The Correlation Between Clinical Features of GHPAs and the Expression of GTF2B and AIP mRNA
| Clinical features . | Number A (%, A/33) . | Low GTF2B mRNA expression (n = 16) a . | . | Low AIP mRNA expression (n = 16) b . | . |
|---|---|---|---|---|---|
| . | . | Number B (%, B/A) . | P value c . | Number C (%, C/A) . | P value c . |
| Age, years | |||||
| <42 | 16(48.48) | 8(43.75) | 0.849 | 9(37.50) | 0.387 |
| ≥42 | 17(51.52) | 8(47.06) | 7(41.18) | ||
| Sex | |||||
| Male | 14(42.42) | 9(57.14) | 0.247 | 7(50.00) | 0.881 |
| Female | 19(57.58) | 7(36.84) | 9(47.37) | ||
| Ki-67 (%) | |||||
| <3 | 21(63.64) | 7(33.33) | 0.021 | 6(28.57) | 0.002 |
| ≥3 | 12(36.36) | 9(75.00) | 10(83.33) | ||
| High graded | |||||
| No | 19(57.58) | 5(26.32) | 0.010 | 6(31.58) | 0.024 |
| Yes | 14(42.42) | 11(78.57) | 10(71.43) |
| Clinical features . | Number A (%, A/33) . | Low GTF2B mRNA expression (n = 16) a . | . | Low AIP mRNA expression (n = 16) b . | . |
|---|---|---|---|---|---|
| . | . | Number B (%, B/A) . | P value c . | Number C (%, C/A) . | P value c . |
| Age, years | |||||
| <42 | 16(48.48) | 8(43.75) | 0.849 | 9(37.50) | 0.387 |
| ≥42 | 17(51.52) | 8(47.06) | 7(41.18) | ||
| Sex | |||||
| Male | 14(42.42) | 9(57.14) | 0.247 | 7(50.00) | 0.881 |
| Female | 19(57.58) | 7(36.84) | 9(47.37) | ||
| Ki-67 (%) | |||||
| <3 | 21(63.64) | 7(33.33) | 0.021 | 6(28.57) | 0.002 |
| ≥3 | 12(36.36) | 9(75.00) | 10(83.33) | ||
| High graded | |||||
| No | 19(57.58) | 5(26.32) | 0.010 | 6(31.58) | 0.024 |
| Yes | 14(42.42) | 11(78.57) | 10(71.43) |
aThe median of relative GTF2B mRNA expression level is 0.033, so the number of low GTF2B mRNA expression is 16 (<0.033).
bThe median of relative AIP mRNA expression level is 0.06, so the number of low AIP mRNA expression is 16 (<0.06).
cAnalysis by chi-square test.
dThe grade classification is based on the criteria by Trouillas et al.19.
The Correlation Between Clinical Features of GHPAs and the Expression of GTF2B and AIP mRNA
| Clinical features . | Number A (%, A/33) . | Low GTF2B mRNA expression (n = 16) a . | . | Low AIP mRNA expression (n = 16) b . | . |
|---|---|---|---|---|---|
| . | . | Number B (%, B/A) . | P value c . | Number C (%, C/A) . | P value c . |
| Age, years | |||||
| <42 | 16(48.48) | 8(43.75) | 0.849 | 9(37.50) | 0.387 |
| ≥42 | 17(51.52) | 8(47.06) | 7(41.18) | ||
| Sex | |||||
| Male | 14(42.42) | 9(57.14) | 0.247 | 7(50.00) | 0.881 |
| Female | 19(57.58) | 7(36.84) | 9(47.37) | ||
| Ki-67 (%) | |||||
| <3 | 21(63.64) | 7(33.33) | 0.021 | 6(28.57) | 0.002 |
| ≥3 | 12(36.36) | 9(75.00) | 10(83.33) | ||
| High graded | |||||
| No | 19(57.58) | 5(26.32) | 0.010 | 6(31.58) | 0.024 |
| Yes | 14(42.42) | 11(78.57) | 10(71.43) |
| Clinical features . | Number A (%, A/33) . | Low GTF2B mRNA expression (n = 16) a . | . | Low AIP mRNA expression (n = 16) b . | . |
|---|---|---|---|---|---|
| . | . | Number B (%, B/A) . | P value c . | Number C (%, C/A) . | P value c . |
| Age, years | |||||
| <42 | 16(48.48) | 8(43.75) | 0.849 | 9(37.50) | 0.387 |
| ≥42 | 17(51.52) | 8(47.06) | 7(41.18) | ||
| Sex | |||||
| Male | 14(42.42) | 9(57.14) | 0.247 | 7(50.00) | 0.881 |
| Female | 19(57.58) | 7(36.84) | 9(47.37) | ||
| Ki-67 (%) | |||||
| <3 | 21(63.64) | 7(33.33) | 0.021 | 6(28.57) | 0.002 |
| ≥3 | 12(36.36) | 9(75.00) | 10(83.33) | ||
| High graded | |||||
| No | 19(57.58) | 5(26.32) | 0.010 | 6(31.58) | 0.024 |
| Yes | 14(42.42) | 11(78.57) | 10(71.43) |
aThe median of relative GTF2B mRNA expression level is 0.033, so the number of low GTF2B mRNA expression is 16 (<0.033).
bThe median of relative AIP mRNA expression level is 0.06, so the number of low AIP mRNA expression is 16 (<0.06).
cAnalysis by chi-square test.
dThe grade classification is based on the criteria by Trouillas et al.19.
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