| Suggested Analgesic Plans for Differing Pain Intensities . | ||
|---|---|---|
| Minimal to Mild Pain | Mild to Moderate Pain | Moderate to Severe Pain |
| Pre-operative: bupivacaine (1–2 mg/kg) local infiltration | Pre-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) | Pre-operative: lidocaine (2–4 mg/kg local infiltration) + long-lasting buprenorphine* once SQ |
| Post-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) every 6–12 h for 1 d, then as needed | Post-operative: carprofen (2–5 mg/kg SQ) once per day for 2 d, then as needed | |
| Pre-operative: lidocaine (2–4 mg/kg local infiltration) | Pre-operative: lidocaine (2–4 mg/kg local infiltration) + buprenorphine (0.05–0.1 mg/kg SQ/IP) | Pre-operative: bupivacaine (1–2 mg/kg local infiltration) + long-lasting buprenorphine* once SQ |
| Post-operative: carprofen (5–10 mg/kg SQ) once, then as needed | Post-operative: carprofen (2–5 mg/kg SQ) once per day for 2 d, then as needed | |
| Pre-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP); effective for 6–8 h | Pre-operative: bupivacaine (1–2 mg/kg local infiltration) + long-lasting buprenorphine* once SQ | Pre-operative: long-lasting buprenorphine* once SQ |
| Post-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) if needed after initial dose has worn off | ||
| Pre-operative: carprofen (5–10 mg/kg SQ) | ||
| Suggested Analgesic Plans for Differing Pain Intensities . | ||
|---|---|---|
| Minimal to Mild Pain | Mild to Moderate Pain | Moderate to Severe Pain |
| Pre-operative: bupivacaine (1–2 mg/kg) local infiltration | Pre-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) | Pre-operative: lidocaine (2–4 mg/kg local infiltration) + long-lasting buprenorphine* once SQ |
| Post-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) every 6–12 h for 1 d, then as needed | Post-operative: carprofen (2–5 mg/kg SQ) once per day for 2 d, then as needed | |
| Pre-operative: lidocaine (2–4 mg/kg local infiltration) | Pre-operative: lidocaine (2–4 mg/kg local infiltration) + buprenorphine (0.05–0.1 mg/kg SQ/IP) | Pre-operative: bupivacaine (1–2 mg/kg local infiltration) + long-lasting buprenorphine* once SQ |
| Post-operative: carprofen (5–10 mg/kg SQ) once, then as needed | Post-operative: carprofen (2–5 mg/kg SQ) once per day for 2 d, then as needed | |
| Pre-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP); effective for 6–8 h | Pre-operative: bupivacaine (1–2 mg/kg local infiltration) + long-lasting buprenorphine* once SQ | Pre-operative: long-lasting buprenorphine* once SQ |
| Post-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) if needed after initial dose has worn off | ||
| Pre-operative: carprofen (5–10 mg/kg SQ) | ||
Commonly used analgesic plans used in mice utilizing preemptive and multimodal analgesia that should be designed based on severity of pain. These can be used as a template and other drugs within a similar class utilized. IP = intraperitoneal; SQ = subcutaneous. *Long-acting buprenorphine formulations are suggested to be administered prior to surgical incision. The 2 currently available formulations of long-acting buprenorphine, Buprenorphine-SR & Ethiqa-XR, are recommended to be administered at 0.5 mg/kg and 3.25 mg/kg SQ and are advertised to provide analgesia for up to 72 hours.
| Suggested Analgesic Plans for Differing Pain Intensities . | ||
|---|---|---|
| Minimal to Mild Pain | Mild to Moderate Pain | Moderate to Severe Pain |
| Pre-operative: bupivacaine (1–2 mg/kg) local infiltration | Pre-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) | Pre-operative: lidocaine (2–4 mg/kg local infiltration) + long-lasting buprenorphine* once SQ |
| Post-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) every 6–12 h for 1 d, then as needed | Post-operative: carprofen (2–5 mg/kg SQ) once per day for 2 d, then as needed | |
| Pre-operative: lidocaine (2–4 mg/kg local infiltration) | Pre-operative: lidocaine (2–4 mg/kg local infiltration) + buprenorphine (0.05–0.1 mg/kg SQ/IP) | Pre-operative: bupivacaine (1–2 mg/kg local infiltration) + long-lasting buprenorphine* once SQ |
| Post-operative: carprofen (5–10 mg/kg SQ) once, then as needed | Post-operative: carprofen (2–5 mg/kg SQ) once per day for 2 d, then as needed | |
| Pre-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP); effective for 6–8 h | Pre-operative: bupivacaine (1–2 mg/kg local infiltration) + long-lasting buprenorphine* once SQ | Pre-operative: long-lasting buprenorphine* once SQ |
| Post-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) if needed after initial dose has worn off | ||
| Pre-operative: carprofen (5–10 mg/kg SQ) | ||
| Suggested Analgesic Plans for Differing Pain Intensities . | ||
|---|---|---|
| Minimal to Mild Pain | Mild to Moderate Pain | Moderate to Severe Pain |
| Pre-operative: bupivacaine (1–2 mg/kg) local infiltration | Pre-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) | Pre-operative: lidocaine (2–4 mg/kg local infiltration) + long-lasting buprenorphine* once SQ |
| Post-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) every 6–12 h for 1 d, then as needed | Post-operative: carprofen (2–5 mg/kg SQ) once per day for 2 d, then as needed | |
| Pre-operative: lidocaine (2–4 mg/kg local infiltration) | Pre-operative: lidocaine (2–4 mg/kg local infiltration) + buprenorphine (0.05–0.1 mg/kg SQ/IP) | Pre-operative: bupivacaine (1–2 mg/kg local infiltration) + long-lasting buprenorphine* once SQ |
| Post-operative: carprofen (5–10 mg/kg SQ) once, then as needed | Post-operative: carprofen (2–5 mg/kg SQ) once per day for 2 d, then as needed | |
| Pre-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP); effective for 6–8 h | Pre-operative: bupivacaine (1–2 mg/kg local infiltration) + long-lasting buprenorphine* once SQ | Pre-operative: long-lasting buprenorphine* once SQ |
| Post-operative: buprenorphine (0.05–0.1 mg/kg SQ/IP) if needed after initial dose has worn off | ||
| Pre-operative: carprofen (5–10 mg/kg SQ) | ||
Commonly used analgesic plans used in mice utilizing preemptive and multimodal analgesia that should be designed based on severity of pain. These can be used as a template and other drugs within a similar class utilized. IP = intraperitoneal; SQ = subcutaneous. *Long-acting buprenorphine formulations are suggested to be administered prior to surgical incision. The 2 currently available formulations of long-acting buprenorphine, Buprenorphine-SR & Ethiqa-XR, are recommended to be administered at 0.5 mg/kg and 3.25 mg/kg SQ and are advertised to provide analgesia for up to 72 hours.
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