Table 1
Open in new tab

Mechanisms of action of trimetazidine

MechanismReferences
Inhibition of β-oxidation of free fatty acid3
Increased pyruvate dehydrogenase activity3,5,6
Increasing sarcolemma mechanical resistance8,9
Inhibiting apoptosis by increased miR-21 expression10
Reduced cardiac fibrosis by decreasing connective tissue growth factor (CTGF) expression in cardiac fibroblasts11
MechanismReferences
Inhibition of β-oxidation of free fatty acid3
Increased pyruvate dehydrogenase activity3,5,6
Increasing sarcolemma mechanical resistance8,9
Inhibiting apoptosis by increased miR-21 expression10
Reduced cardiac fibrosis by decreasing connective tissue growth factor (CTGF) expression in cardiac fibroblasts11
Table 1
Open in new tab

Mechanisms of action of trimetazidine

MechanismReferences
Inhibition of β-oxidation of free fatty acid3
Increased pyruvate dehydrogenase activity3,5,6
Increasing sarcolemma mechanical resistance8,9
Inhibiting apoptosis by increased miR-21 expression10
Reduced cardiac fibrosis by decreasing connective tissue growth factor (CTGF) expression in cardiac fibroblasts11
MechanismReferences
Inhibition of β-oxidation of free fatty acid3
Increased pyruvate dehydrogenase activity3,5,6
Increasing sarcolemma mechanical resistance8,9
Inhibiting apoptosis by increased miR-21 expression10
Reduced cardiac fibrosis by decreasing connective tissue growth factor (CTGF) expression in cardiac fibroblasts11
Close
This Feature Is Available To Subscribers Only

Sign In or Create an Account

Close

This PDF is available to Subscribers Only

View Article Abstract & Purchase Options

For full access to this pdf, sign in to an existing account, or purchase an annual subscription.

Close