transaminitis and it was switched to inhale amikacin. Inhale amikacin was complicated with bronchospasm. | 186 | No | No | Alive |
| 16 | Azithromycin, cefoxitin, and tigecycline | The initial regimen was continued, but tigecycline caused nausea and vomiting. Then the dose of tigecycline was decreased, but it caused transaminitis. The regimen was switched to azithromycin, cefoxitin, and inhaled amikacin. | 220 | No | Yes | Alive |
| 17 | Azithromycin, imipenem-cilastatin, and tigecycline | The initial regimen was complicated with transaminitis likely due to azithromycin and/or tigecycline, and it was switched to inhaled amikacin, imipenem-cilastatin and linezolid. After that, inhaled amikacin was stopped because of worsening respiratory status, and linezolid caused thrombocytopenia. Imipenem-cilastatin and azithromycin were continued. | 296 | Yes | No | Alive |
| 18 | Clarithromycin, tigecycline, and amikacin | After the initial treatment, clarithromycin was switched to azithromycin and tigecycline was switched to cefoxitin due to pancreatitis. And amikacin was stopped because of acute kidney injury. Meantime cefoxitin was initiated but finally clofazimine and imipenem-cilastatin were continued. | 91 | Yes | No | Dead |
| 19 | Not treated | Not treated | Not treated | NA | No | Alive |
| 20 | Not treated | Not treated | Not treated | NA | No | Alive |
| No. . | Initial Regimen . | Comment . | Duration of Therapy, d . | Treatment Failure . | Rejection After Treatment . | Outcome . |
|---|---|---|---|---|---|---|
| 1 | Clarithromycin, levofloxacin, and tigecycline | After initial treatment, tigecycline caused transaminitis and levofloxacin was stopped based on susceptibility result. But treatment was terminated in about 25 d because it was thought that M abscessus was contaminated. | 25 | No | Yes | Alive |
| 2 | Not treated | Not treated | Not treated | No | Yes | Alive |
| 3 | Azithromycin, cefoxitin, and tigecycline | Initial regimen was continued for 3 mo, and then it was stepped down to azithromycin and tigecycline. | 297 | No | Yes | Dead |
| 4 | Azithromycin, imipenem-cilastatin, and tigecycline | After the initial treatment was started, imipenem-cilastatin was switched to cefoxitin 2 d later. Then the patient was discharged to other facility and there was no further follow-up in our system. | NA | NA | NA | NA |
| 5 | Not treated | Not treated | Not treated | No | No | Alive |
| 6 | Not treated | Not treated | Not treated | No | No | Alive |
| 7 | Azithromycin, cefoxitin, and tigecycline | Initial treatment was continued without any significant side effect. | 20 | No | No | Dead |
| 8 | Azithromycin, cefoxitin, and tigecycline | Initial regimen was switched to azithromycin, imipenem-cilastatin, and cefoxitin because of transaminitis. The patient had been on the 3 medications for 8 mo and then azithromycin and imipenem-cilastatin were continued additional 10 mo for relapse. | 523 | No | Yes | Alive |
| 9 | Not treated | The patient was not treated as infection. Azithromycin was given as prophylaxis. | 202 | No | Yes | Alive |
| 10 | Not treated | Not treated | Not treated | No | Yes | Alive |
| 11 | Azithromycin, cefoxitin, and tigecycline | The initial regimen was switched to azithromycin, imipenem-cilastatin, and linezolid in 4 d. But the further information was missing. | NA | No | No | Alive |
| 12 | Azithromycin, imipenem-cilastatin, and cefoxitin | The initial regimen was switched to azithromycin, tigecycline, and amikacin. The patient died of the event not related to M abscessus infection. | 87 | Yes | No | Dead |
| 13 | Azithromycin, cefoxitin, and amikacin | After the initial treatment, amikacin was stopped in 1 mo, then the regimen was switched to azithromycin, cefoxitin, and tigecycline. The treatment was stopped in 4 mo. After the treatment, the infection relapsed. | 136 | No | Yes | Dead |
| 14 | Azithromycin, cefoxitin, and tigecycline | The initial treatment was switched to azithromycin, imipenem-cilastatin, and inhaled amikacin because tigecycline caused transaminitis and imipenem-cilastatin was started for treating Achromobacter infection. | 184 | Yes | No | Alive |
| 15 | Azithromycin, cefoxitin, and amikacin | The initial treatment was switched to azithromycin, cefoxitin, and tigecycline because amikacin caused hearing loss. After that, tigecycline caused transaminitis and it was switched to inhale amikacin. Inhale amikacin was complicated with bronchospasm. | 186 | No | No | Alive |
| 16 | Azithromycin, cefoxitin, and tigecycline | The initial regimen was continued, but tigecycline caused nausea and vomiting. Then the dose of tigecycline was decreased, but it caused transaminitis. The regimen was switched to azithromycin, cefoxitin, and inhaled amikacin. | 220 | No | Yes | Alive |
| 17 | Azithromycin, imipenem-cilastatin, and tigecycline | The initial regimen was complicated with transaminitis likely due to azithromycin and/or tigecycline, and it was switched to inhaled amikacin, imipenem-cilastatin and linezolid. After that, inhaled amikacin was stopped because of worsening respiratory status, and linezolid caused thrombocytopenia. Imipenem-cilastatin and azithromycin were continued. | 296 | Yes | No | Alive |
| 18 | Clarithromycin, tigecycline, and amikacin | After the initial treatment, clarithromycin was switched to azithromycin and tigecycline was switched to cefoxitin due to pancreatitis. And amikacin was stopped because of acute kidney injury. Meantime cefoxitin was initiated but finally clofazimine and imipenem-cilastatin were continued. | 91 | Yes | No | Dead |
| 19 | Not treated | Not treated | Not treated | NA | No | Alive |
| 20 | Not treated | Not treated | Not treated | NA | No | Alive |
Abbreviations: M abscessus, Mycobacterium abscessus; NA, not applicable.
| No. . | Initial Regimen . | Comment . | Duration of Therapy, d . | Treatment Failure . | Rejection After Treatment . | Outcome . |
|---|---|---|---|---|---|---|
| 1 | Clarithromycin, levofloxacin, and tigecycline | After initial treatment, tigecycline caused transaminitis and levofloxacin was stopped based on susceptibility result. But treatment was terminated in about 25 d because it was thought that M abscessus was contaminated. | 25 | No | Yes | Alive |
| 2 | Not treated | Not treated | Not treated | No | Yes | Alive |
| 3 | Azithromycin, cefoxitin, and tigecycline | Initial regimen was continued for 3 mo, and then it was stepped down to azithromycin and tigecycline. | 297 | No | Yes | Dead |
| 4 | Azithromycin, imipenem-cilastatin, and tigecycline | After the initial treatment was started, imipenem-cilastatin was switched to cefoxitin 2 d later. Then the patient was discharged to other facility and there was no further follow-up in our system. | NA | NA | NA | NA |
| 5 | Not treated | Not treated | Not treated | No | No | Alive |
| 6 | Not treated | Not treated | Not treated | No | No | Alive |
| 7 | Azithromycin, cefoxitin, and tigecycline | Initial treatment was continued without any significant side effect. | 20 | No | No | Dead |
| 8 | Azithromycin, cefoxitin, and tigecycline | Initial regimen was switched to azithromycin, imipenem-cilastatin, and cefoxitin because of transaminitis. The patient had been on the 3 medications for 8 mo and then azithromycin and imipenem-cilastatin were continued additional 10 mo for relapse. | 523 | No | Yes | Alive |
| 9 | Not treated | The patient was not treated as infection. Azithromycin was given as prophylaxis. | 202 | No | Yes | Alive |
| 10 | Not treated | Not treated | Not treated | No | Yes | Alive |
| 11 | Azithromycin, cefoxitin, and tigecycline | The initial regimen was switched to azithromycin, imipenem-cilastatin, and linezolid in 4 d. But the further information was missing. | NA | No | No | Alive |
| 12 | Azithromycin, imipenem-cilastatin, and cefoxitin | The initial regimen was switched to azithromycin, tigecycline, and amikacin. The patient died of the event not related to M abscessus infection. | 87 | Yes | No | Dead |
| 13 | Azithromycin, cefoxitin, and amikacin | After the initial treatment, amikacin was stopped in 1 mo, then the regimen was switched to azithromycin, cefoxitin, and tigecycline. The treatment was stopped in 4 mo. After the treatment, the infection relapsed. | 136 | No | Yes | Dead |
| 14 | Azithromycin, cefoxitin, and tigecycline | The initial treatment was switched to azithromycin, imipenem-cilastatin, and inhaled amikacin because tigecycline caused transaminitis and imipenem-cilastatin was started for treating Achromobacter infection. | 184 | Yes | No | Alive |
| 15 | Azithromycin, cefoxitin, and amikacin | The initial treatment was switched to azithromycin, cefoxitin, and tigecycline because amikacin caused hearing loss. After that, tigecycline caused transaminitis and it was switched to inhale amikacin. Inhale amikacin was complicated with bronchospasm. | 186 | No | No | Alive |
| 16 | Azithromycin, cefoxitin, and tigecycline | The initial regimen was continued, but tigecycline caused nausea and vomiting. Then the dose of tigecycline was decreased, but it caused transaminitis. The regimen was switched to azithromycin, cefoxitin, and inhaled amikacin. | 220 | No | Yes | Alive |
| 17 | Azithromycin, imipenem-cilastatin, and tigecycline | The initial regimen was complicated with transaminitis likely due to azithromycin and/or tigecycline, and it was switched to inhaled amikacin, imipenem-cilastatin and linezolid. After that, inhaled amikacin was stopped because of worsening respiratory status, and linezolid caused thrombocytopenia. Imipenem-cilastatin and azithromycin were continued. | 296 | Yes | No | Alive |
| 18 | Clarithromycin, tigecycline, and amikacin | After the initial treatment, clarithromycin was switched to azithromycin and tigecycline was switched to cefoxitin due to pancreatitis. And amikacin was stopped because of acute kidney injury. Meantime cefoxitin was initiated but finally clofazimine and imipenem-cilastatin were continued. | 91 | Yes | No | Dead |
| 19 | Not treated | Not treated | Not treated | NA | No | Alive |
| 20 | Not treated | Not treated | Not treated | NA | No | Alive |
| No. . | Initial Regimen . | Comment . | Duration of Therapy, d . | Treatment Failure . | Rejection After Treatment . | Outcome . |
|---|---|---|---|---|---|---|
| 1 | Clarithromycin, levofloxacin, and tigecycline | After initial treatment, tigecycline caused transaminitis and levofloxacin was stopped based on susceptibility result. But treatment was terminated in about 25 d because it was thought that M abscessus was contaminated. | 25 | No | Yes | Alive |
| 2 | Not treated | Not treated | Not treated | No | Yes | Alive |
| 3 | Azithromycin, cefoxitin, and tigecycline | Initial regimen was continued for 3 mo, and then it was stepped down to azithromycin and tigecycline. | 297 | No | Yes | Dead |
| 4 | Azithromycin, imipenem-cilastatin, and tigecycline | After the initial treatment was started, imipenem-cilastatin was switched to cefoxitin 2 d later. Then the patient was discharged to other facility and there was no further follow-up in our system. | NA | NA | NA | NA |
| 5 | Not treated | Not treated | Not treated | No | No | Alive |
| 6 | Not treated | Not treated | Not treated | No | No | Alive |
| 7 | Azithromycin, cefoxitin, and tigecycline | Initial treatment was continued without any significant side effect. | 20 | No | No | Dead |
| 8 | Azithromycin, cefoxitin, and tigecycline | Initial regimen was switched to azithromycin, imipenem-cilastatin, and cefoxitin because of transaminitis. The patient had been on the 3 medications for 8 mo and then azithromycin and imipenem-cilastatin were continued additional 10 mo for relapse. | 523 | No | Yes | Alive |
| 9 | Not treated | The patient was not treated as infection. Azithromycin was given as prophylaxis. | 202 | No | Yes | Alive |
| 10 | Not treated | Not treated | Not treated | No | Yes | Alive |
| 11 | Azithromycin, cefoxitin, and tigecycline | The initial regimen was switched to azithromycin, imipenem-cilastatin, and linezolid in 4 d. But the further information was missing. | NA | No | No | Alive |
| 12 | Azithromycin, imipenem-cilastatin, and cefoxitin | The initial regimen was switched to azithromycin, tigecycline, and amikacin. The patient died of the event not related to M abscessus infection. | 87 | Yes | No | Dead |
| 13 | Azithromycin, cefoxitin, and amikacin | After the initial treatment, amikacin was stopped in 1 mo, then the regimen was switched to azithromycin, cefoxitin, and tigecycline. The treatment was stopped in 4 mo. After the treatment, the infection relapsed. | 136 | No | Yes | Dead |
| 14 | Azithromycin, cefoxitin, and tigecycline | The initial treatment was switched to azithromycin, imipenem-cilastatin, and inhaled amikacin because tigecycline caused transaminitis and imipenem-cilastatin was started for treating Achromobacter infection. | 184 | Yes | No | Alive |
| 15 | Azithromycin, cefoxitin, and amikacin | The initial treatment was switched to azithromycin, cefoxitin, and tigecycline because amikacin caused hearing loss. After that, tigecycline caused transaminitis and it was switched to inhale amikacin. Inhale amikacin was complicated with bronchospasm. | 186 | No | No | Alive |
| 16 | Azithromycin, cefoxitin, and tigecycline | The initial regimen was continued, but tigecycline caused nausea and vomiting. Then the dose of tigecycline was decreased, but it caused transaminitis. The regimen was switched to azithromycin, cefoxitin, and inhaled amikacin. | 220 | No | Yes | Alive |
| 17 | Azithromycin, imipenem-cilastatin, and tigecycline | The initial regimen was complicated with transaminitis likely due to azithromycin and/or tigecycline, and it was switched to inhaled amikacin, imipenem-cilastatin and linezolid. After that, inhaled amikacin was stopped because of worsening respiratory status, and linezolid caused thrombocytopenia. Imipenem-cilastatin and azithromycin were continued. | 296 | Yes | No | Alive |
| 18 | Clarithromycin, tigecycline, and amikacin | After the initial treatment, clarithromycin was switched to azithromycin and tigecycline was switched to cefoxitin due to pancreatitis. And amikacin was stopped because of acute kidney injury. Meantime cefoxitin was initiated but finally clofazimine and imipenem-cilastatin were continued. | 91 | Yes | No | Dead |
| 19 | Not treated | Not treated | Not treated | NA | No | Alive |
| 20 | Not treated | Not treated | Not treated | NA | No | Alive |
Abbreviations: M abscessus, Mycobacterium abscessus; NA, not applicable.
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