Table 2 shows the pCR rates according to LAR and non-LAR groups for 13 neoadjuvant chemotherapy (NAC) treatment arms across seven clinical trials. Within the LAR group, the pCR response rates ranged from 13.3% to 45.5%, while within the non-LAR group, the pCR rates ranged from 35.6% to 71.7%. The sample size within the LAR group was small for many of the NAC treatment arms; however, in 11 of the 13 NAC treatment arms, the pCR rate was higher in the non-LAR group than in the LAR group. We performed a meta-analysis to summarize the LAR effect across the 13 NAC treatment arms, as measured by the odds ratio [non-LAR vs LAR]. A random-effects logit model was adopted [1]. In the model, the NAC treatment arm effects were treated as random as opposed to fixed to better capture the variability inherent in the system more realistically; furthermore, the model included random LAR effects such that the LAR effect was not constrained to be identical in each trial arm stratum. The odds ratio's expected or average value [95% CI] was 2.11 [1.33, 2.89]. There was strong evidence of a LAR effect such that within the non-LAR group, the odds of achieving a pCR was 2.11 times the odds within the LAR group